2,129 research outputs found
No evidence for intra-allelic complementation at the osmotic-1 locus of Neurospora crassa
The Neurospora crassa osmotic-1 locus (os-1) encodes a protein with homology to two component histidine kinase sensors. We formed forced heterokaryons between each of ten os-1 alleles in all pair-wise combinations and found, in contrast to a previous report, no evidence for intra-allelic complementation
Simulation studies of a phenomenological model for elongated virus capsid formation
We study a phenomenological model in which the simulated packing of hard,
attractive spheres on a prolate spheroid surface with convexity constraints
produces structures identical to those of prolate virus capsid structures. Our
simulation approach combines the traditional Monte Carlo method with a modified
method of random sampling on an ellipsoidal surface and a convex hull searching
algorithm. Using this approach we identify the minimum physical requirements
for non-icosahedral, elongated virus capsids, such as two aberrant flock house
virus (FHV) particles and the prolate prohead of bacteriophage , and
discuss the implication of our simulation results in the context of recent
experimental findings. Our predicted structures may also be experimentally
realized by evaporation-driven assembly of colloidal spheres
Wavelet Based Fractal Analysis of Airborne Pollen
The most abundant biological particles in the atmosphere are pollen grains
and spores. Self protection of pollen allergy is possible through the
information of future pollen contents in the air. In spite of the importance of
airborne pol len concentration forecasting, it has not been possible to predict
the pollen concentrations with great accuracy, and about 25% of the daily
pollen forecasts have resulted in failures. Previous analysis of the dynamic
characteristics of atmospheric pollen time series indicate that the system can
be described by a low dimensional chaotic map. We apply the wavelet transform
to study the multifractal characteristics of an a irborne pollen time series.
We find the persistence behaviour associated to low pollen concentration values
and to the most rare events of highest pollen co ncentration values. The
information and the correlation dimensions correspond to a chaotic system
showing loss of information with time evolution.Comment: 11 pages, 7 figure
Casting Light Upon The Great Endarkenment
While the Enlightenment promoted thinking for oneself independent of religious authority, the ‘Endarkenment’ (Millgram 2015) concerns deference to a new authority: the specialist, a hyperspecializer. Non-specialists need to defer to such authorities as they are unable to understand their reasoning. Millgram describes how humans are capable of being serial hyperspecializers, able to move from one specialism to another. We support the basic thrust of Millgram’s position, and seek to articulate how the core idea is deployed in very different ways in relation to extremely different philosophical areas. We attend to the issue of the degree of isolation of different specialists and we urge greater emphasis on parallel hyperspecialization, which describes how different specialisms can be embodied in one person at one time
Universal microscopic correlation functions for products of independent Ginibre matrices
We consider the product of n complex non-Hermitian, independent random
matrices, each of size NxN with independent identically distributed Gaussian
entries (Ginibre matrices). The joint probability distribution of the complex
eigenvalues of the product matrix is found to be given by a determinantal point
process as in the case of a single Ginibre matrix, but with a more complicated
weight given by a Meijer G-function depending on n. Using the method of
orthogonal polynomials we compute all eigenvalue density correlation functions
exactly for finite N and fixed n. They are given by the determinant of the
corresponding kernel which we construct explicitly. In the large-N limit at
fixed n we first determine the microscopic correlation functions in the bulk
and at the edge of the spectrum. After unfolding they are identical to that of
the Ginibre ensemble with n=1 and thus universal. In contrast the microscopic
correlations we find at the origin differ for each n>1 and generalise the known
Bessel-law in the complex plane for n=2 to a new hypergeometric kernel 0_F_n-1.Comment: 20 pages, v2 published version: typos corrected and references adde
Elective percutaneous coronary intervention in the elderly patient
Elderly patients account for an increasing number and proportion of patients requiring management of coronary artery disease. Whilst medical therapy remains the cornerstone of management, percutaneous coronary intervention (PCI) has been shown to improve symptoms of angina and quality of life in elderly patients. PCI is now a routine treatment for both acute and chronic coronary artery disease. In the last decade, a series of technological and therapeutic developments have reduced in-hospital complications following PCI. The transradial approach is associated with fewer vascular complications, reduced bed utilization and reduced time to ambulation. This has facilitated the introduction and expansion of outpatient PCI, which has been shown to be safe and effective in elderly patients. This article reviews the rationale for outpatient PCI in the elderly and the evidence for its effectiveness and safety
Rates of convergence for empirical spectral measures: a soft approach
Understanding the limiting behavior of eigenvalues of random matrices is the
central problem of random matrix theory. Classical limit results are known for
many models, and there has been significant recent progress in obtaining more
quantitative, non-asymptotic results. In this paper, we describe a systematic
approach to bounding rates of convergence and proving tail inequalities for the
empirical spectral measures of a wide variety of random matrix ensembles. We
illustrate the approach by proving asymptotically almost sure rates of
convergence of the empirical spectral measure in the following ensembles:
Wigner matrices, Wishart matrices, Haar-distributed matrices from the compact
classical groups, powers of Haar matrices, randomized sums and random
compressions of Hermitian matrices, a random matrix model for the Hamiltonians
of quantum spin glasses, and finally the complex Ginibre ensemble. Many of the
results appeared previously and are being collected and described here as
illustrations of the general method; however, some details (particularly in the
Wigner and Wishart cases) are new.
Our approach makes use of techniques from probability in Banach spaces, in
particular concentration of measure and bounds for suprema of stochastic
processes, in combination with more classical tools from matrix analysis,
approximation theory, and Fourier analysis. It is highly flexible, as evidenced
by the broad list of examples. It is moreover based largely on "soft" methods,
and involves little hard analysis
Quadratic-time, linear-space algorithms for generating orthogonal polygons with a given number of vertices
Programa de Financiamento Plurianual, Fundação para a Ciéncia e TecnologiaPrograma POSIPrograma POCTI, FCTFondo Europeo de Desarrollo Regiona
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