250 research outputs found
Einstein-Podolsky-Rosen-Bohm experiment and Bell inequality violation using Type 2 parametric down conversion
We report a new two-photon polarization correlation experiment for realizing the Einstein-Podolsky-Rosen-Bohm (EPRB) state and for testing Bell-type inequalities. We use the pair of orthogonally-polarized light quanta generated in Type 2 parametric down conversion. Using 1 nm interference filters in front of our detectors, we observe from the output of a 0.5mm beta - BaB2O4 (BBO) crystal the EPRB correlations in coincidence counts, and measure an associated Bell inequality violation of 22 standard deviations. The quantum state of the photon pair is a polarization analog of the spin-1/2 singlet state
The photon: Experimental emphasis on its wave-particle duality
Two types of Einstein-Podolsky-Rosen experiments were demonstrated recently in our laboratory. It is interesting to see that in an interference experiment (wave-like experiment) the photon exhibits its particle property, and in a beam-splitting experiment (particle-like experiment) the photon exhibits its wave property. The two-photon states are produced from Type 1 and Type 2 optical spontaneous parametric down conversion, respectively
Magnetic fields of opposite polarity in sunspot penumbrae
Context. A significant part of the penumbral magnetic field returns below the
surface in the very deep photosphere. For lines in the visible, a large portion
of this return field can only be detected indirectly by studying its imprints
on strongly asymmetric and three-lobed Stokes V profiles. Infrared lines probe
a narrow layer in the very deep photosphere, providing the possibility of
directly measuring the orientation of magnetic fields close to the solar
surface.
Aims. We study the topology of the penumbral magnetic field in the lower
photosphere, focusing on regions where it returns below the surface.
Methods. We analyzed 71 spectropolarimetric datasets from Hinode and from the
GREGOR infrared spectrograph. We inferred the quality and polarimetric accuracy
of the infrared data after applying several reduction steps. Techniques of
spectral inversion and forward synthesis were used to test the detection
algorithm. We compared the morphology and the fractional penumbral area covered
by reversed-polarity and three-lobed Stokes V profiles for sunspots at disk
center. We determined the amount of reversed-polarity and three-lobed Stokes V
profiles in visible and infrared data of sunspots at various heliocentric
angles. From the results, we computed center-to-limb variation curves, which
were interpreted in the context of existing penumbral models.
Results. Observations in visible and near-infrared spectral lines yield a
significant difference in the penumbral area covered by magnetic fields of
opposite polarity. In the infrared, the number of reversed-polarity Stokes V
profiles is smaller by a factor of two than in the visible. For three-lobed
Stokes V profiles the numbers differ by up to an order of magnitude.Comment: 11 pages 10 figures plus appendix (2 pages 3 figures). Accepted as
part of the A&A special issue on the GREGOR solar telescop
Bell State Preparation using Pulsed Non-Degenerate Two-Photon Entanglement
We report a novel Bell state preparation experiment. High-purity Bell states
are prepared by using femtosecond pulse pumped \emph{nondegenerate} collinear
spontaneous parametric down-conversion. The use of femtosecond pump pulse {\em
does not} result in reduction of quantum interference visibility in our scheme
in which post-selection of amplitudes and other traditional mechanisms, such
as, using thin nonlinear crystals or narrow-band spectral filters are not used.
Another distinct feature of this scheme is that the pump, the signal, and the
idler wavelengths are all distinguishable, which is very useful for quantum
communications.Comment: 4 pages, submitted to PR
A semiconductor source of triggered entangled photon pairs?
The realisation of a triggered entangled photon source will be of great
importance in quantum information, including for quantum key distribution and
quantum computation. We show here that: 1) the source reported in ``A
semiconductor source of triggered entangled photon pairs''[1. Stevenson et al.,
Nature 439, 179 (2006)]} is not entangled; 2) the entanglement indicators used
in Ref. 1 are inappropriate, relying on assumptions invalidated by their own
data; and 3) even after simulating subtraction of the significant quantity of
background noise, their source has insignificant entanglement.Comment: 5 pages in pre-print format, 1 tabl
Generic entanglement generation, quantum statistics and complementarity
A general and an arbitrarily efficient scheme for entangling the spins (or
any spin-like degree of freedom) of two independent uncorrelated identical
particles by a combination of two particle interferometry and which way
detection is formulated. It is shown that the same setup could be used to
identify the quantum statistics of the incident particles from either the sign
or the magnitude of measured spin correlations. Our setup also exhibits a
curious complementarity between particle distinguishability and the amount of
generated entanglement.Comment: To appear in Phys. Rev. Let
Guiding principles on the education and practice of theranostics.
The recent development and approval of new diagnostic imaging and therapy approaches in the field of theranostics have revolutionised nuclear medicine practice. To ensure the provision of these new imaging and therapy approaches in a safe and high-quality manner, training of nuclear medicine physicians and qualified specialists is paramount. This is required for trainees who are learning theranostics practice, and for ensuring minimum standards for knowledge and competency in existing practising specialists.
To address the need for a training curriculum in theranostics that would be utilised at a global level, a Consultancy Meeting was held at the IAEA in May 2023, with participation by experts in radiopharmaceutical therapy and theranostics including representatives of major international organisations relevant to theranostics practice.
Through extensive discussions and review of existing curriculum and guidelines, a harmonised training program for theranostics was developed, which aims to ensure safe and high quality theranostics practice in all countries.
The guiding principles for theranostics training outlined in this paper have immediate relevance for the safe and effective practice of theranostics
Association between forgone care and household income among the elderly in five Western European countries – analyses based on survey data from the SHARE-study
Background. Studies on the association between access to health care and household income have rarely included an assessment of 'forgone care', but this indicator could add to our understanding of the inverse care law. We hypothesize that reporting forgone care is more prevalent in low income groups. Methods. The study is based on the 'Survey of Health, Ageing and Retirement in Europe (SHARE)', focusing on the non-institutionalized population aged 50 years or older. Data are included from France, Germany, Greece, Italy and Sweden. The dependent variable is assessed by the following question: During the last twelve months, did you forgo any types of care because of the costs you would have to pay, or because this care was not available or not easily accessible? The main independent variable is household income, adjusted for household size and split into quintiles, calculating the quintile limits for each country separately. Information on age, sex, self assessed health and chronic disease is included as well. Logistic regression models were used for the multivariate analyses. Results. The overall level of forgone care differs considerably between the five countries (e.g. about 10 percent in Greece and 6 percent in Sweden). Low income groups report forgone care more often than high income groups. This associ
Clinical and Functional Characterization of a Patient Carrying a Compound Heterozygous Pericentrin Mutation and a Heterozygous IGF1 Receptor Mutation
Intrauterine and postnatal longitudinal growth is controlled by a strong genetic component that regulates a complex network of endocrine factors integrating them with cellular proliferation, differentiation and apoptotic processes in target tissues, particularly the growth centers of the long bones. Here we report on a patient born small for gestational age (SGA) with severe, proportionate postnatal growth retardation, discreet signs of skeletal dysplasia, microcephaly and moyamoya disease. Initial genetic evaluation revealed a novel heterozygous IGF1R p.Leu1361Arg mutation affecting a highly conserved residue with the insulin-like growth factor type 1 receptor suggestive for a disturbance within the somatotropic axis. However, because the mutation did not co-segregate with the phenotype and functional characterization did not reveal an obvious impairment of the ligand depending major IGF1R signaling capabilities a second-site mutation was assumed. Mutational screening of components of the somatotropic axis, constituents of the IGF signaling system and factors involved in cellular proliferation, which are described or suggested to provoke syndromic dwarfism phenotypes, was performed. Two compound heterozygous PCNT mutations (p.[Arg585X];[Glu1774X]) were identified leading to the specification of the diagnosis to MOPD II. These investigations underline the need for careful assessment of all available information to derive a firm diagnosis from a sequence aberration
Insights into the Molecular Evolution of the PDZ/LIM Family and Identification of a Novel Conserved Protein Motif
The PDZ and LIM domain-containing protein family is encoded by a diverse group of genes whose phylogeny has currently not been analyzed. In mammals, ten genes are found that encode both a PDZ- and one or several LIM-domains. These genes are: ALP, RIL, Elfin (CLP36), Mystique, Enigma (LMP-1), Enigma homologue (ENH), ZASP (Cypher, Oracle), LMO7 and the two LIM domain kinases (LIMK1 and LIMK2). As conventional alignment and phylogenetic procedures of full-length sequences fell short of elucidating the evolutionary history of these genes, we started to analyze the PDZ and LIM domain sequences themselves. Using information from most sequenced eukaryotic lineages, our phylogenetic analysis is based on full-length cDNA-, EST-derived- and genomic- PDZ and LIM domain sequences of over 25 species, ranging from yeast to humans. Plant and protozoan homologs were not found. Our phylogenetic analysis identifies a number of domain duplication and rearrangement events, and shows a single convergent event during evolution of the PDZ/LIM family. Further, we describe the separation of the ALP and Enigma subfamilies in lower vertebrates and identify a novel consensus motif, which we call ‘ALP-like motif’ (AM). This motif is highly-conserved between ALP subfamily proteins of diverse organisms. We used here a combinatorial approach to define the relation of the PDZ and LIM domain encoding genes and to reconstruct their phylogeny. This analysis allowed us to classify the PDZ/LIM family and to suggest a meaningful model for the molecular evolution of the diverse gene architectures found in this multi-domain family
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