273 research outputs found
Metabolic rate of major organs and tissues in young adult South Asian women
BACKGROUND/OBJECTIVES:
Major organ-specific and tissue-specific metabolic rate (Ki) values were initially estimated using in vivo methods, and values reported by Elia (Energy metabolism: tissue determinants and cellular corollaries, Raven Press, New York, 1992) were subsequently supported by statistical analysis. However, the majority of work to date on this topic has addressed individuals of European descent, whereas population variability in resting energy metabolism has been reported. We aimed to estimate Ki values in South Asian females.
// SUBJECTS/METHODS:
This cross-sectional study recruited 70 healthy young women of South Asian ancestry. Brain and organs were measured using magnetic resonance imaging, skeletal muscle mass by dual-energy X-ray absorptiometry, fat mass by the 4-component model, and whole-body resting energy expenditure by indirect calorimetry. Organ and tissue Ki values were estimated indirectly using regression analysis through the origin. Preliminary analysis suggested overestimation of heart mass, hence the modeling was repeated with a literature-based 22.5% heart mass reduction.
// RESULTS:
The pattern of derived Ki values across organs and tissues matched that previously estimated in vivo, but the values were systematically lower. However, adjusting for the overestimation of heart mass markedly improved the agreement.
// CONCLUSIONS:
Our results support variability in Ki values among organs and tissues, where some are more metabolically “expensive” than others. Initial findings suggesting lower organ/tissue Ki values in South Asian women were likely influenced by heart mass estimation bias. The question of potential ethnic variability in organ-specific and tissue-specific energy metabolism requires further investigation
Characterizing Quantum Microwave Radiation and its Entanglement with Superconducting Qubits using Linear Detectors
Recent progress in the development of superconducting circuits has enabled
the realization of interesting sources of nonclassical radiation at microwave
frequencies. Here, we discuss field quadrature detection schemes for the
experimental characterization of itinerant microwave photon fields and their
entanglement correlations with stationary qubits. In particular, we present
joint state tomography methods of a radiation field mode and a two-level
system. Including the case of finite quantum detection efficiency, we relate
measured photon field statistics to generalized quasi-probability distributions
and statistical moments for one-channel and two-channel detection. We also
present maximum-likelihood methods to reconstruct density matrices from
measured field quadrature histograms. Our theoretical investigations are
supported by the presentation of experimental data, for which microwave quantum
fields beyond the single-photon and Gaussian level have been prepared and
reconstructed.Comment: 14 pages, 5 figure
Impact of the COVID-19 pandemic on radiology appointments in a tertiary children's hospital: a retrospective study
In this retrospective observational study, we evaluated the impact of the COVID-19 pandemic in London on paediatric radiology activity, as a surrogate of overall hospital activity. We showed a large reduction in overall outpatient imaging activity: 49 250 records occurred in the 371 days post COVID-19 period compared with an expected 67 806 records pre COVID-19 period, representing 18 556 ‘missed’ records. Governmental restrictions were associated with reductions in activity, with the largest reduction in activity during tiers 3 and 4 restrictions. Rescheduling such missed outpatients’ appointments represents considerable resource planning and the associated clinical impact on paediatric healthcare remains to be determined
Quantum Fourier transform, Heisenberg groups and quasiprobability distributions
This paper aims to explore the inherent connection among Heisenberg groups,
quantum Fourier transform and (quasiprobability) distribution functions.
Distribution functions for continuous and finite quantum systems are examined
first as a semiclassical approach to quantum probability distribution. This
leads to studying certain functionals of a pair of "conjugate" observables,
connected via the quantum Fourier transform. The Heisenberg groups emerge
naturally from this study and we take a rapid look at their representations.
The quantum Fourier transform appears as the intertwining operator of two
equivalent representation arising out of an automorphism of the group.
Distribution functions correspond to certain distinguished sets in the group
algebra. The marginal properties of a particular class of distribution
functions (Wigner distributions) arise from a class of automorphisms of the
group algebra of the Heisenberg group. We then study the reconstruction of
Wigner function from the marginal distributions via inverse Radon transform
giving explicit formulas. We consider applications of our approach to quantum
information processing and quantum process tomography.Comment: 39 page
Micro-CT and histological investigation of the spatial pattern of feto-placental vascular density
Introduction:
There are considerable variations in villous morphology within a normal placenta. However, whether there is a reproducible spatial pattern of variation in villous vascular density is not known. Micro-CT provides three-dimensional volume imaging with spatial resolution down to the micrometer scale. In this study, we applied Micro-CT and histological analysis to investigate the degree of heterogeneity of vascularisation within the placenta.
Method:
Ten term placentas were collected at elective caesarean section, perfused with contrast agent and imaged whole with Micro-CT. Eight full depth tissue blocks were then taken from each placenta and imaged. Sections were taken for histological analysis. Data was analysed to investigate vascular fill, and vascular density in relation to location from cord insertion to placental edge at each scale.
Results:
Whole placental imaging revealed no spatially consistent difference in villous vessel density within the main placental tissue, although there was a great degree of heterogeneity. Both block imaging and histological analysis found a large degree of heterogeneity of vascular density within placentas, but no strong correlation between villous vascular density and block location (rs = 0.066, p = 0.7 block imaging, rs = 0.06, p = 0.6 histological analysis).
Discussion:
This work presents a novel method for imaging the human placenta vascular tree using multiscale Micro-CT imaging. It demonstrates that there is a large degree of variation in vascular density throughout normal term human placentas. The three-dimensional data created by this technique could be used, with more advanced computer analysis, to further investigate the structure of the vascular tree
Processing and Transmission of Information
Contains research objectives and reports on four research projects.Lincoln Laboratory, Purchase Order DDL B-00306U. S. ArmyU. S. NavyU. S. Air Force under Air Force Contract AF19(604)-7400National Science Foundation (Grant B-16526)National Institutes of Health (Grant MP-4737
Shape Analysis and Computational Fluid Simulations to Assess Feline Left Atrial Function and Thrombogenesis
In humans, there is a well-established relationship between atrial fibrillation (AF), blood flow abnormalities and thrombus formation, even if there is no clear consensus on the role of left atrial appendage (LAA) morphologies. Cats can also suffer heart diseases, often leading to an enlargement of the left atrium that promotes stagnant blood flow, activating the clotting process and promoting feline aortic thromboembolism. The majority of pathological feline hearts have echocardiographic evidence of abnormal left ventricular filling, usually assessed with 2D and Doppler echocardiography and standard imaging tools. Actually, veterinary professionals have limited access to advanced computational techniques that would enable a better understanding of feline heart pathologies with improved morphological and haemodynamic descriptors. In this work, we applied state-of-the-art image processing and computational fluid simulations based on micro-computed tomography images acquired in 24 cases, including normal cats and cats with varying severity of cardiomyopathy. The main goal of the study was to identify differences in the LA/LAA morphologies and blood flow patterns in the analysed cohorts with respect to thrombus formation and cardiac pathology. The obtained results show significant differences between normal and pathological feline hearts, as well as in thrombus vs non-thrombus cases and asymptomatic vs symptomatic cases, while it was not possible to discern in congestive heart failure with thrombus and from non-thrombus cases. Additionally, in-silico fluid simulations demonstrated lower LAA blood flow velocities and higher thrombotic risk in the thrombus cases
Nonthermal Hard X-ray Emission and Iron Kalpha Emission from a Superflare on II Pegasi
We report on an X-ray flare detected on the active binary system II~Pegasi
with the Swift telescope. The trigger had a 10-200 keV luminosity of
2.2 erg s-- a superflare, by comparison with energies of
typical stellar flares on active binary systems. The trigger spectrum indicates
a hot thermal plasma with T180 K. X-ray spectral analysis
from 0.8--200 keV with the X-Ray Telescope and BAT in the next two orbits
reveals evidence for a thermal component (T80 K) and Fe K 6.4
keV emission. A tail of emission out to 200 keV can be fit with either an
extremely high temperature thermal plasma (TK) or power-law
emission. Based on analogies with solar flares, we attribute the excess
continuum emission to nonthermal thick-target bremsstrahlung emission from a
population of accelerated electrons. We estimate the radiated energy from
0.01--200 keV to be erg, the total radiated energy over
all wavelengths erg, the energy in nonthermal electrons above 20
keV erg, and conducted energy erg. The
nonthermal interpretation gives a reasonable value for the total energy in
electrons 20 keV when compared to the upper and lower bounds on the thermal
energy content of the flare. This marks the first occasion in which evidence
exists for nonthermal hard X-ray emission from a stellar flare. We investigate
the emission mechanism responsible for producing the 6.4 keV feature, and find
that collisional ionization from nonthermal electrons appears to be more
plausible than the photoionization mechanism usually invoked on the Sun and
pre-main sequence stars.Comment: 41 pages, 7 figures, accepted for publication in the Astrophysical
Journa
Learning from cases: Analysis of two cases of craniopharyngioma from the 19th to the 21st centuries. [version 1; peer review: 2 approved]
This manuscript describes the study of two cases of craniopharyngioma, which have been examined repeatedly over three separate centuries. This includes analysis by Josef Engel in 1839, who sought to uncover the physiological role of the pituitary gland; Jacob Erdheim in 1904, who initially described the disease we now call craniopharyngioma, and recent high resolution MRI and micro-CT imaging and attempted DNA analyses of the tumours. The cases highlight how, rightly or wrongly, our interpretation of data is shaped by the technologies, methodologies and prevailing theories of a given time
Chaste: an open source C++ library for computational physiology and biology
Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high performance computational investigations of defibrillation on realistic human cardiac geometries. New models for the initiation and growth of tumours have been developed. In particular, cell-based simulations have provided novel insight into the role of stem cells in the colorectal crypt. Chaste is constantly evolving and is now being applied to a far wider range of problems. The code provides modules for handling common scientific computing components, such as meshes and solvers for ordinary and partial differential equations (ODEs/PDEs). Re-use of these components avoids the need for researchers to "re-invent the wheel" with each new project, accelerating the rate of progress in new applications. Chaste is developed using industrially-derived techniques, in particular test-driven development, to ensure code quality, re-use and reliability. In this article we provide examples that illustrate the types of problems Chaste can be used to solve, which can be run on a desktop computer. We highlight some scientific studies that have used or are using Chaste, and the insights they have provided. The source code, both for specific releases and the development version, is available to download under an open source Berkeley Software Distribution (BSD) licence at http://www.cs.ox.ac.uk/chaste, together with details of a mailing list and links to documentation and tutorials
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