The infrastructure of public catering in the context of tourist city space development

To assess the impact of environmental factors on the activities of catering enterprises of the Belgorod region and the quality of customer service, the authors proposed a method using STEP-analysis and SWOT-analysis. The analysis of environmental factors was carried out on the basis of the expert evaluation results conducted in two stage

The total neutron cross section for natural carbon in the energy range 2 to 148 keV

Abstract. An experimental investigations of the total neutron cross section for natural carbon were done at Kyiv Research Reactor using neutron filtered beams with energies 2, 3.5, 12, 24, 55, 59, 133 and 148 keV. The intense neutron beams formed by composite neutron filters at reactor horizontal channels had the fluxes of about 10 6 -10 7 neutron/cm 2. s at the fixed neutron energies and this enabled to measure the neutron cross sections with accuracy better than 3%. Transmission method was used in these measurements. The results are presented together with the analysis of the known previous experimental data and the evaluated nuclear data from ENDF libraries

Scanning Electron Microscopy Study of Drilling Cuttings in Tomsk Oblast Sites

The research is focused on determining mineralogical composition of drilling cuttings by scanning electron microscope as well as imaging the sample surface of high resolution that allows studying the structural characteristics of the site. In addition, a number of other techniques permit obtaining information on chemical composition of sample in near-surface layers. The study in drilling cuttings by means of scanning microscopy has revealed the presence of titanium, iron, zirconium oxides, iron sulphide, barium sulphate. The former is a mineral that concentrates rare-earth elements, presumably monocyte, as well as uranium silicate, etc. The results obtained confirm the data of previous X-ray structural analysis, i.e. the study samples consist of alumosilicate matrix. Apart from silicon and aluminium oxides, the matrix includes such elements as Na, K, Mg. Such a composition corresponds to rock-forming minerals: quartz, albite, microcline, clinochlore, muscovite, anorthoclase

Plane torsion waves in quadratic gravitational theories

The definition of the Riemann-Cartan space of the plane wave type is given. The condition under which the torsion plane waves exist is found. It is expressed in the form of the restriction imposed on the coupling constants of the 10-parametric quadratic gravitational Lagrangian. In the mathematical appendix the formula for commutator of the variation operator and Hodge operator is proved. This formula is applied for the variational procedure when the gravitational field equations are obtained in terms of the exterior differential forms.Comment: 3 May 1998. - 11

Thermohydraulic simulation of a channel with targets for production of radioactive isotopes in the IVV-2M nuclear reactor

The importance of radioisotope products usage in industry, science and medicine is underlined. The necessity of safety ensuring and radiation protection optimization while transporting the containers with radioactive isotopes is postulated. The information on isotope products making in the IVV-2M nuclear reactor of Research Institute of Nuclear Materials, JSC, from the beginning of 1990-ies is given. The data on application properties of Selenium 75 isotope are presented. The requirements to the thermohydraulic conditions of Se 75 isotope production in the nuclear reactor are formulated. The stages of a solid model development of a target for Se-75 isotope production as a part of an irradiation device of IVV-2M nuclear reactor are described. The results of hydraulic simulation of the coolant flow for various ways of devices arranging in the irradiation channel of the reactor are given. The analysis of thermohydraulic processes was performed with the help of SolidWorks Flow Simulation software. © Published under licence by IOP Publishing Ltd

Prognostic markers in patients with thymus-independent and thymus-dependent myasthenia gravis

МИАСТЕНИЯ ГРЭВИС /ТЕРМИАСТЕНИЯ ТЯЖЕЛАЯ ПСЕВДОПАРАЛИТИЧЕСКАЯ /ТЕРЭРБА-ГОЛЬДФЛАМА БОЛЕЗНЬ /ТЕРТИМУСА ГИПЕРПЛАЗИЯТИМОМАТИМУСНАЯ КАРЦИНОМААНТИЯДЕРНЫЕ АНТИТЕЛАКЛАСТЕРНЫЙ АНАЛИЗБИОЛОГИЧЕСКИЕ МАРКЕРЫЦель. Оценить наличие специфических маркеров у пациентов с тимуснезависимой и тимусзависимой миастенией для выбора тактики лечения. Материал и методы. Обследовано 138 пациентов с тимуснезависимой (М – миастения без морфо-функциональных изменений тимуса) и тимусзависимой (МГ – миастения на фоне гиперплазии тимуса, МТ – миастения на фоне тимомы) миастенией. Использовали методы иммуноферментного анализа (содержание антител к a1 и a7 субъединицам нАХР в сыворотке, к a7 субъединице нАХР в митохондриях тимоцитов, уровень антиядерных антител ANA), иммунофлуоресценции (тип свечения ANA), проточной цитометрии (экспрессия CD14+CD11c+ и CD14+HLA-DR+). Результаты. Выявлена взаимосвязь клинических фенотипов миастении с вариантами диплотипов лейкоцитарных антигенов HLA: у молодых пациентов с тимуснезависимой миастенией (М) выявили высокую гетерогенность генотипических маркеров HLA-DR (DR1, DR2, DR3, DR5, DR7). Пациенты с тимусзависимой миастенией (МТ) имели только дипло- и гаплотипы HLA DR2 и HLA DR7. Наличие гаплотипов HLA DR2 и HLA DR7 у части молодых пациентов с М при прогрессировании заболевания приводило к развитию миастении на фоне тимомы (МТ) в старшем возрасте. Патогенетическая роль также принадлежит инфекции (СMV, EBV, HBV, HCV, HSV-1, HSV-2, HHV-6, микоплазма) и пищевой непереносимости (IgE и IgG4) в развитии и прогрессировании миастении. В качестве дополнительной мишени аутоагрессии при миастении выявили четырехкратное преобладание a7 субъединицы никотиновых ацетилхолиновых рецепторов в митохондриях клеток тимомы. Специфические антинуклеарные антитела к центромерам хромосом были визуализированы у пациентов старшей группы с миастенией на фоне тимомы. Заключение. Прогноз прогрессирования миастении и развития ремиссии может быть осуществлен с помощью геномных (наличие определенных гаплотипов HLA-DR) и молекулярных (антитела ANA к центромерным белкам хромосом, экспрессия СD20+, CD14+CD11c+, CD14+HLA-DR+) биомаркеров, которые могут быть применены для выбора тактики лечения.Objective. To assess the presence of specific markers in patients with thymus-independent and thymus-dependent myasthenia gravis for choosing treatment tactics. Methods. The presence of specific markers was assessed in 138 patients with thymus-independent (M – myasthenia gravis without thymus changes) and thymus-dependent (MH – myasthenia gravis with thymus hyperplasia, MT – myasthenia gravis with thymoma). The method ELISA (the content of antibodies to subunits 1 and 7 nAChR in blood serum, to 7 nAChR subunit in thymocyte mitochondria, a detectable level of antinuclear antibody (ANA), immunofluorescence (ANA glow) and flow cytometry (expression of CD14+CD11c+and CD14 + HLA-DR +) has been used. Results. The relationship between the clinical phenotypes of myasthenia gravis and the variants of HLA diplotypes was revealed: in young patients with thymus-independent myasthenia gravis (M), a high heterogeneity of the genotypic markers HLA-DR (DR1, DR2, DR3, DR5, DR7) was detected. Patients with thymus-dependent myasthenia (MT) had only the HLA DR2 and HLA DR7 diplo- and haplotypes. The presence of HLA DR2 and HLA DR7 haplotypes in some young patients with progressive thymus-independent myasthenia gravis (M) led to the development of myasthenia gravis with thymoma (MT) in the elderly people. The pathogenic role also belongs to infection (СMV, EBV, HBV, HCV, HSV-1, HSV-2, HHV-6, mycoplasma) and food intolerance (IgE and IgG4) in the development and progression of myasthenia gravis. A four-fold prevalence of a7 subunit nicotinic acetylcholine receptors on the thymocyte mitochondria as an additional targets of autoimmune aggression in myasthenia gravis was determined. Specific antinuclear antibodies to centromere chromosome proteins were visualized in the elderly people with thymoma. Conclusion. The prognosis of the myasthenia gravis progression and the development of remission can be made using genomic (the presence of certain HLA-DR haplotypes) and molecular (ANA antibodies to centromere chromosome proteins, expression of CD20+, CD14+CD11c+, CD14+HLA-DR+) biomarkers, that can be used for the choice of treatment tactics

Platelet microvesicles and their role in providing hemostatic capacity (literature review)

In recent years the role of microvesicles in endocrine system transmission, in providing cellular connectivity, in transportation of proteins and nucleic acids from one cell to another, in angiogenesis regulation, in inflammatory reactions and in dissemination of tumors is actively studied. This article reviews the mechanisms of microvesicle formation, the structure of microvesicles and their potential value as biomarkers. Among all essential reactions involving microvesicles one thing especially stands out: their direct participation in providing hemostatic reactions for bleeding control in case of a solution of continuity in blood vessels due to different reasons. Platelet microvesicles play an important role in this process, and it has been proved by several experimental and clinical studies. In this review we evaluate prospects for clinical use of one of modern blood components – cryoprecipitate – as the source of platelet microvesicles

Long-Term Monitoring of Liver Fibrosis and Steatosis in Patients with Chronic Hepatitis C after Achieving a Sustained Virologic Response to Antiviral Therapy

Aim: to analyze the dynamics of fibrosis and steatosis of the liver according to fibroelastometry in patients with chronic hep-atitis C (CHC) after ≥ 6 months from transient elastometry (TE) achieving a sustained virologic response (SVR) to antiviral therapy.Materials and methods. At baseline, a prospective observational study included 628 CHC patients with known stage of liver fibrosis (F) before AVT, some of whom were phased out due to non-compliance with the inclusion criteria. The final analysis included 297 patients who had transient elastometry (TE) data with CAP™ technology on the severity of liver fibrosis (± steatosis) before treatment and after ≥ 6 months after reaching SVR (67 % – interferonfree regimens of therapy). Median follow-up from the moment SVR was confirmed was 3 years [2; 6].Results. At the end of the study, the average age of patients was 49 ± 12 years, of which 53 % were men. In the long-term period after reaching SVR, regression of liver fibrosis was diagnosed in 80 % of cases (including in patients with cirrhosis), and the progression of fibrosis was in 3 % of patient. At the same time, regression of liver steatosis was detected only in 31 % of the patient, worsening of the results was in 23 % (26 % of them had the appearance of steatosis (S) of the liver of 1–3 degrees in persons with no fatty liver before the start of AVT). In the group of patients with liver steatosis, the proportion of men was significantly higher (p = 0.004). Clinically significant stages of fibrosis F3–F4 were significantly more often recorded in patients with hepatic steatosis, both before treatment (46 % S1–S3 and 22 % S0, p < 0.001) and after ≥ 6 months after reaching SVR (19 % S1–S3 and 9 % S0, p = 0.023).Conclusion. In patients with chronic hepatitis C with SVR achieved in the long term, despite a significant regression of liver fibrosis, a high prevalence of hepatic steatosis remains. The data obtained indicate the feasibility of routine diagnosis of both fibrosis and steatosis of the liver in the management of patients with chronic HCV infection before and after successful antiviral therapy

Effect of carbon on cryogenic tensile behavior of CoCrFeMnNi-type high entropy alloys

Therefore in this work we examined cryogenic tensile behavior of the fcc high entropy alloys with different carbon content (0e2 at.%). The alloys had non-equiatomic proportions of principal elements, i.e. Co1Cr0.25Fe1Mn1Ni1. The lower Cr concentration in comparison with the equiatomic alloy led to the higher solubility of carbon confirmed by both ThermoCalc calculations and experimental results; only in the alloy with 2 at.% C a small (<1%) fraction of Crrich M7C3 carbides was found in the as-cast conditio

THE INCREASE OF COOLING RELIABILITY OF THE IRRADIATED FUEL ASSEMBLIES OF IVV-2M RESEARCH REACTOR IN THE STORAGE PIT

The report discusses the task of the increase of the storage pit cooling reliability for the irradiated fuel assemblies of IVV-2M research nuclear reactor in the case of normal use and the case of full core unloading