Cytotoxic Activity of Rosa Damascene Mill, Allium sativum, Allium Hirtifolium Boiss, and Prosopis Farcta Extracts on Human Cervical Carcinoma Cell Line

Background: Cervical cancer is one of the major reasons of cancer-related mortality. Human papillomavirus is the most common sexually transmitted viral infection, which can lead to cervical cancer. There is no powerful chemotherapeutic agent for HPV infection and cervical cancer. Some plants have the proper potential to be used for treatment of cervical cancer caused by HPV type 18.Materials and Methods: In this study, cytotoxic effect of extract of four indigenous Iranian plants including Rosa damascene mill, Allium sativum, Allium hirtifolium boiss and Prosopis farcta were investigated on the HeLa cell line. HeLa cells were incubated with different concentrations of extracts and then the cell viability was measured by MTT assay.Results: The viable cell numbers were decreased by increase of the extracts concentration. The Allium sativum showed the higher cytotoxicity in all concentrations than the other ones. Afterwards, Allium hirtifolium Boiss, Rosa damascene mill, and Prosopis farcta showed maximum efficiency to decrease cell viability, respectively.Conclusion: The above four mentioned plants might be used for death of HeLa cell harboring HPV type 18. Therefore, they could be employed as a chemotherapeutic agent in the cervical cancer treatment in future

From Floppy Disks to 5-Star LOD: FAIR Research Infrastructure for NFDI4Culture

NFDI4Culture is establishing an infrastructure for research data on material and immaterial cultural heritage in the context of the German National Research Data Infrastructure (NFDI) in compliance with the FAIR principles. The NFDI4Culture Knowledge Graph is developed and integrated with the Culture Information Portal to aggregate diverse and isolated data from the culture research landscape and thereby increase the discoverability, interoperability and reusability of cultural heritage data. This paper presents the research data management strategy in the long-term project NFDI4Culture, which combines a CMS and a Knowledge Graph-based infrastructure to enable an intuitive and meaningful interaction with research resources in the cultural heritage domain

From Floppy Disks to 5-Star LOD: FAIR Research Infrastructure for NFDI4Culture

NFDI4Culture is establishing an infrastructure for research data on material and immaterial cultural heritage in the context of the German National Research Data Infrastructure (NFDI) in compliance with the FAIR principles. The NFDI4Culture Knowledge Graph is developed and integrated with the Culture Information Portal to aggregate diverse and isolated data from the culture research landscape and thereby increase the discoverability, interoperability and reusability of cultural heritage data. This paper presents the research data management strategy in the long-term project NFDI4Culture, which combines a CMS and a Knowledge Graph-based infrastructure to enable an intuitive and meaningful interaction with research resources in the cultural heritage domain

Neurological Involvements in COVID-19: A hospital-based study

ObjectivesThe SARS-CoV-2 pandemic is the most challenging crisis in the contemporary world. Besides severe pulmonary involvement, the disease also has several extrapulmonary manifestations, and new signs and symptoms are associated with it every dayThe present study aimed to inquire about the frequency of neurological manifestations and risk factors of COVID-19. Materials & MethodsThis retrospective, descriptive study included patients with neurological involvement admitted to the Alborz University of Medical Sciences academic hospitals from March 2020 to July 2020 with confirmed COVID-19 infection. The data included in the analysis were the patient’s demographic information, underlying diseases, neurological manifestations, and laboratory findings.   ResultsThe study included ninety-five patients with a mean age of fiftynine. Neurological symptoms and signs were observed in 91.6% and 10.5% of the patients, respectively. The most frequently associated neurological symptoms of COVID-19 were fatigue (49.5%), headache (47.4%), and dizziness (45.3%). Furthermore, the most common neurological involvements included gait disorders (6.3%), cerebellar dysfunction (4.2%), and cerebrovascular accidents (3.15%). Positive troponin was shown to be the strongest predictor of neurological signs (OR=21, P=0.017), followed by WBC≥15,000 (OR = 20.75, P=0.018) and a history of respiratory disease (OR=7.42, P=0.007)

The effects of Quiet eye training on the performance of in-phase and anti-phase patterns of bimanual coordination in children with DCD

Objectives: The Quiet eye training (QET) with the latest techniques as an uncomplicated approach has recently entered the field of research, has drawn the researchers’ attention. Therefore, the objective of this study was to examine the effects of quiet eye training on the perform in-phase and anti-phase patterns of bimanual coordination in children with DCD. Materials & Methods: Participants (n=20; aged 8-9 years) were randomly divided into two groups including traditional training (TT) and QET. The participants performed bimanual in-phase and anti-phase movements with their wrists at three levels of speed ranging from slow to fast. Results: Results showed that there is a significant difference between pre-test and post-test in QET group (P=0.001) and bimanual coordination accuracy in post-test phase have increased significantly compared to pre-test (F=5.66). Moreover, there is a significant difference between pre-test and post-test in bimanual coordination accuracy in TT group (P=0.01) and post-test accuracy significantly increased (F=2.32) but increasing is less than QET group. Discussion: Results indicated that the performance of the in-phase and anti-phase coordination mode was strongly influenced by the QET, and we conclude that a successful performance of a bimanual linear task dependents mainly on the availability of visual feedback

PHYSICAL TREA MENTS Ebrahim Norouzi Effects of Proprioceptive and Visual Disturbance on In-phase and Anti-phase Hand Performance A B S T R A C T

Purpose: The present study aimed to investigate the effect of sensory and movement speed manipulations on bimanual coordination dynamics. Here we compared to what extent the absence and or bias of different sensory modalities affect performance of coordination of movements. Methods: Fifteen physical education students of Shahid Beheshti University (aged 18-25 years) were participated in the study. Participants performed bimanual in-phase and anti-phase movements with their wrists at 3 levels of speed ranging from slow to fast and 4 different sensory conditions, including 1) Normal sensory input; 2) Masked vision; 3) Masked proprioception; and 4) Full sensory deprivation. Separate analyses of variance (ANOVA) with repeated measures on speed and sensory conditions were conducted for the in-phase and anti-phase movement patterns, followed by post hoc analyses using the Bonferroni correction. The dependent variable was error of relative phase. Results: In line with observations from previous studies, results of our study showed that increasing movement speed influenced performance of the anti-phase (P=0.001) but not the in-phase (P=0.9) coordination patterns. Specifically, as speed increased from slow to fast, the performance of 1800 anti-phase patterns destabilized, with participants showing higher error scores of relative phase. Sensory manipulation showed that proprioception and vision did influence the accuracy and consistency of the coordination tasks in both the in-phase and antiphase movement patterns (P=0.001). Conclusion: The performance of a bimanual linear coordination task depends mainly on the availability of proprioceptive input

Examining the Effectiveness of a PETTLEP Imagery Intervention on the Football Skill Performance of Novice Athletes

While imagery techniques have been included in most psychological skills training programs for elite athletes, only few studies have investigated the effects of various components of imagery such as physical, environmental, tasking, timing, learning, emotion, and perspective (PETTLEP) in the context of motor learning among novice athletes. We tested whether external PETTLEP imagery and internal PETTLEP imagery were able to improve football pass skill acquisition more than a control condition, and thus enhance motor learning among novice players. A total of 45 male adolescent novice players (M=14.65 years, SD = 1.34) were randomly assigned to the following three study conditions: external PETTLEP imagery, internal PETTLEP imagery, and a control condition. At the beginning, and four weeks after randomization, football pass skill performance was measured objectively. Football pass skill performance improved over time in all groups, but more so in the external PETTLEP imagery and internal PETTLEP imagery condition compared to the control condition. At the retention-test, the highest pass skill performance was observed in the external PETTLEP imagery condition. The findings suggest that among adolescent novice football players, compared to internal PETTLEP imagery and a control condition, external PETTLEP imagery led to the highest improvement in football pass skill performance. The PETTLEP imagery thus appears to have the potential to enhance the gross motor skills acquisition of novice athletes who seek to become elite players

Better sleep quality and higher physical activity levels predict lower emotion dysregulation among persons with major depression disorder

Abstract Background People with Major Depression Disorders (MDD) often complain about sleep problems and experience emotion dysregulation. Prior research suggests physical activity can improve both sleep quality and emotional control. However, there is limited research on emotion regulation and the impact of physical activity and sleep in this population. Objectives The present study examined the relationships between sleep quality, emotion regulation, and physical activity levels among patients with MDD. Methods The sample consisted of 118 patients with MDD (mean age: 31.85 years) who completed questionnaires on sleep quality, physical activity, emotion regulation, and depression. Results Results showed that more sleep problems were associated with worse emotion dysregulation, and more physical activity was associated with fewer sleep problems and less emotion dysregulation. Furthermore, physical activity and sleep quality significantly predicted emotion dysregulation, with physical activity being the stronger predictor. Conclusions Results from this study suggest that individuals with MDD who are able to engage in physical activity and get better sleep could experience emotional regulation benefits

Effect of Foreperiod Duration and Handedness on Simple and Choice Auditory Reaction Time Among the Older People

Objectives Cognitive functions such as reaction time undergo change with aging. Given the importance of preparation in response to reaction time in various life situations, this study aimed to examine the effect of various foreperiods (0.5, 1.5, 2.5, and 3.5 s), and handedness at the time of simple and choice auditory reaction time. Methods & Materials The current research followed a quasi-experimental methodology and was carried out using a self-made software. The study population comprised all old people living in Ahvaz City. Of them, 30 people were selected through purposive sampling method and allocated into two groups of right- and left-handed people. Each individual was randomly tested for simple and selective reaction with randomly chosen foreperiods. Results The findings demonstrated a significant difference (P<0.05) between the different periods, and between simple and choice reaction time. It means that short (0.5 and 1.5 s) foreperiods result in the increase of reaction time and that left-handed individuals are associated with shorter reaction times compared with their right-handed counterparts. Conclusion Since cognitive processing occurs slower in the elderly, it is recommended that foreperiods with very short durations be avoided when preparing elders for different motor skills. In addition, the dominance of the right hemisphere, which contains higher numbers of neurons, among the left-handed might lead them to possess lower reaction times compared with right-handed individuals.peerReviewe

Combined virtual reality and physical training improved the bimanual coordination of women with multiple sclerosis

As their illness progresses, patients with Multiple Sclerosis (MS) may suffer from motor impairments. In the present study, we examined the effectiveness of three interventions for learning a bimanual coordination task: Virtual reality training (VRT), conventional physical training (CPT), and the combination of VRT and CPT (COMB). A total of 45 women with MS were randomly assigned to one of the following study conditions: VRT, CPT or COMB. Bimanual coordination was assessed at baseline, eight weeks later at study completion, and 4 weeks after that at follow-up. Bimanual coordination improved over time from baseline to study completion and to follow-up. Compared to the VRT and CPT conditions, the COMB condition led to higher coordination accuracy and consistency. The combination thus appears to have the potential to speed up the recovery of motor control and rehabilitation of women with MS