Study of aversive and p38 mapk-inhibitory properties of kappa-agonist with analgesic activity-compound RU-1205

The clinical use of kappa-opioid agonists, despite their lack of significant drug potential, is limited by the development of severe sedation, dysphoria, depression, and anhedonia. To this date, there are kappa-opioid receptor agonists lacking these side effects due to the selective activation of intracellular signal transmission pathways without p38-MAPK-kinase activatio

Distribution, excretion and metabolic pathways of a single parenteral administration of kappa-opioid receptor agonist RU-1205

The purpose was to study the pharmacokinetic properties of RU-1205 with the previously identified kappa-agonistic and analgesic effects after parenteral administratio

Effect of adjuvant drugs on the analgesic activity of opioid morphine analgesics and compound RU-1205

Adjuvant medications can be used to increase the analgesic effect of opioid analgesics, reduce the manifestation of side effects, and also for premedication. This paper provides information on the effect of clonidine, haloperidol, metocloparmide, diazepam, midazolam on opioid analgesics: - morphine and the selective kappa-opioid agonist compound RU-120

Body Height of Children with Bronchial Asthma of Various Severities

© 2017 Tatiana I. Eliseeva et al. Influence of bronchial asthma (BA) severity on physical development in children patients was evaluated in comparison with healthy population. Materials and Methods. 1042 children and adolescents (768 boys) with atopic BA were evaluated. All children underwent standard examination in a clinical setting, including anthropometry. The control group included 875 healthy children of a comparable age (423 boys). Results. The fraction of patients with the normal, lower, and increased height among the whole group of patients with BA is close to the corresponding values in the healthy population (χ 2 =3.32, p=0.65). The fraction of BA patients with the reduced physical development is increased monotonically and significantly when the BA severity increases: healthy group, 8.2% (72/875), BA intermittent, 4.2% (6/144), BA mild persistent 9% (47/520), BA moderate persistent, 11.7% (36/308), and BA severe persistent, 24.3% (17/70) (χ 2 =45.6, p=0,0009). Conclusion. The fraction of the children with the reduced height is increased monotonically and significantly in the groups of increasing BA severities. At the same time, the fraction of such children in groups of intermittent and mild persistent BA practically does not differ from the conditionally healthy peers

Возможности психотерапии в комплексном лечении больных бронхиальной астмой

Summary. The aim of this study was to estimate efficiency of psychotherapy in treatment of patients with bronchial asthma and to develop psychotherapeutic schemes. Three treatment modes were used: nonspecific desensitization using the method of neuro linguistic programming; symptomatic psychotherapy; and pathogenic psychotherapy for correction of psychoemotional background. Combined treatment was more effective than medications alone with regard to symptoms of psychological mechanism of bronchial asthma and to clinical signs in longterm followup. In patients with prominent response to allergens we could recommend nonspecific desensitization using the method of neuro linguistic programming. A rapid correction could be achieved by symptomatic psychotherapy. Delayed but longterm effect could be achieved by pathogenic psychotherapy.Резюме. Целью исследования являлась оценка эффективности психотерапии в комплексном лечении больных бронхиальной астмой (БА) и разработка психотерапевтических схем лечения. Использовались следующие три варианта: неспецифическая десенсибилизация методом нейролингвистического программирования, симптоматическая психотерапия и патогенетическая психотерапия для коррекции психоэмоционального фона. Комплексное лечение было более эффективным, чем медикаментозная терапия без психотерапевтического воздействия, в отношении симптомов нервнопсихического механизма патогенеза БА и клинических признаков при долгосрочном наблюдении. При наличии выраженных реакций на аллерген можно рекомендовать неспецифическую десенсибилизацию методом ней ролингвистического программирования, для быстрой коррекции – симптоматическую психотерапию, для отсроченного, но долгосрочного эффекта – патогенетическую психотерапию

Severe inflammatory reaction induced by peritoneal trauma is the key driving mechanism of postoperative adhesion formation

<p>Abstract</p> <p>Background</p> <p>Many factors have been put forward as a driving mechanism of surgery-triggered adhesion formation (AF). In this study, we underline the key role of specific surgical trauma related with open surgery (OS) and laparoscopic (LS) conditions in postoperative AF and we aimed to study peritoneal tissue inflammatory reaction (TIR), remodelling specific complications of open surgery (OS) versus LS and subsequently evaluating AF induced by these conditions.</p> <p>Methods</p> <p>A prospective randomized study was done in 80 anaesthetised female Wistar rats divided equally into 2 groups. Specific traumatic OS conditions were induced by midline incision line (MIL) extension and tissue drying and specific LS conditions were remodelled by intraperitoneal CO₂insufflation at the 10 cm of water. TIR was evaluated at the 24^th, 72^nd, 120^thand 168^thhour by scoring scale. Statistical analysis was performed by the non-parametric t test and two-way ANOVA using Bonferroni post-tests.</p> <p>Results</p> <p>More pronounced residual TIR was registered after OS than after LS. There were no significant TIR interactions though highly significant differences were observed between the OS and LS groups (p < 0.0001) with regard to surgical and time factors. The TIR change differences between the OS and LS groups were pronounced with postoperative time p < 0.05 at the 24^thand 72^nd; p < 0.01 - 120^thand p < 0.001 - 168^thhrs. Adhesion free wounds were observed in 20.0 and 31.0% of cases after creation of OS and LS conditions respectively; with no significant differences between these values (p > 0.05). However larger adhesion size (41.67 ± 33.63) was observed after OS in comparison with LS (20.31 ± 16.38). The upper-lower 95% confidential limits ranged from 60.29 to 23.04 and from 29.04 to 11.59 respectively after OS and LS groups with significant differences (p = 0.03). Analogous changes were observed in adhesion severity values. Subsequently, severe TIR parameters were followed by larger sizes of severe postoperative adhesions in the OS group than those observed in the LS group.</p> <p>Conclusions</p> <p>MIL extension and tissue drying seem to be the key factors in the pathogenesis of adhesion formation, triggering severe inflammatory reactions of the peritoneal tissue surrounding the MIL resulting in local and systemic consequences. CO₂insufflation however, led to moderate inflammation and less adhesion formation.</p