Efficient and practical aerobic radical addition of thiophosphites to alkenes

Thiophosphites, but not phosphites, add onto alkenes under very mild conditions when treated with triethylborane and oxygen, and deliver the expected adducts in high isolated yields. This method, featuring a high atom economy, complements those described in literature and can be used to initiate tandem cascade processes. © 2001 Published by Elsevier Science Ltd

Efficient and practical aerobic radical addition of thiophosphites to alkenes

Thiophosphites, but not phosphites, add onto alkenes under very mild conditions when treated with triethylborane and oxygen, and deliver the expected adducts in high isolated yields. This method, featuring a high atom economy, complements those described in literature and can be used to initiate tandem cascade processes. © 2001 Published by Elsevier Science Ltd

Efficient and practical aerobic radical addition of thiophosphites to alkenes

Thiophosphites, but not phosphites, add onto alkenes under very mild conditions when treated with triethylborane and oxygen, and deliver the expected adducts in high isolated yields. This method, featuring a high atom economy, complements those described in literature and can be used to initiate tandem cascade processes. © 2001 Published by Elsevier Science Ltd

Efficient and practical aerobic radical addition of thiophosphites to alkenes

Thiophosphites, but not phosphites, add onto alkenes under very mild conditions when treated with triethylborane and oxygen, and deliver the expected adducts in high isolated yields. This method, featuring a high atom economy, complements those described in literature and can be used to initiate tandem cascade processes. © 2001 Published by Elsevier Science Ltd

The Preparation of New Phosphorus-Centered Functional Groups for Modified Oligonucleotides and Other Natural Phosphates

Efforts to develop synthetic methodologies allowing the preparation of α,α– difluorophosphonothioates, α,α–difluorophosphonodithioates, α,α–difluorophosphono- trithioates, and α,α–difluorophosphinates are reviewed in the light of applications in the field of modified oligonucleotides and cyclitol phosphates. Two successful approaches have been developed, based either on the addition of phosphorus-centered radicals onto gem–difluoroalkenes or on a process involving the addition of lithiodifluorophosphono- thioates 91 onto a ketone and the subsequent deoxygenation reaction of the adduct. The radical route successfully developed a practical route to α,α–difluoro–H–phosphinates which proved to be useful intermediates to a variety of phosphate isosters. The ionic route led to the first preparation of phosphonodifluoromethyl analogues of nucleoside– 3’–phosphates

I Plan de igualdade entre mulleres e homes no Servizo Galego de Saúde. Período 2021-2024

I Plan de Igualdade entre mulleres e homes no Servizo Galego de Saúde, período 2021-2024, definido como un conxunto ordenado de medidas adoptadas despois de realizar un diagnóstico de situación, tendentes a alcanzar na organización a igualdade de trato e de oportunidades entre mulleres e homes e a eliminar a discriminación por razón de sexo.I Plan de Igualdad entre mujeres y hombres en el Servicio Gallego de Salud, período 2021-2024, definido como un conjunto ordenado de medidas adoptadas después de realizar un diagnóstico de situación, tendentes a alcanzar en la organización la igualdad de trato y de oportunidades entre mujeres y hombres y a eliminar la discriminación por razón de sexo