1,924 research outputs found
Experimental Search for Non-Newtonian Forces in the Nanometer Scale with Slow Neutrons
Improved limits for new gravity-like short-range interactions, in which a
scattering potential is modeled by the Yukawa-type parametrization, have been
obtained by measuring the angular distribution of 6 \AA\ neutrons scattering
from atomic xenon gas. We have collected approximately
small-angle neutron scattering events. The data are interpreted as no evidence
of new forces and show improved upper limits on the coupling strength in the
interaction range of nm to nm. These improved constraints are also
interpreted as new limits for a model, in which a charge of the new forces is
expressed as a linear combination of the baryon number and the lepton number.Comment: 8 pages, 2 figures, 14TH ASIA-PACIFIC PHYSICS CONFERENCE (APPC2019
A new type of lectin discovered in a fish, flathead (Platycephalus indicus), suggests an alternative functional role for mammalian plasma kallikrein*
A skin mucus lectin exhibiting a homodimeric structure and an S–S bond between subunits of ∼40 kDa was purified from flathead Platycephalus indicus (Scorpaeniformes). This lectin, named FHL (FlatHead Lectin), exhibited mannose-specific activity in a Ca2+-dependent manner. Although FHL showed no homology to any previously reported lectins, it did exhibit ∼20% identity to previously discovered plasma kallikreins and coagulation factor XIs of mammals and Xenopus laevis. These known proteins are serine proteases and play pivotal roles in the kinin-generating system or the blood coagulation pathway. However, alignment analysis revealed that while FHL lacked a serine protease domain, it was homologous to the heavy-chain domain of plasma kallikreins and coagulation factor XI therefore suggesting that FHL is not an enzyme but rather a novel animal lectin. On the basis of this finding, we investigated the lectin activity of human plasma kallikrein and revealed that it could indeed act as a lectin. Other genes homologous to FHL were also found in the genome databases of some fish species, but not in mammals. In contrast, plasma kallikreins and coagulation factor XI have yet to be identified in fish. The present findings suggest that these mammalian enzymes may have originally emerged as a lectin and may have evolved into molecules with protease activity after separation from common ancestors
A global disorder of imprinting in the human female germ line
Imprinted genes are expressed differently depending on whether they are carried by a chromosome of maternal or paternal origin. Correct imprinting is established by germline-specific modifications; failure of this process underlies several inherited human syndromes. All these imprinting control defects are cis-acting, disrupting establishment or maintenance of allele-specific epigenetic modifications across one contiguous segment of the genome. In contrast, we report here an inherited global imprinting defect. This recessive maternal-effect mutation disrupts the specification of imprints at multiple, non-contiguous loci, with the result that genes normally carrying a maternal methylation imprint assume a paternal epigenetic pattern on the maternal allele. The resulting conception is phenotypically indistinguishable from an androgenetic complete hydatidiform mole, in which abnormal extra-embryonic tissue proliferates while development of the embryo is absent or nearly so. This disorder offers a genetic route to the identification of trans-acting oocyte factors that mediate maternal imprint establishment
Spiral spin-liquid and the emergence of a vortex-like state in MnScS
Spirals and helices are common motifs of long-range order in magnetic solids,
and they may also be organized into more complex emergent structures such as
magnetic skyrmions and vortices. A new type of spiral state, the spiral
spin-liquid, in which spins fluctuate collectively as spirals, has recently
been predicted to exist. Here, using neutron scattering techniques, we
experimentally prove the existence of a spiral spin-liquid in MnScS by
directly observing the 'spiral surface' - a continuous surface of spiral
propagation vectors in reciprocal space. We elucidate the multi-step ordering
behavior of the spiral spin-liquid, and discover a vortex-like triple-q phase
on application of a magnetic field. Our results prove the effectiveness of the
- Hamiltonian on the diamond lattice as a model for the spiral
spin-liquid state in MnScS, and also demonstrate a new way to realize a
magnetic vortex lattice.Comment: 10 pages, 11 figure
A Low-Mass Planet with a Possible Sub-Stellar-Mass Host in Microlensing Event MOA-2007-BLG-192
We report the detection of an extrasolar planet of mass ratio q ~ 2 x 10^(-4)
in microlensing event MOA-2007-BLG-192. The best fit microlensing model shows
both the microlensing parallax and finite source effects, and these can be
combined to obtain the lens masses of M = 0.060 (+0.028 -0.021) M_sun for the
primary and m = 3.3 (+4.9 -1.6) M_earth for the planet. However, the
observational coverage of the planetary deviation is sparse and incomplete, and
the radius of the source was estimated without the benefit of a source star
color measurement. As a result, the 2-sigma limits on the mass ratio and finite
source measurements are weak. Nevertheless, the microlensing parallax signal
clearly favors a sub-stellar mass planetary host, and the measurement of finite
source effects in the light curve supports this conclusion. Adaptive optics
images taken with the Very Large Telescope (VLT) NACO instrument are consistent
with a lens star that is either a brown dwarf or a star at the bottom of the
main sequence. Follow-up VLT and/or Hubble Space Telescope (HST) observations
will either confirm that the primary is a brown dwarf or detect the low-mass
lens star and enable a precise determination of its mass. In either case, the
lens star, MOA-2007-BLG-192L, is the lowest mass primary known to have a
companion with a planetary mass ratio, and the planet, MOA-2007-BLG-192Lb, is
probably the lowest mass exoplanet found to date, aside from the lowest mass
pulsar planet.Comment: Accepted for publication in the Astrophysical Journal. Scheduled for
the Sept. 1, 2008 issu
Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation
A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the functional significance of deregulated WNT signalling in gastric homoeostasis and cancer is still unclear. In this study we have addressed this by investigating the immediate effects of WNT signalling activation within the stomach epithelium. We have specifically activated the WNT signalling pathway within the mouse adult gastric epithelium via deletion of either glycogen synthase kinase 3 (GSK3) or APC or via expression of a constitutively active β-catenin protein. WNT pathway deregulation dramatically affects stomach homoeostasis at very short latencies. In the corpus, there is rapid loss of parietal cells with fundic gland polyp (FGP) formation and adenomatous change, which are similar to those observed in familial adenomatous polyposis. In the antrum, adenomas occur from 4 days post-WNT activation. Taken together, these data show a pivotal role for WNT signalling in gastric homoeostasis, FGP formation and adenomagenesis. Loss of the parietal cell population and corresponding FGP formation, an early event in gastric carcinogenesis, as well as antral adenoma formation are immediate effects of nuclear β-catenin translocation and WNT target gene expression. Furthermore, our inducible murine model will permit a better understanding of the molecular changes required to drive tumourigenesis in the stomach
Clinical Characteristics and Treatment Outcomes of Mycobacterium kansasii Lung Disease in Korea
*These authors contributed equally to this work. ∙The authors have no financial conflicts of interest. Purpose: While Mycobacterium kansasii is a common cause of nontuberculous mycobacterial (NTM) lung disease in many developed countries, M. kansasii is infrequently isolated in Korea. We investigated the clinical and radiological features and treatment outcomes of M. kansasii lung disease in Korea retrospectively. Materials and Methods: We identified 41 patients with M. kansasii lung disease who met the diagnostic criteria for NTM lung disease in two tertiary referral hospitals in Seoul, Korea, between January 1998 and December 2007. Results: Their median age was 63 years [interquartile range (IQR) 51-75 years] and 33 (81%) were men. Twenty-three patients (56%) were smokers and 13 patients (32%) had previous pulmonary tuberculosis. The most common radiographic findings were nodules (n = 22, 54%) and consolidation (n = 22, 54%). Cavitation was present in 13 patients (32%). Thirty-one patients (76%) were treated with isoniazid, rifampin, and ethambutol. The median treatment duration was 16 months (IQR 9-18 months). The negative conversion rate after 12 months of treatment was 95%. Conclusion: Clinicians should be aware of the various radiographic manifestations of M. kansasii lung disease. With appropriate treatment, these patients have a good prognosis
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