177 research outputs found
Analysis of realization of regional industrial policy in the former Soviet Union: problems and prospects
АНАЛИЗ РЕАЛИЗАЦИИ РЕГИОНАЛЬНОЙ ПРОМЫШЛЕННОЙ
ПОЛИТИКИ НА ПОСТСОВЕТСКОМ ПРОСТРАНСТВЕ:
ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ
д-р экон. наук, проф. В.К. ПАВЛОВ
(Ижевский филиал Российского университета кооперации, Россия);
д-р экон. наук, проф. О.В. НОСОВА
(Харьковский учебно-научный институт университета банковского дела, Украина)The article is devoted to a research of a role of industrial policy in regional development and contains a list
of the main measures for carrying out structural transformations in the former Soviet Union. The theoretical analysis
of variety of approaches confirms the existence of unfair competition and proves the necessity of further empirical
researches for assessment of efficiency of industrial policy. Use of complexity, limited rationality and social and
economic dynamics provides application of cross-disciplinary approach. Process of reforming in regions depends
on success of industrial policy which includes use of various measures, in particular, of support of national
producers (granting subsidies, applications of protectionism in various branches and others). Researches
of interrelation of trade and economic growth demonstrate the existence of correlation between growth rates of
trade and indicators of an economic environment in regions. The assessment of regional imbalances is defined
by indicators of a gross regional product per capita, regional employment and expenses for education.= Исследуется роль промышленной политики в региональном развитии. Представлен перечень основных мер для проведения структурных преобразований на постсоветском пространстве. Теоретический
анализ многообразия подходов подтверждает существование недобросовестной конкуренции и обосновывает необходимость дальнейших эмпирических исследований для оценки эффективности промышленной
политики. Использование комплексности, ограниченной рациональности и социально-экономической динамики предусматривает применение междисциплинарного подхода. Показано, что процесс реформирования в регионах зависит от успеха промышленной политики, которая включает использование различных мер, в частности поддержки национальных производителей (предоставление субсидий, применения
политики протекционизма в различных отраслях и другие). Исследования взаимосвязи торговли и экономического роста свидетельствуют о существовании корреляции между темпами роста торговли
и показателями экономической конъюнктуры в регионах. Оценка региональных дисбалансов определяется показателями валового регионального продукта в расчете на душу населения, региональной занятости и расходами на образование
Knowledge and Possession of Take Home Naloxone Kits Among Street-Involved Youth in a Canadian Setting
BACKGROUND: The distribution of take-home naloxone (THN) kits has been an important strategy in reducing overdose fatalities among people who use drugs. However, little is known about the use of THN among youth who are street-involved. The present study explores knowledge and possession of THN among street-involved youth in a Canadian setting
The Impact of Methadone Maintenance Therapy on Access to Regular Physician Care Regarding Hepatitis C Among People who Inject Drugs
Background & aims People who inject drugs (PWID) living with hepatitis C virus (HCV) infection often experience barriers to accessing HCV treatment and care. New, safer and more effective directacting antiviral-based therapies offer an opportunity to scale-up HCV-related services. Methadone maintenance therapy (MMT) programs have been shown to be effective in linking PWID to health and support services, largely in the context of HIV. The objective of the study was to examine the relationship between being enrolled in MMT and having access to regular physician care regarding HCV among HCV antibody-positive PWID in Vancouver, Canada
Recurrent triploidy due to a failure to complete maternal meiosis II: whole-exome sequencing reveals candidate variants
Triploidy is a relatively common cause of miscarriage; however, recurrent triploidy has rarely been reported. A healthy 34-year-old woman was ascertained because of 18 consecutive miscarriages with triploidy found in all 5 karyotyped losses. Molecular results in a sixth loss were also consistent with triploidy. Genotyping of markers near the centromere on multiple chromosomes suggested that all six triploid conceptuses occurred as a result of failure to complete meiosis II (MII). The proband's mother had also experienced recurrent miscarriage, with a total of 18 miscarriages. Based on the hypothesis that an inherited autosomal-dominant maternal predisposition would explain the phenotype, whole-exome sequencing of the proband and her parents was undertaken to identify potential candidate variants. After filtering for quality and rarity, potentially damaging variants shared between the proband and her mother were identified in 47 genes. Variants in genes coding for proteins implicated in oocyte maturation, oocyte activation or polar body extrusion were then prioritized. Eight of the most promising candidate variants were confirmed by Sanger sequencing. These included a novel change in the PLCD4 gene, and a rare variant in the OSBPL5 gene, which have been implicated in oocyte activation upon fertilization and completion of MII. Several variants in genes coding proteins playing a role in oocyte maturation and early embryonic development were also identified. The genes identified may be candidates for the study in other women experiencing recurrent triploidy or recurrent IVF failur
AN ECO-FRIENDLY STEREOSELECTIVE SYNTHESIS OF NOVEL DERIVATIVES OF INDENO[1,2-b]PYRROLE AND INDENO[1,2-c]PYRIDAZINE
Workplace Violence among Female Sex Workers Who Use Drugs in Vancouver, Canada: Does Client Targeted Policing Increase Safety?
Workplace violence, by clients or predators, poses serious negative health consequences for sex workers. In 2013, the Vancouver (British Columbia), Canada Police Department changed their guidelines with the goal of increasing safety for sex workers by focusing law enforcement on clients and third parties, but not sex workers. We sought to examine the trends and correlates of workplace violence among female sex workers (FSW) before and after the guideline change, using data collected from prospective cohorts of persons who use illicit drugs in Vancouver, Canada. Among 259 FSW, 21.0% reported workplace violence at least once during the study period between 2008 and 2014. There was no statistically significant change in rates of workplace violence after the guideline change. In our multivariable analysis, daily heroin use was independently associated with workplace violence. The 2013 policing guideline change did not appear to have resulted in decreased reports of workplace violence. Increased access to opioid agonist therapies may reduce workplace violence among drug-using FSW
Перспективы и оптимизация цифровизации экономики на постсоветском пространстве как основа ее устойчивого развития
Раскрыты роль и особенности цифровизации экономики, являющейся объективной предпосылкой инновационного развития экономической системы государства. Исследованы результаты и определены перспективы внедрения цифровой экономики в странах на постсоветском пространстве. Рассмотрены особенности цифрового представления информации, предпосылки, реализация и последствия цифровизации
Synthesis and cytotoxic activity of (2-arylquinazolin-4-yl)hydrazones of 2-hydroxybenzaldehydes
2-Phenyl-6,7-difluoro and 2-(4-fluorophenyl)quinazoline derivatives bearing salicylidenhydrazino fragments at position 4 were prepared based on 4,5-difluoroantranilic acid or anthranilamide. Molecular docking to casein kinase 2 was performed; compounds with high in silico activity to CK2 were revealed. Cytotoxic activity of the synthesized compounds was studied on cancer cell line MDA-MB-231 and normal cell line WI26 VA4
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