Contracts for environmental outcomes: the use of financial contracts in environmental markets

In environmental markets, parties frequently exchange obligations through environmental contracts. These contracts imply a distribution of risk between parties. The main focus of our paper is to identify contracts that enable risk in environmental markets to be reduced, distributed at least cost, or managed efficiently. The risks that we consider are: moral hazard risk, price risk, exogenous environmental risk, measurement risk and production risk. The first section of our paper outlines some of the contracts currently utilised in financial and insurance markets to achieve these objectives. These are: futures and options contracts, spread contracts, weather contracts and catastrophe bonds. We then provide a snapshot of current applications of these contracts both in real markets and in the literature. Finally we discuss some possible applications in the environmental sector and indicate how the use of these contracts may alter the way government manages environmental assets and responsibilities. We also suggest a staged process to the introduction of contracts that recognises the current limitations faced by government. This paper does not propose new or novel contracts for tackling the problems of risk in exchange. Rather it extends the application of existing contractual arrangements to a new type of problem: environmental markets.Environmental Economics and Policy,

Distribution of catecholamine fibers in the cochlear nucleus of horseshoe bats and mustache bats

The glyoxylic-acid-induced fluorescence technique was applied to demonstrate patterns of catecholaminergic innervation within the auditory brainstem of echolocating bats and the house mouse. In the cochlear nucleus of the rufous horseshoe bat (Rhinolophus rouxi) and the mustache bat (Pteronotus parnelli), species-specific catecholaminergic innervation patterns are found that contrast with the relatively homogeneous innervation in the rodent. In both bats the subnuclei of the cochlear nucleus receive a differentially dense supply of catecholaminergic fibers, and within the subnuclei, the catecholamine innervation densities can be correlated with the tonotopic frequency representation. The areas devoted to the high-frequency echolocation calls are less densely innervated than those regions which are responsive to lower frequencies. Apart from this common scheme, there are noteworthy distinctions between the two bats which correlate with specialized cytoarchitectural features of the cochlear nucleus. The marginal cell group, located medially to the anteroventral cochlear nucleus of Pteronotus, receives the densest supply of catecholaminergic fibers of all auditory nuclei. This plexus is formed by a morphologically distinct population of catecholaminergic fibers

Engineering local strain for single-atom nuclear acoustic resonance in silicon

Mechanical strain plays a key role in the physics and operation of nanoscale semiconductor systems, including quantum dots and single-dopant devices. Here, we describe the design of a nanoelectronic device, where a single nuclear spin is coherently controlled via nuclear acoustic resonance (NAR) through the local application of dynamical strain. The strain drives spin transitions by modulating the nuclear quadrupole interaction. We adopt an AlN piezoelectric actuator compatible with standard silicon metal-oxide-semiconductor processing and optimize the device layout to maximize the NAR drive. We predict NAR Rabi frequencies of order 200 Hz for a single 123Sb nucleus in a wide region of the device. Spin transitions driven directly by electric fields are suppressed in the center of the device, allowing the observation of pure NAR. Using electric field gradient-elastic tensors calculated by the density-functional theory, we extend our predictions to other high-spin group-V donors in silicon and to the isoelectronic 73Ge atom

Inflammatory cytokines IL-1β and TNF-α regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms

The p75NTR (where NTR is neurotrophin receptor) can mediate many distinct cellular functions, including cell survival and apoptosis, axonal growth and cell proliferation, depending on the cellular context. This multifunctional receptor is widely expressed in the CNS (central nervous system) during development, but its expression is restricted in the adult brain. However, p75NTR is induced by a variety of pathophysiological insults, including seizures, lesions and degenerative disease. We have demonstrated previously that p75NTR is induced by seizures in neurons, where it induces apoptosis, and in astrocytes, where it may regulate proliferation. In the present study, we have investigated whether the inflammatory cytokines IL (interleukin)-1β and TNF-α (tumour necrosis factor-α), that are commonly elevated in these pathological conditions, mediate the regulation of p75NTR in neurons and astrocytes. We have further analysed the signal transduction pathways by which these cytokines induce p75NTR expression in the different cell types, specifically investigating the roles of the NF-κB (nuclear factor κB) and p38 MAPK (mitogen-activated protein kinase) pathways. We have demonstrated that both cytokines regulate p75NTR expression; however, the mechanisms governing this regulation are cytokine- and cell-type specific. The distinct mechanisms of cytokine-mediated p75NTR regulation that we demonstrate in the present study may facilitate therapeutic intervention in regulation of this receptor in a cell-selective manner

La colaboración eficaz y la libre competencia: INDECOPI atrapado en el dilema del prisionero

In this paper, Professor Cecilia O'Neill discusses the regulation of clemency orders (effective collaboration) in the Peruvian rule regarding repression of anticompetitive conduct related to infringements of free competition. She argues that these programs have taken a step forward, but there are still things to improve in order to make more effective the control of collusive behavior.En el presente artículo, la profesora Cecilia O’Neill analiza la regulación de los pedidos de clemencia (colaboración eficaz) en la norma peruana de represión de conductas anticompetitivas aplicable a las infracciones a la libre competencia. Considera que estos programas han dado un paso adelante, pero que aún quedan cosas para mejorar y hacer más efectiva la lucha contra las conductas colusorias

Automatic composition of music by means of Grammatical Evolution

This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in APL Quote Quad, http://dx.doi.org/10.1145/604444.602249Proceedings of the 2002 conference on APL: array processing languages: lore, problems, and applications (Madrid)This work describes how grammatical evolution may be applied to the domain of automatic composition. Our goal is to test this technique as an alternate tool for automatic composition. The AP440 auxiliary processor will be used to play music, thus we shall use a grammar that generates AP440 melodies. Grammar evolution will use fitness functions defined from several well-known single melodies to automatically generate AP440 compositions that are expected to sound like those composed by human musicians.This paper has been sponsored by the Spanish Interdepartmental Commission of Science and Technology (CICYT), project numbers TEL1999-0181 and TIC2001-0685-C02-1

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus

Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against acute uncomplicated influenza. Results: We report the activity of seventeen thiazolide analogs against A/PuertoRico/8/1934(H1N1), a laboratory-adapted strain of the H1N1 subtype of IAV, in a cell culture-based assay. A total of eight analogs showed IC50s in the range of 0.14–5.0 μM. Additionally a quantitative structure–property relationship study showed high correlation between experimental and predicted activity based on a molecular descriptor set. Conclusion: A range of thiazolides show useful activity against an H1N1 strain of IAV. Further evaluation of these molecules as potential new small molecule therapies is justified

Draft genome sequences of seven isolates of Phytophthora ramorum EU2 from Northern Ireland

Here we present draft-quality genome sequence assemblies for the oomycete Phytophthora ramorum genetic lineage EU2. We sequenced genomes of seven isolates collected in Northern Ireland between 2010 and 2012. Multiple genome sequences from P. ramorum EU2 will be valuable for identifying genetic variation within the clonal lineage that can be useful for tracking its spread

Ensayos de derecho contractual financiero

El presente libro da una visión sobre diversos aspectos medulares en la actividad financiera de hoy en día, que permite apreciar el trascendental cambio experimentado en los últimos años en la actividad bancaria del país, así como la dinámica que se viene experimentando en la evolución de su derecho bancario y financiero, que viene acogiendo experiencias de sociedades con una mayor trayectoria y profundidad en estos campos

The Work of Seduction : Intimacy and Subjectivity in the London 'Seduction Community'

This paper explores negotiations of intimate and sexual subjectivity among men involved in the London 'seduction community', a central locus within what is more properly regarded as a community-industry. Herein, heterosexual men undertake various forms of skills training and personal development in order to gain greater choice and control in their relationships with women. As an entry point to this discussion I consider the international media event that enveloped American 'pickup artist' Julien Blanc in November 2014. Shifting focus away from the cultural figure of the 'pickup artist' and onto socially located men, I attempt to complicate a dominant narrative that characterises men who participate in this community-industry as pathetic, pathological or perverse. This analysis makes use of extensive ethnographic research undertaken within the London seduction community, and examines how men who participate in this setting engage a mode of intimate and sexual subjectivity ordered by themes of management and enterprise. Ultimately I argue that the central logics of the seduction community are not dissonant from but are in fact consistent with broader reconfigurations of intimacy and sexuality taking place in the contemporary UK context