Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury:Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

Olfactory ensheathing cell (OEC) transplantation is a candidate cellular treatment approach for human spinal cord injury (SCI) due to their unique regenerative potential and autologous origin. The objective of this study was, through a meta-epidemiologic approach, (i) to assess the efficacy of OEC transplantation on locomotor recovery after traumatic experimental SCI and (ii) to estimate the likelihood of reporting bias and/or missing data. A study protocol was finalized before data collection. Embedded into a systematic review and meta-analysis, we conducted a literature research of databases including PubMed, EMBASE, and ISI Web of Science from 1949/01 to 2014/10 with no language restrictions, screened by two independent investigators. Studies were included if they assessed neurobehavioral improvement after traumatic experimental SCI, administrated no combined interventions, and reported the number of animals in the treatment and control group. Individual effect sizes were pooled using a random effects model. Details regarding the study design were extracted and impact of these on locomotor outcome was assessed by meta-regression. Missing data (reporting bias) was determined by Egger regression and Funnel-plotting. The primary study outcome assessed was improvement in locomotor function at the final time point of measurement. We included 49 studies (62 experiments, 1,164 animals) in the final analysis. The overall improvement in locomotor function after OEC transplantation, measured using the Basso, Beattie, and Bresnahan (BBB) score, was 20.3% (95% CI 17.8-29.5). One missing study was imputed by trim and fill analysis, suggesting only slight publication bias and reducing the overall effect to a 19.2% improvement of locomotor activity. Dose-response ratio supports neurobiological plausibility. Studies were assessed using a 9-point item quality score, resulting in a median score of 5 (interquartile range [IQR] 3-5). In conclusion, OEC transplantation exerts considerable beneficial effects on neurobehavioral recovery after traumatic experimental SCI. Publication bias was minimal and affirms the translational potential of efficacy, but safety cannot be adequately assessed. The data justify OECs as a cellular substrate to develop and optimize minimally invasive and safe cellular transplantation paradigms for the lesioned spinal cord embedded into state-of-the-art Phase I/II clinical trial design studies for human SCI

Persistent economic divergence and institutional dysfunction in post-communist economies: an alternative synthesis

This paper seeks to explain the continuing lack of economic convergence and the persistence of market dysfunctionality, or wild capitalism, in post Communist transformation. An overview of key statistics on economic convergence and market failure are presented. The paper then analyses the causes of malaise through the lens of institutionalist and radical perspectives. In doing so key data is assembled and presented from documents of the international financial institutions and other agencies monitoring crime and corruption. The paper concludes that rather than encourage convergence and tame dysfunctionality, neoliberalism and its offspring of labour market reform has created the conditions for continuing economic divergence and for wild capitalism to survive and thrive

A new approach for developing comprehensive agricultural drought index using satellite-derived biophysical parameters and factor analysis method

The accurate assessment of drought and its monitoring is highly depending on the selection of appropriate indices. Despite the availability of countless drought indices, due to variability in environmental properties, a single universally drought index has not been presented yet. In this study, a new approach for developing comprehensive agricultural drought index from satellite-derived biophysical parameters is presented. Therefore, the potential of satellite-derived biophysical parameters for improved understanding of the water status of pistachio (Pistachio vera L.) crop grown in a semiarid area is evaluated. Exploratory factor analysis with principal component extraction method is performed to select the most in?uential parameters from seven biophysical parameters including surface temperature (Ts), surface albedo (a), leaf area index (LAI), soil heat ?ux (Go), soil-adjusted vegetation index (SAVI), normalized difference vegetation index (NDVI), and net radiation (Rn). Ts and Gowere found as the most effective parameters by this method. However, Ts, LAI, a, and SAVI that accounts for 99.6 % of the total variance of seven inputs were selected to model a new biophysical water stress index (BPWSI). The values of BPWSI were stretched independently and compared with the range of actual evapotranspiration estimated through well-known METRIC (mapping evapotranspiration at high resolution with internal calibration) energy balance model. The results showed that BPWSI can be ef?ciently used for the prediction of the pistachio water status (RMSE of 0.52, 0.31, and 0.48 mm/day on three image dates of April 28, July 17, and August 2, 2010). The study con?rmed that crop water status is accounted by several satellite-based biophysical parameters rather than single parameter