Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

We would like to thank all patients whose samples were used in this study. We are also thankful to the Northern Ireland Biobank and Grampian Biorepository for providing us with tissue blocks and patient data; and Dr HG Coleman (Queen’s University Belfast) for her advice on statistical analyses. This work has been carried out with financial support from Cancer Research UK (grant: C11512/A18067), Experimental Cancer Medicine Centre Network (grant: C36697/A15590 from Cancer Research UK and the NI Health and Social Care Research and Development Division), the Sean Crummey Memorial Fund and the Tom Simms Memorial Fund. The Northern Ireland Biobank is funded by HSC Research and Development Division of the Public Health Agency in Northern Ireland and Cancer Research UK through the Belfast CRUK Centre and the Northern Ireland Experimental Cancer Medicine Centre; additional support was received from Friends of the Cancer Centre. The Northern Ireland Molecular Pathology Laboratory which is responsible for creating resources for the Northern Ireland Biobank has received funding from Cancer Research UK, Friends of the Cancer Centre and Sean Crummey Foundation.Peer reviewedPublisher PD

Food, Brexit and Northern Ireland: Critical Issues

This report is the third in our Food Brexit Briefing series. It argues that the absence of serious consideration of food flows into, out of and through Northern Ireland is a significant policy omission in the ongoing Brexit negotiations. There has been much talk of the importance of Northern Ireland, but next to no detailed attention to the food implications of Brexit for Northern Ireland. The report makes the case that there is an urgent need to get down to detail over border arrangements, contingency planning and resource allocation. This is too important to leave to last-minute makeshift or muddle. Food is central to the economy of Northern Ireland, and the continuing supply of safe, high quality, healthy food is currently dependent on the absence of border controls between Northern Ireland, the Republic of Ireland, Great Britain and the rest of the European Union. Hundreds of thousands of tonnes of food criss-cross these borders every year. They are currently free from inspection because of shared, underpinning EU Single Market regulation. An unplanned or mishandled food border imposition is likely to have powerful, destabilising consequences for the integrated nature of food supply, trade and access within Northern Ireland for many years to come. It would raise important challenges for food safety, put jobs at risk, potentially constrain Northern Ireland’s access to health-supporting foods such as fruit and vegetables, and create opportunities for food fraud and crime. The report, by Gary McFarlane and Tony Lewis, both senior environmental health professionals and officers of the Chartered Institute of Environmental Health, and Professor Tim Lang, of the Centre for Food Policy at City, University of London, is based on a thorough review of food flows into, from and through Northern Ireland, and the practical experience of its authors. The report dismisses talk of ‘technological fixes’ to help maintain the smooth flow of goods as vague, unavailable now and unrealistic. It calls for all the governments and bodies involved in food and Brexit – the European Union, United Kingdom, Republic of Ireland, Scotland, Wales and Northern Ireland itself – to set political differences aside in order to resolve the considerable practical challenges of cross-border food traffic. The authors make more than 30 recommendations to help that process

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines : a two-tier approach

ACKNOWLEDGEMENTS The funders had no role in study design, collection, data analysis or interpretation of the data. This work received funding from the Medical Research Council (D.Mc.C. and J.J.), the Health and Social Care Research and Development Division of the Northern Ireland Public Health Agency (D.M.c.C., J.J., M.Mo.), the Wellcome Trust through the Wellcome-FDS Research Training Fellowship, the Faculty of Dental Surgery of the Royal College of Surgeons of England (A.G.S.) and GlaxoSmithKline Ltd (T.J.). The Northern Ireland OPSCC TMAs used in this research were received from the Northern Ireland Biobank which has received funds from Health and Social Care Research and Development Division of the Public Health Agency in Northern Ireland and the Friends of the Cancer Centre. The Northern Ireland Cancer Registry who receives funding from the Northern Ireland Public Health Agency carried out collection of clinical data for the Northern Ireland OPSCC patients. The Faculty of Dental Surgery of the Royal College of Surgeons of England and the Liverpool Bio-innovation Hub Biobank carried out collection of clinical data for the Liverpool OPSCC patients.Peer reviewedPublisher PD

Interpreting in Northern Ireland

This article examines how interpreter provision in Northern Ireland developed in a very different way from Ireland or indeed England, Scotland or Wales. In general terms, interpreter provision in Northern Ireland is very good in that interpreters are routinely provided for hospitals, social welfare, schools and of course police stations and courts. The majority of interpreters have undergone training, and instead of outsourcing interpreting services to a translation agency, the authorities have opted for an in-house service for health and social welfare, a social economy enterprise for legal interpreting and a community development organisation for other types of interpreting. Each organisation has a register of interpreters

Does risk of progression from Barrett’s esophagus to esophageal adenocarcinoma change based on the number of non-dysplastic endoscopies?

Funding: This study was funded in full by the National Institutes of Health, grant number (NIH P30DK056338‐16). The Northern Ireland Barrett’s register was funded by the UK Medical Research Council, Cancer Focus Northern Ireland (formerly the Ulster Cancer Foundation), NI HSC R&D Office, and Cancer Research UK. The Northern Ireland Cancer Registry is funded by the Public Health Agency.Peer reviewedPostprin

Drug use in Ireland & Northern Ireland 2006/2007: drug prevalence survey bulletin 2: Regional Drugs Task Force (Ireland) & Health and Social Services Board (Northern Ireland) results.

This bulletin presents key findings at a local level from the second drug prevalence survey of households in both Ireland and Northern Ireland. The survey sampled a representative number of people aged between 15 and 64 during late 2006 and early 2007. The survey was carried out by Ipsos MORI in Ireland and by the Central Survey Unit of the Northern Ireland Statistics and Research Agency in Northern Ireland according to standards set by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).This bulletin presents results relating to drug prevalence on a lifetime, last year (recent) and last month (current) basis for illegal and other drugs including alcohol and tobacco for each Regional Drug Task Force Area (former Health Board areas) in Ireland, and Health and Social Service Board (HSSB) in Northern Ireland

Slan 2007: one island - one lifestyle? Health and lifestyles in the Republic of Ireland and Northern Ireland: comparing the population surveys of Slan 2007 and NIHSWS 2005.

The aim of this report is to provide a profile of lifestyles, health attitudes and behaviours, together with activities that promote or damage health, in the Republic of Ireland and Northern Ireland. Regular monitoring of the population in these regions provides essential information for planning and policy regarding population health. Comparisons of present and previous study findings in a given population, and of findings in complementary settings, contribute significantly to our understanding of contemporary trends and the potential effects of interventions. Comparisons between the Republic of Ireland and Northern Ireland have a unique value because of the many similarities and differences between the two parts of the island. However, such comparisons are seldom undertaken. This report takes the opportunity to compare two population surveys – the 2007 Survey of Lifestyle, Attitudes and Nutrition (SLÁN) conducted in the Republic of Ireland and the 2005 Northern Ireland Health and Social Well-being Survey (NIHSWS) conducted in Northern Ireland. • SLÁN 2007 involved 10,364 respondents in the Republic of Ireland (RoI). Fieldwork was conducted from November 2006 to October 2007, and involved face-to-face interviews with adults aged 18 years and older at home addresses. The response rate to the survey was 62%. • NIHSWS 2005 involved 4,245 respondents in Northern Ireland (NI). Fieldwork was conducted from February 2005 to March 2006 and involved face-to-face interviews with people aged 16 years and older at home addresses. The response rate to the survey was 66%

Improving knowledge regarding abortions performed on Irish women in the UK

This report provides an historical analysis of abortion data relating to residents of Ireland, Northern Ireland, England, Scotland and Wales over the period 1975 – 2005. The detailed analysis in this report provides the Crisis Pregnancy Agency and those reviewing the report, with an insight into how abortion patterns may vary across countries and how they have changed over time. Data for women from Ireland are based on those whotravelled to UK abortion clinics and supplied Irish addresses. The analyses in this report are based on data notifications held by the Department of Health in the UK

Improving the dining experience in schools

This resource was originally developed and produced by the Health Promotion Agency for Northern Ireland as part of the School food: top marks programme. "This guidance booklet brings together ideas and suggestions for your school to help improve the experience pupils have at lunch time." - introduction