Banks as shadow directors

In some circumstances, the bank may be classified as a de facto director with attendant legal obligations. This article discusses the role of banks in "intensive care assignments". The article begins with the problem areas in the law found in provisions of the Companies Act 1955 and 1993, as well as in cases like Re Tasbian (No 3) [1991] BCC 436. The article provides possible solutions to the problems, including the bank ensuring that the company engages the external consultant and that the consultant is not directed or instructed by the bank, or for the bank to appoint a receiver and manager under its mortgage or mortgage debenture. The author concludes that the new companies law regime, like a traditional receivership, avoids all the problems of a de facto directorships and shadow directorships. &nbsp

Sustainability in turbulent times: lessons from the Nexus Network for supporting transdisciplinary research

Since its launch in June 2014, the ESRC Nexus Network has worked to support transdisciplinary research at the food-water-energy-environment nexus, and to create meaningful links between communities of researchers, policymakers, business leaders and practitioners. Through its activities, the Network has shown that social science is vital. The language of the nexus highlights the need for interconnected thinking between natural and social sciences, and between the research community and decision makers. This report summarises and reflects on those activities

Providing ethics advice in a pandemic, in theory and in practice: A taxonomy of ethics advice

The pandemic significantly raised the stakes for the translation of bioethics insights into policy. The novelty, range and sheer quantity of the ethical problems that needed to be addressed urgently within public policy were unprecedented and required high-bandwidth two-way transfer of insights between academic bioethics and policy. Countries such as the United Kingdom, which do not have a National Ethics Committee, faced particular challenges in how to facilitate this. This paper takes as a case study the brief career of the Ethics Advisory Board (EAB) for the NHS Covid-19 App, which shows both the difficulty and the political complexity of policy-relevant bioethics in a pandemic and how this was exacerbated by the transience and informality of the structures through which ethics advice was delivered. It analyses how and why, after EAB's demise, the Westminster government increasingly sought to either take its ethics advice in private or to evade ethical scrutiny of its policies altogether. In reflecting on EAB, and these later ethics advice contexts, the article provides a novel framework for analysing ethics advice within democracies, defining four idealised stances: the pure ethicist, the advocate, the ethics arbiter and the critical friend

Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort

Background: There is strong evidence that people born in winter and in spring have a small increased risk of schizophrenia. As this ‘season of birth’ effect underpins some of the most influential hypotheses concerning potentially modifiable risk exposures, it is important to exclude other possible explanations for the phenomenon. Methods: Here we sought to determine whether the season of birth effect reflects gene-environment confounding rather than a pathogenic process indexing environmental exposure. We directly measured, in 136 538 participants from the UK Biobank (UKBB), the burdens of common schizophrenia risk alleles and of copy number variants known to increase the risk for the disorder, and tested whether these were correlated with a season of birth. Results: Neither genetic measure was associated with season or month of birth within the UKBB sample. Conclusions: As our study was highly powered to detect small effects, we conclude that the season of birth effect in schizophrenia reflects a true pathogenic effect of environmental exposure

Harm-reduction approaches for self-cutting in inpatient mental health settings:development and preliminary validation of the Attitudes to Self-cutting Management (ASc-Me) Scale

IntroductionHarm-reduction approaches for self-harm in mental health settings have been under-researched.AimTo develop a measure of the acceptability of management approaches for self-cutting in mental health inpatient settings.MethodsStage one: scale items were generated from relevant literature and staff/service user consultation. Stage two: A cross-sectional survey and statistical methods from classical test theory informed scale development.Results/FindingsAt stage one N=27 staff and service users participated. At stage two N=215 people (n=175 current mental health practitioners and n=40 people with experience of self-cutting as a UK mental health inpatient) completed surveys. Principal components analysis revealed a simple factor structure such that each method had a unique acceptability profile. Reliability, construct validity, and internal consistency were acceptable. The harm-reduction approaches 'advising on wound-care' and 'providing a first aid kit' were broadly endorsed; 'providing sterile razors' and 'maintaining a supportive nursing presence during cutting' were less acceptable but more so than seclusion and restraint.DiscussionThe Attitudes to Self-cutting Management scale is a reliable and valid measure that could inform service design and development.Implications for practiceNurses should discuss different options for management of self-cutting with service users. Harm reduction approaches may be more acceptable than coercive measures. This article is protected by copyright. All rights reserved.</p

Reasons for discontinuing clozapine: a cohort study of patients commencing treatment

Background Clozapine is uniquely effective in the management of treatment-resistant schizophrenia (TRS). However, a substantial proportion of patients discontinue treatment and this carries a poor prognosis. Methods We investigated the risk factors, reasons and timing of clozapine discontinuation in a two-year retrospective cohort study of 316 patients with TRS receiving their first course of clozapine. Reasons for discontinuation of clozapine and duration of treatment were obtained from case notes and Cox regression was employed to test the association of baseline clinical factors with clozapine discontinuation. Results A total of 142 (45%) patients discontinued clozapine within two years. By studying the reasons for discontinuations due to a patient decision, we found that adverse drug reactions (ADRs) accounted for over half of clozapine discontinuations. Sedation was the most common ADR cited as a reason for discontinuation and the risk of discontinuation due to ADRs was highest in the first few months of clozapine treatment. High levels of deprivation in the neighbourhood where the patient lived were associated with increased risk of clozapine discontinuation (HR = 2.12, 95% CI 1.30–3.47). Conclusions Living in a deprived neighbourhood was strongly associated with clozapine discontinuation. Clinical management to reduce the burden of ADRs in the first few months of treatment may have a significant impact and help more patients experience the benefits of clozapine treatment

Reimagining gamification through the lens of Activity Theory

Gamification is maturing as an academic research object, but still suffers from growing pains. Challenges identified in a practical gamification activity are used to anchor a discussion of theoretical challenges currently facing gamification. We argue that some of the pain can be attributed to the exceptionalist and formalist definitions of game, and believe that these interpretations assume a dualistic ontological perspective of the world, resulting in problematic dichotomies. An alternative dialectical perspective from which to reimagine gamification and address some of the challenges is offered. This perspective is concretized through the lens of activity theory. The value of applying activity theory is illustrated by reflecting back on the practical and theoretical challenges identified. Reimagining gamification has the potential to afford participants with greater opportunities for action, and also to drive transformation of existing practices and thus enable agency. It is captured by considering it as an expansive cycle of activity

A Comparison of Interactive Shadows and Multi-View Layouts for Mouse-based 3D Modelling

3D user interfaces allow users to view and interact with objects in a 3D scene and form a key component in many modelling applications used in engineering, medicine and design. Most mouse-based interfaces follow the same multi-view layout (three orthogonal, one perspective). This interface is difficult to understand, as it requires users to integrate all four views and build a 3D mental model. An alternative, Interactive Shadows, has been previously proposed that could improve on the multi-view's shortcomings but has never been formally tested. This paper presents the first quantitative user evaluation (n = 36) of both the multi-view and interactive shadows interfaces to compare their relative effectiveness and usability. Participants completed three types of tasks designed to be representative of object manipulation in current 3D modelling software. Interactive shadows were significantly better (p < 0,05) for tasks requiring participants to estimate distance. This suggests interactive shadows interface might better help users approximate relative object positioning