Impulsive phase solar flare X-ray polarimetry

The pioneering observational work in solar flare X-ray polarimetry was done in a series of satellite experiments by Tindo and his collaborators in the Soviet Union; initial results showed high levels of polarization in X-ray flares (up to 40%), although of rather low statistical significance, and these were generally interpreted as evidence for strong beaming of suprathermal electrons in the flare energy release process. However, the results of the polarimeter flown by the Columbia Astrophysics Laboratory as part of the STS-3 payload on the Space Shuttle by contrast showed very low levels of polarization. The largest value (observed during the impulsive phase of a single event) was 3.4% + or - 2.2%. At the same time but independent of the observational work, Leach and Petrosian (1983) showed that the high levels of polarization in the Tindo results were difficult to understand theoretically, since the electron beam is isotropized on an energy loss timescale. A subsequent comparison by Leach, Emslie, and Petrosian (1985) of the impulsive phase STS-3 result and the above theoretical treatment shows that the former is consistent with several current models and that a factor of approximately 3 improvement in sensitivity is needed to distinguish properly among the possibilities

Housing, Health and Well-Being: An International Perspective

At present around 1,000 million people live in grossly inadequate housing, and 100 million have no shelter whatsoever. Adverse trends in housing status and environmental conditions threaten the health and well-being of additional millions of people world-wide. The relationships between housing and health are reviewed, with an emphasis on the house structure, sanitation, pollution, and overcrowding. Possible approaches to improved housing and municipal planning are examined, and the key requirements include new policies of municipal and national governments, intersectoral coordination, the mobilization and enabling of communities, and strengthened environmental health services

Max '91: Flare research at the next solar maximum

To address the central scientific questions surrounding solar flares, coordinated observations of electromagnetic radiation and energetic particles must be made from spacecraft, balloons, rockets, and ground-based observatories. A program to enhance capabilities in these areas in preparation for the next solar maximum in 1991 is recommended. The major scientific issues are described, and required observations and coordination of observations and analyses are detailed. A program plan and conceptual budgets are provided

Memory and cognitive control in an integrated theory of language processing.

Pickering and Garrod’s integrated model of production and comprehension includes no explicit role for non-linguistic cognitive processes. Yet, how domain-general cognitive functions contribute to language processing has become clearer with well-specified theories and supporting data. We therefore believe that their account can benefit by incorporating functions like working memory and cognitive control into a unified model of language processing

Process Variation-Aware Compact Model of Strip Waveguides for Photonic Circuit Simulation

We report a novel process variation-aware compact model of strip waveguides that is suitable for circuit-level simulation of waveguide-based process design kit (PDK) elements. The model is shown to describe both loss and -- using a novel expression for the thermo-optic effect in high index contrast materials -- the thermo-optic behavior of strip waveguides. A novel group extraction method enables modeling the effective index's ($n_{\mathrm{eff}}$) sensitivity to local process variations without the presumption of variation source. Use of Euler-bend Mach-Zehnder interferometers (MZIs) fabricated in a 300~mm wafer run allow model parameter extraction at widths up to 2.5~$\mu$m (highly multi-mode) with strong suppression of higher-order mode excitation. Experimental results prove the reported model can self-consistently describe waveguide phase, loss, and thermo-optic behavior across all measured devices over an unprecedented range of optical bandwidth, waveguide widths, and temperatures

Should Endovascular Repair Be Reimbursed for Low Risk Abdominal Aortic Aneurysm Patients? Evidence from Ontario, Canada

Background. This paper presents unpublished clinical and economic data associated with open surgical repair (OSR) in low risk (LR) patients and how it compares with EVAR and OSR in high risk (HR) patients with an AAA > 5.5 cm. Design. Data from a 1-year prospective observational study was used to compare EVAR in HR patients versus OSR in HR and LR patients. Results. Between 2003 and 2005, 140 patients were treated with EVAR and 195 with OSR (HR: 52; LR: 143). The 1-year mortality rate with EVAR was statistically lower than HR OSR patients and comparable to LR OSR patients. One-year health-related quality of life was lower in the EVAR patients compared to OSR patients. EVAR was cost-effective compared to OSR HR but not when compared to OSR LR patients. Conclusions. Despite a similar clinical effectiveness, these results suggest that, at the current price, EVAR is more expensive than open repair for low risk patients

Transmisión de Klebsiella pneumoniae resistente a carbapenemes en hospitales de EE.UU.

Antecedentes. La Klebsiella pneumoniae resistente a los carbapenemes (CRKp) es el Enterobacterales resistente a los carbapenemes más prevalente en los Estados Unidos. Se evaluó la agrupación de CRKp en pacientes de hospitales estadounidenses. Métodos. De abril de 2016 a agosto de 2017, 350 pacientes con grupo clonal 258 CRKp se inscribieron en el Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae, un estudio de cohortes prospectivo y multicéntrico. Se construyó un árbol de máxima verosimilitud utilizando RAxML. Los conglomerados estáticos compartían ≤21 polimorfismos de un solo nucleótido (SNP) y un ancestro común más reciente. Los conglomerados dinámicos incorporaron la distancia SNP, el tiempo de cultivo y las tasas de acumulación y transmisión SNP utilizando el programa R TransCluster. Resultados. La mayoría de los pacientes ingresaron desde su domicilio (n=150, 43%) o desde centros de cuidados de larga duración (n=115, 33%). La orina (n=149, 43%) fue el lugar de aislamiento más común. En total, se identificaron 55 conglomerados estáticos y 47 dinámicos en 210 de 350 (60%) y 194 de 350 (55%) pacientes, respectivamente. Aproximadamente la mitad de los clusters estáticos eran idénticos a los dinámicos. Los conglomerados estáticos consistían en 33 (60%) conglomerados intrasistema y 22 (40%) conglomerados intersistema. Los conglomerados dinámicos estaban formados por 32 (68%) conglomerados intrasistema y 15 (32%) conglomerados intersistema y presentaban menos diferencias de SNP que los conglomerados estáticos (8 frente a 9; P=.045; intervalo de confianza [IC] del 95%: -4 a 0). Los conglomerados dinámicos intersistema contenían más pacientes que los conglomerados dinámicos intrasistema (mediana [intervalo intercuartílico], 4 [2, 7] frente a 2 [2, 2]; P=,007; IC del 95%: -3 a 0). Conclusiones. Se identificó una amplia transmisión intrasistémica e intersistémica de CRKp en pacientes estadounidenses hospitalizados. El uso de diferentes métodos para evaluar la similitud genética sólo dio lugar a diferencias menores en la interpretación.Background. Carbapenem-resistant Klebsiella pneumoniae (CRKp) is the most prevalent carbapenem-resistant Enterobacterales in the United States. We evaluated CRKp clustering in patients in US hospitals. Methods. From April 2016 to August 2017, 350 patients with clonal group 258 CRKp were enrolled in the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae, a prospective, multicenter, cohort study. A maximum likelihood tree was constructed using RAxML. Static clusters shared ≤21 single-nucleotide polymorphisms (SNP) and a most recent common ancestor. Dynamic clusters incorporated SNP distance, culture timing, and rates of SNP accumulation and transmission using the R program TransCluster. Results. Most patients were admitted from home (n=150, 43%) or long-term care facilities (n=115, 33%). Urine (n=149, 43%) was the most common isolation site. Overall, 55 static and 47 dynamics clusters were identified involving 210 of 350 (60%) and 194 of 350 (55%) patients, respectively. Approximately half of static clusters were identical to dynamic clusters. Static clusters consisted of 33 (60%) intrasystem and 22 (40%) intersystem clusters. Dynamic clusters consisted of 32 (68%) intrasystem and 15 (32%) intersystem clusters and had fewer SNP differences than static clusters (8 vs 9; P=.045; 95% confidence interval [CI]: −4 to 0). Dynamic intersystem clusters contained more patients than dynamic intrasystem clusters (median [interquartile range], 4 [2, 7] vs 2 [2, 2]; P=.007; 95% CI: −3 to 0). Conclusions. Widespread intrasystem and intersystem transmission of CRKp was identified in hospitalized US patients. Use of different methods for assessing genetic similarity resulted in only minor differences in interpretation