Producing Enactable Protocols in Artificial Agent Societies

This paper draws upon our previous work [7, 16] in which we proposed the organisation of services around the concept of artificial agent societies and presented a framework for representing roles and protocols using LTSs. The agent would apply for a role in the society, which would result in its participation in a number of protocols. We advocated the use of the games-based metaphor for describing the protocols and presented a framework for assessing the admission of the agent to the society on the basis of its competence. In this work we look at the subsequent question: what information should the agent receive upon entry?. We can not provide it with the full protocol because of security and overload issues. Therefore, we choose to only provide the actions pertinent to the protocols that the role the agent applied for participates in the society. We employ branching bisimulation for producing a protocol equivalent to the original one with all actions not involving the role translated into silent (τ) actions. However, this approach sometimes results in non-enactable protocols. In this case, we need to repair the protocol by adding the role in question as a recipient to certain protocol messages that were causing the problems. We present three different approaches for repairing protocols, depending on the number of messages from the original protocol they modify. The modified protocol is adopted as the final one and the agent is given the role automaton that is derived from the branching bisimulation process

Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer: clinical and biomarker results from a phase I trial

Background: Dysregulation of receptor tyrosine kinase MET by various mechanisms occurs in 3%–4% of non-small-cell lung cancer (NSCLC) and is associated with unfavorable prognosis. While MET is a validated drug target in lung cancer, the best biomarker strategy for the enrichment of a susceptible patient population still remains to be defined. Towards this end we analyze here primary data from a phase I dose expansion study of the MET inhibitor capmatinib in patients with advanced MET-dysregulated NSCLC. Patients and methods: Eligible patients [≥18 years; Eastern Cooperative Oncology Group (ECOG) performance status ≤2] with MET-dysregulated advanced NSCLC, defined as either (i) MET status by immunohistochemistry (MET IHC) 2+ or 3+ or H-score ≥150, or MET/centromere ratio ≥2.0 or gene copy number (GCN) ≥5, or (ii) epidermal growth factor receptor wild-type (EGFRwt) and centrally assessed MET IHC 3+, received capmatinib at the recommended dose of 400 mg (tablets) or 600 mg (capsules) b.i.d. The primary objective was to determine safety and tolerability; the key secondary objective was to explore antitumor activity. The exploratory end point was the correlation of clinical activity with different biomarker formats. Results: Of 55 patients with advanced MET-dysregulated NSCLC, 40/55 (73%) had received two or more prior systemic therapies. All patients discontinued treatment, primarily due to disease progression (69.1%). The median treatment dur

Coordination in Software Agent Systems

The objective of this paper is to examine the crucial area of co-ordination in multi-agent systems. It does not attempt to provide a comprehensive overview of the co-ordination literature; rather, it highlights the necessity for co-ordination in agent systems and overviews briefly various co-ordination techniques. It critiques these techniques and presents some conclusions and challenges drawn from this literature

Agent Systems and Applications

We present a formal model of negotiation between autonomous agents. The purpose of the negotiation is to reach an agreement about the provision of a service by one agent for another. The model defines a range of strategies and tactics that agents can employ to generate initial offers, evaluate proposals and offer counter proposals. The model is based on computationally tractable assumptions, demonstrated in the domain of business process management and empirically evaluated