Theoretical and methodological grounds of integration interaction between the subjects of innovative process

The article is devoted to the analysis of research in the sphere of innovative theory where some gnosiological gaps are exposed and the systemic classification of innovation essence with three marked methods of approach is represented. Here are defined the term “subjects of innovative process” and main areas o f effective realization of integration of innovative process subjectsyesБелгородский государственный университе

Monitoring the Financial Status of an Enterprise as the Most Important Component of the Financial Analysis

Статья посвящена мониторингу финансового состояния предприятия как наиболее важному компоненту финансового анализаyesBelgorod State National Research Universit

Modeling of the integrated interaction of the innovation process subjects

Within the scope of the presented article, the category "integration" is used as development process, leading to a new type of innovative process subject interaction with the purpose of growth in competitiveness, uncertainty reduction of innovative product commercialization, cost reductionyesBelgorod State Universit

Genesis of the Russia’s economy innovative development

The innovative development of economy in Russia is possible only if the way of development will be based on the objective basic components, i.e. the corresponding system of premises and factors determining the innovative process. Namely the latter ensure a transformation of the fundamental processes into the application ones, as well as the dynamic development of the economy under the new trends and patterns influenceyesBelgorod State Universit

The analysis of indicators of social development in the macroregion (on the example of the Central federal district) = Анализ показателей развития социальной сферы макрорегиона (на примере Центрального федерального округа)

The article presents the results of the analysis of social development indicators of the Central Federal District of the Russian Federation and reasons that hinder their growth. The aim of the study is to determine the trends of social development of the Central Federal District on the basis of an assessment of monetary income of the population, unemployment rate, life expectancy at birth, infant mortality for the period of 2005-201

Antiplatelet activity of new derivatives of benzimidazole containing sterically hindered phenolic group in their structure

The chemical class of benzimidazole derivatives with a hindered phenolic substituent in their structure is promising for the search for new antiaggregant and antioxidant drug

The influence of styles of family education on emotional-volitional sphere of the senior preschool children

The article discusses the style of family education as its most important characteristic, the most inherent ways of attitude of parents to a child, using certain means and methods of pedagogical influence, which are expressed in a peculiar manner of verbal circulation and interactio

Sub-wavelength-resolution imaging of biological tissues using THz solid immersion microscopy

We have proposed a method of THz soli

In vitro terahertz spectroscopy of gelatin-embedded human brain tumors - a pilot study

We have performed the in vitro terahertz (THz) spectroscopy of human brain tumors. In order to x tissue

Novel Substituted Azoloazines with Anticoagulant Activity

Hypercytokinemia, or cytokine storm, often complicates the treatment of viral and bacterial infections, including COVID-19, leading to the risk of thrombosis. However, the use of currently available direct anticoagulants for the treatment of COVID-19 patients is limited due to safety reasons. Therefore, the development of new anticoagulants remains an urgent task for organic and medicinal chemistry. At the same time, new drugs that combine anticoagulant properties with antiviral or antidiabetic activity could be helpfull in the treatment of COVID-19 patients, especially those suffering from such concomitant diseases as arterial hypertension or diabetes. We have synthesized a number of novel substituted azoloazines, some of which have previously been identified as compounds with pronounced antiviral, antibacterial, antidiabetic, antiaggregant, and anticoagulant activity. Two compounds from the family of 1,2,4-triazolo[1,5-a]pyrimidines have demonstrated anticoagulant activity at a level exceeding or at least comparable with that of dabigatran etexilate as the reference compound. 7,5-Di(2-thienyl)-4,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine has shown the highest ability to prolong the thrombin time, surpassing this reference drug by 2.2 times. This compound has also exhibited anticoagulant activity associated with the inhibition of thrombin (factor IIa). Moreover, the anticoagulant effect of this substance becomes enhanced under the conditions of a systemic inflammatory reaction. © 2023 by the authors.Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2020-777This research was funded by the Ministry of Science and Higher Education of the Russian Federation (agreement on the provision of grants from the federal budget in the form of subsidies under paragraph 4 of article 78.1 of the Budget Code of the Russian Federation, Moscow, 1 October 2020, no. 075-15-2020-777)