Changes in the vector of industrial policy and possibilities for the innovative development of the industrial regions

In the present paper, reasons for the increased interest in industrial policy in both developed and developing countries are explained. The systematisation of the results of the development of Russian industry from 1989 to 2014 showed a lack of systematic selection of its priorities, preventing the formation of a strategic vector of industrial policy. The target diversity of the industrial policy is established at the different economic development stages of the country. In the context of economic sanctions against Russia, it is shown that the emergence of a new industrial policy vector is connected to the need for import substitution and concomitant changes in the development model of the domestic economy. The dynamics and characteristics of the industrial development area are shown by the example of a highly developed region like the Central Urals. The total level of organisational innovation activity continues to be low and composes only 12%, although in the manufacturing sector this index is higher than the regional economy index by four absolute percentage points. The industrial policy of the Central Urals is analysed and innovation drivers of the industrial sector of the regional economy are established. The possibilities of the defence, civil engineering, mining, chemical/pharmaceutical and forestry complexes of the Sverdlovsk Region to implement its import substitution policy are explained. The most significant investment projects that will reduce the import dependence of the regional economy are presented. The possibilities of the research sector and created innovation infrastructure of the region in solving this problem are shown. It is necessary to develop the regional laws on the elaboration of industrial policy according to the basic regulations of the Federal Law “On Industrial Policy in the Russian Federation.”This article has been prepared with the support of the Russian Humanitarian Science Foundation Grant 14-02-00331 «Innovative and technological development of the region: assessment, forecasting and ways of achievement.

Conductivity, weak ferromagnetism and charge instability in α−MnS\alpha-MnS single crystal

The temperature dependence of resistivity, magnetization and electron-spin resonance of the $\alpha- MnS$ single crystal were measured in temperature range of $5 K < T < 550 K$. Magnetization hysteresis in applied magnetic field up to 0.7 T at $T=5 K, 77 K, 300 K$, irreversible temperature behavior of magnetization and resistivity were found . The obtained data were explained in terms of degenerate tight binding model using random phase approximation. The contribution of holes in $t_{2g}$ and $e_g$ bands of manganese ions to the conductivity, optical absorbtion spectra and charge instability in $\alpha -MnS$ were studied. Charge susceptibility maxima resulted from the competition of the on-site Coulomb interaction between the holes in different orbitals and small hybridization of sub-bands were calculated at $T=160 K, 250 K, 475 K$.Comment: 6 pages, 12 figure

Somatic status of adolescent girls with gynecological disorders born with low and excessive weight

In modern conditions, health problems (somatic, reproductive, mental) of adolescent girls occupy a special place in the health care system, as a reserve in reducing maternal and infant mortality, maintaining the fertility of the expectant mother. The aim. To study the frequency and character of extragenital diseases of adolescent girls with gynecological pathology, born with low and excessive body weight. Materials and methods. The project design is a population-based prospective cohort study. To achieve the goal and the implementation of the tasks, a prospective examination of girls and adolescent girls born with deficiency or excess body weight was carried out. The sample size was 77 people. Additionally, statistical processing was carried out using the Excell software. Results. Thus, the study of somatic health indicates its deterioration in the groups of girls born with polar values ​​of body weight. In groups 1 and 3, infectious diseases were identified, which can serve as a starting point in the development of reproductive system disorders. In girls of group 1, mumps prevailed (20.0%), which could cause damage to the follicular apparatus, while in group 3, girls were more likely to have influenza (25.8%), the virus of which has a damaging effect not only on the structure of the ovaries, but also on endometrium. Conclusions. Comparative analysis of the structure of somatic morbidity made it possible to identify the most significant pathology characteristic of each of the groups. Girls born with a large body weight have an increased risk of endocrine pathology. In girls born with low body weight, somatic diseases associated with manifestations of diseases of the musculoskeletal system prevail. This dictates the need to single out girls born with polar values ​​of body weight in the risk group for the development of somatic pathology and requires complex therapeutic and prophylactic measures

The component composition of integrated foreign language competence of future specialists of State Fire Service of the Emergency Ministry of Russia

The authors of the article consider one of the areas of modern vocational education as the formation of integrated foreign language communicative competence of future specialists. It is analyzed the reasons of integration lack of professional and foreign language background in the foreign language qualification in high school. They actualize the education content as a process of integration of vocational and language experience in the field of activity of the future specialist.Рассматривается одна из проблемных областей современного профессионального образования – формирование интегрированной иноязычной коммуникативной компетентности будущих специалистов. Анализируются причины отсутствия единства освоения профессионального и языкового опыта в иноязычной подготовке вуза. Актуализируются вопросы содержания образования как процесс интеграции профессионального и языкового опыта в сфере деятельности будущего специалиста

Hydrodynamic Simulations of Counterrotating Accretion Disks

Hydrodynamic simulations have been used to study accretion disks consisting of counterrotating components with an intervening shear layer(s). Configurations of this type can arise from the accretion of newly supplied counterrotating matter onto an existing corotating disk. The grid-dependent numerical viscosity of our hydro code is used to simulate the influence of a turbulent viscosity of the disk. Firstly, we consider the case where the gas well above the disk midplane rotates with angular rate +\Omega(r) and that well below has the same properties but rotates with rate -\Omega(r). We find that there is angular momentum annihilation in a narrow equatorial boundary layer in which matter accretes supersonically with a velocity which approaches the free-fall velocity and the average accretion speed of the disk can be enormously larger than that for a conventional \alpha-disk rotating in one direction. Secondly, we consider the case of a corotating accretion disk for rr_t. In this case we observed, that matter from the annihilation layer lost its stability and propagated inward pushing matter of inner regions of the disk to accrete. Thirdly, we investigated the case where counterrotating matter inflowing from large radial distances encounters an existing corotating disk. Friction between the inflowing matter and the existing disk is found to lead to fast boundary layer accretion along the disk surfaces and to enhanced accretion in the main disk. These models are pertinent to the formation of counterrotating disks in galaxies and possibly in Active Galactic Nuclei and in X-ray pulsars in binary systems.Comment: LaTeX, 18 pages, to appear in Ap

Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum

BACKGROUND: Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated protein degradation pathway. Recombinant proteins can also be degraded by the vacuolar protease complex. Human urokinase type plasminogen activator (uPA) is poorly secreted by yeast but the mechanisms interfering with its secretion are largely unknown. RESULTS: We show that in Hansenula polymorpha overexpression worsens uPA secretion and stimulates its intracellular aggregation. The absence of the Golgi modifications in accumulated uPA suggests that aggregation occurs within the endoplasmic reticulum. Deletion analysis has shown that the N-terminal domains were responsible for poor uPA secretion and propensity to aggregate. Mutation abolishing N-glycosylation decreased the efficiency of uPA secretion and increased its aggregation degree. Retention of uPA in the endoplasmic reticulum stimulates its aggregation. CONCLUSIONS: The data obtained demonstrate that defect of uPA secretion in yeast is related to its retention in the endoplasmic reticulum. Accumulation of uPA within the endoplasmic reticulum disturbs its proper folding and leads to formation of high molecular weight aggregates

Features of cytomegalovirus activation in children and young adults after allogeneic hematopoietic stem cell transplantation

The article presents the frequency of activation of cytomegalovirus infection in patients after allogeneic hematopoietic stem cell transplantation. The features of reactivation and clinical forms of cytomegalovirus infection are givenВ статье приведены частота активации цитомегаловирусной инфекции у пациентов после аллогенной трансплантации гемопоэтических стволовых клеток. Даны особенности реактивации и клинические формы цитомегаловирусной инфекции

Strongly anisotropic magnetocaloric effect in a dipolar magnet LiGdF4_4

We report the detailed study of the magnetocaloric effect (MCE) in a dipolar-Heisenberg magnet LiGdF$_4$ using magnetization measurements performed on a single crystal sample. Entropy variation on isothermal demagnetization from the magnetic field up to 3 T is determined in the temperature range 2-10 K for two principal directions of the applied field (parallel and perpendicular to the tetragonal $c$-axis of the crystal). The MCE is found to be highly anisotropic, with the cooling efficiency being up to twice higher at $H\parallel c$. The results are nicely interpreted in the frame of a conventional molecular field approach taking into account considerable anisotropy of the paramagnetic Curie-Weiss temperature. These results are compared to earlier studies of MCE in powder samples of LiGdF$_4$ [T. Numazawa et al., AIP Conf. Proc. 850, 1579 (2006)] as well as with analogous data for other well known magnetocaloric materials. Our findings may open new possibilities to enhance the efficiency of magnetic refrigeration in the liquid helium-4 temperature range.Comment: 4 pages, 3 figure

Superconducting properties of sulfur-doped iron selenide

The recent discovery of high-temperature superconductivity in single-layer iron selenide has generated significant experimental interest for optimizing the superconducting properties of iron-based superconductors through the lattice modification. For simulating the similar effect by changing the chemical composition due to S doping, we investigate the superconducting properties of high-quality single crystals of FeSe$_{1-x}$S$_{x}$ ($x$=0, 0.04, 0.09, and 0.11) using magnetization, resistivity, the London penetration depth, and low temperature specific heat measurements. We show that the introduction of S to FeSe enhances the superconducting transition temperature $T_{c}$, anisotropy, upper critical field $H_{c2}$, and critical current density $J_{c}$. The upper critical field $H_{c2}(T)$ and its anisotropy are strongly temperature dependent, indicating a multiband superconductivity in this system. Through the measurements and analysis of the London penetration depth $\lambda _{ab}(T)$ and specific heat, we show clear evidence for strong coupling two-gap $s$-wave superconductivity. The temperature-dependence of $\lambda _{ab}(T)$ calculated from the lower critical field and electronic specific heat can be well described by using a two-band model with $s$-wave-like gaps. We find that a $d$-wave and single-gap BCS theory under the weak-coupling approach can not describe our experiments. The change of specific heat induced by the magnetic field can be understood only in terms of multiband superconductivity.Comment: 13 pages, 7 figure

Microscopic spin Hamiltonian for a dipolar-Heisenberg magnet LiGdF4 from EPR measurements

Low-temperature electron paramagnetic resonance measurements are performed on single crystals of LiY_{1-x}Gd_xF_4 with weak x=0.005 and moderate x=0.05 concentration of Gd ions. Modeling of the experimental spectra allows us to precisely determine microscopic parameters of the spin Hamiltonian of the parent LiGdF4 material, including the nearest-neighbor exchange constant. The obtained parameters are further tested by comparing a strongly anisotropic Curie-Weiss temperature obtained for LiGdF4 in our static magnetization measurements with theoretically computed values. We find a fine balance between principal magnetic interactions in LiGdF4, which results in a hidden magnetic frustration presumably leading to a delayed magnetic ordering and an enhanced magnetocaloric effect at low temperatures.Comment: 6 pages, 6 figure