504 research outputs found
The influence of the concentration of montmorillonite containing sorbent and pH of the culture medium on the antibiotic sensitivity of Escherichia coli, as well as the effect of ground on growth of Escherichia
The aim of this work was the comparative sensitivity test of E. coli to enrofloxacin and doxycycline and bactericidal action of montmorillonite containing sorbent and its combination with enrofloxacin, as well as the influence of the concentration of the enriched montmorillonite containing sorbent and pH of the culture medium on the antibiotic sensitivity of Escherichia coli. The sensitivity test of Escherichia coli to enrofloxacin, and the combination of enrofloxacin with sorbent was performd by the method of double serial dilutions of drugs in a liquid culture mediu
Influence of the enterosorbent on quality of eggs
In this article research the influence of natural montmorillonite containing sorbent used as a mineral supplement in animal feed in an amount of 30 g per 1 kg of sorbent feed on commercial quality table eggs at his dacha hens-layers. Found that feeding hensβ mineral feed additive reduces the toxic chemical elements in a chicken egg. It was found that the weight of the eggs in the experimental group compared to the control group, was significantly increased by 3,5% (p <0,05) after the completion of feeding the mineral sorbent. Despite the fact that in the control group, egg weight did not change and remained virtually unchange
ΠΠ½ΡΡΡΡΠΌΠ΅Π½ΡΡ ΠΊΠΎΠΌΠΌΠ΅ΡΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΈΠ½Π½ΠΎΠ²Π°ΡΠΈΠΉ: ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΠ° FMCG1
The research objective is in definition of the main tools participating in process of commercialization of grocery and marketing on the basis of expansion and deepening of the existing theory and methodology of commercialization, and also development of recommendations to improvement of tools that will promote finally to increase of efficiency of process of acceptance of a novelty by the market. Research is conducted on the basis of two-stage methodology including at the first stage carrying out questioning among the employees occupied in the course of commercialization in the large companies FMCG of the market, and at the second stage a case - research of two - players of the Russian market of juice. Confirmation of the made hypothesis that in most cases the innovations put on the market, can be considered grocery that is explainable that such innovations are capable to give to consumers essentially new advantages is result of research. The interrelation between stages of commercialization and the tools applied during this period is also confirmed. In the analysis of separate tools the tools informing the consumer on new products showed the greatest importance. Among them the special importance is played by TV advertizing. Practical application of results consists in identification tools for each of stages of commercialization of innovations the FMCG companies, and also those from them which play a paramount role on each of stages are defined.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π½Π°Β ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π²ΡΡ
ΡΡΠ°ΠΏΠ½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅ΠΉ Π½Π°Β ΠΏΠ΅ΡΠ²ΠΎΠΌ ΡΡΠ°ΠΏΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ΅Π΄ΠΈ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ², Π·Π°Π½ΡΡΡΡ
Π²Β ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΊΠΎΠΌΠΌΠ΅ΡΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π²Β ΠΊΡΡΠΏΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΡΡ
Π½Π°Β ΡΡΠ½ΠΊΠ΅ FMCG, Π°Β Π½Π°Β Π²ΡΠΎΡΠΎΠΌ ΡΡΠ°ΠΏΠ΅ β ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π²ΡΡ
ΠΈΠ³ΡΠΎΠΊΠΎΠ² ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠ³ΠΎ ΡΡΠ½ΠΊΠ° ΡΠΎΠΊΠΎΠ².ΠΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° Π³ΠΈΠΏΠΎΡΠ΅Π·Π° ΠΎΒ ΡΠΎΠΌ, ΡΡΠΎΒ Π²Β Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΠΈΠ½Π½ΠΎΠ²Π°ΡΠΈΠΈ ΠΌΠΎΠ³ΡΡ ΡΡΠΈΡΠ°ΡΡΡΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ²ΡΠΌΠΈ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΠΈΠΌΠ΅ΡΡ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½ΠΎ Π½ΠΎΠ²ΡΠ΅ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° Π΄Π»ΡΒ ΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»Π΅ΠΉ. Π’Π°ΠΊΠΆΠ΅ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠ°ΠΏΠ°ΠΌΠΈ ΠΊΠΎΠΌΠΌΠ΅ΡΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΈΒ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°ΠΌΠΈ, ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΠΌΠΈ Π²Β Π΄Π°Π½Π½ΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄. ΠΡΠΈΒ Π°Π½Π°Π»ΠΈΠ·Π΅ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΡΡ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΡ, ΠΈΠ½ΡΠΎΡΠΌΠΈΡΡΡΡΠΈΠ΅ ΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»Ρ ΠΎΒ Π½ΠΎΠ²ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠ°Ρ
. Π‘ΡΠ΅Π΄ΠΈ Π½ΠΈΡ
ΠΎΡΠΎΠ±ΡΡ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΠΈΠΌΠ΅Π΅Ρ ΡΠ΅Π»Π΅Π²ΠΈΠ·ΠΈΠΎΠ½Π½Π°Ρ ΡΠ΅ΠΊΠ»Π°ΠΌΠ°.ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΡ, ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΠ΅ Π²Β ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΊΠΎΠΌΠΌΠ΅ΡΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ²ΡΡ
ΠΈΒ ΠΌΠ°ΡΠΊΠ΅ΡΠΈΠ½Π³ΠΎΠ²ΡΡ
ΠΈΠ½Π½ΠΎΠ²Π°ΡΠΈΠΉ Π½Π°Β ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΡ ΠΈΒ ΡΠ³Π»ΡΠ±Π»Π΅Π½ΠΈΡ ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠ΅ΠΉ ΡΠ΅ΠΎΡΠΈΠΈ ΠΈΒ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠΎΠΌΠΌΠ΅ΡΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎΒ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ², ΡΡΠΎΒ Π²Β ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΠΌ ΠΈΡΠΎΠ³Π΅ Π±ΡΠ΄Π΅Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΏΡΠΈΠ½ΡΡΠΈΡ Π½ΠΎΠ²ΠΈΠ½ΠΊΠΈ ΡΡΠ½ΠΊΠΎΠΌ
Ubiquinol ameliorates endothelial dysfunction and increases expression of miRNA-34a in a rat model of pulmonary hypertension
In this research, we evaluate the effect of intravenously administrated solubilized ubiquinol on 4-week monocrotalin-induced pulmonary hypertension (PH) in rat
Research into in-service deterioration of ball-rolling rolls
This work features research findings on causes of deterioration occurring in ball-rolling rolls. The causes of such deterioration may originate not only in the excessive loads application and the use of bottleneck operating parameters but also in the specific process being implemented and the equipment used to heat-treat the rolling rolls. The deterioration occurring in roll flanges having a relatively small thickness was used to demonstrate that, to prevent the deterioration of ball-rolling roll flanges, the mill design must accommodate the minimum allowable flange widths obtained as a function of maximum allowable loads and the roll pass calculations. The next example of roll deterioration involved the use of a gas furnace to implement the heating stage of the quench hardening process for rolls made of 35KhGSA steel, which, as a result, developed roll deterioration. The use of rolls of the same steel grade, which were heat-treated in an arc furnace prior to being quenched, has been shown to deliver long-lasting positive results evidenced by many years of their operation. Rolls made of 5KhNM steel have also been shown to respond well to the heat treatment preceding the quenching process, but this time, the treatment was implemented in a gas furnace. Β© Published under licence by IOP Publishing Ltd
Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients
Background: The study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer. Methods: In 171 patients with non-small cell lung cancer (T1-4N0-3M0) in small-caliber bronchi taken at a distance of 3β5 cm from the tumor, various variants of morphological changes in the bronchial epithelium (basal cell hyperplasia (BCH), squamous cell metaplasia (SM), and dysplasia (D)) were assessed. Long-term results of treatment, namely, distant metastasis, were assessed after 2 and 5 years. Results: During the follow-up period, distant metastases were found in 35.1% (60/171) of patients. Most often, they were observed in patients of the high-risk group: BCH+SMβDβ(51.6%, 40/95) and BCHβSM+D+ (54.4%, 6/11). Less often, distant metastases were observed in low-risk group patients: BCH+SM+Dβ (6.7%, 3/45) and BCHβSMβDβ(10.0%, 2/20). Tumor size, grade, and stage were significant predictors of metastasis only in the high-risk group. The 5-year metastasis-free survival was better in the low-risk group of distant metastases. Conclusions: Isolated BCH or dysplasia in small bronchi distant from foci of tumor isassociated with a high-risk distant metastasis and less 5-year metastasis-free survival
ΠΠΠΠΠΠΠΠ‘ΠΠΠ― ΠΠΠΠΠ‘ΠΠΠΠΠ§ΠΠ‘ΠΠΠ― ΠΠΠΠΠΠΠ‘Π’ΠΠΠ Π ΠΠΠΠΠ₯ Π ΠΠ¦ΠΠΠΠΠΠ Π£ ΠΠΠΠ¬ΠΠ«Π₯, ΠΠΠΠ ΠΠ ΠΠΠΠΠΠ«Π₯ ΠΠ ΠΠΠΠΠΠ£ Π ΠΠΠ ΠΠΠΠΠΠΠ
The purpose of the study: to evaluate the effectiveness of postoperative management of the bronchial stump in lung cancer patients. material and methods. Forty-four patients with stage III lung cancer underwent endoscopic examination of the bronchial tree 3, 6, 9 and 12 months after surgery. The EVIS EXERAII and LUCERA videoendoscopic complexes with consistent use of white light mode, autofluorescence and narrow- spectrum mode were used. Endoscopic results were compared with morphological findings. Results. X-ray of the chest was negative for tumor recurrence in 3 (6.8 %) cases and early metachronous tumor of the trachea was revealed in 1 (2.3 %) case. The main endoscopic symptoms of early local recurrence in the bronchial stump were the marked lilac glow identified in the AFI mode and the mucosal vascular pattern deformation Timely diagnosis of recurrence allows a special treatment to be performed.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - ΠΎΡΠ΅Π½ΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΊΡΠ»ΡΡΠΈ ΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π±ΡΠΎΠ½Ρ
Π° Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π£ 44 Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ III ΡΡΠ°Π΄ΠΈΠΈ, Π² ΡΡΠΎΠΊΠΈ ΡΠ΅ΡΠ΅Π· 3, 6, 9 ΠΈ 12 ΠΌΠ΅Ρ ΠΏΠΎΡΠ»Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ΅ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΡΠ΅Π²Π° Π½Π° Π²ΠΈΠ΄Π΅ΠΎΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°Ρ
EVIS EXERAII ΠΈ LUCERA Ρ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΠΌ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ΅ΠΆΠΈΠΌΠ° Π±Π΅Π»ΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ°, Π°ΡΡΠΎΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ ΠΈ ΡΠ΅ΠΆΠΈΠΌΠ° ΡΠ·ΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΠΈ ΡΠΎΠΏΠΎΡΡΠ°Π²Π»ΡΠ»ΠΈ Ρ Π΄Π°Π½Π½ΡΠΌΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π 3 (6,8 %) ΡΠ»ΡΡΠ°ΡΡ
Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΡΠ°ΠΏΠ°Ρ
ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° Π±ΡΠ»ΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ½Π΅Π³Π°ΡΠΈΠ²Π½ΡΠ΅ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²Ρ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, Π² 1 (2,3 %) - ΡΠ°Π½Π½ΡΡ ΠΌΠ΅ΡΠ°Ρ
ΡΠΎΠ½Π½Π°Ρ ΠΎΠΏΡΡ
ΠΎΠ»Ρ ΡΡΠ°Ρ
Π΅ΠΈ. ΠΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΠΌΠΈ ΡΠ°Π½Π½ΠΈΡ
ΠΌΠ΅ΡΡΠ½ΡΡ
ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΎΠ² Π² ΠΊΡΠ»ΡΡΠ΅ ΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π±ΡΠΎΠ½Ρ
Π° ΡΠ²Π»ΡΡΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ΅ ΡΠΈΡΠ΅Π½Π΅Π²ΠΎΠ΅ ΡΠ²Π΅ΡΠ΅Π½ΠΈΠ΅, Π²ΡΡΠ²Π»ΡΠ΅ΠΌΠΎΠ΅ Π² ΡΠ΅ΠΆΠΈΠΌΠ΅ AFI, ΠΈ ΡΠ°Π·Π»ΠΈΡΠ½Π°Ρ Π΄Π΅ΡΠΎΡΠΌΠ°ΡΠΈΡ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠ³ΠΎ ΡΠΈΡΡΠ½ΠΊΠ° ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ. Π‘Π²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½Π°Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° ΡΠ΅ΡΠΈΠ΄ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΡΠΎΠ²Π΅ΡΡΠΈ ΡΠΏΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈ
ΠΠ ΠΠ ΠΠΠΠΠΠΠ‘Π’ΠΠ§ΠΠ‘ΠΠΠ ΠΠΠΠΠΠΠΠΠ― ΠΠ ΠΠΠ₯ΠΠΠΠ¬ΠΠΠΠ ΠΠΠΠ’ΠΠΠΠ― ΠΠ Π ΠΠΠΠ‘ΠΠΠΠΠΠ’ΠΠ§ΠΠΠ Π ΠΠΠ Π ΠΠΠΠΠΠΠΠ Π¦ΠΠΠΠΠ ΠΠΠΠΠΠΠ
The data on modern views on the problem of pre-cancerous changes (epithelial hyperplasia, squamous metaplasia, preneoplasia (dysplasia I) and neoplasia (dysplasia II-III) when squamous cell cancer and adenocarcinoma of the lung are summarizes in the present review. Atypical adenomatous hyperplasia, which is considered precancerous process for adenocarcinoma of the lung, due to the rare occurrence in the review is not considered. The attention is focused on the classification of morphological characteristics of precancerous changes in respiratory epithelium. The analysis of frequency and reversibility of preand neoplastic changes in bronchial epithelium. We discuss the connection between the nature of the changes of respiratory epithelium in the bronchi, developing simultaneously with squamous cell cancer or adenocarcinoma of the lung, with tumour progression.ΠΠ°ΡΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΠΉ ΠΈΠ½ΡΡΠΈΡΡΡ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ Π‘ΠΈΠ±ΠΈΡΡΠΊΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΡ Π ΠΠΠ, Π’ΠΎΠΌΡΠΊ, ΠΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΠΉ Π’ΠΎΠΌΡΠΊΠΈΠΉ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅Ρ, Π’ΠΎΠΌΡΠΊΠ Π½Π°ΡΡΠΎΡΡΠ΅ΠΌ ΠΎΠ±Π·ΠΎΡΠ΅ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Π²Π·Π³Π»ΡΠ΄Π°Ρ
Π½Π° ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΏΡΠ΅Π΄ΡΠ°ΠΊΠΎΠ²ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ (ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½Π°Ρ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ, ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½Π°Ρ ΠΌΠ΅ΡΠ°ΠΏΠ»Π°Π·ΠΈΡ, ΠΏΡΠ΅Π½Π΅ΠΎΠΏΠ»Π°Π·ΠΈΡ (Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΡ I ΡΡΠ΅ΠΏΠ΅Π½ΠΈ) ΠΈ Π½Π΅ΠΎΠΏΠ»Π°Π·ΠΈΡ (Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΠΈ IIβIII ΡΡΠ΅ΠΏΠ΅Π½ΠΈ)) ΠΏΡΠΈ ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΌ ΡΠ°ΠΊΠ΅ ΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ΅ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ. ΠΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠ°Ρ Π°Π΄Π΅Π½ΠΎΠΌΠ°ΡΠΎΠ·Π½Π°Ρ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ, ΡΡΠΈΡΠ°ΡΡΠ°ΡΡΡ ΠΏΡΠ΅Π΄ΡΠ°ΠΊΠΎΠ²ΡΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠΌ Π΄Π»Ρ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, Π² ΡΠΈΠ»Ρ ΡΠ΅Π΄ΠΊΠΎΠΉ Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΠΎΡΡΠΈ Π² ΠΎΠ±Π·ΠΎΡΠ΅ Π½Π΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ. ΠΠΊΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½ΠΎ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ, ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΡ ΠΏΡΠ΅Π΄ΡΠ°ΠΊΠΎΠ²ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΡΠ°ΡΡΠΎΡΡ Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΠΎΡΡΠΈ ΠΈ ΠΎΠ±ΡΠ°ΡΠΈΠΌΠΎΡΡΠΈ ΠΏΡΠ΅ΠΈ Π½Π΅ΠΎΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ. Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΡΠ²ΡΠ·Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ Π² Π±ΡΠΎΠ½Ρ
Π°Ρ
, ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠΈΡ
ΡΡ ΡΠΈΠ½Ρ
ΡΠΎΠ½Π½ΠΎ Ρ ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ ΠΈΠ»ΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠΎΠΉ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, Ρ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ
Π€Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠΎΡΠΈΠ»Ρ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠΎΠ½ΠΎΡΠΈΡΠ°ΡΠ½ΠΎ-ΠΌΠ°ΠΊΡΠΎΡΠ°Π³Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΄Π° Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ
The mechanism of the relationship between pretumor changes in the bronchial respiratory epithelium and the risk of progression of non-small cell lung cancer (NSCLC) remains unclear. It has been suggested that the relationship between reactive changes in the bronchial mucosa and NSCLC progression may be caused by the functional status of monocytic-macrophage cells as important participants in infammation, which determines both the risk of premalignant changes in the epithelium and malignant progression. The purpose of the study was to investigate the phenotypic profle of peripheral blood monocytes and macrophages induced from monocytes in vitro depending on the state of respiratory epithelium in NSCLC patients. Material and Methods. The study included 39 patients with newly diagnosed NSCLC. Based on the morphological examination of small bronchi taken at the distance of 3β5 cm from the tumor, patients were divided into the following groups depending on the type of pretumor changes: no pretumor changes (n=6), isolated basal cell hyperplasia (BCH) (n=13), combination of BCH and squamous metaplasia (SM) (n=3), combination of unchanged epithelium and focal BCH (n=17). The phenotypic features of peripheral blood monocytes and in vitro-induced macrophages were assessed before treatment using fow cytometry. Results. The state of the respiratory epithelium in NSCLC patients prior to the start of anticancer treatment was associated with the phenotypic features of peripheral blood monocytes, but not with the profle of macrophages induced from them. Distortion of the response of induced macrophages to the polarizing stimuli was observed in NSCLC patients: the cultured cells responded to both M1 and M2 inducers (LPS and IL-4, respectively) with a phenotype shift to M2, while the CD206 marker expression varied depending on the presence and type of pretumor changes. Conclusion. The phenotypic profle of peripheral blood monocytes was associated with the state of the respiratory epithelium in NSCLC patients before anti-tumor treatment, but not with the phenotypic features of induced macrophages.ΠΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΏΡΠ΅Π΄ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠΌ ΡΠΏΠΈΡΠ΅Π»ΠΈΠΈ Π±ΡΠΎΠ½Ρ
ΠΎΠ² Ρ ΡΠΈΡΠΊΠΎΠΌ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (ΠΠΠ Π) ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π΅ΡΡΠ½ΡΠΌ. ΠΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΡΡΡ, ΡΡΠΎ ΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ Π² ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΠ² ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΠΠ Π ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π° ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ ΡΡΠ°ΡΡΡΠΎΠΌ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠΎΠ½ΠΎΡΠΈΡΠ°ΡΠ½ΠΎ-ΠΌΠ°ΠΊΡΠΎΡΠ°Π³Π°Π»ΡΠ½ΠΎΠΉ Π»ΠΈΠ½ΠΈΠΈ, ΡΠ²Π»ΡΡΡΠΈΡ
ΡΡ Π²Π°ΠΆΠ½ΡΠΌΠΈ ΡΡΠ°ΡΡΠ½ΠΈΠΊΠ°ΠΌΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ ΠΊΠ°ΠΊ ΡΠΈΡΠΊ ΠΏΡΠ΅Π΄ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² ΡΠΏΠΈΡΠ΅Π»ΠΈΠΈ, ΡΠ°ΠΊ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ»Ρ ΠΌΠΎΠ½ΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ², ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΈΠ· ΠΌΠΎΠ½ΠΎΡΠΈΡΠΎΠ² in vitro, Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠΠ Π. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΎ 39 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΠΠ Π. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅Π»ΠΊΠΈΡ
Π±ΡΠΎΠ½Ρ
ΠΎΠ², Π²Π·ΡΡΡΡ
Π½Π° ΡΠ°ΡΡΡΠΎΡΠ½ΠΈΠΈ 3β5 ΡΠΌ ΠΎΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΠΏΡΠ΅Π΄ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π±ΠΎΠ»ΡΠ½ΡΠ΅ Π±ΡΠ»ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ Π½Π° ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ Π³ΡΡΠΏΠΏΡ: ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΏΡΠ΅Π΄ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ (n=6), ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ Π±Π°Π·Π°Π»ΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½Π°Ρ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ (ΠΠΠ) (n=13), ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ ΠΠΠ ΠΈ ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΌΠ΅ΡΠ°ΠΏΠ»Π°Π·ΠΈΠΈ (ΠΠ) (n=3), ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ Π½Π΅ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ ΠΈ ΠΎΡΠ°Π³ΠΎΠ²ΠΎΠΉ ΠΠΠ (n=17). ΠΡΠ΅Π½ΠΊΠ° ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΌΠΎΠ½ΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
in vitro ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ² ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ Π΄ΠΎ Π½Π°ΡΠ°Π»Π° ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΠΌΠ΅ΡΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π‘ΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠΠ Π Π΄ΠΎ Π½Π°ΡΠ°Π»Π° ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½ΠΎ Ρ ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ ΠΌΠΎΠ½ΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ, Π½ΠΎ Π½Π΅ Ρ ΠΏΡΠΎΡΠΈΠ»Π΅ΠΌ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΈΠ· Π½ΠΈΡ
ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ². Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠΠ Π ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΈΡΠΊΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΎΡΠ²Π΅ΡΠ° ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ² Π½Π° ΠΏΠΎΠ»ΡΡΠΈΠ·ΡΡΡΠΈΠ΅ ΡΡΠΈΠΌΡΠ»Ρ: ΠΊΠ°ΠΊ Π½Π° Π1-, ΡΠ°ΠΊ ΠΈ Π½Π° Π2-ΠΈΠ½Π΄ΡΠΊΡΠΎΡΡ (LPS ΠΈ IL-4, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ) ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΡΠ΅ΠΌΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΎΡΠ²Π΅ΡΠ°Π»ΠΈ ΡΠ΄Π²ΠΈΠ³ΠΎΠΌ ΡΠ΅Π½ΠΎΡΠΈΠΏΠ° Π² Π2-ΡΡΠΎΡΠΎΠ½Ρ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ° CD206 Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π»Π° Π² Π½Π΅ΠΊΠΎΡΠΎΡΠΎΠΌ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π½Π°Π»ΠΈΡΠΈΡ ΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΠΏΡΠ΅Π΄ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π€Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠΎΡΠΈΠ»Ρ ΠΌΠΎΠ½ΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½ Ρ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠΠ Π Π΄ΠΎ Π½Π°ΡΠ°Π»Π° ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ, Π½ΠΎ Π½Π΅ Ρ ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ².
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