Round-Optimal Secure Two-Party Computation from Trapdoor Permutations

In this work we continue the study on the round complexity of secure two-party computation with black-box simulation. Katz and Ostrovsky in CRYPTO 2004 showed a 5 (optimal) round construction assuming trapdoor permutations for the general case where both players receive the output. They also proved that their result is round optimal. This lower bound has been recently revisited by Garg et al. in Eurocrypt 2016 where a 4 (optimal) round protocol is showed assuming a simultaneous message exchange channel. Unfortunately there is no instantiation of the protocol of Garg et al. under standard polynomial-time hardness assumptions. In this work we close the above gap by showing a 4 (optimal) round construction for secure two-party computation in the simultaneous message channel model with black-box simulation, assuming trapdoor permutations against polynomial-time adversaries. Our construction for secure two-party computation relies on a special 4-round protocol for oblivious transfer that nicely composes with other protocols in parallel. We define and construct such special oblivious transfer protocol from trapdoor permutations. This building block is clearly interesting on its own. Our construction also makes use of a recent advance on non-malleability: a delayed-input 4-round non-malleable zero knowledge argument

Isolation and characterization of microsatellite markers for Araucaria angustifolia (Araucariaceae).

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Isolamento e caracterização de marcadores microssatélites para Araucaria angustifólia (Araucariaceae).

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Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study.

In endothelial cells, erythropoietin receptors (EPORs) mediate the protective, proliferative and angiogenic effects of EPO and its analogues, which act as EPOR agonists. Because hormonal receptors undergo functional changes upon chronic exposure to agonists and because erythropoiesis-stimulating agents (ESAs) are used for the long-term treatment of anemia, it is critical to determine the mechanism by which EPOR responsiveness is regulated at the vascular level after prolonged exposure to ESAs. Here, we investigated EPOR desensitization/resensitization in human umbilical vein endothelial cells (HUVECs) upon exposure to three ESAs with different pharmacokinetic profiles, epoetin alpha (EPOα), darbepoetin alpha (DarbEPO) and continuous EPOR activator (CERA). These agonists all induced activation of the transcription factor STAT-5, which is a component of the intracellular pathway associated with EPORs. STAT-5 activation occurred with either monophasic or biphasic kinetics for EPOα/DarbEPO and CERA, respectively. ESAs, likely through activation of the STAT-5 pathway, induced endothelial cell proliferation and stimulated angiogenesis in vitro, demonstrating a functional role for epoetins on endothelial cells. All epoetins induced EPOR desensitization with more rapid kinetics for CERA compared to EPOα and DarbEPO. However, the recovery of receptor responsiveness was strictly dependent on the type of epoetin, the agonist concentration and the time of exposure to the agonist. EPOR resensitization occurred with more rapid kinetics after exposure to low epoetin concentrations for a short period of desensitization. When the highest concentration of agonists was tested, the recovery of receptor responsiveness was more rapid with CERA compared to EPOα and was completely absent with DarbEPO. Our results demonstrate that these three ESAs regulate EPOR resensitization by very different mechanisms and that both the type of molecule and the length of EPOR stimulation are factors that are critical for the control of EPOR functioning in endothelial cells. The differences observed in receptor resensitization after stimulation with the structurally different ESAs are most likely due different control mechanisms of receptor turnover at the intracellular level

Low inbreeding and high pollen dispersal distances in populations of two Amazonian Forest tree species.

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Round Optimal Secure Multiparty Computation from Minimal Assumptions

We construct a four round secure multiparty computation (MPC) protocol in the plain model that achieves security against any dishonest majority. The security of our protocol relies only on the existence of four round oblivious transfer. This culminates the long line of research on constructing round-efficient MPC from minimal assumptions (at least w.r.t. black-box simulation)

Four-Round Concurrent Non-Malleable Commitments from One-Way Functions

How many rounds and which assumptions are required for concurrent non-malleable commitments? The above question has puzzled researchers for several years. Pass in [TCC 2013] showed a lower bound of 3 rounds for the case of black-box reductions to falsifiable hardness assumptions with respect to polynomial-time adversaries. On the other side, Goyal [STOC 2011], Lin and Pass [STOC 2011] and Goyal et al. [FOCS 2012] showed that one-way functions (OWFs) are sufficient with a constant number of rounds. More recently Ciampi et al. [CRYPTO 2016] showed a 3-round construction based on subexponentially strong one-way permutations. In this work we show as main result the first 4-round concurrent non-malleable commitment scheme assuming the existence of any one-way function. Our approach builds on a new security notion for argument systems against man-in-the-middle attacks: Simulation-Witness-Independence. We show how to construct a 4-round one-many simulation-witnesses-independent argument system from one-way functions. We then combine this new tool in parallel with a weak form of non-malleable commitments constructed by Goyal et al. in [FOCS 2014] obtaining the main result of our work

Additive Beneficial Effects of Beta-Blockers to Angiotensin-Converting Enzyme Inhibitors in the Survival and Ventricular Enlargement (SAVE) Study fn1fn1This study was supported by a University-Industry grant from the Medical Research Council, Ottawa, Ontario, Canada and Bristol Myers Squibb, Montreal, Quebec, Canada.

AbstractObjectives. This study assessed whether treatment with a beta-adrenergic blocking agent in addition to the use of the angiotensin-converting enzyme (ACE) inhibitor captopril decreases cardiovascular mortality and morbidity in patients with asymptomatic left ventricular dysfunction after myocardial infarction (MI) and whether the presence of neurohumoral activation at the time of hospital discharge predicts the effects of beta-blocker treatment in these patients.Background. Both beta-blockers and ACE inhibitors have been shown to have beneficial effects in patients with left ventricular dysfunction but no overt heart failure after MI. These patients often have persistent neurohumoral activation at the time of hospital discharge, and one would expect that patients with activation of the sympathetic nervous system derive the most benefit from treatment with beta-blockers. However, beta-blockers are underutilized in this high risk group of patients, and it is unknown whether their beneficial effects are additive to those of ACE inhibitors.Methods. We performed a retrospective analysis of data from the Survival and Ventricular Enlargement (SAVE) study and its neurohumoral substudy. The relations between beta-blocker use at the time of randomization and neurohumoral activation and the subsequent development of cardiovascular events were analyzed by use of Cox proportional hazards models controlling for covariates.Results. After adjustment for baseline imbalances, beta-blocker use was associated with a significant reduction in risk of cardiovascular death (30%, 95% confidence interval [CI] 12% to 44%) and development of heart failure (21%, 95% CI 3% to 36%), but the reduction in recurrent MI (11%, 95% CI 13% to 31%) was not significant. These reductions were independent of the use of captopril. Beta-blockers were not found to have a greater effect in patients with neurohumoral activation at the time of hospital discharge.Conclusions. The beneficial effects of beta-blocker use at the time of hospital discharge in patients with asymptomatic left ventricular dysfunction after MI appear to be additive to those of captopril and other interventions known to improve prognosis. Neurohumoral activation at the time of hospital discharge fails to identify those patients who will derive the greatest benefit from treatment with beta-blockers.(J Am Coll Cardiol 1997;29:229–36

Morphological and molecular characteristics do not confirm popular classification of the Brazil nut tree in Acre, Brazil.

In the State of Acre, the Brazil nut tree, Bertholletia excelsa (Lecythidaceae), is classified by the local population into two types according to morphological characteristics, including color and quality of wood, shape of the trunk and crown, and fruit production. We examined thereliability of this classification by comparing morphological and molecular data of four populations of Brazil nut trees from Vale do Rio Acre in the Brazilian Amazon. For the morphological analysis, we evaluated qualitative and quantitative information of the trees, fruits, and seeds. The molecular analysis was performed using RAPD and ISSR markers, with cluster analysis. Significant differences were found between the two types of Brazil nut trees for the characters diameter at breast height, fruit yield, fruit size,and number of seeds per fruit. Despite the significant correlation between the morphological characteristics and the popular classification, we observed all possible combinations of morphological characteristics in both types of Brazil nut trees. In some individuals, the classification did not correspond to any of the characteristics. The results obtained with molecular markers showed that the two locally classified types of Brazil nut trees did not differ genetically, indicating that there is no consistent separation between them