Which factors affect the Italian consumer's intention to insect-eating? An application of an integrated attitude-intention-eating model

This research explored the role of key socio-psychological dimensions on individuals' intention to eat insectbased foods (IEIBF). In particular, the theoretical framework included biospheric values and social norms, whose impact on pro-environmental choices has been largely evidenced, but also those factors related to animal welfare and neophobia/neophilia attitudes. An online survey was carried out in different Italian regions intercepting 1402 individuals to verify the relationships predicted by our proposed model, i.e. the Integrated Sustainable Neophilic Insect-based Eating Model (ISNIEM), for predicting IEIBF. Participants completed a survey containing measures of IEIBF, biospheric values, general pro-environmental beliefs, attitude toward sustainability, food neophilia, concern for insect welfare, and social norms (both injunctive and descriptive). Structural Equation Modelling (SEM) technique was used for testing the ISNIEM. The main findings show that individuals having higher concern about environmental and ethical sustainability are more open to eating insects, especially if the latter are treated ethically. Overall, these results suggest that a typical consumer of insect foods is likely to be driven to their consumption from one side by curiosity (related to the neophilia dimension), and from the other side either by the sense of responsibility towards the environment or by the concern for ethical issues (i.e., animal welfare). The integrated attitude-food-intention model used to explore intention to eat insect foods (IEIBF) with a visual scheme represents an innovative approach in the study of consumer behaviour

ODRL Policy Modelling and Compliance Checking

This paper addresses the problem of constructing a policy pipeline that enables compliance checking of business processes against regulatory obligations. Towards this end, we propose an Open Digital Rights Language (ODRL) profile that can be used to capture the semantics of both business policies in the form of sets of required permissions and regulatory requirements in the form of deontic concepts, and present their translation into Answer Set Programming (via the Institutional Action Language (InstAL)) for compliance checking purposes. The result of the compliance checking is either a positive compliance result or an explanation pertaining to the aspects of the policy that are causing the noncompliance. The pipeline is illustrated using two (key) fragments of the General Data Protect Regulation, namely Articles 6 (Lawfulness of processing) and Articles 46 (Transfers subject to appropriate safeguards) and industrially-relevant use cases that involve the specification of sets of permissions that are needed to execute business processes. The core contributions of this paper are the ODRL profile, which is capable of modelling regulatory obligations and business policies, the exercise of modelling elements of GDPR in this semantic formalism, and the operationalisation of the model to demonstrate its capability to support personal data processing compliance checking, and a basis for explaining why the request is deemed compliant or not

Social distance during the covid-19 pandemic reflects perceived rather than actual risk

Interpersonal space (IPS) is the area surrounding our own bodies in which we interact comfortably with other individuals. During the COVID-19 pandemic, keeping larger IPS than usual, along with wearing a face mask, is one of the most effective measures to slow down the COVID-19 outbreak. Here, we explore the contribution of actual and perceived risk of contagion and anxiety levels in regulating our preferred social distance from other people during the first wave of the COVID-19 pandemic in Italy. In this study, 1293 individuals from six Italian regions with different levels of actual risk of infection participated in an online survey assessing their perceived risk to be infected, level of anxiety and IPS. Two tasks were adopted as measures of interpersonal distance: the Interpersonal Visual Analogue Scale and a questionnaire evaluating interpersonal distance with and without face mask. The results showed that the IPS regulation was affected by how people subjectively perceived COVID-19 risk and the related level of anxiety, not by actual objective risk. This clarifies that the role of threat in prompting avoidant behaviors expressed in increased IPS does not merely reflect environmental events but rather how they are subjectively experienced and represented

Interleukin-2/interferon-α2a/13-retinoic acid-based chemoimmunotherapy in advanced renal cell carcinoma: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN)

We performed a prospectively randomised clinical trial to compare the efficacy of four subcutaneous interleukin-2-(sc-IL-2) and sc interferon-α2a (sc-IFN-α2a)-based outpatient regimens in 379 patients with progressive metastatic renal cell carcinoma. Patients with lung metastases, an erythrocyte sedimentation rate ⩽70 mm h−1 and neutrophil counts ⩽6000 μl−1 (group I) were randomised to arm A: sc-IL-2, sc-IFN-α2a, peroral 13-cis-retinoic acid (po-13cRA) (n=78), or arm B: arm A plus inhaled-IL-2 (n=65). All others (group II) were randomised to arm C: arm A plus intravenous 5-fluorouracil (iv-5-FU) (n=116), or arm D: arm A plus po-Capecitabine (n=120). Median overall survival (OS) was 22 months (arm A; 3-year OS: 29.7%) and 18 months (arm B; 3-year OS: 29.2%) in group I, and 18 months (arm C; 3-year OS: 25.7%) and 16 months (arm D; 3-year OS: 32.6%) in group II. There were no statistically significant differences in OS, progression-free survival, and objective response between arms A and B, and between arms C and D, respectively. Given the known therapeutic efficacy of sc-IL-2/sc-INF-α2a/po-13cRA-based outpatient chemoimmunotherapies, our results did not establish survival advantages in favour of po-Capecitabine vs iv-5-FU, and in favour of short-term inhaled-IL-2 in patients with advanced renal cell carcinoma receiving systemic cytokines

Conserved and variable correlated mutations in the plant MADS protein network

<p>Abstract</p> <p>Background</p> <p>Plant MADS domain proteins are involved in a variety of developmental processes for which their ability to form various interactions is a key requisite. However, not much is known about the structure of these proteins or their complexes, whereas such knowledge would be valuable for a better understanding of their function. Here, we analyze those proteins and the complexes they form using a correlated mutation approach in combination with available structural, bioinformatics and experimental data.</p> <p>Results</p> <p>Correlated mutations are affected by several types of noise, which is difficult to disentangle from the real signal. In our analysis of the MADS domain proteins, we apply for the first time a correlated mutation analysis to a family of interacting proteins. This provides a unique way to investigate the amount of signal that is present in correlated mutations because it allows direct comparison of mutations in various family members and assessing their conservation. We show that correlated mutations in general are conserved within the various family members, and if not, the variability at the respective positions is less in the proteins in which the correlated mutation does not occur. Also, intermolecular correlated mutation signals for interacting pairs of proteins display clear overlap with other bioinformatics data, which is not the case for non-interacting protein pairs, an observation which validates the intermolecular correlated mutations. Having validated the correlated mutation results, we apply them to infer the structural organization of the MADS domain proteins.</p> <p>Conclusion</p> <p>Our analysis enables understanding of the structural organization of the MADS domain proteins, including support for predicted helices based on correlated mutation patterns, and evidence for a specific interaction site in those proteins.</p