The optical variability of the narrow line Seyfert 1 galaxy IRAS 13224-3809

We report on a short optical monitoring programme of the narrow-line Seyfert 1 Galaxy IRAS 13224-3809. Previous X-ray observations of this object have shown persistent giant variability. The degree of variability at other wavelengths may then be used to constrain the conditions and emission processes within the nucleus. Optical variability is expected if the electron population responsible for the soft X-ray emission is changing rapidly and Compton-upscattering infrared photons in the nucleus, or if the mechanism responsible for X-ray emission causes all the emission processes to vary together. We find that there is no significant optical variability with a firm upper limit of 2 per cent and conclude that the primary soft X-ray emission region produces little of the observed optical emission. The X-ray and optical emission regions must be physically distinct and any reprocessing of X-rays into the optical waveband occurs some distance from the nucleus. The lack of optical variability indicates that the energy density of infrared radiation in the nucleus is at most equal to that of the ultraviolet radiation since little is upscattered into the optical waveband. The extremely large X-ray variability of IRAS 13224-3809 may be explained by relativistic boosting of more modest variations. Although such boosting enhances X-ray variability over optical variability, this only partially explains the lack of optical variability.Comment: 5 pages with 8 postscript figures. Accepted for publication in MNRA

“I wish I’d told them”: a qualitative study examining the unmet psychosexual needs of prostate cancer patients during follow-up after treatment

<b>Objective</b> To gain insight into patients' experiences of follow-up care after treatment for prostate cancer and identify unmet psychosexual needs.<p></p> <b>Methods</b> Semi-structured interviews were conducted with a purposive sample of 35 patients aged 59-82 from three UK regions. Partners were included in 18 interviews. Data were analyzed using constant comparison. <p></p> <b>Results</b> (1) Psychosexual problems gained importance over time, (2) men felt they were rarely invited to discuss psychosexual side effects within follow-up appointments and lack of rapport with health care professionals made it difficult to raise problems themselves, (3) problems were sometimes concealed or accepted and professionals' attempts to explore potential difficulties were resisted by some, and (4) older patients were too embarrassed to raise psychosexual concerns as they felt they would be considered 'too old' to be worried about the loss of sexual function.<p></p> <b>Conclusion</b> Men with prostate cancer, even the very elderly, have psychosexual issues for variable times after diagnosis. These are not currently always addressed at the appropriate time for the patient.Practice implications Assessments of psychosexual problems should take place throughout the follow-up period, and not only at the time of initial treatment. Further research examining greater willingness or reluctance to engage with psychosexual interventions may be particularly helpful in designing future intervention

Editorial: Supply networks design and management

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Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate

AbstractEvolution of facial morphology arises from variation in the activity of developmental regulatory networks that guide the formation of specific craniofacial elements. Importantly, the acquisition of novel morphology must be integrated with a phylogenetically inherited developmental program. We have identified a unique region of the secondary palate associated with the periodic formation of rugae during the rostral outgrowth of the face. Rugae function as SHH signaling centers to pattern the elongating palatal shelves. We have found that a network of signaling genes and transcription factors is spatially organized relative to palatal rugae. Additionally, the first formed ruga is strategically positioned at the presumptive junction of the future hard and soft palate that defines anterior–posterior differences in regional growth, mesenchymal gene expression, and cell fate. We propose a molecular circuit integrating FGF and BMP signaling to control proliferation and differentiation during the sequential formation of rugae and inter-rugae domains in the palatal epithelium. The loss of p63 and Sostdc1 expression and failed rugae differentiation highlight that coordinated epithelial–mesenchymal signaling is lost in the Fgf10 mutant palate. Our results establish a genetic program that reiteratively organizes signaling domains to coordinate the growth of the secondary palate with the elongating midfacial complex

Spectral damping without quasiparticle decay: The dynamic structure factor of two-dimensional quantum Heisenberg antiferromagnets

Two-dimensional Heisenberg antiferromagnets play a central role in quantum magnetism, yet the nature of dynamic correlations in these systems at finite temperature has remained poorly understood for decades. We solve this long-standing problem by using a novel quantum-classical duality to calculate the dynamic structure factor analytically and, paradoxically, find a broad frequency spectrum despite the very long quasiparticle lifetime. The solution reveals new multi-scale physics whereby an external probe creates a classical radiation field containing infinitely-many quanta. Crucially, it is the multi-scale nature of this phenomenon which prevents a conventional renormalization group approach. We also challenge the common wisdom on static correlations and perform Monte Carlo simulations which demonstrate excellent agreement with our theory.Comment: 13 pages, 7 figures, 1 tabl