Capabilities for transdisciplinary research

Problems framed as societal challenges have provided fresh impetus for transdisciplinary research. In response, funders have started programmes aimed at increasing transdisciplinary research capacity. However, current programme evaluations do not adequately measure the skills and characteristics of individuals and collectives doing this research. Addressing this gap, we propose a systematic framework for evaluating transdisciplinary research based on the Capability Approach, a set of concepts designed to assess practices, institutions, and people based on public values. The framework is operationalized through a mixed-method procedure which evaluates capabilities as they are valued and experienced by researchers themselves. The procedure is tested on a portfolio of ‘pump-priming’ research projects in the UK. We find these projects are sites of capability development in three ways: through convening cognitive capabilities required for academic practice; cultivating informal tacit capabilities; and maintaining often unacknowledged backstage capabilities over durations that extend beyond the lifetime of individual projects. Directing greater attention to these different modes of capability development in transdisciplinary research programmes may be useful formatively in identifying areas for ongoing project support, and also in steering research system capacity towards societal needs

What is robotics made of? The interdisciplinary politics of robotics research

Under framings of grand challenges, robotics has been proposed as a solution to a wide range of societal issues such as road safety, ageing society, economic productivity and climate change. However, what exactly is robotics research? From its inception, robotics has been an inherently interdisciplinary field, bringing together diverse domains such as engineering, cognitive science, computer science and, more recently, knowledge from social sciences and humanities. Previous research on interdisciplinarity shows that this mode of knowledge production is often driven by societal concerns and political choices. The politics of who gets to make these choices and on what terms is the focus of empirical research in this paper. Using a novel mixed-method approach combining bibliometrics, desk-based analysis and fieldwork, this article builds a narrative of interdisciplinarity at the UK’s largest public robotics lab, the Bristol Robotics Laboratory. This paper argues for the recognition of the plural ways of knowing interdisciplinarity. From citation analysis, through tracing of the emerging fields and disciplines, to, finally, the investigation of researchers’ experiences; each method contributes a distinct and complementary outlook on “what robotics is made of”. While bibliometrics allows visualising prominent disciplines and keywords, document analysis reveals influential and missing stakeholders. Meanwhile, fieldwork explores the logics underpinning robotics and identifies the capabilities necessary to perform the research. In doing so, the paper synthesises plural ways of locating politics in interdisciplinary research and provides recommendations for enabling “structural preparedness for interdisciplinarity”

Workshop: Lassoing unicorns: how to map capabilities for better interdisciplinary research

Sometimes doing interdisciplinary work feels like trying to lasso unicorns. Working with big players from foreign disciplines and interdepartmental drifters. Negotiating over language and frameworks. Agreeing common research questions. All the while trying to gather data and do good work. Building on methods developed in ESRC and Horizon 2020 funded projects on interdisciplinary research, this workshop will: a) introduce the concept interdisciplinary capabilities - the disciplinary skills and informal aptitudes needed for people like environmental engineers, ecological economists and machine learning developers to work well together. b) present a mixed-method approach to mapping capabilities using bibliometric analysis and interviews. c) offer hands-on reflexive exercises on personal ‘capability mapping’, tailored to workshop participants The session will help scholars of all levels recognise power and knowledge in research and identify opportunities to steer that research together

Associations of body mass index and sarcopenia with screen-detected mild cognitive impairment in older adults in Colombia

Background and objective: More research is required to understand associations of body mass index (BMI) and sarcopenia with cognition, especially in Latin America. The objective of this study was to investigate associations of BMI and sarcopenia with mild cognitive impairment in Colombia. Design setting and participants: Data were from the National Survey of Health, Wellbeing and Aging in Colombia (SABE Colombia, in Spanish). Community-dwelling adults aged 60 years or older were invited to participate. Methods: Trained interviewers administered a shorter version of the mini-mental state examination and mild cognitive impairment was defined as a score of 12 or less out of 19. Body mass index was defined using standard cut-offs. Sarcopenia was defined as low grip strength or slow chair stands. Logistic regression models were adjusted for age, sex, height, education, income, civil status, smoking, and alcohol drinking. Results: The prevalence of mild cognitive impairment was 20% in 23,694 participants in SABE Colombia and 17% in 5,760 participants in the sub-sample in which sarcopenia was assessed. Overweight and obesity were associated with decreased risk of mild cognitive impairment and sarcopenia was associated with increased risk. Sarcopenia was a risk factor for mild cognitive impairment in those with normal BMI (adjusted model included 4,911 men and women). Compared with those with normal BMI and without sarcopenia, the odds ratio for mild cognitive impairment was 1.84 in those with normal BMI and sarcopenia (95% confidence interval: 1.25, 2.71). Sarcopenia was also a risk factor in those with obesity but did not present a greater risk than sarcopenia alone. Compared with those with normal BMI and without sarcopenia, the odds ratio was 1.62 in those with obesity and sarcopenia (95% confidence interval: 1.07, 2.48). Sarcopenia was not a risk factor for mild cognitive impairment in those with overweight. Similar results were observed when reference values from Colombia were used to set cut-offs for grip strength. Similar results were also observed in cross-validation models, which suggests the results are robust. Conclusion: This is the first study of the combined associations of sarcopenia and obesity with cognition in Colombia. The results suggest that sarcopenia is the major predictor of screen-detected mild cognitive impairment in older adults, not overweight or obesity

TrES-1: The Transiting Planet of a Bright K0V Star

We report the detection of a transiting Jupiter-sized planet orbiting a relatively bright (V=11.79) K0V star. We detected the transit light-curve signature in the course of the TrES multi-site transiting planet survey, and confirmed the planetary nature of the companion via multicolor photometry and precise radial velocity measurements. We designate the planet TrES-1; its inferred mass is 0.75 +/- 0.07 Jupiter masses, its radius is 1.08 (+0.18/-0.04) Jupiter radii, and its orbital period is 3.030065 +/- 0.000008 days. This planet has an orbital period similar to that of HD 209458b, but about twice as long as those of the OGLE transiting planets. Its mass is indistinguishable from that of HD 209458b, but its radius is significantly smaller and fits the theoretical models without the need for an additional source of heat deep in the atmosphere, as has been invoked by some investigators for HD 209458b.Comment: 15 pages, 3 figures, 2 tables. To be published in Astrophysical Journal Letters. Ascii data in http://www.hao.ucar.edu/public/research/stare/data/TrES1.as

The burden of mild cognitive impairment attributable to physical inactivity in Colombia

BACKGROUND: Mild cognitive impairment often precedes dementia. The purpose of this analysis was to estimate the population attributable fraction for physical activity in Colombia, which is the reduction in cases that would occur if all participants were physically active. METHODS: The sample included 20,174 men and women aged 70.04 +/- 7.68 years (mean +/- SD) from the National Survey of Health, Wellbeing and Ageing. Trained interviewers administered a shorter version of the mini-mental state examination and mild cognitive impairment was defined as a score of 12 or less out of 19. Logistic regression models were fitted and population attributable fractions for physical activity were calculated. All analyses were adjusted for age, sex, height, education, income, civil status, smoking, and alcohol drinking. RESULTS: The prevalence of physical activity was approximately 50% when defined as walking between 9 and 20 blocks at least three times per week. Theoretically, 19% of cases of mild cognitive impairment would be eliminated if all adults were to walk (95% confidence interval: 16%, 22%). The prevalence was approximately 20% when defined as taking part in vigorous sport or exercise at least three times per week. Theoretically, 23% of cases of mild cognitive impairment would be eliminated if all adults were to take part in vigorous sport or exercise (16%, 30%). Similar results were observed after removing those who reported mental health problems. CONCLUSION: Physical activity, whether walking or vigorous sport and exercise, has the potential to substantially reduce the burden of mild cognitive impairment in Colombia

Methylation panel is a diagnostic biomarker for Barrett’s oesophagus in endoscopic biopsies and non-endoscopic cytology specimens

Objective Barrett’s Oesophagus is a premalignant condition that occurs in the context of gastro-oesophageal reflux. However, most Barrett’s cases are undiagnosed because of reliance on endoscopy. We have developed a non-endoscopic tool; the Cytosponge™ which when combined with TFF3 immunohistochemistry can diagnose Barrett’s. We investigated whether a quantitative methylation test that is not reliant on histopathological analysis could be used to diagnose Barrett’s oesophagus. Design Differentially methylated genes between Barrett’s and normal squamous oesophageal biopsies were identified from whole methylome data and confirmed using MethyLight PCR in biopsy samples of squamous oesophagus, gastric cardia and Barrett’s oesophagus. Selected genes were then tested on Cytosponge™ BEST2 trial samples comprising a pilot cohort (n=20 cases, n=10 controls) and a validation cohort (n=149 cases, n=129 controls). Results Eighteen genes were differentially methylated in patients with Barrett’s compared to squamous controls. Hypermethylation of TFPI2, TWIST1, ZNF345 and ZNF569 was confirmed in Barrett’s biopsies compared with biopsies from squamous oesophagus and gastric cardia (p<0.05). When tested in Cytosponge™ samples these four genes were hypermethylated in patients with Barrett’s oesophagus compared to patients with reflux symptoms (p<0.001). The optimum biomarker to diagnose Barrett’s was TFPI2 with a sensitivity and specificity of 82.2% and 95.7 % respectively. Conclusion TFPI2, ZNF345 and ZNF569 CpG methylation has promise as a diagnostic biomarker panel for Barrett’s when used in combination with a simple and cost effective non-endoscopic cell collection device.The BEST2 study was funded by Cancer Research UK (C14478/ A12088). RCF receives core funding from the Medical Research Council. The study received infrastructure support from the Cambridge Human Research Tissue Bank, which is supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre and the Experimental Cancer Medicine Centre

The c axis optical conductivity of layered systems in the superconducting state

In this paper, we discuss the c axis optical conductivity Re [sigma_c(omega)] in the high T_c superconductors, in the superconducting state. The basic premise of this work is that electrons travelling along the c axis between adjacent CuO_2 layers must pass through several intervening layers. In earlier work we found that, for weak inter-layer coupling, it is preferable for electrons to travel along the c axis by making a series of interband transitions rather than to stay within a single (and very narrow) band. Moreover, we found that many of the properties of the normal state optical conductivity, including the pseudogap could be explained by interband transitions. In this work we examine the effect of superconductivity on the interband conductivity. We find that, while the onset of superconductivity is clearly evident in the spectrum, there is no clear signature of the symmetry of the superconducting order parameter.Comment: 6 pages, 4 figure

Predicting Carotid Artery Disease and Plaque Instability from Cell-derived Microparticles

ObjectivesCell-derived microparticles (MPs) are small plasma membrane-derived vesicles shed from circulating blood cells and may act as novel biomarkers of vascular disease. We investigated the potential of circulating MPs to predict (a) carotid plaque instability and (b) the presence of advanced carotid disease.MethodsThis pilot study recruited carotid disease patients (aged 69.3 ± 1.2 years [mean ± SD], 69% male, 90% symptomatic) undergoing endarterectomy (n = 42) and age- and sex-matched controls (n = 73). Plaques were classified as stable (n = 25) or unstable (n = 16) post surgery using immunohistochemistry. Blood samples were analysed for MP subsets and molecular biomarkers. Odds ratios (OR) are expressed per standard deviation biomarker increase.ResultsEndothelial MP (EMP) subsets, but not any vascular, inflammatory, or proteolytic molecular biomarker, were higher (p < .05) in the unstable than the stable plaque patients. The area under the receiver operator characteristic curve for CD31+41− EMP in discriminating an unstable plaque was 0.73 (0.56–0.90, p < .05). CD31+41− EMP predicted plaque instability (OR = 2.19, 1.08–4.46, p < .05) and remained significant in a multivariable model that included transient ischaemic attack symptom status. Annexin V+ MP, platelet MP (PMP) subsets, and C-reactive protein were higher (p < .05) in cases than controls. Annexin V+ MP (OR = 3.15, 1.49–6.68), soluble vascular cell adhesion molecule-1 (OR = 1.64, 1.03–2.59), and previous smoking history (OR = 3.82, 1.38–10.60) independently (p < .05) predicted the presence of carotid disease in a multivariable model.ConclusionsEMP may have utility in predicting plaque instability in carotid patients and annexin V+ MPs may predict the presence of advanced carotid disease in aging populations, independent of established biomarkers