ЭТИОПАТОГЕНЕТИЧЕСКИЕ ОСОБЕННОСТИ ЯЗВЕННОЙ БОЛЕЗНИ У ЛИЦ МОЛОДОГО ВОЗРАСТА В ЗАВИСИМОСТИ ОТ НАСЛЕДСТВЕННОЙ ПРЕДРАСПОЛОЖЕННОСТИ

Etiopathogenetic ulcer is of particular interest because of its great role in hereditary predisposition to formation of this pathology. The authors detail not only the risk factors but the features of the neuro-psychic sphere, the clinical picture, and endoscopic features in their interrelation with genetic predisposition to the disease.Особенности этиопатогенеза язвенной болезни представляют особый интерес ввиду большой роли наследственной предрасположенности в формировании данной патологии. Авторами детально рассмотрены не только факторы риска, но и особенности нервно-психической сферы, клинической картины и эндоскопических характеристик во взаимосвязи с генетической обусловленностью к заболеванию

КЛИНИКО-ПАТОГЕНЕТИЧЕСКИЕ ВАРИАНТЫ ТЕЧЕНИЯ ЯЗВЕННОЙ БОЛЕЗНИ

The authors present some variants of the peptic ulcer course, with pathogenesis of the pathology being taken into account. Attention has been paid to the role of the central nervous system and of the vegetative nervous system as well as to psychosomatic mechanisms of the given pathology development.Изложены варианты течения язвенной болезни с учетом патогенеза заболевания. Во внимание принимаются роль центральной нервной системы, вегетативной нервной системы, а также психосоматические механизмы формирования данного заболевания

Experimental Demonstration of the Carbamazepine Crystallization from Non-photochemical Laser-Induced Nucleation in Acetonitrile and Methanol

International audienceThis paper reports for the first time the crystallization of the carbamazepine (CBZ) molecule in two solvents (methanol and acetonitrile) using the non-photochemical laser-induced nucleation (NPLIN) technique. The metastable zone of CBZ is first determined experimentally for different temperatures in both solvents. Then, the prepared solutions are irradiated by a 532 nm wavelength nanosecond pulsed laser and permitted to obtain CBZ crystals of phases I and III. The impact of laser power and polarization (circularly (CP) and linearly (LP)) on the CBZ crystallization efficiency in both solvents is determined through experiments. According to the results, the crystallization efficiency is significantly higher in methanol than in acetonitrile, and it is higher in solutions irradiated by CP laser than those by LP laser. Moreover, the irradiation of an acetonitrile solution by a LP laser results in CBZ phases I and III, whereas irradiation by the CP laser leads to CBZ phase III crystals. An ab initio determination of the interaction energy of different pairs of CBZ has been carried-out that enables the explanation of the nucleation in acetonitrile for both polarizations. In methanol, only CBZ phase III is obtained, which is in agreement with the ability of methanol to create noncovalent interactions preventing the CBZ phase I and II nucleation