Structure, phase behavior and inhomogeneous fluid properties of binary dendrimer mixtures

The effective pair potentials between different kinds of dendrimers in solution can be well approximated by appropriate Gaussian functions. We find that in binary dendrimer mixtures the range and strength of the effective interactions depend strongly upon the specific dendrimer architecture. We consider two different types of dendrimer mixtures, employing the Gaussian effective pair potentials, to determine the bulk fluid structure and phase behavior. Using a simple mean field density functional theory (DFT) we find good agreement between theory and simulation results for the bulk fluid structure. Depending on the mixture, we find bulk fluid-fluid phase separation (macro-phase separation) or micro-phase separation, i.e., a transition to a state characterized by undamped periodic concentration fluctuations. We also determine the inhomogeneous fluid structure for confinement in spherical cavities. Again, we find good agreement between the DFT and simulation results. For the dendrimer mixture exhibiting micro-phase separation, we observe rather striking pattern formation under confinement.Comment: 8 pages, 10 figure

Dynamical density functional theory for dense atomic liquids

Starting from Newton's equations of motion, we derive a dynamical density functional theory (DDFT) applicable to atomic liquids. The theory has the feature that it requires as input the Helmholtz free energy functional from equilibrium density functional theory. This means that, given a reliable equilibrium free energy functional, the correct equilibrium fluid density profile is guaranteed. We show that when the isothermal compressibility is small, the DDFT generates the correct value for the speed of sound in a dense liquid. We also interpret the theory as a dynamical equation for a coarse grained fluid density and show that the theory can be used (making further approximations) to derive the standard mode coupling theory that is used to describe the glass transition. The present theory should provide a useful starting point for describing the dynamics of inhomogeneous atomic fluids.Comment: 14 pages, accepted for publication in J. Phys.: Condens. Matte

Criticality and phase separation in a two-dimensional binary colloidal fluid induced by the solvent critical behavior

We present an experimental and theoretical study of the phase behavior of a binary mixture of colloids with opposite adsorption preferences in a critical solvent. As a result of the attractive and repulsive critical Casimir forces, the critical fluctuations of the solvent lead to a further critical point in the colloidal system, i.e. to a critical colloidal-liquid--colloidal-liquid demixing phase transition which is controlled by the solvent temperature. Our experimental findings are in good agreement with calculations based on a simple approximation for the free energy of the system.Comment: 5 pages, 5 figures, to be published in Europhysics Letter

Reply to Comment on "Cosmic rays, carbon dioxide, and climate"

In our analysis [Rahmstorf et al., 2004], we arrived at two main conclusions: the data of Shaviv and Veizer [2003] do not show a significant correlation of cosmic ray flux (CRF) and climate, and the authors' estimate of climate sensitivity to CO2 based on a simple regression analysis is questionable. After careful consideration of Shaviv and Veizer's comment, we want to uphold and reaffirm these conclusions. Concerning the question of correlation, we pointed out that a correlation arose only after several adjustments to the data, including shifting one of the four CRF peaks and stretching the time scale. To calculate statistical significance, we first need to compute the number of independent data points in the CRF and temperature curves being correlated, accounting for their autocorrelation. A standard estimate [Quenouille, 1952] of the number of effective data points is urn:x-wiley:00963941:media:eost14930:eost14930-math-0001 where N is the total number of data points and r1, r2 are the autocorrelations of the two series. For the curves of Shaviv and Veizer [2003], the result is NEFF = 4.8. This is consistent with the fact that these are smooth curves with four humps, and with the fact that for CRF the position of the four peaks is determined by four spiral arm crossings or four meteorite clusters, respectively; that is, by four independent data points. The number of points that enter the calculation of statistical significance of a linear correlation is (NEFF− 2), since any curves based on only two points show perfect correlation; at least three independent points are needed for a meaningful result

How does geological heterogeneity control floodplain groundwater dynamics?

Upland floodplains provide an important function in regulating river flows and controlling the coupling of hillslope runoff with rivers. A floodplain in an upland area of the River Tweed catchment, Scotland, was characterised using geophysics, 3D geological mapping, hydrogeological testing and geochemical sampling, and monitored from September 2011 to February 2013 for variations in groundwater levels, river stage, soil moisture and meteorological parameters, including a period of nine months of exceptionally high rainfall. The floodplain contains an unconsolidated, permeable alluvial and glaciofluvial aquifer 8 to 15 m thick, with transmissivity 50 to 1000 m2/d, which is coupled to the hillslope by permeable solifluction deposits. The floodplain aquifer is a significant store of, and conduit for, catchment water. It gains recharge from the river and the adjacent hillslope, transmitting groundwater downstream and acting as a buffer to restrict water flowing from the hillslope from directly entering the river. Floodplain groundwater level fluctuations are driven primarily by changes in river level and the propagation of pressure waves through the floodplain aquifer. There is significant lateral variation in floodplain groundwater response. Most of the floodplain aquifer is hydraulically connected to the river, but groundwater at the edge of the floodplain is strongly controlled by hillslope sub-surface flow. The geological structure and lithology of the hillslope-floodplain transition is an important hydrological control. It can enhance the influence of subsurface hillslope runoff to the floodplain, which has implications for runoff modelling, flood prevention interventions on hillslopes aimed at reducing runoff, and development at floodplain edges. Vertical heterogeneity in hydrological properties within the floodplain aquifer alters hydrological response, causing different depths of the floodplain to respond differently to hillslope and river inputs. These vertical variations need to be better taken into account in floodplain and hillslope-floodplain studies. This research demonstrates the importance of understanding the 3D geology and hydrogeology of floodplains in order to advance catchment research and effective flood management measures

How a realistic magnetosphere alters the polarizations of surface, fast magnetosonic, and Alfvén waves

Funding: MOA holds a UKRI (STFC / EPSRC) Stephen Hawking Fellowship EP/T01735X/1. DJS was supported by STFC grant ST/S000364/1. MDH was supported by NASA grant 80NSSC19K0127. A.N.W. was partially funded by STFC grant ST/N000609/1.System-scale magnetohydrodynamic (MHD) waves within Earth?s magnetosphere are often understood theoretically using box models. While these have been highly instructive in understanding many fundamental features of the various wave modes present, they neglect the complexities of geospace such as the inhomogeneities and curvilinear geometries present. Here we show global MHD simulations of resonant waves impulsively-excited by a solar wind pressure pulse. Although many aspects of the surface, fast magnetosonic (cavity/waveguide), and Alfvén modes present agree with the box and axially symmetric dipole models, we find some predictions for large-scale waves are significantly altered in a realistic magnetosphere. The radial ordering of fast mode turning points and Alfvén resonant locations may be reversed even with monotonic wave speeds. Additional nodes along field lines that are not present in the displacement/velocity occur in both the perpendicular and compressional components of the magnetic field. Close to the magnetopause the perpendicular oscillations of the magnetic field have the opposite handedness to the velocity. Finally, widely-used detection techniques for standing waves, both across and along the field, can fail to identify their presence. We explain how all these features arise from the MHD equations when accounting for a non-uniform background field and propose modified methods which might be applied to spacecraft observations.Publisher PDFPeer reviewe

Coupling of groundwater, river level and rainfall in an upland floodplain

Upland floodplains provide an important function in regulating river flows and controlling the coupling of hillslope runoff with rivers. To investigate the responses of floodplain groundwater to river flows and rainfall events, a small floodplain in an upland area of the River Tweed catchment, Scotland, was characterised using geophysics, 3D geological mapping and hydrogeological testing; and monitoring undertaken from September 2011 to February 2013 of: groundwater levels in five pairs of piezometers; river stage and flow at the upstream and downstream limits of the study site; soil moisture on the adjacent hillslope; and meteorological parameters. Periodical groundwater chemistry and residence data were also collected. The floodplain aquifer is permeable throughout but partially stratified, comprising dominantly alluvial and glaciofluvial sandy gravels between 8 and 15m interspersed with thin, intermittent layers of low permeability silts, clays and peats. Overlying the gravel aquifer is a partial thin cover of low permeability alluvial silts, and it is underlain dominantly by low permeability glaciolacustrine silts and clays. High permeability solifluction deposits mantle much of the adjacent hillslope and provide a rapid connection to the floodplain aquifer. The unusually wet year of 2012 provides a good example of how a temperate upland floodplain responds to consistently high rainfall. Statistical analysis and graphical interpretation of groundwater level, rainfall, soil moisture and river stage demonstrates that: 1) dominant groundwater flow within the floodplain is in the same direction as the river, from up-valley to down-valley; 2) soil moisture in the hillslope is strongly correlated with local rainfall, but groundwater across much of the floodplain is more strongly influenced by river stage; except 3) groundwater near the edge of floodplain, which responds more slowly to local rainfall and river stage changes ; and 4) subsurface flow from the hillslope to the floodplain occurs during high rainfall events. A detailed investigation of three flood events, when the river rose above bank level and flooded adjacent fields and groundwater became artesian in parts of the floodplain, suggests that antecedent moisture conditions can partly explain the differences in groundwater response during different flood events, where high intensity or long duration rainfall can cause saturated soil conditions, reducing soil water storage capacity and hence promoting flood conditions. A conceptual model based on field data of groundwater flow after storm events during antecedent unsaturated and saturated soil conditions is presented

The transition from medical student to junior doctor: today's experiences of Tomorrow's Doctors.

CONTEXT Medical education in the UK has recently undergone radical reform. Tomorrow's Doctors has prescribed undergraduate curriculum change and the Foundation Programme has overhauled postgraduate education. OBJECTIVES This study explored the experiences of junior doctors during their first year of clinical practice. In particular, the study sought to gain an understanding of how junior doctors experienced the transition from the role of student to that of practising doctor and how well their medical school education had prepared them for this. METHODS The study used qualitative methods comprising of semi-structured interviews and audio diary recordings with newly qualified doctors based at the Peninsula Foundation School in the UK. Purposive sampling was used and 31 of 186 newly qualified doctors self-selected from five hospital sites. All 31 participants were interviewed once and 17 were interviewed twice during the year. Ten of the participants also kept audio diaries. Interview and audio diary data were transcribed verbatim and thematically analysed with the aid of a qualitative data analysis software package. RESULTS The findings show that, despite recent curriculum reforms, most participants still found the transition stressful. Dealing with their newly gained responsibility, managing uncertainty, working in multi-professional teams, experiencing the sudden death of patients and feeling unsupported were important themes. However, the stress of transition was reduced by the level of clinical experience gained in the undergraduate years. CONCLUSIONS Medical schools need to ensure that students are provided with early exposure to clinical environments which allow for continuing 'meaningful' contact with patients and increasing opportunities to 'act up' to the role of junior doctor, even as students. Patient safety guidelines present a major challenge to achieving this, although with adequate supervision the two aims are not mutually exclusive. Further support and supervision should be made available to junior doctors in situations where they are dealing with the death of a patient and on surgical placements

Ubiq: A System to Build Flexible Social Virtual Reality Experiences

While they have long been a subject of academic study, social virtual reality (SVR) systems are now attracting increasingly large audiences on current consumer virtual reality systems. The design space of SVR systems is very large, and relatively little is known about how these systems should be constructed in order to be usable and efficient. In this paper we present Ubiq, a toolkit that focuses on facilitating the construction of SVR systems. We argue for the design strategy of Ubiq and its scope. Ubiq is built on the Unity platform. It provides core functionality of many SVR systems such as connection management, voice, avatars, etc. However, its design remains easy to extend. We demonstrate examples built on Ubiq and how it has been successfully used in classroom teaching. Ubiq is open source (Apache License) and thus enables several use cases that commercial systems cannot