375 research outputs found

    Spatial Distribution of Disease-associated Variants in Three-dimensional Structures of Protein Complexes

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    Plant breeding evaluation of the red currant cultivar ‘Podarok Pobeditelyam’ and its inbred progeny

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    Background. Inbreeding, as a way to produce progenies from organisms in different degrees of kinship, is an important genetic and breeding technique used to improve various crops, including fruit and berry plants. Inbreeding has not been extensively used with red currant, so a study of the possibility to employ closely related crosses in breeding practice with this crop remains relevant. The purpose of this study was to assess the breeding potential of the red currant cultivar ‘Podarok Pobeditelyam’ by disclosing economic and biological characteristics in its inbred progeny.Methods and materials. The research was carried out at the red currant breeding site of the Russian Research Institute of Fruit Crop Breeding (VNIISPK, Orel) in 2016–2018. The seedlings obtained from the self-pollination of a new red currant cultivar, ‘Podarok Pobeditelyam’, were the objects of the study. Records and observations were carried out according to the program and methodology for breeding and variety studies of fruit, berry and nut crops.Results and conclusion. The percentage of long-cluster seedlings (cluster length > 10 cm) in the inbred progeny of cv. ‘Podarok Pobeditelyam’ was 21.8%; segregation of large-fruited seedlings (berry weight > 0.65 g) was observed at the level of 17%; the maximum degree of transgression (Tsmax) was 42%; and the incidence of transgressive seedlings was 37%. The analysis of the progeny showed that cv. ‘Podarok Pobeditelyam’ is a homozygote for the dominant Rc gene that controls the red color of the berries, and displays donor properties for the trait “dry detachment of berries”. The study of the cultivar’s self-pollinated progeny did not reveal any inbreeding depression in F1 seedlings from closely related crosses as far as plant condition or productivity is concerned. The selected seedlings are of interest for further variety research and use in breeding practice as new source material

    Изменение тактики дифференциального диагноза в процессе клинического наблюдения больного

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    The complicated ratios of clinical symptoms of internal lesions during central lung cancer are demonstrated in the article when changes of differential diagnosis tactics were required for diagnosing that necessary keeping is priority of the clinical appraisal of the results inspection patient.В статье обоснованы сложные соотношения клинических симптомов поражения внутренних органов при центральном раке легкого, когда для постановки диагноза требовались изменения тактики дифференциального диагноза, при котором необходимо сохранять прио ритет общей клинической оценки результатов обследования больного

    STRUCTURAL DECOMPOSING OF INNOVATIONS AND INVESTMENTS PROJECTS

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    The article is devoted to the study of the process of investing and planning innovative projects. A systematization of a variety of factors influencing business models and investment aspects of innovative investment projects in their stepwise (iterative) reflection is given. Specialattention is given to the classification of innovations, a matrix of types of innovations has been developed in the process of analysis. A conceptual framework for structuring innovation and investment activities has been proposed with the goal of generalized systematization of the stages and factors of structuring innovation and investment projects. The thesis on the systemic nature of open innovation is argued and principles for evaluating the effectiveness of innovative investment projects are proposed. In the course of the study, a model for the distribution of investment sources was developed, taking into account the planned rate of return

    PROBLEMATICS OF ENTERPRISE DEVELOPMENT IN THE ECONOMY OF KNOWLEDGE BASED ON LOGISTIC APPROACH

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    The theoretical approach of the knowledge economy to the development of the strategy of industrial enterprises on the basis of the logistical methodology are covered. The definition of strategy and strategic planning for the knowledge economy is presented. The process of strategy development is characterized and the algorithm of strategic planning of an industrial enterprise is proposed taking into account the knowledge economy

    Modern concept analysis of failure modes and consequences for quality assurance of products and processes

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    Human needs in certain types of products, in new goods and services are constantly developing, changing, clarifying. To meet these needs, new goods samples are being created, and the products are being improved. Production processes are being developed, new equipment, tools and techniques are being created. New technical solutions, new operations application as well asit execution methods can produce constructive errors and dangerous situations both during production and during its exploitation. The Failure Mode and Effects Analysis (FMEA) allows to predict that product lifecycle processes can functioning not properly. FMEA helps ensure the products and processes quality at the earliest stages of it design. The American approach (AIAG - Automotive Industry Action Group) and the German approach (VDA - Verband der Automobilindustrie) have now been harmonized. In 2019, the FMEA Handbook was published, reflecting the new FMEA implementation concept. Experience has emerged with a new approach. The work considers the possibilities of applying a new approach in the conditions of Russian companies, which allows to find new technical solutions. © Published under licence by IOP Publishing Ltd

    INVESTMENTS IN DEVELOPMENT OF SUPPLY CHAINS

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    The problems of investment in the development of supply chains are considered. The trends that are characteristic of investment processes in the industry are investigated, and problems of investing in the supply chain are highlighted, namely, the lack of a wellcoordinated partnership between the state and private business, underestimation of projects due to incomplete information about the characteristics of investment projects and underdeveloped investment assessment methodology. The authors confirmed the thesis that the development of investment in innovative solutions for supply chains is ensured by more active participation of stakeholders in the investment process

    ProtChemSI: a network of protein–chemical structural interactions

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    Progress in structure determination methods means that the set of experimentally determined 3D structures of proteins in complex with small molecules is growing exponentially. ProtChemSI exploits and extends this useful set of structures by both collecting and annotating the existing data as well as providing models of potential complexes inferred by protein or chemical structure similarity. The database currently includes 7704 proteins from 1803 organisms, 11 324 chemical compounds and 202 289 complexes including 178 974 predicted. It is publicly available at http://pcidb.russelllab.org

    Modern concept analysis of failure modes and consequences for quality assurance of products and processes

    Full text link
    Human needs in certain types of products, in new goods and services are constantly developing, changing, clarifying. To meet these needs, new goods samples are being created, and the products are being improved. Production processes are being developed, new equipment, tools and techniques are being created. New technical solutions, new operations application as well asit execution methods can produce constructive errors and dangerous situations both during production and during its exploitation. The Failure Mode and Effects Analysis (FMEA) allows to predict that product lifecycle processes can functioning not properly. FMEA helps ensure the products and processes quality at the earliest stages of it design. The American approach (AIAG - Automotive Industry Action Group) and the German approach (VDA - Verband der Automobilindustrie) have now been harmonized. In 2019, the FMEA Handbook was published, reflecting the new FMEA implementation concept. Experience has emerged with a new approach. The work considers the possibilities of applying a new approach in the conditions of Russian companies, which allows to find new technical solutions. © Published under licence by IOP Publishing Ltd
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