Effects of bischofite gel on reparative processes in wound healing

The study showed that the best results were obtained with external use of the gel with bischofite. Actovegin has a less significant but pronounced reparative effect on this model. The least satisfactory results were obtained when applying Contractube

RATAN-600 7.6-cm Deep Sky Strip Surveys at the Declination of the SS433 Source During the 1980-1999 Period. Data Reduction and the Catalog of Radio Sources in the Right-Ascension Interval 7h < R.A. < 17h

We use two independent methods to reduce the data of the surveys made with RATAN-600 radio telescope at 7.6 cm in 1988-1999 at the declination of the SS433 source. We also reprocess the data of the "Cold" survey (1980-1981). The resulting RCR (RATAN COLD REFINED) catalog contains the right ascensions and fluxes of objects identified with those of the NVSS catalog in the right-ascension interval 7h < R.A. < 17h. We obtain the spectra of the radio sources and determine their spectral indices at 3.94 and 0.5 GHz. The spectra are based on the data from all known catalogs available from the CATS, Vizier, and NED databases, and the flux estimates inferred from the maps of the VLSS and GB6 surveys. For 245 of the 550 objects of the RCR catalog the fluxes are known at two frequencies only: 3.94 GHz (RCR) and 1.4 GHz (NVSS). These are mostly sources with fluxes smaller than 30 mJy. About 65% of these sources have flat or inverse spectra (alpha > -0.5). We analyze the reliability of the results obtained for the entire list of objects and construct the histograms of the spectral indices and fluxes of the sources. Our main conclusion is that all 10-15 mJy objects found in the considered right-ascension interval were already included in the decimeter-wave catalogs.Comment: 26 pages, 18 figure

Study of the Power Beam Pattern of RATAN-600 During the Deep RZF Survey (1998-2003)

This paper proposes a method for constructing an experimental power beam pattern (PB) of RATAN-600 based on the sample of NVSS sources observed in the process of a deep sky survey near local zenith. The data obtained from observations of radio sources at wave 7.6 cm in nine bands of the survey (the 2002 and 2003 sets) are used to construct vertical PB of the telescope at rather large offsets from the central horizontal section of the PB (+/-36'). The experimental PBs obtained using different methods are compared and the root-mean-square deviations of the experimental PB from the corresponding computed PB are determined. The stability of the power beam pattern in its central part (+/-6') during the RATAN-600 Zenith Field (RZF) survey (1998-2003) and the accuracies of the fluxes of the sources observed within the framework of this survey and included into the RZF catalog are estimated.Comment: 15 pages, 17 figure

Investigação do efeito reparador do gel de ectoína em modelo de queima térmica

Due to the ability to create complexes of water molecules on the surface of the mucous membrane, ectoine is a promising compound for the treatment of burns. In male rats (n=30), 2 thermal burns were counteracted under counter-anesthesia, one of which was treated by topical application of the test drugs for 7 days, and the other served as a control. On the 8th day, skin samples in the area of the burn were taken for morphological examination. Histological sections were then scored by independent experts. The best histological picture of thermally damaged tissues was demonstrated by animals receiving ectoine. A less significant, but pronounced reparative effect was observed in histological samples of the actovegin group. The least significant reparative effect was demonstrated by contractubex. Ectoine improved the histological picture, improved repair and reduced the inflammatory response of the tissues and can be recommended for further preclinical studies as a treatment for burns.Debido a la capacidad de crear complejos de moléculas de agua en la superficie de la membrana mucosa, la ectoina es un compuesto prometedor para el tratamiento de las quemaduras. En ratas macho (n = 30), 2 quemaduras térmicas se contrarrestaron con contraestesia, una de las cuales se trató mediante la aplicación tópica de los fármacos de prueba durante 7 días, y la otra sirvió como control. En el octavo día, se tomaron muestras de piel en el área de la quemadura para un examen morfológico. Las secciones histológicas fueron calificadas por expertos independientes. El mejor cuadro histológico de los tejidos dañados térmicamente fue demostrado por los animales que recibieron ectoína. Se observó un efecto reparador menos significativo, pero pronunciado en muestras histológicas del grupo actovegin. El efecto reparador menos significativo fue demostrado por contractubex. Ectoine mejoró el cuadro histológico, mejoró la reparación y redujo la respuesta inflamatoria de los tejidos y puede recomendarse para estudios preclínicos adicionales como tratamiento para las quemaduras.Devido à capacidade de criar complexos de moléculas de água na superfície da membrana mucosa, a ectoína é um composto promissor para o tratamento de queimaduras. Em ratos machos (n = 30), duas queimaduras térmicas foram combatidas sob anestesia, uma das quais foi tratada por aplicação tópica das drogas de teste por 7 dias, e a outra serviu como controle. No oitavo dia, amostras de pele na área da queimadura foram retiradas para exame morfológico. As secções histológicas foram então classificadas por especialistas independentes. O melhor quadro histológico dos tecidos termicamente lesados foi demonstrado pelos animais que receberam ectoína. Um efeito reparador menos significativo, mas pronunciado, foi observado em amostras histológicas do grupo da actovegina. O efeito reparador menos significativo foi demonstrado pelo contratoubex. Ectoine melhorou o quadro histológico, melhorou o reparo e reduziu a resposta inflamatória dos tecidos e pode ser recomendado para estudos pré-clínicos adicionais como tratamento para queimaduras

Catalog of Radio Galaxies with z>0.3. I:Construction of the Sample

The procedure of the construction of a sample of distant ($z>0.3$) radio galaxies using NED, SDSS, and CATS databases for further application in statistical tests is described. The sample is assumed to be cleaned from objects with quasar properties. Primary statistical analysis of the list is performed and the regression dependence of the spectral index on redshift is found.Comment: 9 pages, 6 figures, 2 table

Correlation properties of the maps of the NVSS survey and WMAP ILC

In this paper we study one-dimensional sections of the maps of WMAP ILC and of the NVSS survey on scale lengths of 0.75, 3, 4.5, and 6.75 degrees and analyze the correlation properties of the sections. On these maps we identify the domains where the absolute value of the correlation coefficient exceeds 0.5. The catalog of such domains is presented. It is shown that the number of the domains agrees with the number of such domains on simulated maps and this fact may be indicative of just statistical agreement of the arrangement of the domains considered.Comment: 8 pages, 2 figure

Multiband Study of Radio Sources of the RCR Catalogue with Virtual Observatory Tools

We present early results of our multiband study of the RATAN Cold Revised (RCR) catalogue obtained from seven cycles of the “Cold” survey carried with the RATAN-600 radio telescope at 7.6 cm in 1980-1999, at the declination of the SS 433 source. We used the 2MASS and LAS UKIDSS infrared surveys, the DSS-II and SDSS DR7 optical surveys, as well as the USNO-B1 and GSC-II catalogues, the VLSS, TXS, NVSS, FIRST and GB6 radio surveys to accumulate information about the sources. For radio sources that have no detectable optical candidate in optical or infrared catalogues, we additionally looked through images in several bands from the SDSS, LAS UKIDSS, DPOSS, 2MASS surveys and also used co-added frames in different bands. We reliably identified 76% of radio sources of the RCR catalogue. We used the ALADIN and SAOImage DS9 scripting capabilities, interoperability services of ALADIN and TOPCAT, and also other Virtual Observatory (VO) tools and resources, such as CASJobs, NED, Vizier, and WSA, for effective data access, visualization and analysis. Without VO tools it would have been problematic to perform our study

An Integrated Approach to the Management of a Multimorbid Patient with Atrial Fibrillation from the Standpoint of Modern Guidelines: Rivaroxaban is in Focus

Atrial fibrillation (AF) is a complex pathology that requires an integrated approach in both diagnosis and treatment, including optimal prevention of thrombosis, control of clinical symptoms, and identification and treatment of cardiovascular risk factors and comorbidities. The article analyzes some of the new positions of the recommendations of the European Society of Cardiology on atrial fibrillation, presented in 2020. Effective diagnostic and therapeutic approaches are discussed in the management of patients with AF in conditions of multimorbidity. The basic principles of the CC to ABC concept, introduced with the aim of improving a structured approach to the treatment of patients with AF, and the 4S-AF regimen necessary for decision on the use of oral anticoagulants, choosing a method of control of the rhythm and / or its frequency, choosing between ablation, cardioversion and antiarrhythmic drugs, as well as to determine the mode of treatment of major cardiovascular diseases. To improve the prognosis and achieve the best results in these patients, the most important is to reduce the risk of stroke, control cardiovascular risks and comorbidities, and ensure high adherence to the therapy within the framework of the concept of comprehensive patient protection. Rivaroxaban is considered by the authors of the article as one of the drugs that provides comprehensive anticoagulant protection of patients with AF. The efficacy profile of rivaroxaban in the prevention of acute cerebrovascular accident and high safety rates were confirmed in a population of multimorbid AF patients of different ages and the highest risk of stroke and / or bleeding

Результаты применения этравирина в течение 48 недель у пациентов в Санкт-Петербурге в реальной клинической практике

The aim of the work was to evaluate the efficacy, safety and tolerability of etravirine-containing regimens in patients with treatment experience in real clinical practice.Materials and methods. A retrospective analysis of 300 outpatient records of HIV-infected patients with treatment experience, which were converted to regimens containing etravirine (ETR) as the third component, was performed. The reasons for switching to ETR-containing regimens were adverse events, comorbidities, and virological failure. The main criterion for the effectiveness of the scheme was the proportion of patients with an undetectable level of viral load at 48 weeks of treatment. Additional criteria for evaluating the effectiveness and safety of the scheme were the dynamics of the number of CD4-lymphocytes, the frequency and nature of adverse reactions.Results. The proportion of patients with virologic suppression less than 50 kop/mL was 83% versus 77,3% at the time of switching (p&lt;0.005). The percentage of patients with CD4-lymphocytes level &gt;500 ctlls/um increased from 40,3% to 58%, and the percentage of patients with CD4 level &lt;200 cells/um decrease more than twice from 13% to 6% (p&lt;0.005). The mean level os ALT decreased significantly from 47,52±66,45 units/L to 42,65±55,18 units/L (p=0,019). The average level of total cholesterol decreased by 8.7% from 5,64±1,37 mmol/L to 5.15±0.98 mmol/L (p&lt;0,001). The average BMI after switching to ETR did not change and amounted to 24,07±4,07, 24,2±4,05, respectively (p=0,347).Conclusions. The results of this study confirm that etravirine is well tolerated and may be an option for patients who have HIV RNA suppression on ART but develop adverse reactions, and may also be part of a second-line ART regimen in patients who fail first-line regimen.Цель: оценка эффективности, безопасности и переносимости схем, содержащих этравирин, у пациентов с опытом лечения в реальной клинической практике.Материалы и методы. Проведен ретроспективный анализ 300 амбулаторных карт ВИЧ-инфицированных пациентов с опытом лечения, которые были переведены на схемы, содержащие в качестве 3-го компонента препарат этравирин (ETR, ETV). Причинами переключения на ETR-содержащие схемы были нежелательные явления, сопутствующие заболевания, а также вирусологическая неэффективность. Основным критерием эффективности схемы явилась доля пациентов с неопределяемым уровнем вирусной нагрузки на 48-й неделе лечения. Дополнительными критериями оценки эффективности и безопасности схемы являлись динамика количества CD4+-лимфоцитов, частота и характер нежелательных побочных реакций.Результаты. Доля пациентов с вирусологической супрессией менее 50 коп/мл составила 83% против 77,3% на момент переключения (p &lt;0,005). Доля пациентов, имеющих уровень CD4+-лимфоцитов более 500 кл/мкл., возросла с 40,3% до 58%, а доля пациентов, имеющих уровень CD4+-лимфоцитов менее 200 кл/мкл, уменьшилась более чем в 2 раза с 13% до 6% (p&lt;0,005). Получено достоверное снижение среднего уровня АЛТ с 47,52±66,45 Ед/л до 42,65±55,18 Ед/л (p=0,019). Средний уровень общего холестерина снизился на 8,7% с 5,64±1,37 ммоль/л до 5,15±0,98 ммоль/л (p&lt;0,001). Средний ИМТ после переключения на ETV не изменился и составил 24,07±4,07, 24,2±4,05 соответственно (p=0,347).Выводы. Результаты этого исследования подтверждают, что этравирин хорошо переносится и может быть вариантом для пациентов, у которых наблюдается супрессия РНК ВИЧ на АРТ, но развились побочные реакции, а также может стать частью схемы АРТ второго ряда у пациентов с неэффективностью схемы первого ряда