All Shook Up: A Review of Sport-related Concussions in High School Athletes

Background: Concussions comprise 24.8% of the total injuries in high school athletes, putting developing brains at risk for neurocognitive dysfunction. Recent research has been geared towards finding the most effective process for (a) diagnosing, (b) treating and (c) preventing concussions. The most recent data from the Centers for Disease Control and Prevention (CDC) show that 329,290 children were diagnosed with a sports related concussion or traumatic brain injury (TBI) in 2012. Methods: A systematic review of current literature was performed using the Long Island University online library database and Google Scholar. Search terms included: (a) concussion, (b) sports, (c) high school; (d) screening; (e) risk factors; (f) symptoms; (g) complications, and (h) pathophysiology, including the years 2011 to 2018 and in the English language. Results: A concussion is a form of traumatic brain injury resulting in transient neurologic impairment that can resolve spontaneously or have lingering symptoms without structural changes on routine neuroimaging studies. Concussions are the most common injury among high school student-athletes, rising from 9.1% of all injuries in the 2005-2006 school year to 24.8% in the 2016-2017 school year. The overall prevalence is 2.5 concussions per 10,000 athletic exposures (competition or practice). Football has the highest overall rate of concussion with 6.4 per 10,000 athletic exposures, while soccer has the highest rate among girls’ sports with 3.4 per 10,000 athletic exposures. In gender comparable sports, girls have a higher rate of concussion than boys. In general, concussion rates are higher in competition than in practice. Current protocols center around early recognition of symptoms and removal from the field of play. Several screening tools have been developed, including the Sport Concussion Assessment Tool (SCAT-5) to aid in identifying potential concussions on the sideline and initiating proper treatment. Gradual return-to-school and return-to-play criteria have been developed to allow adequate healing time and prevent re-injury. Concussions, especially repetitive, may have long term effects such as (a) post-concussive syndrome, (b) post-traumatic seizures, (c) chronic traumatic encephalopathy (CTE), and (d) decreased neurocognitive function. The CDC offers recommendations for concussion prevention based on each sport, but in general, strict enforcement of the rules and proper protective equipment are key. Conclusions and Recommendations: Prevention and early recognition of symptoms can help reduce the number of concussions as well as long term effects. Athletes should wear all required protective equipment and the equipment should be fully functional. For contact sports, emphasis should be placed on proper form and safe techniques, as well as a limit on the number of full-contact practices per season. These measures can help to prevent concussions from occurring. In addition, officials should be trained to look for concussion symptoms and not hesitate to remove a player from action if they suspect a concussion. Athletes should not be permitted to return to play unless they are cleared by a medical practitioner and there should be stiff penalties for coaches who pressure players into returning prematurely

Transformed Dissipation in Superconducting Quantum Circuits

Superconducting quantum circuits must be designed carefully to avoid dissipation from coupling to external control circuitry. Here we introduce the concept of current transformation to quantify coupling to the environment. We test this theory with an experimentally-determined impedance transformation of $\sim 10^5$ and find quantitative agreement better than a factor of 2 between this transformation and the reduced lifetime of a phase qubit coupled to a tunable transformer. Higher-order corrections from quantum fluctuations are also calculated with this theory, but found not to limit the qubit lifetime. We also illustrate how this simple connection between current and impedance transformation can be used to rule out dissipation sources in experimental qubit systems.Comment: 4 pages, 4 figure

Impaired Orthostatic Blood Pressure Recovery is associated with Unexplained and Injurious Falls

Background/Objectives: Cardiovascular disorders are recognised as important modifiable risk factors for falls. However the association between falls and orthostatic hypotension (OH) remains ambivalent, particularly because of poor measurement methods of previous studies. Our goal was to determine for the first time to what extent OH (and variants) are risk factors for incident falls, unexplained falls (UF), injurious falls (IF) and syncope using dynamic blood pressure (BP) measurements in a population study. Design: Nationally Representative Longitudinal Cohort Study - The Irish Longitudinal Study on Ageing (TILDA) – wave 1 (2009-2011) with 2 year follow-up at wave 2 (2012-2013). Setting: Community dwelling adults. Participants: 4127 participants were randomly sampled from the population of older adults aged ≥50 years resident in Ireland. Measurements: Continuous BP recordings measured during active stands were analysed. OH and variants (initial OH and impaired orthostatic BP stabilisation OH(40)) were defined using dynamic BP measurements. Associations with the number of falls, UF, IF and syncope reported two years later were assessed using negative binomial and modified Poisson regression. Results: Participants had a mean age 61.5(8.2) years (54.2% female). OH(40) was associated with increased relative risk of UF (RR:1.52 95%CI:1.03-2.26). OH was associated with all-cause falls (IRR:1.40 95%CI:1.01-1.96), UF(RR:1.81 95%CI:1.06-3.09), and IF(RR:1.58 95%CI:1.12-2.24). IOH was not associated with any outcome. Conclusion: With the exception of initial orthostatic hypotension, beat-to-beat measures of impaired orthostatic BP recovery (delayed or incomplete stabilisation) are independent risk factors for future falls, unexplained falls, and injurious falls

Numerical Simulation of a Simplified High-Lift CRM Configuration Embedded with Fluidic Actuators

Numerical simulations have been performed for a simplified high-lift configuration that is representative of a modern transport airplane. This configuration includes a leading-edge slat, fuselage, wing, nacelle-pylon and a simple hinged flap. The suction surface of the flap is embedded with multiple rows of fluidic actuators to reduce the extent of reversed flow regions and improve the aerodynamic performance of the configuration with flap in a deployed state. In the current paper, a Lattice Boltzmann Method based high-fidelity computational fluid dynamics (CFD) code, known as PowerFLOW is used to simulate the entire flow field associated with this configuration, including the flow inside the actuators. A fully compressible version of the PowerFLOW code that has been validated for high speed flows is used for the present simulations to accurately represent the transonic flow regimes that are encountered in the flow field generated by the actuators operating at higher mass flow (momentum) rates required to mitigate reverse flow regions on the suction surfaces of the main wing and the flap. The numerical solutions predict the expected trends in aerodynamic forces as the actuation levels are increased. More efficient active flow control (AFC) systems and actuator arrangement for lift augmentation are emerging based on the parametric studies conducted here prior to wind tunnel tests. These numerical solutions will be compared with experimental data, once such data becomes available

Reduced phase error through optimized control of a superconducting qubit

Minimizing phase and other errors in experimental quantum gates allows higher fidelity quantum processing. To quantify and correct for phase errors in particular, we have developed a new experimental metrology --- amplified phase error (APE) pulses --- that amplifies and helps identify phase errors in general multi-level qubit architectures. In order to correct for both phase and amplitude errors specific to virtual transitions and leakage outside of the qubit manifold, we implement "half derivative" an experimental simplification of derivative reduction by adiabatic gate (DRAG) control theory. The phase errors are lowered by about a factor of five using this method to $\sim 1.6^{\circ}$ per gate, and can be tuned to zero. Leakage outside the qubit manifold, to the qubit $|2\rangle$ state, is also reduced to $\sim 10^{-4}$ for $20\%$ faster gates.Comment: 4 pages, 4 figures with 2 page supplementa

Time-Series Photometry of M67: W UMa Systems, Blue Stragglers, and Related Systems

We present an analysis of over 2200 V images taken on 14 nights at the Mt. Laguna 1 m telescope of the open cluster M67. Our observations overlap but extend beyond the field analyzed by Gilliland et al. (1991), and complement data recently published by van den Berg et al. (2002) and Stassun et al. (2002). We show variability in the light curves of all 4 of the known W UMa variables on timescales ranging from a day to decades (for AH Cnc). We have modeled the light curve of AH Cnc, and the total eclipses allow us to determine q = 0.16 +0.03/-0.02 and i = 86 +4/-8 degrees. The position of this system near the turnoff of M67 makes it useful for constraining the turnoff mass for the cluster. We have also detected two unusual features in the light curve of AH Cnc that may be caused by prominences. We have also monitored cluster blue stragglers for variability, and we present evidence hinting at low level variations in the stragglers S752, S968, and S1263, and we place limits on the variability of a number of other cluster blue stragglers. Finally, we provide photometry of the sub-subgiant branch star S1063 showing variability on timescales similar to the orbital period, while the ``red straggler'' S1040 shows evidence of an unexplained drop in brightness at phases corresponding to the passage of the white dwarf in front of the giant.Comment: 44 pages, 16 figures, AASTeX, accepted for A

Generation of Three-Qubit Entangled States using Superconducting Phase Qubits

Entanglement is one of the key resources required for quantum computation, so experimentally creating and measuring entangled states is of crucial importance in the various physical implementations of a quantum computer. In superconducting qubits, two-qubit entangled states have been demonstrated and used to show violations of Bell's Inequality and to implement simple quantum algorithms. Unlike the two-qubit case, however, where all maximally-entangled two-qubit states are equivalent up to local changes of basis, three qubits can be entangled in two fundamentally different ways, typified by the states $|\mathrm{GHZ}> = (|000> + |111>)/\sqrt{2}$ and $|\mathrm{W}> = (|001> + |010> + |100>)/\sqrt{3}$. Here we demonstrate the operation of three coupled superconducting phase qubits and use them to create and measure $|\mathrm{GHZ}>$ and $|\mathrm{W}>$ states. The states are fully characterized using quantum state tomography and are shown to satisfy entanglement witnesses, confirming that they are indeed examples of three-qubit entanglement and are not separable into mixtures of two-qubit entanglement.Comment: 9 pages, 5 figures. Version 2: added supplementary information and fixed image distortion in Figure 2

Vacuum Stability, Perturbativity, and Scalar Singlet Dark Matter

We analyze the one-loop vacuum stability and perturbativity bounds on a singlet extension of the Standard Model (SM) scalar sector containing a scalar dark matter candidate. We show that the presence of the singlet-doublet quartic interaction relaxes the vacuum stability lower bound on the SM Higgs mass as a function of the cutoff and lowers the corresponding upper bound based on perturbativity considerations. We also find that vacuum stability requirements may place a lower bound on the singlet dark matter mass for given singlet quartic self coupling, leading to restrictions on the parameter space consistent with the observed relic density. We argue that discovery of a light singlet scalar dark matter particle could provide indirect information on the singlet quartic self-coupling.Comment: 25 pages, 10 figures; v2 - fixed minor typos; v3 - added to text discussions of other references, changed coloring of figures for easier black and white viewin

Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10

Type I interferon (IFN) α/β is critical for host defense. During endotoxicosis or highly lethal bacterial infections where systemic inflammation predominates, mice deficient in IFN-α/β receptor (IFNAR) display decreased systemic inflammation and improved outcome. However, human sepsis mortality often occurs during a prolonged period of immunosuppression and not from exaggerated inflammation. We used a low lethality cecal ligation and puncture (CLP) model of sepsis to determine the role of type I IFNs in host defense during sepsis. Despite increased endotoxin resistance, IFNAR−/− and chimeric mice lacking IFNAR in hematopoietic cells display increased mortality to CLP. This was not associated with an altered early systemic inflammatory response, except for decreased CXCL10 production. IFNAR−/− mice display persistently elevated peritoneal bacterial counts compared with wild-type mice, reduced peritoneal neutrophil recruitment, and recruitment of neutrophils with poor phagocytic function despite normal to enhanced adaptive immune function during sepsis. Importantly, CXCL10 treatment of IFNAR−/− mice improves survival and decreases peritoneal bacterial loads, and CXCL10 increases mouse and human neutrophil phagocytosis. Using a low lethality sepsis model, we identify a critical role of type I IFN–dependent CXCL10 in host defense during polymicrobial sepsis by increasing neutrophil recruitment and function

Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149741/1/hep41353.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149741/2/hep41353_am.pd