Ultrasonographic evaluation of endometrial growth in women undergoing assisted reproduction during the luteal phase in fresh and frozen embryo transfer cycles

published_or_final_versio

Control of mosaic disease using microbial biostimulants: insights from mathematical modelling

A major challenge to successful crop production comes from viral diseases of plants that cause significant crop losses, threatening global food security and the livelihoods of countries that rely on those crops for their staple foods or source of income. One example of such diseases is a mosaic disease of plants, which is caused by begomoviruses and is spread to plants by whitefly. In order to mitigate negative impact of mosaic disease, several different strategies have been employed over the years, including roguing/replanting of plants, as well as using pesticides, which have recently been shown to be potentially dangerous to the environment and humans. In this paper we derive and analyse a mathematical model for control of mosaic disease using natural microbial biostimulants that, besides improving plant growth, protect plants against infection through a mechanism of RNA interference. By analysing the stability of the system’s steady states, we will show how properties of biostimulants affect disease dynamics, and in particular, how they determine whether the mosaic disease is eradicated or is rather maintained at some steady level. We will also present the results of numerical simulations that illustrate the behaviour of the model in different dynamical regimes, and discuss biological implications of theoretical results for the practical purpose of control of mosaic disease

Pengaruh Pembelajaran Problem Posing Terhadap Kemampuan Pemahaman Konsep Matematika Siswa Kelas XI IPA SMA Negeri 6 Palembang

Tujuan dari penelitian ini adalah (1) Mengetahui perbedaan kemampuan pemahaman konsep matematika antara siswa pada kelas yang memperoleh pembelajaran problem posing dengan siswa pada kelas yang memperoleh pembelajaran konvensional. (2) Mengetahui perbedaan kemampuan pemahaman konsep matematika antara siswa dalam kelompok tinggi, sedang dan rendah ditinjau dari tingkat penguasaan matematika. (3) Mengetahui interaksi antara model pembelajaran dan tingkat penguasaan matematika dalam kemampuan pemahaman konsep matematika. Penelitian ini merupakan penelitian eksperimen dengan unit-unit penelitian ditentukan berdasarkan kelompok pembelajaran dan tingkat penguasaan matematika siswa. Kelompok pembelajaran dibedakan menjadi dua yaitu pembelajaran problem posing dan pembelajaran konvensional. Sedangkan tingkat penguasaan matematika siswa dibedakan ke dalam kelompok tinggi, sedang dan rendah. Populasi dalam penelitian ini adalah seluruh siswa kelas XI IPA SMAN 6 Palembang tahun ajaran 2009/2010. Sampel penelitian adalah kelas XI IPA 1 sebagai kelas eksperimen dan kelas XI IPA 2 sebagai kelas kontrol. Berdasarkan hasil analisis data diperoleh kesimpulan sebagai berikut: (1) Terdapat perbedaan kemampuan pemahaman konsep matematika antara siswa yang memperoleh pembelajaran problem posing dengan siswa yang memperoleh pembelajaran konvensional. (2) Terdapat perbedaan kemampuan pemahaman konsep matematika antara siswa pada kelompok tinggi dan sedang serta tinggi dan rendah. Tetapi tidak terdapat perbedaan kemampuan pemahaman konsep matematika antara siswa pada kelompok sedang dan rendah. (3) Terdapat interaksi antara pembelajaran (Problem Posing dan Konvensional) dengan tingkat penguasaan matematika siswa dalam kemampuan pemahaman konsep matematika. Interaksi terjadi antara pembelajaran (PP dan KV) dengan tingkat penguasaan matematika siswa pada kelompok tinggi dan sedang serta tinggi dan rendah dalam kemampuan pemahaman konsep matematika. Tetapi tidak terdapat interaksi antara pembelajaran (PP dan KV) dengan tingkat penguasaan matematika siswa dalam kelompok sedang dan rendah

Antiplasmodial and chloroquine chemosensitizing and resistance reversal effects of coumarin derivatives against Plasmodium falciparum 3D7 and K1

Background Emergence of chloroquine (CQ) resistance among different strains of Plasmodium falciparum is the worst incident that has ever faced the dedicated efforts to eradicate malaria. The main cause of CQ resistance is over-activity of the pumping mechanism that ousts CQ outside the DV. This urged the scientists to look for other alternatives or adjuvants that augment its action. CQ The study aimed to test the potential of five coumarin derivatives, namely; umbeliferon, esculetin, scopoletine, herniarin and 3-aminocoumarine to inhibit plasmodium growth and reverse CQ resistance in Plasmodium falciparum K1 and 3D7. They are highly ubiquitous in nature and are famous by their diverse pharmacological effects. SYBRE green-1 based drug sensitivity assay was used to screen the effect of CQ and each coumarin on the parasite growth and isobologram technique was to assess the interaction of the coumarins with CQ. Effect of each coumarin on both RBCs and Vero cells stability as well as on RBCs fragility were screened to exclude any toxic impact on normal cells. On the other hand, their effect on hemozoin formation was screened to investigate about their molecular mechanism. For molecular characterization, Their antioxidant properties were determined using the conventional in vitro tests and their characters were obtained from Molinspiration Simulation Software. Results showed that all of them were safe to human cells, have weak to moderate plasmodial growth inhibitory effect and only umbeliferon, 3- aminocoumarin and esculetin has interacted effectively with CQ. These actions are neither correlated with hemozoin formation inhibition nor to the antioxidant mechanisms. Further studies recommended to investigate the mechanism of their action. Overall, all the tested coumarins are not ideal to be used in the conventional malaria therapy and only umbeliferon, 3-aminocoumarin and esculetin can be suggested to potentiate CQ action

TCT-66 Door to Impella Placement in Acute Coronary Syndrome Complicated by Cardiogenic Shock: An Updated Meta-analysis

Background: The impact of time to hemodynamic support in acute myocardial infarction complicated by cardiogenic shock (AMICS) has yet to be defined. The aim of this meta-analysis was to evaluate the impact of timing of mechanical circulatory support (MCS) with Impella. Methods: a systematic literature review and meta-analysis was conducted using PubMed and Cochrane databases. All studies reporting short-term mortality rates and timing of Impella insertion, pre vs during/post PCI, were included. Primary end point was short-term mortality (≤30 days), while secondary end pointswere midterm mortality, device-related bleeding and limb ischemia. Results: Of 1,289 studies identified, 13 studies (6,810 patients; 2,970 patients identified as receiving Impella before PCI and 3,840 patients receiving Impella during/after PCI) were included in this analysis. Median age was 63.8 years (IQR 63-65.7 years), 76% of patients were male, and a high prevalence of cardiovascular risk factors was noted across the entire population. Short-term mortality was significantly reduced in those receiving pre-PCI Impella support, 37.2% vs 53.6% (RR 0.7; CI 0.56-0.88). Midterm mortality was also lower in the pre-PCI group, 47.9% vs 73% (RR 0.81; CI 0.68-0.97). The rates of device-related bleeding (RR 1.05; CI 0.47-2.33) and limb ischemia (RR 1.6; CI 0.63-2.15) were similar between the two groups. Conclusion: This analysis suggests that MCS placement with Impella prior to PCI in AMICS may have a positive impact on short- and midterm mortality compared with post-PCI placement, with similar outcome in terms of safety. Categories: CORONARY: Hemodynamic Support and Cardiogenic Shoc

Impact of Prior Coronary Artery Bypass Grafting in Patients ≥75 Years Old Presenting With Acute Myocardial Infarction (From the National Readmission Database)

Patients ≥75 years old presenting with acute myocardial infarction (AMI) have complex coronary anatomy in part due t Patients ≥75 years old presenting with acute myocardial infarction (AMI) have complex coronary anatomy in part due to prior coronary artery bypass grafting (CABG), percutaneous coronary interventions (PCI), calcific and valvular disease. Using the National Readmission Database from January 2016 to November 2017, we identified hospital admissions for acute myocardial infarction in patients ≥75 years old and divided them based on a history of CABG. We evaluated in-hospital outcomes, 30-day mortality, 30-day readmission and predictors of PCI in cohorts. Out of a total of 296,062 patients ≥75 years old presenting with an AMI, 42,147 (14%) had history of previous CABG. Most presented with a non-ST segment elevation myocardial infarction, and those with previous CABG had higher burden of co-morbidities and were more commonly man. The in-hospital mortality was significantly lower in those with previous CABG (6.7% vs 8.8%, adjusted odds ratio, 0.88, 95% confidence interval, 0.82 to 0.94). Medical therapy was more common in those with previous CABG and 30-day readmission rates were seen more frequently in those with prior CABG. Predictors of not undergoing PCI included previous PCI, female, older ager groups, heart failure, dementia, malignancy, and higher number of co-morbidities. In conclusion, in patients ≥75 years old with AMI the presence of prior CABG was associated with lower odds of in-hospital and 30-day mortality, as well as lower complications rates, and a decreased use of invasive strategies (PCI, CABG, and MCS). However, 30-day MACE readmission was higher in those with previous CABG. o prior coronary artery bypass grafting (CABG), percutaneous coronary interventions (PCI), calcific and valvular disease. Using the National Readmission Database from January 2016 to November 2017, we identified hospital admissions for acute myocardial infarction in patients ≥75 years old and divided them based on a history of CABG. We evaluated in-hospital outcomes, 30-day mortality, 30-day readmission and predictors of PCI in cohorts. Out of a total of 296,062 patients ≥75 years old presenting with an AMI, 42,147 (14%) had history of previous CABG. Most presented with a non-ST segment elevation myocardial infarction, and those with previous CABG had higher burden of co-morbidities and were more commonly man. The in-hospital mortality was significantly lower in those with previous CABG (6.7% vs 8.8%, adjusted odds ratio, 0.88, 95% confidence interval, 0.82 to 0.94). Medical therapy was more common in those with previous CABG and 30-day readmission rates were seen more frequently in those with prior CABG. Predictors of not undergoing PCI included previous PCI, female, older ager groups, heart failure, dementia, malignancy, and higher number of co-morbidities. In conclusion, in patients ≥75 years old with AMI the presence of prior CABG was associated with lower odds of in-hospital and 30-day mortality, as well as lower complications rates, and a decreased use of invasive strategies (PCI, CABG, and MCS). However, 30-day MACE readmission was higher in those with previous CABG

Timing of impella placement in PCI for acute myocardial infarction complicated by cardiogenic shock: An updated meta-analysis

INTRODUCTION: The timing of hemodynamic support in acute myocardial infarction complicated by cardiogenic shock (AMICS) has yet to be defined. The aim of this meta-analysis was to evaluate the impact of timing of Impella initiation on early and midterm mortality. METHODS: A systematic literature review and meta-analysis was conducted using PubMed and Cochrane databases. All studies reporting short-term mortality rates and timing of Impella placement in AMICS were included. Meta-regression analysis and sensitivity analysis were performed on the primary endpoint, short-term mortality (≤30 days), and secondary endpoints (midterm mortality, device-related bleeding, and limb ischemia). RESULTS: Of 1289 studies identified, 13 studies (6810 patients; 2970 patients identified as receiving Impella pre-PCI and 3840 patients receiving Impella during/post-PCI) were included in this analysis. Median age was 63.8 years (IQR 63-65.7); 76% of patients were male, and a high prevalence of cardiovascular risk factors was noted across the entire population. Short-term mortality was significantly reduced in those receiving pre-PCI vs. during/post-PCI Impella support (37.2% vs 53.6%, RR 0.7; CI 0.56-0.88). Midterm mortality was also lower in the pre-PCI Impella group (47.9% vs 73%, RR 0.81; CI 0.68-0.97). The rate of device-related bleeding (RR 1.05; CI 0.47-2.33) and limb ischemia (RR 1.6; CI 0.63-2.15) were similar between the two groups. CONCLUSION: This analysis suggests that Impella placement prior to PCI in AMICS may have a positive impact on short- and midterm mortality compared with post-PCI, with similar safety outcomes. Due to the observational nature of the included studies, further studies are needed to confirm this hypothesis (CRD42022300372)

Left Atrial-Veno-Arterial Extracorporeal Membrane Oxygenation: Step-By-Step Procedure and Case Example

Veno-arterial extracorporeal membrane oxygenation is used in patients requiring biventricular support; however, its use increases the afterload. In patients with severe aortic insufficiency or severe left ventricular disfunction, it will increase left-side filling pressures, hence the need for left ventricle unloading with an additional mechanical circulatory support device. We present a case of a patient with cardiogenic shock and severe aortic insufficiency who underwent left atrial veno-arterial extracorporeal membrane oxygenation and provide a step-by-step explanation of the technique

High-level information fusion for risk and accidents prevention in pervasive oil industry environments

Proceedings of: 12th International Conference on Practical Applications of Agents and Multi-Agent Systems, University of Salamanca (Spain), 4th-6th June, 2014.Information fusion studies theories and methods to effectively combine data from multiple sensors and related information to achieve more specific inferences that could be achieved by using a single, independent sensor. Information fused from sensors and data mining analysis has recently attracted the attention of the research community for real-world applications. In this sense, the deployment of an Intelligent Offshore Oil Industry Environment will help to figure out a risky scenario based on the events occurred in the past related to anomalies and the profile of the current employee (role, location, etc.). In this paper we propose an information fusion model for an intelligent oil environment in which employees are alerted about possible risk situations while their are moving around their working place. The layered architecture, implements a reasoning engine capable of intelligently filtering the context profile of the employee (role, location) for the feature selection of an inter-transaction mining process. Depending on the employee contextual information he will receive intelligent alerts based on the prediction model that use his role and his current location. This model provides the big picture about risk analysis for that employee at that place in that moment.This work was partially funded by CNPq BJT Project 407851/2012-