Analysis of electroencephalograms in Alzheimer's disease patients with multiscale entropy

The aim of this study was to analyse the electroencephalogram (EEG) background activity of Alzheimer’s disease (AD) patients using the Multiscale Entropy (MSE). The MSE is a recently developed method that quantifies the regularity of a signal on different time scales. These time scales are inspected by means of several coarse-grained sequences formed from the analysed signals. We recorded the EEGs from 19 scalp electrodes in 11 AD patients and 11 age-matched controls and estimated the MSE profile for each epoch of the EEG recordings. The shape of the MSE profiles reveals the EEG complexity, and it suggests that the EEG contains information in deeper scales than the smallest one. Moreover, the results showed that the EEG background activity is less complex in AD patients than control subjects. We found significant difference

An experimental study of the breakage of liquid bridges at stability limit of minimum volume

An experimental apparatus to study the breaking process of axisymmetric liquid bridges has been developed, and the breaking sequences of a large number of liquid bridge configurations at minimum-volume stability limit have been analyzed. Experimental results show that very close to the breaking moment the neck radius of the liquid bridge varies as t1/3, where t is the time to breakage, irrespective of the value of the distance between the solid disks that support the liquid column

A systematic review on the ecosystem services provided by green infrastructure

Urbanization and climate change are endangering the sustainability of public spaces through increased land artificialization, ecological fragmentation, reduced resource availability, and limited accessibility to natural and seminatural areas. Properly managing Green Infrastructure (GI) can contribute to mitigating these challenges by delivering multiple provisioning, regulating, supporting and cultural Ecosystem Services (ES). This would facilitate the implementation of strategically planned GI networks in cities for urban regeneration purposes. In this context, this study developed a systematic review on the ES provided by GI using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The analysis of 199 eligible articles indicated that more efforts should be made to address more ES at once, which connects to the need for conceiving GI as a strategically planned network of areas aimed at delivering diverse benefits. Based on the methods used in the items reviewed, geoprocessing tools and multi-criteria decision analysis are proposed to develop systems of indicators capable of accounting for multiple ES. These systems should also rely on multidisciplinary and participative procedures to encompass various facets of GI and represent the priorities of all relevant stakeholders

Comentario sobre la reacción del iodo con la metionina. Técnicas iodimétricas para su valoración en muestras conteniendo proteínas

En este trabajo se estudian algunas técnicas iodimétricas para la dosificación d' e metionina. Después de haber ensayado diferentes pH y estudiado la.s posibles interferencias de las sustancias que más frecuentemente suelen ir asociadas a la metionina, se estabIecen los procedimientos para la valoración de metionina en medicamentos y otras muestras en cuya composición entra a formar parte alguna proteina. La determinación se practica a un pH 4,5 - 5 en un medio regulado con ácido acético-acetato sódico.Sorne iodimetric techniques are employed in this work for the purPose of evaluating of methionine. Arter having assayed various pH and studied the possible interference of sorne ·compounds that frequently accompany methionine the procedures are stablished for the titration of methionine in medicines and other samples in whose composition is integrated some protein. The determination is practised at pH 4,5 - 5 in a buffered solution with acetic acid and sodium acetate

Universal Predictions for Statistical Nuclear Correlations

We explore the behavior of collective nuclear excitations under a multi-parameter deformation of the Hamiltonian. The Hamiltonian matrix elements have the form $P(|H_{ij}|)\propto 1/\sqrt{|H_{ij}|}\exp(-|H_{ij}|/V)$, with a parametric correlation of the type $\log \langle H(x)H(y)\rangle\propto -|x-y|$. The studies are done in both the regular and chaotic regimes of the Hamiltonian. Model independent predictions for a wide variety of correlation functions and distributions which depend on wavefunctions and energies are found from parametric random matrix theory and are compared to the nuclear excitations. We find that our universal predictions are observed in the nuclear states. Being a multi-parameter theory, we consider general paths in parameter space and find that universality can be effected by the topology of the parameter space. Specifically, Berry's phase can modify short distance correlations, breaking certain universal predictions.Comment: Latex file + 12 postscript figure

NaV1.1 is essential for proprioceptive signaling and motor behaviors

The voltage-gated sodium channel (NaV), NaV1.1, is well-studied in the central nervous system; conversely, its contribution to peripheral sensory neuron function is more enigmatic. Here, we identify a new role for NaV1.1 in mammalian proprioception. RNAscope analysis and in vitro patch-clamp recordings in genetically identified mouse proprioceptors show ubiquitous channel expression and significant contributions to intrinsic excitability. Notably, genetic deletion of NaV1.1 in sensory neurons caused profound and visible motor coordination deficits in conditional knockout mice of both sexes, similar to conditional Piezo2-knockout animals, suggesting that this channel is a major contributor to sensory proprioceptive transmission. Ex vivo muscle afferent recordings from conditional knockout mice found that loss of NaV1.1 leads to inconsistent and unreliable proprioceptor firing characterized by action potential failures during static muscle stretch; conversely, afferent responses to dynamic vibrations were unaffected. This suggests that while a combination of Piezo2 and other NaV isoforms is sufficient to elicit activity in response to transient stimuli, NaV1.1 is required for transmission of receptor potentials generated during sustained muscle stretch. Impressively, recordings from afferents of heterozygous conditional knockout animals were similarly impaired, and heterozygous conditional knockout mice also exhibited motor behavioral deficits. Thus, NaV1.1 haploinsufficiency in sensory neurons impairs both proprioceptor function and motor behaviors. Importantly, human patients harboring NaV1.1 loss-of-function mutations often present with motor delays and ataxia; therefore, our data suggest that sensory neuron dysfunction contributes to the clinical manifestations of neurological disorders in which NaV1.1 function is compromised. Collectively, we present the first evidence that NaV1.1 is essential for mammalian proprioceptive signaling and behaviors

A COMPARISON OF THREE METHODS FOR MARKERS SELECTION IN UNTARGETED LIPIDOMICS

In the present paper is analyzed different algorithms for the marker’s selection of mass-spectrometry data in lipidomics. The goal of the investigation is to highlight the shortcomings and advantages of the processes and determine the most suitable.The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged

Molecular Marker Mapping of Leaf Rust Resistance Gene Lr46 and Its Association with Stripe Rust Resistance Gene Yr29 in Wheat

Leaf and stripe rusts, caused by Puccinia triticina and P. striiformis, respectively, are globally important fungal diseases of wheat that cause significant annual yield losses. A gene that confers slow rusting resistance to leaf rust, designated as Lr46, has recently been located on wheat chromosome 1B. The objectives of our study were to establish the precise genomic location of gene Lr46 using molecular approaches and to determine if there was an association of this locus with adult plant resistance to stripe rust. A population of 146 F5 and F6 lines produced from the cross of susceptible ‘Avocet S’ with resistant ‘Pavon 76’ was developed and classified for leaf rust and stripe rust severity for three seasons. Using patterns of segregation for the two diseases, we estimated that at least two genes with additive effects conferred resistance to leaf rust and three to four genes conferred resistance to stripe rust. Bulked segregant analysis and linkage mapping using amplified fragment length polymorphisms with the ‘Avocet’ × ‘Pavon 76’ population, F3 progeny lines of a single chromosome recombinant line population from the cross ‘Lalbahadur’ × ‘Lalbahadur (Pavon 1B)’, and the International Triticeae Mapping Initiative population established the genomic location of Lr46 at the distal end of the long arm of wheat chromosome 1B. A gene that is closely linked to Lr46 and confers moderate levels of adult plant resistance to stripe rust is identified and designated as Yr29

Pelletized Forage-Based Rations as Alternative Feeds for Improving Goat Productivity

Goat farming is very popular in the Philippines as it is considered by many to be a viable rural enterprise. Despite this, the goat industry is faced with many challenges, including problems relating to high pre-weaning mortality, poor nutrition and lack of strategic approaches to accelerate genetic improvement. The long term rate of increase of goat numbers is only 0.97% per annum, due to high offtake rates and low productivity. Thus, the Philippine goat population is only expected to reach 4.27million by 2020 (compared with the target of 6.2 million), given the 3.88million population in 2010 (Alo 2012). Interventions are needed to accelerate growth of the goat population. Goats are typically fed on locally available resources which are characterised by low quality and highly variable availability. These characteristics can be overcome through processing techniques such as sun drying and pelleting to ensure year round feed supply. Pelleting offers particular advantages. Feeding animals with pellets provides better feed efficiency, greater starch digestibility, less feed waste, non-selective feeding, better handling and storage, and increased income due to more efficient feeding and higher productivity. While pellets are available for swine, poultry and buffalo in the Philippine market, pellets for goats are not currently available. The aim of this study was to develop pelletized forage-based rations for goats and evaluate them for their technical and financial viability