Holographic description of SCFT5 compactifications

We present three infinite families of supersymmetric Type IIB backgrounds with AdS4, AdS3 and AdS2 factors, dual to SCFTs in 3, 2 and 1 space-time dimensions respectively. These field theories emerge at low energies, after a twisted compactification of a family of five dimensional N = 1 SCFTs on hyperbolic spaces. The holographic flows across dimensions are explicitly computed. We also discuss a family of SUSY breaking backgrounds, dual to a QCD-like quiver with massive (bi)fundamental matter. Some field theoretical observables are computed for these theories at the fixed points and along the flow

Electrostatic description of five-dimensional SCFTs

In this paper we discuss an infinite class of AdS6 backgrounds in Type IIB supergravity dual to five dimensional SCFTs whose low energy description is in terms of linear quiver theories. The quantisation of the Page charges imposes that each solution is determined once a convex, piece-wise linear function is specified. In the dual field theory, we interpret this function as encoding the ranks of colour and flavour groups in the associated quiver. We check our proposal with several examples and provide general expressions for the holographic central charge and the Wilson loop VEV. Some solutions outside this general class, with less clear quiver interpretation, are also discussed

Electrostatic description of 3d N \mathcal{N} = 4 linear quivers

We present the holographic dual for the strongly coupled, low energy dynamics of balanced N = 4 field theories in (2 + 1) dimensions. The infinite family of Type IIB backgrounds with AdS4 × S2 × S2 factors is described in terms of a Laplace problem with suitable boundary conditions. The system describes an array of D3, NS5 and D5 branes. We study various aspects of these Hanany-Witten set-ups (number of branes, linking numbers, dimension of the Higgs and Coulomb branches) and encode them in holographic calculations. A generic expression for the Free Energy/Holographic Central Charge is derived. These quantities are then calculated explicitly in various general examples. We also discuss how Mirror Symmetry is encoded in our Type IIB backgrounds. The connection with previous results in the bibliography is made

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity

Patients with pancreatic ductal adenocarcinoma (PC) have a poor prognosis due to metastases and chemoresistance. PC is characterized by extensive fibrosis, which creates a hypoxic microenvironment, and leads to increased chemoresistance and intracellular oxidative stress. Thus, proteins that protect against oxidative stress are potential therapeutic targets for PC. A key protein that maintains genomic integrity against oxidative damage is MutY-Homolog (MYH). No prior studies have investigated the function of MYH in PC cells. Using siRNA, we showed that knockdown of MYH in PC cells 1) reduced PC cell proliferation and increased apoptosis; 2) further decreased PC cell growth in the presence of oxidative stress and chemotherapy agents (gemcitabine, paclitaxel and vincristine); 3) reduced PC cell metastatic potential; and 4) decreased PC tumor growth in a subcutaneous mouse model in vivo. The results from this study suggest MYH may be a novel therapeutic target for PC that could potentially improve patient outcome by reducing PC cell survival, increasing the efficacy of existing drugs and reducing metastatic spread

Evaluacion economica plan de reconversion cultivo de arroz a plantacion de vinedo

102 p.En los últimos anos el país ha vivido transformaciones sociales, políticas y económicas que en el sector agrícola han sido especialmente significativas. La globalización de las economías y la apertura de los mercados esta obligando a este sector a generar nuevas capacidades de gestión, de manera de alcanzar un mayor nivel de competitividad frente a otras alternativas de inversión. El tema principal de esta memoria consiste en realizar una evaluación económica de un plan de reconversión de cultivo de arroz a plantación de viñedos. La propuesta incluye a un grupo de pequeños agricultores de la Séptima Región del Maule. Considerando las fuertes fluctuaciones de precios, los cambios en la demanda y los factores meteorológicos desfavorables, Ios productores arroceros han estado enfrentando permanentemente una alta inestabilidad en los ingresos; debido a lo anterior se ha planteado la necesidad de implementar políticas de estabilización de precios, o bien, generar oportunidades para alternativas distintas de inversión. En este sentido, el sector vitivinícola se presenta como atractivo, ya que durante las últimas temporadas se ha observado una demanda y precios crecientes tanto de los productos finales como intermedios. Dados los costos de siembra, mantención y cosecha de arroz y los costos de plantación y mantención de viñedos, en este estudio se estimo la rentabilidad económica del plan de reconversión. Para la determinación de los ingresos asociados al proyecto se realice un análisis incremental de los flujos de caja para distintos escenarios de rendimientos y precios de ambos cultivos. Para descontar los flujos netos se estimo la tasa de costo de capital relevante utilizando el Modelo CAPM. Los principales parámetros de la estructura de financiamiento propuesta para el plan de reconversión fueron tomados de las condiciones de financiamiento de proyectos agropecuarios del 1NDAP. Se utilizaron los criterios tradicionales de rentabilidad, Valor Actual Neto (VAN) y Tasa lnterna de Retorno (TIR), para determinar la conveniencia económica y financiera de adoptar el plan de reconversión. La principal conclusión es que el proyecto es rentable bajo los escenarios analizados. Palabras claves: Evaluación económica, reconversión, análisis incremental

What happens at the aroma of coffee beans after roasting?

The coffee aroma is one of the most important quality evaluation criteria employed for coffee commercialization and consumption. The purpose of this study was following the roasting process VOCs creations with the novel Electronic Nose equipped whit 2 of 6 MOX nanowire sensors. The nanowires exhibit exceptional crystalline quality and a very high length-to-width ratio, resulting in enhanced sensing capability as well as long-term material stability for prolonged operation. Four different methods of roasting, made by ROSTAMATIC (Table 1) machine, were applied to gain a clearer picture of the differences in roasted coffee aromas by means of a volatile compound analysis. Different methods applied on four different origins of green coffee (India, Indonesia, Honduras, Santos and Nicaragua). The commercial coffees products are made from a blending from minimum five different kinds of coffee and the consumers have developed an addiction/expectation to a specific flavor and taste. Different methods of roasting process will provide the coffee different aroma that will add flexibility to those one that already posses the matrix due to different origins. This work tests and illustrates the broad spectrum of potential uses of the EN technique in food quality control

Matrix Models and Holography: Mass Deformations of Long Quiver Theories in 5d and 3d

We enlarge the dictionary between matrix models for long linear quivers preserving eight supercharges in $d=5$ and $d=3$ and type IIB supergravity backgrounds with AdS$_{d+1}$ factors. We introduce mass deformations of the field theory that break the quiver into a collection of interacting linear quivers, which are decoupled at the end of the RG flow. We find and solve a Laplace problem in supergravity which realises these deformations holographically. The free energy and expectation values of antisymmetric Wilson loops are calculated on both sides of the proposed duality, finding agreement. Our matching procedure sheds light on the F-theorem in five dimensions.Comment: 46 pages plus appendices. Various figures. Some improvements and references added. SciPost Physics versio

The transition from school to work among Chile Solidario and Oportunidades beneficiaries

textConditional Cash Transfer (CCT) programs aim to reduce the inter-generational reproduction of poverty through human capital investment. By 2010, most Latin American countries offered these programs covering almost one fifth of the regional population. CCTs have remained in spite of government changes, economic crises and growth. However, long-term impact evaluations are not encouraging. CCTs have not promoted the completion of high school (the minimal level to obtain a salary above the poverty line), neither labor market mobility among youth. Therefore, CCTs are not achieving their long term goal. In order to shed light on the aspects that explain this failure, my study explores the structural limitations that long-term CCT beneficiaries face in the transition from school to work, a crucial phase in the transition to adulthood and, therefore, in the reproduction of poverty. I analyze two emblematic CCTs in the region: Chile Solidario (Chile) and Oportunidades (Mexico). While Oportunidades is a pioneer CCT and is strictly focused on human capital investment (without connection with the labor market), Chile Solidario is the regional CCT that offers more connections with social programs, especially employment. With an exploratory-descriptive approach, I apply mixed-methods. I analyze CCTs surveys (Panel Chile Solidario for Chile and ENCELURB for Mexico) and in-depth interviews with long-term young beneficiaries and their mothers (cash recipients), from an assets and vulnerability framework. The dissertation sheds light on the heterogeneous characteristics of long-term beneficiaries and the variables that contribute the most to youth's transition from school to work. It also accounts for the main challenges faced by these policies to succeed: lack of local educational and employment opportunities, as well as lack of efficient connections between scholarships' worth, training programs and grants with beneficiaries' needs and situation.Sociolog

Electronic nose for the early detection of different types of indigenous mold contamination in green coffee

In the last few years Electronic Noses (ENs) have been revealed to be a very effective and fast tool for monitoring the microbiological spoilage and food quality control. European regulations report the maximum concentration of mycotoxins permitted in green coffee beans. The aim of this study was to test the ability of a novel EN, equipped with an array of MOX gas sensors based on thin films as well as nanowires, to early detect mold contaminations from Aspergillus spp., in cooperation with classical microbiological and chemical techniques like Gas Chromatography coupled with Mass Spectroscopy with SPME technique. In general the selection of the green coffee is controlled by visual inspection of shape, color and size. However, this process in often not enough to prevent the entrance in the food chains of contaminated products. We have demonstrated that the novel EN is able to early detect the qualitative and quantitative differences between contaminate and uncontaminated samples. Achieved results vividly recommend the use of our EN as a quality control tool in coffee producer industr