SeaSoar observations during the GLOBEC NEP California Current survey IV (R0208) : 31 July - 19 August 2002

As part of the GLOBEC NEP collaborative research project on the California Current (CC), this was the second of two cruises in 2002 to study the physical and biological oceanographic distributions and processes that influence juvenile salmonid habitat along the Oregon and northern California coast. The 2002 cruises followed similar cruises in 2000 in an effort to assess interannual variability in the northern CC. The goal is to understand how physical circulation features (such as upwelling fronts, coastal jets, and circulation around submarine banks) influence distributions of phytoplankton, zooplankton and larval fish. We made mesoscale surveys at the beginning and end of our study, along with finescale surveys south of Newport centered on Heceta Bank, and north of the Oregon-California border up to Cape Blanco (Figure 1)

SEASOAR observations during a COARE surveys cruise, W9211B, 12 December 1992 to 16 January 1993

An international Coupled Ocean-Atmosphere Response Experiment (COARE) was conducted in the warm-pool region of the western equatorial Pacific Ocean over a four-month period from November 1992 through February 1993 (Webster and Lukas, 1992). Most of the oceanographic and meteorological observations were concentrated in the Intensive Flux Array (IFA) centered at 1'45'S, 156000'E. As part of this experiment, the R/V Wecoma conducted three survey cruises; each cruise included measurements of the temperature, salinity and velocity distribution in the upper 300 m of the ocean, and continuous meteorological measurements of wind, air temperature, humidity, etc. Most of these measurements were along a butterfly pattern that was sampled repeatedly during the three COARE Surveys cruises, W9211A and W9211B, and W9211 C

SEASOAR and CTD observations during a COARE surveys cruise, W9211C, 22 January to 22 February 1993

An international Coupled Ocean-Atmosphere Response Experiment (COARE) was conducted in the warm-pool region of the western equatorial Pacific Ocean over a four-month period from November 1992 through February 1993 (Webster and Lukas, 1992). Most of the oceanographic and meteorological observations were concentrated in the Intensive Flux Array (IFA) centered at 1° 45'S,156°00'E. As part of this experiment, the R/V Wecoma conducted three survey cruises on the R/V Wecoma; each cruise included measurements of the temperature, salinity and velocity distribution in the upper 300 m of the ocean, and continuous meteorological measurements of wind, air temperature, humidity, etc. Most of these measurements were along a butterfly pattern that was sampled repeatedly during the three COARE Surveys cruises, W9211A and W9211B, and W9211C.This report summarizes the Seasoar and CTD observations from Wecoma's third COARE Surveys cruise, W9211C. It also provides a cruise narrative, and a brief description of the data processing procedures

SeaSoar and CTD observations during coastal jet separation cruise W9408A, August to September 1994

This report summarizes the SeaSoar and CTD observations from R/V Wecoma cruise W9408A (23 August to 2 September 1994) conducted as part of the Coastal Jet Separation (CJS) experiment, under funding from the National Science Foundation. The goal of this study is to establish how and why a strong alongshore coastal upwelling jet turns offshore in the vicinity of a coastal promontory, crosses the steep topography of the continental margin and becomes an oceanic jet. Unique aspects of the sampling discussed in this report are: the first use of the OSU SeaSoar vehicles over shallow topography by towing them on a bare cable (without fairing); the first use of dual Sea-Bird CTD sensors where one of the conductivity-temperature sensor pairs is mounted pointing forward through the SeaSoar nose; and post-processing of the SeaSoar conductivity-temperature data using an optimal thermal mass correction, while allowing the time constant to be weakly proportional to the observed lag between temperature and conductivity

SEASOAR and CTD observations during EBC cruises W9306A and W9308B, June to September 1993

This report summarizes the Seasoar and CTD observations from Wecoma cruises W9306A (5 June to 12 July, 1993) and W9308B (14 August to 22 September 1993) conducted as part of the Eastern Boundary Currents Accelerated Research Initiative, under funding by the Office of Naval Research. The cruises were designed to study the spatial and temporal variability of the mesoscale eddy/jet field in the eastern boundary current region off northern California

Improbability mapping: a metric for satellite-detection of submarine volcanic eruptions

Submarine volcanic eruptions can result in both real and apparent changes in marine algal communities, e.g., increases in phytoplankton biomass and/or growth rates that can cover thousands of square kilometers. Satellite ocean color monitoring detects these changes as increases in chlorophyll and particulate backscattering. Detailed, high resolution analysis is needed to separate the optical effects of volcanic products from the response of the marine algal community. It is possible to calculate an index, which maps the magnitude of improbable change (relative to long term average conditions) following known volcanic eruptions by using low resolution, initial estimates of chlorophyll and backscatter along with an archived history of satellite data. We apply multivariate probability analysis to changes in global satellite ocean chlorophyll and particulate backscatter data to create a new metric for observing apparent biological responses to submarine eruptions. Several examples are shown, illustrating the sensitivity of our improbability mapping index to known submarine volcanic events, yielding a potentially robust method for the detection of new events in remote locations.Keywords: Improbability mapping index, Submarine volcanic eruptions, Satellite detectio

Satellite-detected fluorescence reveals global physiology of ocean phytoplankton

© 2009 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 License. The definitive version was published in Biogeosciences 6 (2009): 779-794, doi: 10.5194/bg-6-779-2009Phytoplankton photosynthesis links global ocean biology and climate-driven fluctuations in the physical environment. These interactions are largely expressed through changes in phytoplankton physiology, but physiological status has proven extremely challenging to characterize globally. Phytoplankton fluorescence does provide a rich source of physiological information long exploited in laboratory and field studies, and is now observed from space. Here we evaluate the physiological underpinnings of global variations in satellite-based phytoplankton chlorophyll fluorescence. The three dominant factors influencing fluorescence distributions are chlorophyll concentration, pigment packaging effects on light absorption, and light-dependent energy-quenching processes. After accounting for these three factors, resultant global distributions of quenching-corrected fluorescence quantum yields reveal a striking consistency with anticipated patterns of iron availability. High fluorescence quantum yields are typically found in low iron waters, while low quantum yields dominate regions where other environmental factors are most limiting to phytoplankton growth. Specific properties of photosynthetic membranes are discussed that provide a mechanistic view linking iron stress to satellite-detected fluorescence. Our results present satellite-based fluorescence as a valuable tool for evaluating nutrient stress predictions in ocean ecosystem models and give the first synoptic observational evidence that iron plays an important role in seasonal phytoplankton dynamics of the Indian Ocean. Satellite fluorescence may also provide a path for monitoring climate-phytoplankton physiology interactions and improving descriptions of phytoplankton light use efficiencies in ocean productivity models.This work was supported by grants from the NASA Ocean Biology and Biogeochemistry Program and the NSF Biological Oceanography Program

Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial

Background: Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma. Methods: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients from 87 hospitals and cancer centres across 11 countries. Eligible patients were aged 18 years or older, had a platinum-sensitive, high-grade serous or endometrioid ovarian, primary peritoneal, or fallopian tube carcinoma, had received at least two previous platinum-based chemotherapy regimens, had achieved complete or partial response to their last platinum-based regimen, had a cancer antigen 125 concentration of less than the upper limit of normal, had a performance status of 0–1, and had adequate organ function. Patients were ineligible if they had symptomatic or untreated central nervous system metastases, had received anticancer therapy 14 days or fewer before starting the study, or had received previous treatment with a poly(ADP-ribose) polymerase inhibitor. We randomly allocated patients 2:1 to receive oral rucaparib 600 mg twice daily or placebo in 28 day cycles using a computer-generated sequence (block size of six, stratified by homologous recombination repair gene mutation status, progression-free interval after the penultimate platinum-based regimen, and best response to the most recent platinum-based regimen). Patients, investigators, site staff, assessors, and the funder were masked to assignments. The primary outcome was investigator-assessed progression-free survival evaluated with use of an ordered step-down procedure for three nested cohorts: patients with BRCA mutations (carcinoma associated with deleterious germline or somatic BRCA mutations), patients with homologous recombination deficiencies (BRCA mutant or BRCA wild-type and high loss of heterozygosity), and the intention-to-treat population, assessed at screening and every 12 weeks thereafter. This trial is registered with ClinicalTrials.gov, number NCT01968213; enrolment is complete. Findings: Between April 7, 2014, and July 19, 2016, we randomly allocated 564 patients: 375 (66%) to rucaparib and 189 (34%) to placebo. Median progression-free survival in patients with a BRCA-mutant carcinoma was 16·6 months (95% CI 13·4–22·9; 130 [35%] patients) in the rucaparib group versus 5·4 months (3·4–6·7; 66 [35%] patients) in the placebo group (hazard ratio 0·23 [95% CI 0·16–0·34]; p<0·0001). In patients with a homologous recombination deficient carcinoma (236 [63%] vs 118 [62%]), it was 13·6 months (10·9–16·2) versus 5·4 months (5·1–5·6; 0·32 [0·24–0·42]; p<0·0001). In the intention-to-treat population, it was 10·8 months (8·3–11·4) versus 5·4 months (5·3–5·5; 0·36 [0·30–0·45]; p<0·0001). Treatment-emergent adverse events of grade 3 or higher in the safety population (372 [99%] patients in the rucaparib group vs 189 [100%] in the placebo group) were reported in 209 (56%) patients in the rucaparib group versus 28 (15%) in the placebo group, the most common of which were anaemia or decreased haemoglobin concentration (70 [19%] vs one [1%]) and increased alanine or aspartate aminotransferase concentration (39 [10%] vs none). Interpretation: Across all primary analysis groups, rucaparib significantly improved progression-free survival in patients with platinum-sensitive ovarian cancer who had achieved a response to platinum-based chemotherapy. ARIEL3 provides further evidence that use of a poly(ADP-ribose) polymerase inhibitor in the maintenance treatment setting versus placebo could be considered a new standard of care for women with platinum-sensitive ovarian cancer following a complete or partial response to second-line or later platinum-based chemotherapy. Funding: Clovis Oncology

Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women

While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5×10−8), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1×10−29) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes