The Perceptions of Community Gardeners at Jones Valley Urban Farm and the Implications for Dietary Interventions

The purpose of this study was to assess the reasons community gardeners at Jones Valley Urban Farm in Birmingham, Alabama participate in the community garden program, as well as to explore the potential impacts such participation has on the members’ health, community, and diet. Twenty active gardeners participated in four focus groups. Gardeners reported prior experience, cost savings, taste, sustainability issues, and provision of fresh and organic food as reasons for participating. Gardeners also reported issues related to sharing, community development, mental health, personal pride, perceived health benefits, and new - found food variety as impacts of their participation. Finding s from this study will hopefully serve to guide future quantitative research evaluating community gardening as a potentially healthful dietary intervention

Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

Abstract: The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in individual patients considering all types of damaging alterations simultaneously. Analysing 261 EACs from the OCCAMS Consortium, we discover helper genes that, alongside well-known drivers, promote cancer. We confirm the robustness of our approach in 107 additional EACs. Unlike recurrent alterations of known drivers, these cancer helper genes are rare or patient-specific. However, they converge towards perturbations of well-known cancer processes. Recurrence of the same process perturbations, rather than individual genes, divides EACs into six clusters differing in their molecular and clinical features. Experimentally mimicking the alterations of predicted helper genes in cancer and pre-cancer cells validates their contribution to disease progression, while reverting their alterations reveals EAC acquired dependencies that can be exploited in therapy

“Prescribed fire shrub consumption in a Sierra Nevada mixed-conifer forest

Live shrubs in forest understories pose a challenge for mitigating wildfire risk with prescribed fire. Factors driving shrub consumption in prescribed fires are variable and difficult to explain. This study investigated spatial patterns and drivers of Sierra Nevada mixed-conifer forest shrub consumption in prescribed fires through analysis of high-resolution imagery taken before and after prescribed fire. We applied a spatially explicit, generalized additive model to assess tree cover and coarse woody material as potential drivers of shrub consumption. Shrub cover in two experimental stands prior to burning was 38% and 59% and was 36% and 45% one-year post burn. In both stands shrub patch density increased, while area-weighted mean patch size and largest patch index decreased. Increased local percent cover of coarse woody material was associated with increased shrub consumption. These findings provide information for prescribed fire managers to help better anticipate shrub consumption and patchiness outcomes under similar conditions.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author