Eliseeva, M.

Kalzhanov, Z.

Kosmas, I.

Malvasi, A.

Medvediev, M.

Mynbaev, O.

Stark, M.

Tinelli, A.

Repository for DZ &quot;DMA&quot;

Accepted ManuscriptAn inexact study design produced misleading conclusions: To perform operativeprocedures in an optimized local atmosphere: Can it reduce post-operativeadhesion formation? de Vries A, Mårvik R, Kuhry E. [Int J Surg 2013 Sep 27. pii:S1743-9191(13)01053-4. doi: 10.1016/j.ijsu.2013.09.005]O.A. Mynbaev, MYu Eliseeva, A. Tinelli, A. Malvasi, I.P. Kosmas, M.V. Medvediev,ZhR. Kalzhanov, M. StarkPII: S1743-9191(13)01109-6DOI: 10.1016/j.ijsu.2013.11.009Reference: IJSU 1235To appear in: International Journal of SurgeryReceived Date: 6 October 2013Accepted Date: 15 November 2013Please cite this article as: Mynbaev O, Eliseeva M, Tinelli A, Malvasi A, Kosmas I, Medvediev M,Kalzhanov Z, Stark M, An inexact study design produced misleading conclusions: To perform operativeprocedures in an optimized local atmosphere: Can it reduce post-operative adhesion formation?de Vries A, Mårvik R, Kuhry E. [Int J Surg 2013 Sep 27. pii: S1743-9191(13)01053-4. doi: 10.1016/j.ijsu.2013.09.005], International Journal of Surgery (2013), doi: 10.1016/j.ijsu.2013.11.009.This is a PDF file of an unedited manuscript that has been accepted for publication. As a service toour customers we are providing this early version of the manuscript. The manuscript will undergocopyediting, typesetting, and review of the resulting proof before it is published in its final form. Pleasenote that during the production process errors may be discovered which could affect the content, and alllegal disclaimers that apply to the journal pertain.MANUSCRIPT ACCEPTEDACCEPTED MANUSCRIPTTITLE PAGE An inexact study design produced misleading conclusions: To perform operative procedures in an optimized local atmosphere: Can it reduce post-operative adhesion formation? de Vries A, Mårvik R, Kuhry E. [Int J Surg 2013 Sep 27. pii: S1743-9191(13)01053-4. doi: 10.1016/j.ijsu.2013.09.005].  Mynbaev OA1,2,3,4*, Eliseeva MYu3, Tinelli A5, Malvasi A6, Kosmas IP7, Medvediev MV8, Kalzhanov ZhR9, Stark M4.   1Moscow Institute of Physics & Technology (State University), Dolgoprudny, Moscow region, Russia 2Moscow State University of Medicine & Dentistry, Delegatskaya str 20/1, Moscow, 127374, Russia 3The Department of Obstetrics, Gynecology & Reproductive Medicine, Peoples’ Friendship University of Russia, Miklukho-Maklay, 21 Build 3, 117198, Moscow, Russia 4The New European Surgical Academy, Berlin, Germany 5Department of Obstetrics and Gynaecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Piazza Muratore, 73100 Lecce, Italy 6Obstetrics and Gynecology Department, Santa Maria Hospital, Bari, Italy 7Xatzikosta General Hospital, Ioannina, 45110, Ioannina, Greece 8Dnepropetrovsk State Medical University, Dnepropetrovsk, Ukraine 9School of Health and Human Sciences, University of Essex, UK*Address correspondence to: Prof. Ospan A Mynbaev,  E-mail: ospanmynbaev@hotmail.com MANUSCRIPT ACCEPTEDACCEPTED MANUSCRIPTMANUSCRIPT:  Dear Sir, Since adhesion formation pathogenesis has been our research interest for a long time we read with great interest a recently published article in your journal entitled “To perform operative procedures in an optimized local atmosphere: Can it reduce post-operative adhesion formation?” by de Vries et al.1 The authors concluded that during surgery the rats exposed to the warmed and humidified artificial atmosphere consisting of more than 75% carbon dioxide and 3-4% oxygen had more severe and more post-operative adhesions compared to the rats that were exposed to the ambient air during surgery.  In our opinion technical factors highlighted by the authors1 in discussion section may have been biased, the results were probably exaggerated and their conclusions therefore misleading. The design of this study1 is not clear and is inexact due to differences in adhesion model creation modes which were done in different circumstances either inside of the Perspex box with limited space for surgeon’s manipulations or in the ambient air without limitations for surgeon. Subsequently it is difficult to be sure of their conclusions.  In a series of experimental studies we have shown that CO2 insufflation did not increase parameters of adhesion formation in comparison with those of open surgery2 nor in an open laparoscopy model3 with and without CO2-insufflation when surgical procedures were strictly standardized. Analogously the absence of any impact of CO2-insufflation/CO2-pneumoperitoneum or even its antiadhesiogenic properties has been demonstrated in many well-designed studies4-7 with exploration of underlying pathways and pathophysiological mechanisms8-12. Moreover a crucial impact of surgical technique on adhesion formation was demonstrated in many studies with different modes of surgical trauma2,3,13-21. We previously have discussed2,3,22,23 methodological shortcomings with subsequent untenable conclusions of studies showing an impact of CO2 insufflation/pneumoperitoneum with small-scale gas mixtures, in which were cited the authors in this article1 whereas studies proving an opposite opinion were not cited at all. In such study with uncertain conclusions, the authors1 should have discussed opposite positions. Therefore a well-designed study with standardized surgical procedures could cast light on the highly complex pathophysiology of adhesion formation and the impact of gas-environment on this process. References 1.de Vries A, Mårvik R, Kuhry E. To perform operative procedures in an optimized local atmosphere: Can it reduce post-operative adhesion formation? Int J Surg 2013 Sep 27. pii: S1743-9191(13)01053-4. doi: 10.1016/j.ijsu.2013.09.005. [Epub ahead of print] 2.Pismensky SV, Kalzhanov ZhR, Eliseeva MYu, Kosmas IP, Mynbaev OA. Severe inflammatory reaction induced by peritoneal trauma is the key driving mechanism of postoperative adhesion formation. BMC Surg 2011; 11: 30. Published online 2011 November 14. doi: 10.1186/1471-2482-11-30 3.Mynbaev OA, Eliseeva MYu, Kalzhanov ZhR, Lyutova LV, Pismensky SP, Tinelli A, Malvasi A, Ioannis P Kosmas. Surgical trauma and CO2-insufflation impact on adhesion formation in parietal and visceral peritoneal lesions. Int J Clin Exp Med 2013; 6(3): 153–165. Published online 2013 March 21.  4.Shimomura M, Hinoi T, Ikeda S, Adachi T, Kawaguchi Y, Tokunaga M, Sasada T, Egi H, Tanabe K, Okajima M, Ohdan H. Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery. Surgery 2013 Mar;153(3):344-56. doi: 10.1016/j.surg.2012.07.037. Epub 2012 Dec 4. 5.Rosch R, Binnebosel M, Klink CD, Otto J, Junge K, Neumann UP. Impact of pressure and gas type on adhesion formation and biomaterial integration in laparoscopy. Surg Endosc 2011;25:3605–3612.[PubMed] MANUSCRIPT ACCEPTEDACCEPTED MANUSCRIPT6. Kece C, Ulas M, Ozer I, Ozel U, Bilgehan A, Aydog G, Dalgic T, Oymaci E, Bostanci B. Carbondioxide pneumoperitoneum prevents postoperative adhesion formation in a rat cecal abrasion model. J Laparoendosc Adv Surg Tech A 2010;20:25–30.[PubMed] 7. Miyano G, Yamataka A, Doi T, Okawada M, Takano Y, Kobayashi H, Lane GJ, Miyano T. Carbon dioxide pneumoperitoneum prevents intraperitoneal adhesions after laparotomy in rats. J Pediatr Surg 2006;41:1025–1028.[PubMed] 8.Lee SW, Feingold DL, Carter JJ, Zhai C, Stapleton G, Gleason N, Whelan RL. Peritoneal macrophage and blood monocyte functions after open and laparoscopic-assisted cecectomy in rats. Surg Endosc 2003;17:1996–2002.[PubMed] 9. Ziprin P, Ridgway PF, Peck DH, Darzi AW. Laparoscopic-type environment enhances mesothelial cell fibrinolytic activity in vitro via a down-regulation of plasminogen activator inhibitor-1 activity. Surgery 2003;134:758–765.[PubMed] 10. Hanly EJ, Aurora AA, Shih SP, Fuentes JM, Marohn MR, De MA, Talamini MA. Peritoneal acidosis mediates immunoprotection in laparoscopic surgery. Surgery 2007;142:357–364.[PubMed] 11. Kopernik G, Avinoach E, Grossman Y, Levy R, Yulzari R, Rogachev B, Douvdevani A. The effect of a high partial pressure of carbon dioxide environment on metabolism and immune functions of human peritoneal cells-relevance to carbon dioxide pneumoperitoneum. Am J Obstet Gynecol. 1998;179:1503–1510.[PubMed] 12.Mynbaev OA, Koninckx PR, Bracke M. A possible mechanism of peritoneal pH changes during carbon dioxide pneumoperitoneum. Surg Endosc. 2007 Mar;21(3):489-91. 13. Hirota Y, Tsukada K, Nishio E, Yoshida M, Tada S, Udagawa Y. Postoperative adhesion formation after laparoscopic uterine horn resection in a porcine model: comparison of five instruments. J Laparoendosc Adv Surg Tech A. 2005;15:581–585.[PubMed] 14. Forestier D, Slim K, Joubert-Zakeyh J, Nini E, Dechelotte P, Chipponi J. [Do bipolar scissors increase postoperative adhesions? An experimental double-blind randomized trial] . Ann Chir. 2002;127:680–684.[PubMed] 15. Wallwiener CW, Kraemer B, Wallwiener M, Brochhausen C, Isaacson KB, Rajab TK. The extent of adhesion induction through electrocoagulation and suturing in an experimental rat study. Fertil Steril. 2010;93:1040–1044.[PubMed] 16. Vetere PF, Lazarou G, Mondesir C, Wei K, Khullar P, Ogden L. Strategies to minimize adhesion formation after surgery. JSLS. 2011;15:350–354. [PMC free article][PubMed] 17. Rappaport WD, Hunter GC, Allen R, Lick S, Halldorsson A, Chvapil T, Holcomb M, Chvapil M. Effect of electrocautery on wound healing in midline laparotomy incisions. Am J Surg. 1990;160:618–620.[PubMed] 18. Ten Broek RP, Wilbers J, van GH. Electrocautery causes more ischemic peritoneal tissue damage than ultrasonic dissection. Surg Endosc. 2011;25:1827–1834. [PMC free article][PubMed] 19. Bhatta N, Isaacson K, Flotte T, Schiff I, Anderson RR. Injury and adhesion formation following ovarian wedge resection with different thermal surgical modalities. Lasers Surg Med. 1993;13:344–352.[PubMed] 20. Bellina JH, Hemmings R, Voros JI, Ross LF. Carbon dioxide laser and electrosurgical wound study with an animal model: a comparison of tissue damage and healing patterns in peritoneal tissue. Am J Obstet Gynecol. 1984;148:327–334.[PubMed] 21. Riedel HH, Stamer U, Mecke H. [Results of electron microscopy studies of the uterine horn of the New Zealand rabbit following use of 4 different coagulation methods] . Zentralbl Gynakol. 1987;109:1350–1367.[PubMed] 22. Mynbaev OA, Corona R. Possible mechanisms of peritoneal tissue-oxygen tension changes during CO2-pneumoperitoneum: the role of design, methodology and animal models. Hum Reprod. 2009 Jun;24(6):1242-6 23. Mynbaev OA. Re: The addition of O2 to the CO2 does not prevent the systemic effects of the CO2 pneumoperitoneum in a rabbit model. Surg Lap Endosc Percut Tech. 2005;15(5):271-274. Surg Laparosc Endosc Percutan Tech. 2006 Apr;16(2):123-5; author reply 125-6.  

An inexact study design produced misleading conclusions: To perform operative procedures in an optimized local atmosphere: Can it reduce post-operative adhesion formation?

http://repo.dma.dp.ua/90/1/j.ijsu.2013.11.009.pdf

An inexact study design produced misleading conclusions: To perform operative procedures in an optimized local atmosphere: Can it reduce post-operative adhesion formation?

Abstract

Similar works

Full text

Available Versions

Repository for DZ "DMA"

An inexact study design produced misleading conclusions: To perform operative procedures in an optimized local atmosphere: Can it reduce post-operative adhesion formation?

Abstract

Similar works

Full text

Available Versions

Repository for DZ &quot;DMA&quot;

Repository for DZ "DMA"