143 research outputs found
The multistatutory nature of the adjective "Right" in adjectival English lexicon
This article provides an outline on an adjective in modern English language, and in particular, the multistatus lexical item βrightβ, which carries different meanings in different variants of combinatorics. The authors analyse the combinations used with the adjectival lexical item βrightβ and identify categories that determine the semantic content of each given statemen
The devices, experimental scaffolds, and biomaterials ontology (DEB): a tool for mapping, annotation, and analysis of biomaterials' data
The size and complexity of the biomaterials literature makes systematic data analysis an excruciating manual task. A practical solution is creating databases and information resources. Implant design and biomaterials research can greatly benefit from an open database for systematic data retrieval. Ontologies are pivotal to knowledge base creation, serving to represent and organize domain knowledge. To name but two examples, GO, the gene ontology, and CheBI, Chemical Entities of Biological Interest ontology and their associated databases are central resources to their respective research communities. The creation of the devices, experimental scaffolds, and biomaterials ontology (DEB), an open resource for organizing information about biomaterials, their design, manufacture, and biological testing, is described. It is developed using text analysis for identifying ontology terms from a biomaterials gold standard corpus, systematically curated to represent the domain's lexicon. Topics covered are validated by members of the biomaterials research community. The ontology may be used for searching terms, performing annotations for machine learning applications, standardized meta-data indexing, and other cross-disciplinary data exploitation. The input of the biomaterials community to this effort to create data-driven open-access research tools is encouraged and welcomed.Preprin
Detection of specific antibodies to Schmallenberg virus using microneutralisation test
The article presents data on microneutralization test for detection of specific antibodies to Schmallenberg virus. The method is characterized by high sensitivity and specificity. It can be used for analysis of blood sera of different species of animals
Detection of tick-borne pathogens in wild birds and their ticks in Western Siberia and high level of their mismatch
Abstract: The Tomsk region located in the south of Western Siberia is one of the most high-risk areas for tick-borne diseases due to elevated incidence of tick-borne encephalitis and Lyme disease in humans. Wild birds may be considered as one of the reservoirs for tick-borne pathogens and hosts for infected ticks. A high mobility of wild birds leads to unpredictable possibilities for the dissemination of tick-borne pathogens into new geographical regions. The primary goal of this study was to evaluate the prevalence of tick-borne pathogens in wild birds and ticks that feed on them as well as to determine the role of different species of birds in maintaining the tickborne infectious foci. We analysed the samples of 443 wild birds (60 species) and 378 ticks belonging to the genus Ixodes Latraille, 1795 collected from the wild birds, for detecting occurrence of eight tick-borne pathogens, the namely tick-borne encephalitis virus (TBEV), West Nile virus (WNV), and species of Borrelia, Rickettsia, Ehrlichia, Anaplasma, Bartonella and Babesia Starcovici, 1893, using RT-PCR/or PCR and enzyme immunoassay. One or more tick-borne infection markers were detected in 43 species of birds. All markers were detected in samples collected from fieldfare Turdus pilaris Linnaeus, Blythβs reed warbler Acrocephalus dumetorum Blyth, common redstart Phoenicurus phoenicurus (Linnaeus), and common chaffinch Fringilla coelebs Linnaeus. Although all pathogens have been identified in birds and ticks, we found that in the majority of cases (75.5%), there were mismatches of pathogens in birds and ticks collected from them. Wild birds and their ticks may play an extremely important role in the dissemination of tick-borne pathogens into different geographical regions
ΠΠ°ΡΠ΅ΠΌΠ°ΡΠΈΠΊΠΎ-ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΠΏΠ΅ΡΡΠΈΡΡΠΈΡΡΡΡΠΈΡ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ ΠΊΠ°ΠΊ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ° Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠΈ ΠΈ ΠΎΡΡΡΠΎΠ³ΠΎ Π±ΡΠΎΠ½Ρ ΠΈΡΠ° Ρ Π΄Π΅ΡΠ΅ΠΉ
The aim of this study was to determine the relationship between infection with βpersistentβ agents of children and the possibility of the development of inflammatory diseases of the respiratory tract such as community-acquired pneumonia and acute bronchitis on the basis of risk management concepts.Materials and methods. 701 children in age from 15 days to 16 years were examined in Nizhny Novgorod and the Nizhny Novgorod region with clinically and radiologically confirmed diagnosis: community-acquired pneumonia, acute bronchitis. This study was performed in the period from 2005 to 2014. The control group consisted of 127 healthy children of different ages. The detection of M. pneumoniae, Π‘ytomegalovirus, Herpes simplex I/II C. pneumoniae was performed by PCR. The concept of risk determination was based on the determination of the absolute risk in the exposed and the no exposed groups, attributable risk, relative risk, the population attributable risk, as well as determining the standard errors for each type of risk and confidence interval.Results. Attributable risk, relative risk, population-attributable risk are statistically significant figures. Attributable risk of development of community-acquired pneumonia was 29,26%; 27,37%; 25,70%; 20,21% for the M. pneumoniae, C. pneumoniae, CMV, HSV I / II respectively. The relative risk was 1,43 for the M. pneumoniae; 1,38 β for C. pneumoniae and CMV; 1,28- for HSV I / II. The presence of persistent pathogens is resulting in increased incidence of communityacquired pneumonia throughout the population (population attributable risk): 4,75% for M. pneumoniae, 0,23% for C. pneumoniae, 5,59% for the CMV and 1,08% for the HSV I/II. Similar calculations were performed for patients with acute bronchitis. The statistical analysis allowed to exclude C. pneumoniae and HSV I / II of the risk factors for communityacquired pneumonia and acute bronchitis.Conclusion. The findings suggest the influence of M. pneumoniae and CMV in the development of communityacquired pneumonia and acute bronchitis in children. C. pneumoniae, and HSV I / II do not play a statistically significant role in the overall landscape of etiologic agents of community-acquired pneumonia and acute bronchitis.Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΡΡ Β«ΠΏΠ΅ΡΡΠΈΡΡΠΈΡΡΡΡΠΈΠΌΠΈΒ» Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»ΡΠΌΠΈ Π΄Π΅ΡΠ΅ΠΉ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ°, ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½Π°Ρ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΡ ΠΈ ΠΎΡΡΡΡΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠΎΠ².ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2005 ΠΏΠΎ 2014 Π³. ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ 701 ΡΠ΅Π±Π΅Π½ΠΎΠΊ ΠΈΠ· Π³. ΠΠΈΠΆΠ½Π΅Π³ΠΎ ΠΠΎΠ²Π³ΠΎΡΠΎΠ΄Π° ΠΈ ΠΠΈΠΆΠ΅Π³ΠΎΡΠΎΠ΄ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 15 Π΄Π½Π΅ΠΉ Π΄ΠΎ 16 Π»Π΅Ρ Ρ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π½ΡΠΌΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π°ΠΌΠΈ: Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½Π°Ρ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΡ, ΠΎΡΡΡΡΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΡ. ΠΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 127 ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ ΡΠ°Π·Π½ΡΡ
Π²ΠΎΠ·ΡΠ°ΡΡΠΎΠ². ΠΠ΅ΡΠ΅ΠΊΡΠΈΡ M. pneumoniae, Π‘ytomegalovirus, Herpes simplex I/II C. pneumoniae ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠ¦Π . ΠΠΎΠ½ΡΠ΅ΠΏΡΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΈΡΠΊΠΎΠ² ΡΡΡΠΎΠΈΠ»Π°ΡΡ Π½Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ Π°Π±ΡΠΎΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ° Π² ΡΠΊΡΠΏΠΎΠ½ΠΈΡΡΠ΅ΠΌΠΎΠΉ ΠΈ Π½Π΅ ΡΠΊΡΠΏΠΎΠ½ΠΈΡΡΠ΅ΠΌΠΎΠΉ Π³ΡΡΠΏΠΏΠ°Ρ
, Π°ΡΡΠΈΠ±ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ°, ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ°, ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°ΡΡΠΈΠ±ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΡ
ΠΎΡΠΈΠ±ΠΎΠΊ Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ Π²ΠΈΠ΄Π° ΡΠΈΡΠΊΠ° ΠΈ Π΄ΠΎΠ²Π΅ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΠ²Π»ΡΡΡΡΡ Π°ΡΡΠΈΠ±ΡΡΠΈΠ²Π½ΡΠΉ ΡΠΈΡΠΊ, ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠΈΡΠΊ, ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½ΡΠΉ Π°ΡΡΠΈΠ±ΡΡΠΈΠ²Π½ΡΠΉ ΡΠΈΡΠΊ. ΠΡΡΠΈΠ±ΡΡΠΈΠ²Π½ΡΠΉ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ» 29,26%; 27,37%; 25,70%; 20,21% Π΄Π»Ρ M. pneumoniae, Π‘. pneumoniae, CMV, HSV I/II ΡΠΎΠΎΡ- Π²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. ΠΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠΈΡΠΊ ΡΠΎΡΡΠ°Π²ΠΈΠ» 1,43 Π΄Π»Ρ M. pneumoniae; 1,38 β Π΄Π»Ρ Π‘. pneumoniae ΠΈ Π΄Π»Ρ CMV; 1,28 β Π΄Π»Ρ HSV I/II. ΠΠ°Π»ΠΈΡΠΈΠ΅ ΠΏΠ΅ΡΡΠΈΡΡΠΈΡΡΡΡΠΈΡ
Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠ΅ΠΉ ΠΏΠΎ Π²ΡΠ΅ΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ (ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½ΡΠΉ Π°ΡΡΠΈΠ±ΡΡΠΈΠ²Π½ΡΠΉ ΡΠΈΡΠΊ): Π½Π° 4,75% Π΄Π»Ρ M. pneumoniae, 0,23% Π΄Π»Ρ Π‘. pneumoniae, 5,59% Π΄Π»Ρ CMV ΠΈ 1,08% Π΄Π»Ρ HSV I/II. ΠΠ½Π°Π»ΠΎΠ³ΠΈΡΠ½ΡΠ΅ ΡΠ°ΡΡΠ΅ΡΡ Π±ΡΠ»ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π΄Π»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΡΡΡΡΠΌ Π±ΡΠΎΠ½Ρ
ΠΈΡΠΎΠΌ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠΉ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» ΠΈΡΠΊΠ»ΡΡΠΈΡΡ Π‘. pneumoniae ΠΈ HSV I/II ΠΈΠ· ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠΈ ΠΈ ΠΎΡΡΡΠΎΠ³ΠΎ Π±ΡΠΎΠ½Ρ
ΠΈΡΠ°.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ Π³ΠΎΠ²ΠΎΡΠΈΡΡ ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΈ M. pneumoniae ΠΈ CMV Π½Π° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠΈ ΠΈ ΠΎΡΡΡΠΎΠ³ΠΎ Π±ΡΠΎΠ½Ρ
ΠΈΡΠ° Ρ Π΄Π΅ΡΠ΅ΠΉ. Π‘. pneumoniae ΠΈ HSV I/II Π½Π΅ ΠΈΠ³ΡΠ°ΡΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π²Π°ΠΆΠ½ΠΎΠΉ ΡΠΎΠ»ΠΈ Π² ΠΎΠ±ΡΠ΅ΠΌ ΠΏΠ΅ΠΉΠ·Π°ΠΆΠ΅ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π³Π΅Π½ΡΠΎΠ² Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠΈ ΠΈ ΠΎΡΡΡΠΎΠ³ΠΎ Π±ΡΠΎΠ½Ρ
ΠΈΡΠ°
European registry on the management of helicobacter pylori infection (HP-EUREG protocol): The first results of Russian centers
Aim: To assess the clinical practice of diagnosis and treatment in patients with Helicobacter pylori infection and to compare this practice with the international guidelines in the European Registry on the management of Helicobacter pylori infection, Hp-EuReg protocol), a multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group. Materials and methods: The data of 813 patients infected with H. pylori and entered in the Hp-EuReg register by the Russian centers in 2013-2015 were analyzed. Results: The most common methods for the primary diagnosis of H. pylori infection are histology (40.3%), rapid urease test (35.7%), and serology (17.2%). The duration of H. pylori eradication therapy was 7, 10, and 14 days in 18.0, 49.3, and 25.1%, respectively. To monitor the effectiveness of treatment, the investigators used a histological examination (34%), a urea breath test (27.3%), H. pylori stool antigen (22.8%), and a rapid urease test (16.3%). A serological test was carried out in 2.5% of the cases. No monitoring was done in 13.5% of the patients. The average eradication efficiency was 82.6%. If the therapy was ineffective, 80% of physicians did not intend to prescribe a new cycle of treatment. Conclusion: Significant differences were found between clinical practice and the current guidelines
Circulation of Lyssaviruses (Lyssavirus) among the Small Mammals in the Territory of the Republic of Guinea
Objective is to study the role of small mammals, habitant in the Republic of Guinea, in Lyssavirus circulation. Materials and methods. Investigations were conducted using RT-PCR; nucleotide sequence of Lyssavirus cDNA fragments was identified with the help of sequencing with further phylogenetic analysis. Results and conclusions. Tested have been 356 brain samples from small mammals for the presence of Lyssavirus RNA using RT-PCR with genus-specific primers. The animals were caught in the suburbs of Kindia city in 2016. The samples were obtained from wild animals pertaining to Rodentia, Chiroptera, Eulipotyphla, and Carnivora orders.Lyssavirus RNA was detected in 31 samples (8.7 %). For 14 PCR positive samples the appurtenance to Lyssavirus was confirmed through identification and analysis of nucleotide sequences of the collected short cDAN fragments of viral genome. The presence of rabies virus RNA in positive tests was excluded from PCR with the help of species specific primers. The pool of samples from black rats, Rattus rattus, positive for Lyssavirus RNA, contained RNA characteristic of Mokola lyssavirus species. Specified has been nucleotide sequence of matrix protein M gene fragment of Mokola virus. Genetic material of Mokola virus was detected in the Republic of Guinea for the first time ever
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠΎΡΡ Π±ΠΎΠ»ΡΡΠΈΡ ΠΏΠΎΠ»ΡΡΠ°ΡΠΈΠΉ ΠΌΠΎΠ·Π³Π° Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ·ΠΎΠΌ
Background.Β Arthrogryposis is one of the most severe congenital abnormalities of the musculoskeletal system characterized by 2 or more contractures of the large joints, muscle and anterior grey column pathology. One of the main problems making selfcare limited or impossible for the patients is an absence of the active movements in the joints of the upper extremities which can be restored through autologous transplantation from the various donor areas. Processes of the rehabilitation after these operations are associated with neuronal remodeling in the central nervous system both in the spinal cord and the brain, in the cortial regions in particular.The objectiveΒ is to evaluate possible reflection of arthrogryposis in the amplitude and neurodynamical characteristics of the electroencephalogram (EEG) in children.Materials and methods.Β Electrophysiological characteristics of the cerebral cortex in children with arthrogryposis and healthy children of the same age were examined. Such EEG characteristics as power and long-range temporal correlations (evaluation of the neuronal activity dynamics) in ranges of 4β8, 8β12, and 12β16 Hz were measured. The results were evaluated in accordance with clinical scales.Results.Β Data analysis has shown that children with arthrogryposis have significantly decreased EEG power in all of the studied ranges compared to healthy children. Additionally, a significant correlation between EEG power and the level of restoration of motor functions in the upper extremities after autologous transplantation of various muscle groups in the position of the biceps was observed. The obtained results reflect correlation between the electrophysiological parameters of the cerebral cortex and processes associated with arthrogryposis pathology. However, neurodynamical parameters in children with arthrogryposis are similar to those in healthy children. The results allow to state that arthrogryposis is reflected through decreased electrical activity of the cerebral cortex in 4β16 Hz range with preservation of neurodynamic characteristics typical for disease-free children.Conclusion.Β In this study, a significant difference in EEG power in 4β8, 8β12, and 12β16 Hz ranges between children with arthrogryposis and healthy children was demonstrated. However, there was no difference in such an important neurodynamical characteristic as longrange temporal correlations. It is possible that decreased amplitude of EEG rhythms in children with arthrogryposis is caused by their lower motor activity in general.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅.Β ΠΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ· β ΠΎΠ΄ΠΈΠ½ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΠΆΠ΅Π»ΡΡ
Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
ΠΏΠΎΡΠΎΠΊΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΠΏΠΎΡΠ½ΠΎ-Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ°, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠΉΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ 2 ΠΈ Π±ΠΎΠ»Π΅Π΅ ΠΊΠΎΠ½ΡΡΠ°ΠΊΡΡΡ ΠΊΡΡΠΏΠ½ΡΡ
ΡΡΡΡΠ°Π²ΠΎΠ², ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΌΡΡΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠ΅ΡΠ΅Π΄Π½ΠΈΡ
ΡΠΎΠ³ΠΎΠ² ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°. ΠΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»ΠΈΠ²Π°ΡΡΠΈΡ
ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΈΠ»ΠΈ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΠ°ΠΌΠΎΠΎΠ±ΡΠ»ΡΠΆΠΈΠ²Π°Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΉ Π² ΡΡΡΡΠ°Π²Π°Ρ
Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠ΅ΠΉ, ΠΊΠΎΡΠΎΡΠΎΠ΅ Π²ΠΎΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π΅ΡΡΡ ΠΏΡΡΠ΅ΠΌ Π°ΡΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΌΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π΄ΠΎΠ½ΠΎΡΡΠΊΠΈΡ
ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ. ΠΡΠΎΡΠ΅ΡΡΡ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ°ΠΊΠΈΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ ΡΠ²ΡΠ·Π°Π½Ρ Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΈ Ρ Π½Π΅ΠΉΡΠΎΠ½Π°Π»ΡΠ½ΡΠΌΠΈ ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠ°ΠΌΠΈ Π² ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΊΠ°ΠΊ Π² ΡΠΏΠΈΠ½Π½ΠΎΠΌ, ΡΠ°ΠΊ ΠΈ Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ Π² ΠΊΠΎΡΠΊΠΎΠ²ΡΡ
Π΅Π³ΠΎ ΠΎΡΠ΄Π΅Π»Π°Ρ
.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΒ β ΠΎΡΠ΅Π½ΠΈΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ΅ ΠΎΡΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π°ΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ·ΠΎΠΌ Ρ Π΄Π΅ΡΠ΅ΠΉ Π² Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄Π½ΡΡ
ΠΈ Π½Π΅ΠΉΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡ
ΡΠ»Π΅ΠΊΡΡΠΎΡΠ½ΡΠ΅ΡΠ°Π»ΠΎΠ³ΡΠ°ΠΌΠΌΡ (ΠΠΠ).ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ.Β ΠΠ·ΡΡΠ°Π»ΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠΎΡΡ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π°ΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ·Π° ΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ ΡΡ
ΠΎΠ΄Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. ΠΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΡΠ°ΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΠΠ, ΠΊΠ°ΠΊ ΠΌΠΎΡΠ½ΠΎΡΡΡ ΠΈ Π΄Π»ΠΈΠ½Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ (ΠΌΠ΅ΡΠΎΠ΄ ΠΎΡΠ΅Π½ΠΊΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Π½Π΅ΠΉΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ) Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π°Ρ
4β8, 8β12 ΠΈ 12β16 ΠΡ. ΠΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΊΠ°Π».Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ.Β ΠΠ½Π°Π»ΠΈΠ· Π΄Π°Π½Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ·ΠΎΠΌ, ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄Π΅ΡΡΠΌΠΈ Π±Π΅Π· ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΉ, ΠΈΠΌΠ΅Π΅ΡΡΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΌΠΎΡΠ½ΠΎΡΡΠΈ ΠΠΠ ΠΏΠΎ Π²ΡΠ΅ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΠΌ ΡΠ°ΡΡΠΎΡΠ½ΡΠΌ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π°ΠΌ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠΎΡΠ½ΠΎΡΡΠΈ ΠΠΠ ΡΠΎ ΡΡΠ΅ΠΏΠ΅Π½ΡΡ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠ΅ΠΉ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ ΠΏΠΎ Π°ΡΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ ΠΌΡΡΡ Π² ΠΏΠΎΠ·ΠΈΡΠΈΡ Π΄Π²ΡΠ³Π»Π°Π²ΠΎΠΉ ΠΌΡΡΡΡ ΠΏΠ»Π΅ΡΠ°. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΎΡΡΠ°ΠΆΠ°ΡΡ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΊΠΎΡΡ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Ρ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌΠΈ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠΌΠΈ Ρ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ Π°ΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ·Π°. ΠΡΠΈ ΡΡΠΎΠΌ Π½Π΅ΠΉΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ·ΠΎΠΌ Π½Π΅ ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΠΎΡ ΡΠ°ΠΊΠΎΠ²ΡΡ
Ρ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΌΠΎΠΆΠ½ΠΎ ΠΊΠΎΠ½ΡΡΠ°ΡΠΈΡΠΎΠ²Π°ΡΡ ΡΠ°ΠΊΡ ΠΎΡΡΠ°ΠΆΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π°ΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ·ΠΎΠΌ Π² ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠΈ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠΎΡΡ Π±ΠΎΠ»ΡΡΠΈΡ
ΠΏΠΎΠ»ΡΡΠ°ΡΠΈΠΉ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Π² ΡΠ°ΡΡΠΎΡΠ½ΠΎΠΌ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ 4β16 ΠΡ ΠΏΡΠΈ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠΈ Π½Π΅ΠΉΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, ΡΡ
ΠΎΠ΄Π½ΡΡ
Ρ Π³ΡΡΠΏΠΏΠΎΠΉ Π΄Π΅ΡΠ΅ΠΉ Π±Π΅Π· Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅.Β Π Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΠΎΡΠ»ΠΈΡΠΈΠ΅ ΠΌΠΎΡΠ½ΠΎΡΡΠΈ ΠΠΠ Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π°Ρ
4β8, 8β12 ΠΈ 12β16 ΠΡ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΡΡΠΎΠ³ΡΠΈΠΏΠΎΠ·ΠΎΠΌ ΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ. ΠΠ΄Π½Π°ΠΊΠΎ ΡΠ°Π·Π½ΠΈΡΡ Π² ΡΠ°ΠΊΠΎΠΌ Π²Π°ΠΆΠ½ΠΎΠΌ Π½Π΅ΠΉΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅, ΠΊΠ°ΠΊ Π΄Π»ΠΈΠ½Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ, Π½Π΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ. ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΡΠ°ΠΊΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄Ρ ΡΠΈΡΠΌΠΎΠ² Π² ΠΠΠ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ ΠΎΠ±ΡΡΡΠ½ΡΠ΅ΡΡΡ ΠΈΡ
Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΎΠ±ΡΠ΅ΠΉ ΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ
Effectiveness of empirical <i>Helicobacter pylori</i> eradication therapy with furazolidone in Russia: results from the European Registry on <i>Helicobacter pylori</i> Management (Hp-EuReg)
Background. First-line therapy does not always provide a high level of Helicobacter pylori eradication due to the increase of H. pylori resistance to antibiotics; therefore, it remains necessary to identify the most effective rescue treatments. The purpose of this study was to evaluate the efficacy and safety of empirical H. pylori furazolidone-containing regimens.
Materials and methods. Adult H. pylori infected patients empirically treated with furazolidone-containing eradication regimens were registered in an international, prospective, multicenter non-intervention European registry on H. pylori management (Hp-EuReg). Data were collected at AEG-REDCap e-CRF from 2013 to 2021 and the quality was reviewed. Modified intention-to-treat (mITT) effectiveness analyses were performed.
Results. Overall 106 patients received empirical furazolidone-containing therapy in Russia. Furazolidone was prescribed in a sequential scheme along with amoxicillin, clarithromycin and a proton pump inhibitor in 68 (64%) cases, triple regimens were prescribed in 28 (26%) patients and quadruple regimens in 10 (9.4%). Treatment duration of 7 days was assigned to 2 (1.9%) patients, 10-day eradication therapy in case of 80 (75%) and 14 days in 24 (23%) patients. Furazolidone was mainly used in first- (79%) and second-line (21%) regimens. The methods used to diagnose H. pylori infection were: histology (81%), stool antigen test (64%), 13C-urea breath test (6.6%), and rapid urease test (1.9%). The mITT effectiveness of sequential therapy was 100%; 93% with the triple therapy and 75.5% with quadruple therapy. Compliance was reported in 98% of cases. Adverse events were revealed in 5.7% of patients, mostly nausea (3.8%). No serious adverse events were reported.
Conclusion. Furazolidone containing eradication regimens appear to be an effective and safe empirical therapy in Russia
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