Treading the fine white line: cocaine trafficking

The illicit drug’s trade is a highly profitable business that grasps the interest of millions of people and equally affects millions of others. Cocaine is a highly addictive drug that plagues many countries. It is trafficked through various routes using a variety of methods by traffickers who adapt to the efforts of the authorities. This paper reviews all aspects of the cocaine trade: from how a market came to exist for cocaine to the well-established lucrative market that it is today. A thorough understanding of all aspects of the cocaine market is essential in order to be able to assess the effectiveness of the current methods that are being employed to combat the illicit cocaine trade. To discuss, seeking to reach a conclusion as to whether cocaine trafficking can be completely eradicated when such a lucrative market for cocaine exists

Connected Hopf algebras and iterated Ore extensions

We investigate when a skew polynomial extension T = R[x; {\sigma}, {\delta}] of a Hopf algebra R admits a Hopf algebra structure, substantially generalising a theorem of Panov. When this construction is applied iteratively in characteristic 0 one obtains a large family of connected noetherian Hopf algebras of finite Gelfand-Kirillov dimension, including for example all enveloping algebras of finite dimensional solvable Lie algebras and all coordinate rings of unipotent groups. The properties of these Hopf algebras are investigated

The vicinal difluoro motif : the synthesis and conformation of erythro- and threo-diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives

Background: It is well established that vicinal fluorines (RCHF-CHFR) prefer to adopt a gauche rather than an anti conformation when placed along aliphatic chains. This has been particularly recognised for 1,2-difluoroethane and extends to 2,3-difluorobutane and longer alkyl chains. It follows in these latter cases that if erythro and threo vicinal difluorinated stereoisomers are compared, they will adopt different overall conformations if the fluorines prefer to be gauche in each case. This concept is explored in this paper with erythro- and threo- diastereoisomers of 2,3-difluorosuccinates. Results: A synthetic route to 2,3-difluorosuccinates has been developed through erythro- and threo- 1,2-difluoro-1,2-diphenylethane which involved the oxidation of the aryl rings to generate the corresponding 2,3- difluorosuccinic acids. Ester and amide derivatives of the erythro- and threo- 2,3-difluorosuccinic acids were then prepared. The solid and solution state conformation of these compounds was assessed by X-ray crystallography and NMR. Ab initio calculations were also carried out to model the conformation of erythro- and threo- 1,2-difluoro-1,2-diphenylethane as these differed from the 2,3-difluorosuccinates. Conclusion: In general the overall chain conformations of the 2,3-difluorosuccinates diastereoisomers were found to be influenced by the fluorine gauche effect. The study highlights the prospects of utilising the vicinal difluorine motif (RCHF-CHFR) as a tool for influencing the conformation of performance organic molecules and particularly tuning conformation by selecting specific diastereoisomers (erythro or threo).Publisher PDFPeer reviewe

The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer

Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC. There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs have an inflammatory component that contributes to their progression. At sites of inflammation, epithelial cells are exposed to increased levels of inflammatory mediators such as reactive oxygen species, cytokines, prostaglandins, and growth factors that contribute to increased cell division, and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the pro-inflammatory tumor microenvironment environment (TME) contributes to EOC metastasis and chemoresistance. In this review we will discuss the roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC

Crisis Translation Training Challenges Arising from New Contexts of Translation

Focused on material design and self-reflective practices, this article discusses a Crisis Translation Training pitched at master-level translation and interpreting students, developed within the research activities carried out for the INTERACT International Crisis Translation Network. The course was designed to enable them to develop a broader skillset in support of multilingual crisis settings. The learning objectives underpinning the materials address training lacunae in enabling linguists to be involved in relief operations (Federici, 2016; O’Brien, 2016). The authors perceive the complementary skills as crucial in the development of language mediation services assisting linguists operating in such zones of liminality as are crisis settings. Multilingual communication in crisis includes professional forms of translation, signing, and interpreting, as well as forms of intercultural mediation, and social work (Drugan, 2017). Emergencies and prolonged crises have an impact on the communicative dynamics among international relief operators, local institutions, and crisis-affected populations. The authors developed training materials to prepare students to work in crisis settings by harnessing their language competences in crisis translation as a form of community translation (Taibi and Ozolins, 2016). Culturally and linguistically diverse (CALD) communities often need support in language combinations that rarely match commercially viable combinations (Federici and Cadwell, 2018; Shackleton, 2018). This article critically reviews non-language specific Crisis Translation Training, delivered in three iterations across two sites. Reporting on the first phases of the process of material design and enhancement, the article reflects on how issues in delivery, emerging findings regarding the authentic needs of mostly untrained translators, and different pathways of delivery shaped the re-definition of the initial learning objectives and pushed towards a translator trainer approach that would suit a range of new contexts of language mediation

First Measurements with NeXtRAD, a Polarimetric X/L Band Radar Network

NeXtRAD is a fully polarimetric, X/L Band radar network. It is a development of the older NetRAD system and builds on the experience gained with extensive deployments of NetRAD for sea clutter and target measurements. In this paper we will report on the first measurements with NeXtRAD, looking primarily at sea clutter and some targets, as well as early attempts at calibration using corner reflectors, and an assessment of the polarimetric response of the system. We also highlight innovations allowing for efficient data manipulation post measurement campaigns, as well as the plans for the coming years with this system

To what extent has the United Kingdom law on psychoactive substances been successful?

This review examines the law in relation to psychoactive substances and investigating how dangerous they really are and how much the law is required, together with how its enforcement is really impacting on the number of arrests and convictions and its prevalence in prisons. The law that was enforced on the 26th May 2016 across the United Kingdom has been the subject of some criticism, due to questionable gaps within this law, making it difficult to secure convictions. The 'blanket ban' approach has too been questioned, due to its lack of success with other legislations. Whilst this is not the first time a law like this has been enforced, the UK's approach to the global problem, may not be the answer, or if it is following/making the same mistakes other countries have made. The United Kingdom policing system is already under an immense amount of pressure, and whilst the problem on psychoactive substances is clear, the law is not. So, while UK police are enforcing this law, their conviction rates are ceasing to be parallel with the number of arrests. Drugs, classified under the Misuse of Drugs Act 1971, are prominent in society, even almost fifty year after the legislation came into force. A new approach was adopted to overcome the problem with psychoactive substances, it will not be a surprise if they are too, just as prominent in later years to come

Crime scene to court: a study on finger-mark aging

Fingerprint evidence is at the forefront of most criminal cases, with important issues raised regarding the age of the mark. Was the finger-mark deposited during the crime, or at a time not related for legitimate reasons? An in-depth understanding of their change over time from the initial to the aged stage, is paramount to applying a robust aging model. Focusing on the influential factors, including donor variability and environmental conditions, along with their effects on physical or chemical characteristics as aging parameters, previously proposed techniques have been analysed in attempt to find suitable parameters to solve the dating issue. This review suggests that despite the variation of methods trialled, the question of fingermark dating remains largely unanswered. Whilst some techniques showed promise, they all possessed limitations, mainly due to the large effects of influential factors inconsistently altering the deposit over time. Without reproducible aging trends, estimating an accurate and reliable age is unrealistic. Considering additional research, there is requirement for an aging method to be tested using large donor volumes and contaminants on a wide range of substrates. Each must be subjected to ranging environmental conditions to plot aging curves. Reviewing and comparing the techniques, benefits have been identified for selecting target lipid compounds and obtaining ratios between them. Proposing a spectroscopic method, coupled with an analytical instrument enables for quantification to observe a model for application to a multitude of scenarios. In the ideal situation, the method should be validated and undertaken in an accredited laboratory, meaning results obtained would stand up to cross- examination when employed in court

From prescription to addiction: a study of prescription drug abuse

General practitioners are dispensing an increasing number of painkillers to their patients at a time when drug abuse is rife in Britain’s prisons and addiction to prescription drugs is in the headlines due to the fall from grace of a high-profile celebrity. This study seeks to investigate how widespread the abuse of prescription drugs has become and what possible solutions there may be. It will examine which drugs are most widely abused and the role of prescription drugs as a more easily obtainable source of illicit highs in the prison population. It will consider what action needs to be taken as a result. The study indicates that pregabalin and gabapentin are drugs most widely abused within the prison population and that drugs are being dispensed with too little consideration of their addictive properties. It is concluded that further research into this area is required with consideration of possible changes to the law in relation to which drugs are controlled, but acknowledges the difficulties due to the medicinal benefits and large numbers of NHS patients currently reliant on these drugs, and underfunding of alternative services such as cognitive behavioural therapy (CBT) and psychotherapy