1,434 research outputs found

    Structure and Hydrogen Dynamics of Alkaline Earth Metal Hydrides Investigated with Neutron Scattering

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    Solid-state proton conductors are highly sought after due to their immense appeal for a variety of energy related applications. Metal hydrides are a type of solid-state hydrogen storage material that can possess the ability for fast ionic transport of hydrogen. Fast kinetics and excellent reversibility are typically desirable properties for applications because the ease of hydrogen storage and retrieval is a key rate limiting step in the operation of functional devices. While some metal hydrides exhibit fast ionic conduction, many are hampered by sluggish hydrogen dynamics. We have chosen three different alkaline earth metal hydrides with vastly different hydrogen kinetics for this investigation, i.e. BaH2 [barium hydride], CaH2 [calcium hydride], and MgH2 [magnesium hydride]. Despite the attractiveness of the high storage densities of MgH2, the hydrogen kinetics are notoriously poor in this material. On the other hand, BaH2 has modest storage densities but exhibits fast ionic conduction that rivals the leading proton and oxide ionic conductors in use today. The motivation of this study is to understand the factors that influence the hydrogen dynamics in these materials. Neutron scattering techniques will be used to probe the atomic scale hydrogen diffusion process and to determine how the crystal structure and hydrogen bonding influence the transport properties

    Association of inferior vena cava filter placement for venous thromboembolic disease and a contraindication to anticoagulation with 30-day mortality

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    Importance: Despite the absence of data from randomized clinical trials, professional societies recommend inferior vena cava (IVC) filters for patients with venous thromboembolic disease (VTE) and a contraindication to anticoagulation therapy. Prior observational studies of IVC filters have suggested a mortality benefit associated with IVC filter insertion but have often failed to adjust for immortal time bias, which is the time before IVC filter insertion, during which death can only occur in the control group. Objective: To determine the association of IVC filter placement with 30-day mortality after adjustment for immortal time bias. Design, Setting, and Participants: This comparative effectiveness, retrospective cohort study used a population-based sample of hospitalized patients with VTE and a contraindication to anticoagulation using the State Inpatient Database and the State Emergency Department Database, part of the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality, from hospitals in California (January 1, 2005, to December 31, 2011), Florida (January 1, 2005, to December 31, 2013), and New York (January 1, 2005, to December 31, 2012). Data analysis was conducted from September 15, 2015, to March 14, 2018. Exposure: Inferior vena cava filter placement. Main Outcomes and Measures: Multivariable Cox proportional hazard models were constructed with IVC filters as a time-dependent variable that adjusts for immortal time bias. The Cox model was further adjusted using the propensity score as an adjustment variable. Results: Of 126 030 patients with VTE, 61 281 (48.6%) were male and the mean (SD) age was 66.9 (16.6) years. In this cohort, 45 771 (36.3%) were treated with an IVC filter, whereas 80 259 (63.7%) did not receive a filter. In the Cox model with IVC filter status analyzed as a time-dependent variable to account for immortal time bias, IVC filter placement was associated with a significantly increased hazard ratio of 30-day mortality (1.18; 95% CI, 1.13-1.22; P \u3c .001). When the propensity score was included in the Cox model, IVC filter placement remained associated with an increased hazard ratio of 30-day mortality (1.18; 95% CI, 1.13-1.22; P \u3c .001). Conclusions and Relevance: After adjustment for immortal time bias, IVC filter placement was associated with increased 30-day mortality in patients with VTE and a contraindication to anticoagulation. Randomized clinical trials are needed to determine the efficacy of IVC filter placement in patients with VTE and a contraindication to anticoagulation

    Increased hazard of myocardial infarction with insulin‐provision therapy in actively smoking patients with diabetes mellitus and stable ischemic heart disease: The BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial

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    Background In the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial, randomization of diabetic patients with stable ischemic heart disease to insulin provision ( IP ) therapy, as opposed to insulin sensitization ( IS ) therapy, resulted in biochemical evidence of impaired fibrinolysis but no increase in adverse clinical outcomes. We hypothesized that the prothrombotic effect of IP therapy in combination with the hypercoagulable state induced by active smoking would result in an increased risk of myocardial infarction ( MI ). Methods and Results We analyzed BARI 2D patients who were active smokers randomized to IP or IS therapy. The primary end point was fatal or nonfatal MI . PAI ‐1 (plasminogen activator inhibitor 1) activity was analyzed at 1, 3, and 5 years. Of 295 active smokers, MI occurred in 15.4% randomized to IP and in 6.8% randomized to IS over the 5.3 years ( P =0.023). IP therapy was associated with a 3.2‐fold increase in the hazard of MI compared with IS therapy (hazard ratio: 3.23; 95% confidence interval, 1.43–7.28; P =0.005). Baseline PAI ‐1 activity (19.0 versus 17.5 Au/mL, P =0.70) was similar in actively smoking patients randomized to IP or IS therapy. However, IP therapy resulted in significantly increased PAI ‐1 activity at 1 year (23.0 versus 16.0 Au/mL, P =0.001), 3 years (24.0 versus 18.0 Au/mL, P =0.049), and 5 years (29.0 versus 15.0 Au/mL, P =0.004) compared with IS therapy. Conclusions Among diabetic patients with stable ischemic heart disease who were actively smoking, IP therapy was independently associated with a significantly increased hazard of MI . This finding may be explained by higher PAI ‐1 activity in active smokers treated with IP therapy. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 00006305. </jats:sec

    DEMAND ESTIMATION FOR AGRICULTURAL PROCESSING CO-PRODUCTS

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    Co-products of processing agricultural commodities are often marketed through private transaction rather than through public markets or those in which public transaction information is recorded or available. The resulting lack of historical price information prohibits the use of positive time series techniques to estimate demand. Demand estimates for co-products are of value to both livestock producers, who obtain them for use in livestock rations, and processors, who must sell or otherwise dispose of them. Linear programming has long been used, first by researchers and later as a mainstream tool for nutritionists and producers, to formulate least cost livestock rations. Here it is used as a normative technique to estimate step function demand schedules for co-products by individual livestock classes within a region. Regression is then used to smooth step function demand schedules by fitting demand data to generalized Leontief cost functions. Seemingly unrelated regression is used to estimate factor demand first adjusted for data censoring using probit analysis. Demand by individual livestock classes is aggregated over the number of livestock within a region. Species important to demand for each co-product are identified and own price elasticity for individual livestock classes and all livestock are estimated.Agribusiness, Demand and Price Analysis,

    DEMAND ESTIMATION FOR AGRICULTURAL PROCESSING CO-PRODUCTS

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    Co-products of processing agricultural commodities are often marketed through private transaction rather than through public markets or those in which public transaction information is recorded or available. The resulting lack of historical price information prohibits the use of positive time series techniques to estimate demand. Demand estimates for co-products are of value to both livestock producers, who obtain them for use in livestock rations, and processors, who must sell or otherwise dispose of them. Linear programming has long been used, first by researchers and later as a mainstream tool for nutritionists and producers, to formulate least-cost livestock rations. Here it is used as a normative technique to estimate step function demand schedules for co-products by individual livestock classes within a crop-reporting district. Regression is then used to smooth step function demand schedules by fitting demand data to generalized Leontief cost functions. Seemingly unrelated regression is used to estimate factor demand first adjusted for data censoring using probit analysis. Demand by individual livestock classes is aggregated over the number of livestock within a region. Quantities demanded by beef cows for each of the three co-products considered, sugarbeet pulp, wheat middlings, and potato waste, are large relative to other species because of their predominance in the district. At the current price for sugarbeet pulp, quantity demanded by district livestock is low. However quantity demanded is price elastic and becomes much greater at lower prices. Wheat middlings can be an important component of livestock rations, even at higher prices. At a price slightly below the current price, local livestock demand would exhaust the wheat middlings produced at the district's only wheat processing plant. Potato waste is most appropriate for ruminant diets because these animals are able to consume a large quantity of this high moisture feedstuff. Potato waste can be a cost-effective component in beef and dairy rations. Practically, livestock markets for potato waste must be in close proximity to a potato processing plant. Its high moisture content limits the distance it can be economically transported. At current prices, potato waste can be economically included in the ration for beef cows on a farm nearly 100 miles from the processing plant, although storage challenges may restrict use of the feed to closer operations.co-products, demand estimation, econometrics, linear programming, Agribusiness,

    Improved constrained scheme for the Einstein equations: An approach to the uniqueness issue

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    Uniqueness problems in the elliptic sector of constrained formulations of Einstein equations have a dramatic effect on the physical validity of some numerical solutions, for instance when calculating the spacetime of very compact stars or nascent black holes. The fully constrained formulation (FCF) proposed by Bonazzola, Gourgoulhon, Grandcl\'ement, and Novak is one of these formulations. It contains, as a particular case, the approximation of the conformal flatness condition (CFC) which, in the last ten years, has been used in many astrophysical applications. The elliptic part of the FCF basically shares the same differential operators as the elliptic equations in CFC scheme. We present here a reformulation of the elliptic sector of CFC that has the fundamental property of overcoming the local uniqueness problems. The correct behavior of our new formulation is confirmed by means of a battery of numerical simulations. Finally, we extend these ideas to FCF, complementing the mathematical analysis carried out in previous studies.Comment: 17 pages, 5 figures. Minor changes to be consistent with published versio
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