A Systematic Review of Evidence for the Clubhouse Model of Psychosocial Rehabilitation

The Clubhouse Model has been in existence for over sixty-five years; however, a review that synthesizes the literature on the model is needed. The current study makes use of the existing research to conduct a systematic review of articles providing a comprehensive understanding of what is known about the Clubhouse Model, to identify the best evidence available, as well as areas that would benefit from further study. Findings are summarized and evidence is classified by outcome domains. Fifty-two articles met the selection criteria of Randomized Clinical Trials (RCT\u27s), quasi-experimental studies, or observational studies for domains of employment (N = 29); quality of life/satisfaction (N = 10); reductions in psychiatric hospitalization(s) (N = 10); social relationships (N = 10); education (N = 3); and health promotion activities (N = 2). RCT results support the efficacy of the Clubhouse Model in promoting employment, reducing hospitalization(s), and improving quality of life. Quasi-experimental and observational studies offer support in education and social domains. The findings from this review indicate that Clubhouses are a promising practice but additional studies using rigorous methods that report the strength of the outcomes are needed to evaluate Clubhouse programs with fidelity to the Clubhouse Model

New Frontiers in Food Production Beyond LEO

New technologies will be needed as mankind moves towards exploration of cislunar space, the Moon and Mars. Although many advances in our understanding of the effects of spaceflight on plant growth have been achieved in the last 40 years, spaceflight plant growth systems have been primarily designed to support space biology studies. Recently, the need for a sustainable and robust food system for future missions beyond Low Earth Orbit (LEO) has identified gaps in current technologies for food production. The goal is to develop safe and sustainable food production systems with reduced resupply mass and crew time compared to current systems

Bose–Einstein condensation in large time-averaged optical ring potentials

Interferometric measurements with matter waves are established techniques for sensitive gravimetry, rotation sensing, and measurement of surface interactions, but compact interferometers will require techniques based on trapped geometries. In a step towards the realisation of matter wave interferometers in toroidal geometries, we produce a large, smooth ring trap for Bose–Einstein condensates using rapidly scanned time-averaged dipole potentials. The trap potential is smoothed by using the atom distribution as input to an optical intensity correction algorithm. Smooth rings with a diameter up to 300 μm are demonstrated. We experimentally observe and simulate the dispersion of condensed atoms in the resulting potential, with good agreement serving as an indication of trap smoothness. Under time of flight expansion we observe low energy excitations in the ring, which serves to constrain the lower frequency limit of the scanned potential technique. The resulting ring potential will have applications as a waveguide for atom interferometry and studies of superfluidity

GROWTH on S190426c: Real-time Search for a Counterpart to the Probable Neutron Star–Black Hole Merger using an Automated Difference Imaging Pipeline for DECam

The discovery of a transient kilonova following the gravitational-wave (GW) event GW170817 highlighted the critical need for coordinated rapid and wide-field observations, inference, and follow-up across the electromagnetic spectrum. In the southern hemisphere, the Dark Energy Camera (DECam) on the Blanco 4 m telescope is well suited to this task, as it is able to cover wide fields quickly while still achieving the depths required to find kilonovae like the one accompanying GW170817 to ~500 Mpc, the binary neutron star (NS) horizon distance for current generation of LIGO/Virgo collaboration (LVC) interferometers. Here, as part of the multi-facility follow-up by the Global Relay of Observatories Watching Transients Happen collaboration, we describe the observations and automated data movement, data reduction, candidate discovery, and vetting pipeline of our target-of-opportunity DECam observations of S190426c, the first possible NS–black hole merger detected in GWs. Starting 7.5 hr after S190426c, over 11.28 hr of observations, we imaged an area of 525 deg^2 (r band) and 437 deg^2 (z band); this was 16.3% of the total original localization probability, and nearly all of the probability visible from the southern hemisphere. The machine-learning-based pipeline was optimized for fast turnaround, delivering transients for human vetting within 17 minutes, on average, of shutter closure. We reported nine promising counterpart candidates 2.5 hr before the end of our observations. One hour after our data-taking ended (roughly 20 hr after the announcement of S190426c), LVC released a refined skymap that reduced the probability coverage of our observations to 8.0%, demonstrating a critical need for localization updates on shorter (~hour) timescales. Our observations yielded no detection of a bona fide counterpart to m_z = 21.7 and m_r = 22.2 at the 5σ level of significance, consistent with the refined LVC positioning. We view these observations and rapid inferencing as an important real-world test for this novel end-to-end wide-field pipeline

Zero Launch Mass Three Dimensional Print Head

NASA's strategic goal is to put humans on Mars in the 2030s. The NASA Human Spaceflight Architecture Team (HAT) and NASA Mars Design Reference Architecture (DRA) 5.0 has determined that in-situ resource utilization (ISRU) is an essential technology to accomplish this mission. Additive construction technology using in-situ materials from planetary surfaces will reduce launch mass, allow structures to be three dimensionally (3D) printed on demand, and will allow building designs to be transmitted digitally from Earth and printed in space. This will ultimately lead to elimination of reliance on structural materials launched from Earth (zero launch mass of construction consumables). The zero launch mass (ZLM) 3D print head project addressed this need by developing a system that 3D prints using a mixture of in-situ regolith and polymer as feedstock, determining the optimum mixture ratio and regolith particle size distribution, developing software to convert g-code into motion instructions for a FANUC robotic arm, printing test samples, performing materials testing, and printing a reduced scale habitable structure concept. This paper will focus on the ZLM 3D Print Head design, materials selection, software development, and lessons learned from operating the system in the NASA KSC Swamp Works Granular Mechanics & Regolith Operations (GMRO) Laboratory

Patient preferences and priorities for haemophilia gene therapy in the US: A discrete choice experiment

From Wiley via Jisc Publications RouterHistory: received 2021-04-29, rev-recd 2021-06-23, accepted 2021-07-15, pub-electronic 2021-07-26Article version: VoRPublication status: PublishedAbstract: Introduction: Gene therapy has shown promise in clinical trials for patients with haemophilia, but patient preference studies have focused on factor replacement treatments. Aim: We conducted a discrete choice experiment (DCE) to investigate the relative importance and differential preferences patients provide for gene therapy attributes. Methods: We surveyed male adults with haemophilia in the United States recruited from patient panels including the National Hemophilia Foundation Community Voices in Research platform using an online survey over 4 months in 2020/21. Participants indicated preferences for gene therapy attributes including dosing frequency/durability, effect on annual bleeding, uncertainty related to side effects, impact on daily activities, impact on mental health, and post‐treatment requirements. The relative importance of each attribute was analysed overall and for subgroups based on haemophilia type and severity. Results: A total of 183 males with haemophilia A (n = 120) or B (n = 63) were included. Half (47%) had severe haemophilia; most (75%) were White. Overall, participants gave effect on bleeding rate the greatest relative importance (31%), followed by dose frequency/durability (26%), uncertainty regarding safety issues (17%), and impact on daily activities (11%). Dose frequency/durability had the greatest importance for those with haemophilia B (35%). Conclusion: People with haemophilia prioritised reduced bleeding and treatment burden; the former was more important in haemophilia A and the latter in haemophilia B, followed by safety and impact on daily life in this DCE of gene therapy attributes. These findings and differences can inform clinical and health policy decisions to improve health equity for people with haemophilia

Role of C-C Motif Ligand 2 and C-C Motif Receptor 2 in Murine Pulmonary Graft-versus-Host Disease after Lipopolysaccharide Inhalations

Environmental exposures are a potential trigger of chronic pulmonary graft-versus-host disease (pGVHD) after successful recovery from hematopoietic cell transplant (HCT). We hypothesized that inhalations of LPS, a prototypic environmental stimulus, trigger pGVHD via increased pulmonary recruitment of donor-derived antigen-presenting cells (APCs) through the C-C motif ligand 2 (CCL2)–C-C motif receptor 2 (CCR2) chemokine axis. B10.BR(H2k) and C57BL/6(H2b) mice underwent allogeneic (Allo) or syngeneic (Syn) HCT with wild-type (WT) C57BL/6, CCL2−/−, or CCR2−/− donors. After 4 weeks, recipient mice received daily inhaled LPS for 5 days and were killed at multiple time points. Allo mice exposed to repeated inhaled LPS developed prominent lymphocytic bronchiolitis, similar to human pGVHD. The increase in pulmonary T cells in Allo mice after LPS exposures was accompanied by increased CCL2, CCR2, and Type-1 T-helper cytokines as well as by monocytes and monocyte-derived dendritic cells (moDCs) compared with Syn and nontransplanted controls. Using CCL2−/− donors leads to a significant decrease in lung DCs but to only mildly reduced CD4 T cells. Using CCR2−/− donors significantly reduces lung DCs and moDCs but does not change T cells. CCL2 or CCR2 deficiency does not alter pGVHD pathology but increases airway hyperreactivity and IL-5 or IL-13 cytokines. Our results show that hematopoietic donor-derived CCL2 and CCR2 regulate recruitment of APCs to the Allo lung after LPS exposure. Although they do not alter pathologic pGVHD, their absence is associated with increased airway hyperreactivity and IL-5 and IL-13 cytokines. These results suggest that the APC changes that result from CCL2–CCR2 blockade may have unexpected effects on T cell differentiation and physiologic outcomes in HCT

ZTF Early Observations of Type Ia Supernovae. III. Early-time Colors As a Test for Explosion Models and Multiple Populations

Colors of Type Ia supernovae (SNe Ia) in the first few days after explosion provide a potential discriminant between different models. In this paper, we present g-r colors of 65 SNe Ia discovered within 5 days from first light by the Zwicky Transient Facility in 2018, a sample that is about three times larger than that in the literature. We find that g-r colors are intrinsically rather homogeneous at early phases, with about half of the dispersion attributable to photometric uncertainties (σnoise ∼ σ int ∼ 0.18 mag). Colors are nearly constant starting from 6 days after first light (g-r ∼-0.15 mag), while the time evolution at earlier epochs is characterized by a continuous range of slopes, from events rapidly transitioning from redder to bluer colors (slope of ∼-0.25 mag day-1) to events with a flatter evolution. The continuum in the slope distribution is in good agreement both with models requiring some amount of 56Ni mixed in the outermost regions of the ejecta and with "double-detonation"models having thin helium layers MHe=0.01 M⊙) and varying carbon-oxygen core masses. At the same time, six events show evidence for a distinctive "red bump"signature predicted by double-detonation models with larger helium masses. We finally identify a significant correlation between the early-time g-r slopes and supernova brightness, with brighter events associated to flatter color evolution (p-value = 0.006). The distribution of slopes, however, is consistent with being drawn from a single population, with no evidence for two components as claimed in the literature based on B-V colors

ZTF Early Observations of Type Ia Supernovae. III. Early-time Colors As a Test for Explosion Models and Multiple Populations

Colors of Type Ia supernovae (SNe Ia) in the first few days after explosion provide a potential discriminant between different models. In this paper, we present g − r colors of 65 SNe Ia discovered within 5 days from first light by the Zwicky Transient Facility in 2018, a sample that is about three times larger than that in the literature. We find that g − r colors are intrinsically rather homogeneous at early phases, with about half of the dispersion attributable to photometric uncertainties (σ_(noise)∼σ_(int) ~ 0.18 mag). Colors are nearly constant starting from 6 days after first light (g − r ~ −0.15 mag), while the time evolution at earlier epochs is characterized by a continuous range of slopes, from events rapidly transitioning from redder to bluer colors (slope of ~−0.25 mag day⁻¹) to events with a flatter evolution. The continuum in the slope distribution is in good agreement both with models requiring some amount of ⁵⁶Ni mixed in the outermost regions of the ejecta and with "double-detonation" models having thin helium layers (M_(He) = 0.01 M_⊙) and varying carbon–oxygen core masses. At the same time, six events show evidence for a distinctive "red bump" signature predicted by double-detonation models with larger helium masses. We finally identify a significant correlation between the early-time g − r slopes and supernova brightness, with brighter events associated to flatter color evolution (p-value = 0.006). The distribution of slopes, however, is consistent with being drawn from a single population, with no evidence for two components as claimed in the literature based on B − V colors

Catching Element Formation In The Act

Gamma-ray astronomy explores the most energetic photons in nature to address some of the most pressing puzzles in contemporary astrophysics. It encompasses a wide range of objects and phenomena: stars, supernovae, novae, neutron stars, stellar-mass black holes, nucleosynthesis, the interstellar medium, cosmic rays and relativistic-particle acceleration, and the evolution of galaxies. MeV gamma-rays provide a unique probe of nuclear processes in astronomy, directly measuring radioactive decay, nuclear de-excitation, and positron annihilation. The substantial information carried by gamma-ray photons allows us to see deeper into these objects, the bulk of the power is often emitted at gamma-ray energies, and radioactivity provides a natural physical clock that adds unique information. New science will be driven by time-domain population studies at gamma-ray energies. This science is enabled by next-generation gamma-ray instruments with one to two orders of magnitude better sensitivity, larger sky coverage, and faster cadence than all previous gamma-ray instruments. This transformative capability permits: (a) the accurate identification of the gamma-ray emitting objects and correlations with observations taken at other wavelengths and with other messengers; (b) construction of new gamma-ray maps of the Milky Way and other nearby galaxies where extended regions are distinguished from point sources; and (c) considerable serendipitous science of scarce events -- nearby neutron star mergers, for example. Advances in technology push the performance of new gamma-ray instruments to address a wide set of astrophysical questions.Comment: 14 pages including 3 figure