Conservative Management of Keratocystic Odontogenic Tumors of Jaws

Purpose. The aim of this study was to evaluate different surgical treatment methods for keratocystic odontogenic tumors (KCOTs) and the outcome of those treatments over a 9-year period. Patients and Methods. A retrospective review was performed on 43 KCOTs in 39 patients. In radiographic evaluations for diagnosis, follow ups and before and after treatment, panoramic, 3D CT and MR images were used. The three groups of different surgical treatment were (1) enucleation for small unilocular lesions without certainty of histology; (2) enucleation with Carnoy's solution, for small unilocular lesions after previous histological confirmation of KOCT; (3) marsupialization followed by enucleation with Carnoy's solution implemented for large often multilocular KCOTs with intact or destruction of cortical bone without infiltration of neighbouring tissue. Results. 43 KCOT cases were mostly localized in mandible (76.7%), radiologically unilocular (72%), and parakeratocysts (88.4%). Inflammation and satellite cysts (daughter cysts) were detected histopathologically in 14 (32.5%) and 7 (16.3%), respectively. Among the 43 cysts, 20 (46.5%) were associated with the impacted third molar and of 21 (48.8%) was in tooth bearing area, and 5 (11, 6%) located on edentulous areas. It was located mostly in the anterior region of maxilla (90%) and in mandibular molar and ramus (62.8%). The treatments of KCOTs were 18 (41.9%) for group 1, and 10 (23.3%) group 2, and 15 (34.8%) group 3. A statistically significant relationship was found between the radiographic appearance and treatment methods (P = 0.00). No recurrence was found on 40.54 ± 23.02 months follow up. Conclusion. We concluded that successful treatment methods were enucleation and Carnoy's solution in small lesions and marsupialization in lesions that have reached a very large size, but because KCOT was observed in second decade mostly, long-term follows up are suggested

Ki-67 and MCM-2 in Dental Follicle and Odontogenic Cysts: The Effects of Inflammation on Proliferative Markers

The aim of this study was to investigate whether there is any association between inflammation and the expression of markers of cell cycle entry (Ki-67 and MCM-2) in dental follicle (DF) of asymptomatic impacted teeth and odontogenic cysts. The study consisted of 70 DFs and 20 odontogenic cysts (radicular cyst (RC), dentigerous cyst (DC) and keratocytic odontogenic tumor (KCOT) located at posterior mandibular region. Histological findings of inflammation for all specimen and mucous cell prosoplasia, squamous metaplasia, glandular epithelium for all DFs were stained with hematoxyline and eosin, periodic acid schiff, alcian blue, and mucin. Epithelial cell proliferation was determined by using immunohistochemical labeling for Ki-67 and MCM-2. The histologic examinations showed 16% mucous cell prosoplasia, 54% squamous metaplasia, 20% glandular epithelium, 37% inflammation. Inflammation was detected in all RCs and %62 in DF, %43 in DC and KCOT. Positive correlation was found between the inflammation of DF and odontogenic cysts (P<0.01). The mean Ki-67 and MCM-2 expressions were found 9,64±5,99 and 6,34±3,81 in DF, 11,85±9,01 and 13,6±9,94 in odontogenic cysts, respectively. While the mean Ki-67 expressions were statistically significant in DF and KCOT (P<0.01), MCM-2 were significant in RC and KCOT (P<0.01). MCM-2 expresion in RCs were statistically significant than KCOT (P<0.01). The results of this study indicated that the higher MCM-2 expressions in RC than the KCOT might be related to the inflammation and this protein might be more sensitive to inflammation

Superficial cervical plexus block on pain control in patients with temporomandibular joint internal derangement with headache: A retrospective cohort study

OBJECTIVES: Temporomandibular disorders (TMDs) are a group of disorders with varied pathophysiology and clinical manifestations. Masticatory and cervical motor systems have a functional relationship. Superficial cervical muscles have greater hyperactivity in myogenous and mixed TMDs than in healthy individuals, demonstrating an abnormal pattern of contraction. This study aimed to demonstrate the effects of superficial cervical plexus block (SCPB) anesthesia during arthrocentesis in patients with temporomandibular joint (TMJ) internal derangement and headache. METHOD AND MATERIALS: This retrospective cohort study included 2 men and 23 women with cervicogenic headache and TMJ internal derangement treated by arthrocentesis, and 40 TMJs with established cervicogenic headaches. The average follow-up period was 9.36 ± 2.679 months. TMJ and muscle pain during mastication, maximum and non-assisted mouth opening, and lateral excursion were recorded. Pain and dysfunction were determined using the visual analog scale. Patients were monitored before, during, and after arthrocentesis while inducing SCPB anesthesia, and vital findings were recorded. In addition, skin surface temperature was measured. RESULTS: Patients experienced a significant increase in their clinical values. Changes in non-assisted mouth opening (mean from 29.65 ± 6.31 to 33.3 ± 5.21 mm) (P < .05), assisted mouth opening (mean from 38.98 ± 7.62 to 43.35 ± 6.17 mm), right excursions (mean from 7.28 ± 2.08 to 9.13 ± 1.86 mm), and left excursions (mean from 7.48 ± 1.71 to 8.90 ± 1.82 mm) were statistically significant (P < .05). Patients were relieved after SCPB, resulting in decreased pain and hemodynamic values. Increase in mean temperature after SCPB was statistically significant (P = .002, P < .05). CONCLUSION: This study presents a straightforward novel protocol, clinically efficient for arthrocentesis on pain control in patients with TMJ internal derangement and cervicogenic headache

determination of incidence of complications and life quality after mandibular impacted third molar surgery

Ama&ccedil;: Bu &ccedil;alışmanın amacı; mandibuler g&ouml;m&uuml;l&uuml; &uuml;&ccedil;&uuml;nc&uuml; molar diş cerrahisi sonrası gelişen komp-likasyonların g&ouml;r&uuml;lme sıklığı, şiddeti ve &ccedil;eşidinin saptanması, nedenlerin araştırılması, g&ouml;r&uuml;len komp-likasyonların &ouml;nlenmesi ve hastaların cerrahi operasyon sonrası yaşam kalitesinin belirlenmesidir. Gere&ccedil; ve Y&ouml;ntem: &Ccedil;alışma, yaşları 16 ile 83 arasında değişen, 77&#39;si bayan, 28&#39;i erkek toplam 105 hastanın 121 mandibuler g&ouml;m&uuml;l&uuml; &uuml;&ccedil;&uuml;nc&uuml; molar dişi &uuml;zerinde y&uuml;r&uuml;t&uuml;ld&uuml;. T&uuml;m hastaların yaşı, cinsiyeti, sistemik durumu, k&ouml;t&uuml; alışkanlıkları, ağız hijyenleri, oral kontraseptif kullanımı ve menst&uuml;rasyon d&ouml;nemleri ayrıca mandibuler g&ouml;m&uuml;l&uuml; &uuml;&ccedil;&uuml;nc&uuml; molar sınıflaması, ağrı, &ouml;dem, trismus, parestezi gibi postoperatif komplikasyonlar kaydedildi. Bulgular: &Ouml;dem varlığı (94, 5.5&plusmn;3.06, p=0.004) ve kanama komplikasyonu arasında (29, 6.24&plusmn;2.77, p=0.019), operasyon s&uuml;resi ile &ouml;dem varlığı arasında (94, 30.65&plusmn;15.49, p=0.005) ve operasyon s&uuml;resi ile parestezi komplikasyonu arasında (10, 41.2&plusmn;15.15, p=0.006) istatistiksel olarak anlamlı bir fark kaydedildi. Sonu&ccedil;: Yaşam kalitesinin k&ouml;t&uuml;leşmesine neden olan postoperatif bulgular, ağrı, &ouml;dem, trismus ve parestezi olup, dikkatli bir cerrahi teknik, operatif &ouml;zen ve hastaların postoperatif &ouml;nerileri uygulaması komplikasyonların sıklığını ve şiddetini azaltacaktır. Anahtar kelimeler: Mandibuler g&ouml;m&uuml;l&uuml; &uuml;&ccedil;&uuml;nc&uuml; molar, komplikasyon, g&ouml;rsel analog skala, yaşam kalite

Diabetic radiculoplexus neuropathy ınvolving the upper extremity : A case report

Diyabetik radikülopeksus nöropati diyabetli hastalarda akut veya subakut gelişen genellikle kalça çevresini tutan tek veya iki yanlı proksimal kas gücü kaybı ile seyreden, göreceli olarak nadir görülen bir nöropati tipidir. 71 yaşındaki diyabetli erkek hastada 3 ay içerisinde sağ omuz ve kol kaslarında atrofiyle seyreden kas zafiyeti gelişti. Hastanın sağ omuz hareketleri kısıtlıydı ve sol kolunu kaldıramıyordu. Klinik ve elektrodiagnostik bulgularla hastaya diyabetik radikülopeksus nöropati tanısı kondu. Bu yayında olgu literatür eşliğinde sunuldu.Diabetic radiculoplexus neuropathy is a relatively rare condition, in which unilateral or bilateral muscular weakness that acutely or subacutely develops mainly around the hip in type 2 diabetes patients. A 71-year-old man with diabetes mellitus presented with asymmetrical weakness and atrophy of the right shoulder girdle muscles for the last 3 months. He had limitation of right shoulder range of motions and could not raise his right arm. Our patient, who fulfilled the criteria for the diagnosis of diabetic radiculoplexus neuropathy based on clinical and electrodiagnostic features, is reported and discussed in the light of the literature

The Effect of Bovine Bone Graft With or Without Platelet-Rich Plasma on Maxillary Sinus Floor Augmentation

WOS: 000296071200015PubMed ID: 21798642Purpose: The purpose of this study was to compare Unilab Surgibone (USB) (Mississauga, Ontario, Canada), a bone xenograft (bovine), with platelet-rich plasma (PRP) and USB without PRP to augment the human maxillary sinus in preparation to receive dental implants. Patients and Methods: Patients who had bilateral pneumatized maxillary sinuses were included. Sinuses on one side were augmented with the USB-PRP combination and formed the study group, whereas the opposite-side sinuses were augmented with USB alone and served as controls. Bone biopsy specimens were taken during implant placement at 6.8 +/- 0.9 months after maxillary sinus floor augmentation. Resonance frequency analysis measurements were performed at implant placement (first control) and before the prosthetic stage (second control), at 6.5 +/- 0.7 months after implant surgery. Results: There were 10 patients (7 men and 3 women; mean age, 53.7 +/- 0.8 years). Integration between new bone and residual grafts was histologically observed in all samples. The volumes of soft tissue were 59.9% +/- 7.5% and 57.8% +/- 4.4% in the control and study groups, respectively; residual graft, 21.9% +/- 6.6% and 23.6% +/- 5.9%, respectively; new bone, 15.8% +/- 4.8% and 16.0% +/- 3.8%, respectively; and trabecular bone, 64.7% +/- 22.5% and 69.1% +/- 18.6%, respectively. A positive correlation was found between new bone volume and trabecular bone volume (P = .0001). The mean Implant Stability Quotient (ISQ) values were 71.7 +/- 4.9 and 70.3 +/- 5.7 in the control and study groups, respectively, at first control and 75.4 +/- 6.4 and 74.4 +/- 6.4, respectively, at second control. The mean ISQ values at second control in both groups were significantly higher than at first control (P = .043 and P = .028, respectively). No statistically significant differences were observed between groups (P > .05). Conclusion: The combination of USB and PRP does not have any effect on new bone formation and implant stabilization. (C) 2011 American Association of Oral and Maxillofacial Surgeons J Oral Mcaillofac Surg 692537-2547, 201

Statik tepe boşluğu-gaz kromatografik metot kullanılarak set-tip yoğurtlarda uçucu bileşenlerin belirlenmesi

In this study, cows’ milk and aromatic cultures such as CH-1, YF-3331 and YC-350 used in production of yogurts. The volatile compounds in the samples were determined on the 1st, 7 th, 14th and 21st days of storage by using static headspace gas chromatographic method. During storage, the amount of individual volatile compounds varied significantly in yogurts depending on type of culture used. The volatile compounds acetaldehyde, acetone, ethanol, acetoin, 2-furanmethanol and ethyl phthalate were determined in all samples. On day 1, acetaldehyde (82 mg/kg) was the highest compound in yogurt made using culture CH-1 which followed by yoghurts with YC-350 (66 mg/kg) and YF-3331 (54 mg/kg). Even though the amounts of acetaldehyde and ethanol decreased at the end of storage, acetoin increased in all the samples. While the amount of acetone in yogurt made using culture CH-1 showed fluctuations during storage, its levels in yogurts with cultures YF-3331 and YC-350 steadily increased and decreased, respectively.Bu çalışmada, yoğurt üretimleri inek sütüne CH-1, YF-3331 ve YC-350 aromatik yoğurt kültürleri ilave edilerek gerçekleştirilmiştir. Uçucu bileşenler, statik tepe boşluğu metodu kullanılarak gaz kromatografisinde depolamanın 1, 7, 14 ve 21. günlerinde belirlenmiştir. Depolama süresince her bir uçucu bileşen kullanılan kültürün çeşidine bağlı olarak istatistiksel olarak önemli bir değişim göstermiştir. Uçucu bileşenlerinden, asetaldehit, aseton, etanol, asetoin, 2-furan methanol ve etil fitalat tüm örneklerde tespit edilmiştir. Depolamanın 1. gününde, CH-1 kültürü ile yapılan yoğurtta en yüksek seviyede asetaldehit (82 mg/kg ) belirlenmiş, onu YC-350 (66 mg/kg) ve YF-3331 (54 mg/kg) kültürleri ile yapılan yoğurtlar izlemiştir. Tüm örneklerde asetaldehit ve etanol depolamanın sonunda azalma göstermesine rağmen asetoin artmıştır. Asetoin miktarı, CH-1 kültürü ile yapılan yoğurtta depolama süresince dalgalanmalar göstermesine karşın, YF-3331 kültürlü yoğurtta artma ve YC-350 kültürlü yoğurtta ise azalma eğilimi göstermiştir

Gossypin protects against renal Ischemia-Reperfusion Injury in rats

*Akaras, Nurhan ( Aksaray, Yazar )Renal injury occurring as a result of renal ischemia-reperfusion may lead to renal failure or even death. The aim of this study is to investigate possible protective effects of Gossypin on tissue damage occurred due to ischemia-reperfusion in rat kidney tissue. A total of 48 male Wistar albino rats were used in the study. These rats were randomly divided into 6 groups equally (n = 8). The created groups were control (C), sham (S), ischemia-reperfusion (I/R), I/R + DMSO, I/R + 400 mu g/kg gossypin and I/R + 4 mg/kg gossypin. In the rats of sham group, the right nephrectomy was performed. In the rats of other groups rather than sham, the left renal artery was clamped after performing the right nephrectomy. Gossypin was administered intraperitoneally before the reperfusion. 24 h reperfusion was applied to the left renal after 1 h of ischemia. TNF-alpha, IL-1 beta, IL-6 and IL-10 levels were measured with spectrophotometric methods in the kidney tissues after the procedures were completed. Apoptosis and inflammatory pathways were evaluated histopathologically using Caspase 3 and NF-kappa B antibodies. There was a statistically significant decrease in IL-1 beta and IL-6 levels of the gossypin groups compared to the I/R group (P<0.05). As the level of TNF-alpha was decreased in the gossypin administered groups compared to the I/R group although not statistically significant, the level of IL-10 was increased. In the present study, we aimed to show that gossypin in renal I/R model is effective on inflammatory process and apoptosis and that it can be used in routine treatment to decrease the damage in all reasons that may cause I/R. In addition, this study can shed light on the studies to be done in this field in the future...