35 research outputs found

    Walls talk: Microbial biogeography of homes spanning urbanization.

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    Westernization has propelled changes in urbanization and architecture, altering our exposure to the outdoor environment from that experienced during most of human evolution. These changes might affect the developmental exposure of infants to bacteria, immune development, and human microbiome diversity. Contemporary urban humans spend most of their time indoors, and little is known about the microbes associated with different designs of the built environment and their interaction with the human immune system. This study addresses the associations between architectural design and the microbial biogeography of households across a gradient of urbanization in South America. Urbanization was associated with households' increased isolation from outdoor environments, with additional indoor space isolation by walls. Microbes from house walls and floors segregate by location, and urban indoor walls contain human bacterial markers of space use. Urbanized spaces uniquely increase the content of human-associated microbes-which could increase transmission of potential pathogens-and decrease exposure to the environmental microbes with which humans have coevolved

    An experimental study of air flow and temperature distribution in a room with displacement ventilation and a chilled ceiling

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    Displacement ventilation and chilled ceiling panel systems are potentially more energy efficient than conventional air conditioning systems and are characterized by the presence of vertical temperature gradients and significant radiant asymmetry. The characteristics of this type of system have been studied by making temperature and air flow measurements in a test chamber over a range of operating parameters typical of office applications. Results from the displacement ventilation study are consistent with other studies and show that normalized temperature profiles are independent of internal heat gain. Linear temperature gradients in the lower part of the room were found, in all cases, to be driven by convection from the adjacent walls. Significant mixing, indicated by reduced temperature gradients, was evident in the upper part of the room in the chilled ceiling results at higher levels of heat gain. Visualization experiments, velocity measurements and related numerical studies indicated that with greater heat gains the plumes have sufficient momentum to drive flow across the ceiling surface and down the walls. The significance of forced, as opposed to natural convection, is also suggested by relatively low Richardson Number (Ri) values found near the ceiling. Furthermore, in cases with moderately high internal gains, comparison of the temperature gradients indicated that the effect of ceiling surface temperature on the degree of mixing and the magnitude of the temperature gradient were of secondary importance. These findings are in contrast to the view that it is natural convection at the ceiling that causes enhanced mixing

    Burkitt’s lymphoma arising in the pancreas

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