Harmful traditional practices in a newborn: A case report

Ninetynine percent of the nearly four million newborn deaths occur in developing countries with newborn deaths remaining relatively invisible and neglected1. In these countries, traditional attitudes and practices dominate newborn care and are often harzadous2. As most births and newborn deaths in developing countries occur outside health care facilities, a reduction in neonatal mortality may depend significantly on interventions involving adaptation of traditional care behaviours practiced at home3. However, despite the importance of traditional practices in the newborn period, little is known about the impact of these practices on newborn health2. We herein present a case of an eighteen day old female who was rushed to the hospital with severe wasting, recto-vaginal prolapse and septic umbilical cord resulting from repeated traditional homecare practices by her mother and grandmother. This case highlights the impact of harmful traditional home care practices on newborn health and emphasizes the urgent need for public enlightenment campaigns and other policy decisions and interventions aimed at reducing this societal menace.Keywords: Harmful traditional practices, newborn, neonatal morbidity, neonatal mortalit

Understanding Subsurface Reservoir Pressure through Accurate Geo-Mechanical Characterization

So far, Bulk modulus, Shear modulus, combined modulus of strength and shear modulus to compressibility ratio have been actively employed as geo-mechanical parameters that have been used in characterizing subsurface reservoir in Niger delta wells in Nigeria. These can be further utilized to enhance understanding of the pressure in the formation with depth. To successfully maximize hydrocarbon recovery, to minimize sanding rate, and to ensure safety of personnel during and after drilling, pore pressure gradient and its associated fracture pressure has been predicted for each of the abnormally pressured intervals discovered in one of the Niger Delta oil fields by applying Eaton’s method. This is aimed at identifying fragile sections. However, empirical relations have been established using geo-mechanical principles. From the two wells studied, geo-mechanical strength increases with depth and tends toward the acceptable range for a competent formation. In the second well, the fracture pressure increases with increasing pore pressure and decreasing Bulk modulus at various depths, while abnormal formation pressure occurred throughout the formation especially at greater depths. The relationship established between geo-mechanical factors and fracture pressure is such that as one decreases, the other increases vice versa. Keywords: Formation strength; fracture; mud weight; pore pressure; sand production and sand contro

Particle Swarm Optimization Tuned Flatness-Based Generator Excitation Controller

An optimal transient controller for a synchronous generator in a multi-machine power system is designed using the concept of flatness-based feedback linearization in this paper. The computation of the flat output and corresponding controller for reduced order model of the synchronous generator is presented. The required feedback gains used to close the linearization loop is optimized using particle swarm optimization for maximum damping. Typical results obtained for transient disturbances on a two-area, four-generator power system equipped with the proposed controller on one generator and conventional power system stabilizers on the remaining generators are presented. The effectiveness of the flatness-based controller for multi-machine power systems is discussed

Nutritional, psychosocial and physiological assessment of the elderly 60 years and above in Umudagu Mbieri Mbaitoli Local Government Area, Imo State, Nigeria

Background: Adequate nutrition and care is paramount for successful aging. Objectives: The study was to determine the nutritional, psychosocial and physiological status of the elderly.  Subjects and Methods: Two hundred and eighty elderly (≥60) were randomly selected in Umudagu Mberi, Mbaitolu Local Government, Imo State. Structured and pre-tested questionnaire was used to collect information on socio-economic characteristics, dietary pattern, psychosocial and physiological status. Anthropometric and blood pressure measurement were obtained using standard methods. Statistical Product for Service Solution (SPSS) version 22.0 was used to analyze data. Result: Digestive problem (8.2%) was the major eating problem among the elderly. Psychosocial conditions of the elderly indicate that 56.1% of the subjects cooked food by themselves, while nanny prepared food for 0.4% of the elderly. Most (62.1%) of the elderly received 5,000-10,000 from their children and relations per month, while 68.2% of the subjects spent 5,000 on food and 50.4% shopped by themselves. The mean body mass index of males (24.2 + 3.2kg/m2) did not differ significantly (P > 0.05) from that of the females (24.9 + 6.2kg/m2). The mean waist-hip ratio of males (0.88 + 0.06cm) was significantly higher (P < 0.005) than that of females (0.85 + 0.08cm). Sever systolic and diastolic blood pressure was 10.7% and 4.3% respectively. Majority (80.4%) ate three times daily while 18.6% skipped meals. Daily breakfast intake shows that 57.5% took beverage with bread, 45.4% took foo-foo for lunch while 60.4% took foo-foo and soup for dinner.  Fifty-five percent of the elderly were on a therapeutic diet, 33.6% of the subjects were suffering from hypertension and 22.9% were diabetic, 56.8% visits hospital frequently. Conclusion: There are different forms of malnutrition in the study area. The elderly needs support and care for successful agin

Disposition kinetics of ceftriaxone and determination of its therapeutic dose in dogs

Purpose: To evaluate the disposition kinetics of ceftriaxone (CFZ) in dogs with a view to determining its therapeutic dose and dosing frequency.Methods: Twelve (12) Basenji dogs (n = 4), divided into 3 groups (A, B and C), were used for the study. Ceftriaxone was administered intramuscularly at doses of 12.5, 25, and 50 mg/kg once to groups A, B and C respectively. Plasma CFZ concentration was determined by agar well diffusion assay at 0.25, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, and 24 h post-treatment, and the pharmacokinetic parameters were determined.Results: Intramuscular injection of CFZ to dogs resulted in rapid absorption, distribution and elimination (p < 0.05). The elimination half-life was short and did not change significantly with increase in dose. Serum concentration of CFZ changed significantly (p < 0.05) with increase in dose of CFZ. The maximum serum concentration (Cmax, 15.00 ± 1.18, 141.37 ± 15.87 and 259 ± 5.21 μg/mL) for groups A, B and C respectively were significantly (p < 0.05) different. The steady state CFZ concentrations; 0.94, 8.81 and 16.19 μg/mL for groups A, B and C, respectively, were significantly (p < 0.05) different. However, there was no significant difference in the time to reach steady state concentrations (Tmax, 00±0.021, 4.00±0.10 and 4.30±0.12 for groups A, B and C respectively). The therapeutic dose of CFZ was therefore determined to be 25 – 50 mg/kg every 4 h.Conclusion: Ceftriaxone undergoes rapid elimination in dogs with a short elimination half-life, thus making it an inconvenient prescription for out-patients in veterinary clinics. Keywords: Ceftriaxone, Pharmacokinetic profile, Dogs, Therapeutic dose, Veterinary clini

Comparative evaluation of the chemotherapeutic efficacies of two salts of diminazene aceturate in Trypanosoma brucei brucei infected dogs

Purpose: To compare the anti-trypanosomal efficacies of 4,4-(diazoaminedibenzamidinetrihydrate) diacetate (4,4-DDBT) and 4,4-(diazoamino) benzamidine (4,4-DB) in experimental canine trypanosomosis. Methods: The efficacies of 4,4-DDBT and 4,4-DB were evaluated in 4 groups of dogs (n = 3) designated A-D. Group A was normal control without infection or drug treatment, group B did not receive any drug treatment but was infected with Trypanosoma brucei brucei, while groups C and D were infected with T. b. brucei and treated with 4,4-DDBT(3.5 mg/kg) and 4,4-DB (3.5 mg/kg), respectively. Results: The incubation period of the infection was 6 - 9 days post-infection. Treatment of the dogs with 4,4-DDBT led to zero parasitaemia 48 h post-treatment, while there was only a decrease in parasitemia to log 6 in 4,4-DB-treated dogs. Resurgence of parasite into the blood stream occurred in 4,4-DDBTtreated dogs 6 days after initial parasite clearance. Blood analyses post-treatment revealed elevated leucocytes and lymphocytes in 4,4-DB-treated dogs (p < 0.05). Packed cell volume was also observed to be higher in 4,4-DDBT-treated group when compared to 4,4-DB group (p < 0.05). Conclusion: These findings suggest that 4,4-DDBT is more efficacious in the clinical management of canine trypanosomosis caused by T. b. brucei. However, it does not prevent relapse of infection. Based on these findings, therefore, 4,4-DDBT should be the diminazene salt of choice when indicated in the clinical management of T. b. brucei infection in dogs

Association of feed efficiency with organ characteristics and fatty liver haemorrhagic syndrome in laying hens

Poor feed efficiency (FE) in hens impacts body weight (BW) and may reflect suboptimal health. Fatty Liver Haemorrhagic Syndrome (FLHS) is mostly observed in laying hens and affects egg production and hen performance. The aim of this study was to investigate the relationships of FE and BW with organ characteristics, liver composition and incidence of FLHS of 150 individually housed ISA Brown hens ranked on the basis of feed conversion ratio (FCR) attained from early lay. At 45 weeks, 10 birds per FE group (HFE—High feed efficient; MFE—medium feed efficient; LFE—low feed efficient) were randomly selected and euthanized. Hen BW was positively associated with feed intake and FCR. The HFE hens had a lower abdominal fat pad and liver weight compared to LFE hens. FLHS lesion score was higher (worse) in the LFE than HFE hen group and was moderately positively associated with BW and abdominal fat pad, but strongly positively associated with liver weight. Liver pathology of LFE hens showed hepatocytes with abnormal retention of lipids causing distended cytoplasmic vacuoles compared to the HFE hens. Hens which exhibited poorer FE in early lay had heavier abdominal fat pads, heavier, fatter livers and were more prone to FLHS

Variation and Association of Hen Performance and Egg Quality Traits in Individual Early-Laying ISA Brown Hens

Uniformity in hen and egg traits is an important consideration in commercial layer flocks. There is little information on how individual hen feed consumption and body weight affect egg quality measurements. This study investigated the variation in performance traits of individual hens and associations with egg quality characteristics. Four hundred and fifty-five ISA Brown caged hens in early lay were monitored for 42 days (25 to 30 weeks of age) to collect hen feed consumption and egg production measurements. Forty-four hens from the flock were randomly selected and eggs were collected from the same hen once weekly for albumen, yolk, and shell assessment. The means ± standard deviation of average daily feed intake (ADFI), albumen height, initial body weight (IBW), and final body weight (FBW) were 124 g ± 15, 10.3 mm ± 1.5, 1802 g ± 129, and 2000 g ± 175, respectively. Albumen height was not associated with ADFI (r = 0.18, p = 0.21), IBW (r = −0.04, p = 0.79), or FBW (r = −0.06, p = 0.69). This study showed variation in feed intake, body weight, and albumen quality of individual early-lay hens. Feed intake and body weight did not influence albumen quality

Clinico-toxicological effects of ceftriaxone after intramuscular administration of graded doses in Basenji dogs

Purpose: The recent ceftriaxone-induced anaemia and mortalities at the dose of 50 mg/kg in Veterinary Teaching Hospital, University of Nigeria prompted this study which sought to assess the clinicotoxicological effects of ceftriaxone (CFZ) after intramuscular administration of graded doses in Basenji dogs.Methods: The effects of CFZ on the haematological indices, physiological parameters, liver and kidney functions were assessed in 4 group of dogs (n = 4) designated A – D. They were given CFZ intramuscularly for 21 days at doses of 12, 25 and 50 mg/kg for groups A, B, C, respectively, while thecontrol (group D) received the diluent (lignocaine 0.2 mL)Results: The mean pulse and heart rate of dogs in group C were significantly (p < 0.05) higher than those of group A, B and D. Significant (p < 0.05) decrease in red blood cell count (RBC), haemoglobin concentration (Hb) and packed cell volume (PCV) was observed in group C on days 7 and 14, while on day 21, these parameters were significantly (p < 0.05) higher in group D than in the treated groups. On day 14 of CFZ administration, the alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities of dogs in group C was significantly (p < 0.05) elevated than the control group.Conclusion: These findings suggest that CFZ, at the doses of 12.5 - 25 mg/kg, appears safe in dogs as most of the adverse effects observed are reversed following the withdrawal of the drug on day 28. However, CFZ at 50 mg/kg causes anaemia, tachycardia and bilateral paralysis of the hind limbs which did not revert to normal after one week; hence, it is not recommended for use in dogs at this dose

SFPQ promotes an oncogenic transcriptomic state in melanoma.

The multifunctional protein, splicing factor, proline- and glutamine-rich (SFPQ) has been implicated in numerous cancers often due to interaction with coding and non-coding RNAs, however, its role in melanoma remains unclear. We report that knockdown of SFPQ expression in melanoma cells decelerates several cancer-associated cell phenotypes, including cell growth, migration, epithelial to mesenchymal transition, apoptosis, and glycolysis. RIP-seq analysis revealed that the SFPQ-RNA interactome is reprogrammed in melanoma cells and specifically enriched with key melanoma-associated coding and long non-coding transcripts, including SOX10, AMIGO2 and LINC00511 and in most cases SFPQ is required for the efficient expression of these genes. Functional analysis of two SFPQ-enriched lncRNA, LINC00511 and LINC01234, demonstrated that these genes independently contribute to the melanoma phenotype and a more detailed analysis of LINC00511 indicated that this occurs in part via modulation of the miR-625-5p/PKM2 axis. Importantly, analysis of a large clinical cohort revealed that elevated expression of SFPQ in primary melanoma tumours may have utility as a prognostic biomarker. Together, these data suggest that SFPQ is an important driver of melanoma, likely due to SFPQ-RNA interactions promoting the expression of numerous oncogenic transcripts