Design, Construction and Characterization of a Sliding- Plate- Evaporator Freezer (Spef)

This work embodied the design, construction and characterization of a sliding plate evaporator freezer, a modified version of the conventional freezer. The presence of a sliding plate evaporator reduces the freezing area, to increase the freezing rate and with a reduced freezing time. The freezer is intended to freeze agro and allied products in a record time. This is achieved by incorporating sliding plate evaporators to a conventional freezer to have two or more freezing sources, thereby, also giving the freezer with the option of a deferring freezing area to increase freezing rate. The results obtained are not exactly matched with the designed objectives because of construction flaws; and modifications can be made to improve the Coefficient of performance. The Coefficient of performance of the SPFE is obtained   to be 7.26. The SPEF is recommended for use in household and agro based industries for faster and effective freezing. Keyword: Freezer, Sliding Plate, Evaporator, and Refrigerator, Freezer chamber, Compressor power, Condenser power and Co-efficient of performance

PARTUM AND POST-PARTUM BEHAVIOURS OF WEST AFRICAN DWARF DOES AND KIDS

Seventeen West African Dwarf does housed intensively were used for this study. Does were naturally mated and pregnancy was confirmed by non-return to oestrus. The predicted parturition date was calculated. Two days to the predicted date of parturition, the does were closely monitored until the day they actually kidded. The behaviours of the does (duration of parturition, and latency to groom kids) and the kids (latency to stand) were recorded. Data were subjected to independent T-test of SPSS statistical package. The mean duration of parturition in WAD does was 9.5±2.65 min and the latency of kids to stand was 10.5±3.45mins. Duration of parturition was greater (P<0.05) in the 1st than 2nd parity does. A significant negative correlation was established between parity and duration of parturition (r =-0.635, P˂0.05). Kids from 1st parity does stood up earlier (P<0.05) compared to those from the 2nd parity does. A positive correlation was established between parity and the latency of the kids to stand (r = 0.598, P˂0.05). In conclusion, the duration of parturition and latency of kid to stand were not affected by the sex of the kid delivered, however WAD does groomed female kids earlier than the male kids.    &nbsp

Collecting biological material from palliative care patients in the last weeks of life: a feasibility study

Objective To assess the feasibility of prospectively collecting biological samples (urine) from palliative care patients in the last weeks of life. Setting A 30-bedded specialist hospice in the North West of England. Participants Participants were adults with a diagnosis of advanced disease and able to provide written informed consent. Method Potential participants were identified by a senior clinician over a 12-week period in 2014. They were then approached by a researcher and invited to participate according to a developed recruitment protocol. Outcomes Feasibility targets included a recruitment rate of 50%, with successful collection of samples from 80% who consented. Results A total of 58 patients were approached and 33 consented (57% recruitment rate). Twenty-five patients (43%) were unable to participate or declined; 10 (17%) became unwell, too fatigued, lost capacity, died or were discharged home; and 15 (26%) refused, usually these patients had distressing pain, low mood or profound fatigue. From the 33 recruited, 20 participants provided 128 separate urine samples, 12 participants did not meet the inclusion criteria at the time of consent and 1 participant was unable to provide a sample. The criterion for a urinary catheter was removed for the latter 6 weeks. The collection rate during the first 6 weeks was 29% and 93% for the latter 6 weeks. Seven people died while the study was ongoing, and another 4 participants died in the following 4 weeks. Conclusions It is possible to recruit and collect multiple biological samples over time from palliative care patients in the last weeks and days of life even if they have lost capacity. Research into the biological changes at the end of life could develop a greater understanding of the biology of the dying process. This may lead to improved prognostication and care of patients towards the end of life

EVALUATION OF THE MICROBIOLOGICAL STATUS AND ANTIBACTERIAL SUSCEPTIBILITY PATTERN OF SOME HERBAL REMEDIES ADMINISTERED ORALLY IN NIGERIA

The use of herbal remedies in preventive and curative medicine dates back to the primitive era and progressively gave birth to the modern day chemotherapy and medicine. Investigation into the microbiological quality of ten well packaged herbal drugs produced and commonly administered in Nigeria was carried out using standard methods. Antibiotic susceptibility test was demonstrated by Kirby- Bauer method and McFarland standard. Aliquot portions of decimally diluted drug suspensions were inoculated onto bacteriological and mycological media. Total counts were determined and expressed as colony forming units per grams /milliliters. Total heterotrophic and coliform bacteria count was 4.3 × 107-2.61 × 1011 and 1.0 × 107- 1.87 × 1010 on respectively. Total heterotrophic fungi count was 3.0 × 107- 1.55 × 1010. Five species of bacteria, namely, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Corynebacteriun diptheriae and Micrococcus luteus and five species of fungi, namely, Aspergillus flavus, Penicillium notatum, Rhizopus stolonifer, Mucor and Saccharomyces species were isolated from the herbal remedies. Most of the isolates are resident in the soil, water, air and vegetations, and their public health implications had been reported. Staphylococcus aureus produce potent enterotoxins associated with food borne intoxication, toxic shock syndrome and staphylococcal scalded skin syndrome. Bacillus species, an endospore former also produce an exotoxin implicated in food borne infection. The presence of Enterococcus faecalis indicates feacal contamination. Some species of Aspergillus, Penicillium and Rhizopus are known to produce mycotoxins that cause cancer and other mycotoxicoses as well as mycotic infections of the liver, kidney and skin. Staphylococcus aureus, Enterococcus faecalis and Bacillus sp were susceptible to seven of the ten oxoid commercial antibiotics. The high incidence of bacteria and fungi fall short of international standard and portends danger to consumers. Contamination may result from inadequate sanitary measures employed during production, packaging and storage. Good manufacturing practices (GMP) are recommended to ensure products with wholesome quality that meets international safety standar

Enhancing Graduate Employability: Why Higher Education Institutions have problems with teaching generic skills?

One debate among business owners and policymakers centres on whether higher education institutions (HEIs) have failed to transform the younger generation by developing their competencies, skills, values and behaviours to enable them to be fit for the world of work. While previous studies have considered the importance of skills development and its assessment in many contexts, there appears to have been limited scholarly research on employability issues within the higher education system (HES) in Nigeria. In seeking to address this, it is vital to understand how HEIs in Nigeria conceptualize generic skills and why HEIs have problems with teaching generic skills in their programmes. By adopting a qualitative approach, based on interviews with senior academics, industry executives and final-year undergraduates, this study found that many of the HEIs do not facilitate the teaching of high-level generic skills in their programmes. Some of the factors attributed to this include poor learning environment, lack of staff with industry experience, and over-dependence on theoretical content teaching. The findings are significant for reorienting the HE curriculum developers to align with the needs of the industry and society. Regarding implications for policy, we recommend that enterprise education be made mandatory for primary, secondary and tertiary education curriculum in Nigeria. Finally, we advocate more inclusive and interpretive research for greater understanding of the issues, and to offer useful data for policy-making and decision-making on the perspectives of preparing graduates for work

Genetic Variation for Striga hermonthica Resistance and Yield Among Sorghum Accessions in Nigeria

Striga hermonthica (Delile) Benth., commonly referred to as witch weed, is a major constraint to sorghum (Sorghum bicolor (L.) Moench) production in the Northern region of Nigeria because of high yield losses due to infestation. To identify parental lines useful in breeding for S. hermonthica resistant sorghum genotypes adapted to Nigeria, twenty-five sorghum accessions were evaluated in Nigeria across three test environments. Both phenotypic and genetic components influenced the variation observed in the sorghum accessions. The estimates for the genetic coefficient of variation, heritability and genetic advance for the area under Striga number progress curve (ASUNPC), Striga emergence counts, yield and other agronomic traits, obtained in this study revealed that genetic gain for resistance to S. hermonthica could be realized through selection. Based on the performance of the 25 sorghum accessions SRN39, Danyana, Sepon82, and SAMSORG40 were the top four accessions found to be most resistant to S. hermonthica. Assessment of resistance was based on the low Striga emergence counts and the ASUNPC values. These accessions can be used as donor sources of S. hermonthica resistant genes for introgression into cultivars adapted to Nigeria, followed by recombination breeding for pyramiding the different resistance mechanisms

Marker Assisted Foreground Selection for Identification of Striga Resistant Backcross Lines in Sorghum bicolor

Striga is a major constraint to sorghum production causing high yield loss due to increasing infestation. Locally-adapted cultivars with resistant genes/QTLs could be an effective control strategy for Striga. Marker-Assisted Foreground Selection was used to select backcross lines possessing Striga resistance QTLs from N13. Marker polymorphism was conducted for the donor parent N13 and 10 recurrent parents using 10 Simple Sequence Repeat (SSR) markers. Recurrent parents with SSR alleles, polymorphic to the donor parent allele were selected. F1 lines were developed by making a cross between the selected recurrent parent and the donor. The F1 were confirmed for heterozygosity using SSR markers. Selected heterozygote F1s were backcrossed to their recurrent parent to develop backcross populations (BC1F1 and BC2F1). BC1F1 and BC2F1 populations were genotyped using SSR markers flanking the Striga resistant QTLs in N13. Forty two DANYANA-N13 BC2F1 lines (with 4 QTLs in 3 lines, 3 QTLs in 10 lines and other 28 lines having 1 to 2 QTLs) were selected for the presence of N13 QTLs. Forty three SAMSORG39-N13 BC2F1 lines (with 3 QTLs in 2 lines while 41 lines had 1 to 2 QTLs) were also selected for the presence of N13 QTLs. Although, selected lines will be genotyped for the recovery of recurrent parent background and evaluated to identify elite genotypes for possible release as varieties, the successful introgression of Striga resistance QTLs using Marker Assisted Selection suggests that in developing superior sorghum varieties, breeders could make use of molecular marker technologies to speed up breeding programmes

Children with type 1 diabetes who experienced a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis

IMPORTANCE: Landmark studies showed that partial clinical remission in new-onset type 1 diabetes is associated with reduced prevalence of long-term complications, but early clinical indicators of this favorable outcome are poorly characterized. AIM: To determine if there were any differences in lipid parameters, especially LDL-cholesterol, between remitters and non-remitters 4 to 5 years after the diagnosis of type 1 diabetes after controlling for hemoglobin A1c, body mass index, and pubertal status. SUBJECTS AND METHODS: A longitudinal retrospective cohort study of 123 subjects of mean age 11.9 +/- 2.9 years, [male 11.7 +/- 2.9 years, (n = 55); female 12.0 +/- 2.9 years, (n = 68), p = 0.60] with type 1 diabetes of 4-5 years duration. Anthropometric and biochemical data were collected at the 4th or 5th year after diagnosis in line with the American Diabetes Association recommendation to initiate screening for complications in children either at the beginning of puberty or 4-5 years after diagnosis. Puberty was defined by Tanner stages II-V. Partial clinical remission was defined by the gold-standard insulin-dose adjusted hemoglobin A1c (IDAA1c) of \u3c /=9. RESULTS: There were 44 (35.8%) remitters (age 13.0 +/- 2.5y; male 52.3%). Both the total cholesterol and LDL-cholesterol were significantly lower in remitters compared to non-remitters: LDL-C: 78.8 +/- 28.7 mg/dL vs. 91.6 +/- 26.5 mg/dL, p = 0.023; and total cholesterol: 151.5 +/- 32.6 mg/dL vs. 167.0 +/- 29.6 mg/dL, p = 0.015. Other lipid fractions were similar between the groups. There were no differences between the groups for glycemic control, body mass index z score, thyroid function, celiac disease occurrence, or vitamin D status. A greater number of remitters were in puberty compared to non-remitters (86.4% vs. 60.8%, p = 0.006). LDL-C concentration was similar in prepubertal remitters vs. non-remitters (p = 0.93), but was significantly lower in remitters in puberty compared to non-remitters in puberty (p = 0.018) after adjusting for age and duration of diabetes. CONCLUSIONS: Children with type 1 diabetes who underwent a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis. This early divergence in lipidemia may explain the dichotomy in the prevalence of long-term complication in type 1 diabetes between remitters and non-remitters. It also offers a pathway for targeted lipid monitoring in type 1 diabetes, by establishing non-remission as a non-modifiable risk factor for vascular complication in type 1 diabetes