SYSTEMS-2: a randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma

SYSTEMS-2 is a randomised study of radiotherapy dose escalation for pain control in 112 patients with malignant pleural mesothelioma (MPM). Standard palliative (20Gy/5#) or dose escalated treatment (36Gy/6#) will be delivered using advanced radiotherapy techniques and pain responses will be compared at week 5. Data will guide optimal palliative radiotherapy in MPM

Quasi-degenerate self-trapping in one-dimensional charge transfer exciton

The self-trapping by the nondiagonal particle-phonon interaction between two quasi-degenerate energy levels of excitonic system, is studied. We propose this is realized in charge transfer exciton, where the directions of the polarization give the quasi-degeneracy. It is shown that this mechanism, unlike the conventional diagonal one, allows a coexistence and resonance of the free and self-trapped states even in one-dimensional systems and a quantitative theory for the optical properties (light absorption and time-resolved luminescence) of the resonating states is presented. This theory gives a consistent resolution for the long-standing puzzles in quasi-one-dimensional compound A-PMDA.Comment: accepted to Phys. Rev. Letter

An attempt to observe economy globalization: the cross correlation distance evolution of the top 19 GDP's

Economy correlations between the 19 richest countries are investigated through their Gross Domestic Product increments. A distance is defined between increment correlation matrix elements and their evolution studied as a function of time and time window size. Unidirectional and Bidirectional Minimal Length Paths are generated and analyzed for different time windows. A sort of critical correlation time window is found indicating a transition for best observations. The mean length path decreases with time, indicating stronger correlations. A new method for estimating a realistic minimal time window to observe correlations and deduce macroeconomy conclusions from such features is thus suggested.Comment: to be published in the Dyses05 proceedings, in Int. J. Mod Phys C 15 pages, 5 figures, 1 tabl

Gyrofluid simulations of collisionless reconnection in the presence of diamagnetic effects

The effects of the ion Larmor radius on magnetic reconnection are investigated by means of numerical simulations, with a Hamiltonian gyrofluid model. In the linear regime, it is found that ion diamagnetic effects decrease the growth rate of the dominant mode. Increasing ion temperature tends to make the magnetic islands propagate in the ion diamagnetic drift direction. In the nonlinear regime, diamagnetic effects reduce the final width of the island. Unlike the electron density, the guiding center density does not tend to distribute along separatrices and at high ion temperature, the electrostatic potential exhibits the superposition of a small scale structure, related to the electron density, and a large scale structure, related to the ion guiding-center density

Gyrofluid simulations of collisionless reconnection in the presence of diamagnetic effects

The effects of the ion Larmor radius on magnetic reconnection are investigated by means of numerical simulations, with a Hamiltonian gyrofluid model. In the linear regime, it is found that ion diamagnetic effects decrease the growth rate of the dominant mode. Increasing ion temperature tends to make the magnetic islands propagate in the ion diamagnetic drift direction. In the nonlinear regime, diamagnetic effects reduce the final width of the island. Unlike the electron density, the guiding center density does not tend to distribute along separatrices and at high ion temperature, the electrostatic potential exhibits the superposition of a small scale structure, related to the electron density, and a large scale structure, related to the ion guiding-center density

Gyrofluid simulations of collisionless reconnection in the presence of diamagnetic effects

The effects of the ion Larmor radius on magnetic reconnection are investigated by means of numerical simulations, with a Hamiltonian gyrofluid model. In the linear regime, it is found that ion diamagnetic effects decrease the growth rate of the dominant mode. Increasing ion temperature tends to make the magnetic islands propagate in the ion diamagnetic drift direction. In the nonlinear regime, diamagnetic effects reduce the final width of the island. Unlike the electron density, the guiding center density does not tend to distribute along separatrices and at high ion temperature, the electrostatic potential exhibits the superposition of a small scale structure, related to the electron density, and a large scale structure, related to the ion guiding-center density

Exact solution and interfacial tension of the six-vertex model with anti-periodic boundary conditions

We consider the six-vertex model with anti-periodic boundary conditions across a finite strip. The row-to-row transfer matrix is diagonalised by the `commuting transfer matrices' method. {}From the exact solution we obtain an independent derivation of the interfacial tension of the six-vertex model in the anti-ferroelectric phase. The nature of the corresponding integrable boundary condition on the $XXZ$ spin chain is also discussed.Comment: 18 pages, LaTeX with 1 PostScript figur

Physical Properties of Asteroid (308635) 2005 YU55 derived from multi-instrument infrared observations during a very close Earth-Approach

The near-Earth asteroid (308635) 2005 YU55 is a potentially hazardous asteroid which was discovered in 2005 and passed Earth on November 8th 2011 at 0.85 lunar distances. This was the closest known approach by an asteroid of several hundred metre diameter since 1976 when a similar size object passed at 0.5 lunar distances. We observed 2005 YU55 from ground with a recently developed mid-IR camera (miniTAO/MAX38) in N- and Q-band and with the Submillimeter Array (SMA) at 1.3 mm. In addition, we obtained space observations with Herschel/PACS at 70, 100, and 160 micron. Our thermal measurements cover a wide range of wavelengths from 8.9 micron to 1.3 mm and were taken after opposition at phase angles between -97 deg and -18 deg. We performed a radiometric analysis via a thermophysical model and combined our derived properties with results from radar, adaptive optics, lightcurve observations, speckle and auxiliary thermal data. We find that (308635) 2005 YU55 has an almost spherical shape with an effective diameter of 300 to 312 m and a geometric albedo pV of 0.055 to 0.075. Its spin-axis is oriented towards celestial directions (lam_ecl, beta_ecl) = (60 deg +/- 30deg, -60 deg +/- 15 deg), which means it has a retrograde sense of rotation. The analysis of all available data combined revealed a discrepancy with the radar-derived size. Our radiometric analysis of the thermal data together with the problem to find a unique rotation period might be connected to a non-principal axis rotation. A low to intermediate level of surface roughness (r.m.s. of surface slopes in the range 0.1 - 0.3) is required to explain the available thermal measurements. We found a thermal inertia in the range 350-800 Jm^-2s^-0.5K^-1, very similar to the rubble-pile asteroid (25143) Itokawa and indicating a mixture of low conductivity fine regolith with larger rocks and boulders of high thermal inertia on the surface.Comment: Accepted for publication in Astronomy & Astrophysics, 12 pages, 10 figure

Exponential Distribution of Locomotion Activity in Cell Cultures

In vitro velocities of several cell types have been measured using computer controlled video microscopy, which allowed to record the cells' trajectories over several days. On the basis of our large data sets we show that the locomotion activity displays a universal exponential distribution. Thus, motion resulting from complex cellular processes can be well described by an unexpected, but very simple distribution function. A simple phenomenological model based on the interaction of various cellular processes and finite ATP production rate is proposed to explain these experimental results.Comment: 4 pages, 3 figure

Shape modeling technique KOALA validated by ESA Rosetta at (21) Lutetia

We present a comparison of our results from ground-based observations of asteroid (21) Lutetia with imaging data acquired during the flyby of the asteroid by the ESA Rosetta mission. This flyby provided a unique opportunity to evaluate and calibrate our method of determination of size, 3-D shape, and spin of an asteroid from ground-based observations. We present our 3-D shape-modeling technique KOALA which is based on multi-dataset inversion. We compare the results we obtained with KOALA, prior to the flyby, on asteroid (21) Lutetia with the high-spatial resolution images of the asteroid taken with the OSIRIS camera on-board the ESA Rosetta spacecraft, during its encounter with Lutetia. The spin axis determined with KOALA was found to be accurate to within two degrees, while the KOALA diameter determinations were within 2% of the Rosetta-derived values. The 3-D shape of the KOALA model is also confirmed by the spectacular visual agreement between both 3-D shape models (KOALA pre- and OSIRIS post-flyby). We found a typical deviation of only 2 km at local scales between the profiles from KOALA predictions and OSIRIS images, resulting in a volume uncertainty provided by KOALA better than 10%. Radiometric techniques for the interpretation of thermal infrared data also benefit greatly from the KOALA shape model: the absolute size and geometric albedo can be derived with high accuracy, and thermal properties, for example the thermal inertia, can be determined unambiguously. We consider this to be a validation of the KOALA method. Because space exploration will remain limited to only a few objects, KOALA stands as a powerful technique to study a much larger set of small bodies using Earth-based observations.Comment: 15 pages, 8 figures, 2 tables, accepted for publication in P&S