Scientists' coping strategies in an evolving research system: the case of life scientists in the UK

Scientists in academia have struggled to adjust to a policy climate of uncertain funding and loss of freedom from direction and control. How UK life scientists have negotiated this challenge, and with what consequences for their research and the research system, is the empirical entrance point of this paper. We find that policy impacts can be modulated and buffered by strategies and compromises devised and deployed at research performer level. This shifts conceptualisation from terms of responses to one of more or less proactive strategies of scientists and science organisations which add up, intentionally or unintentionally, to shifts in the overall system

Introduction to computers and information systems

Based on the premise that information is essential to survival and that computers are essential to the best use of information, this book explains how computers and information system work, where they work, and how the affect society’s physical, political, and ethical environment. It is a reflection of our commitment to students and their need to prepare for the demands of the information age. Whether a student wishessimply to understand the use of computers and the role they play in today’s world, to work with computers to manage information n his or her own life, or to design information system, this text offers a comprehensive, up to date look at computers and their considerable impact

A Likely Story: The Da Vinci Code as Work on Myth

Theory of myth is used as an explanatory framework within which to explore the enormous and controversial popular appeal of the novel The Da Vinci Code, first published in 2003. The Da Vinci Code is a site of contestation between truth and falsity. Modernity has used the category of myth to contain and control false stories that claim to be true. Myth is characterised here as story-with-significance but also as story believed by people other than scholars and the guardians of legitimate culture. The novel reinserts story into religious history, finding 'natural' significances to replace those progressively exposed and expunged by scholarship and liberal theology. Code's major themes, the sacred feminine and the bloodline of Jesus and Mary Magdalene, endorse popular knowledge about religion, inheritance, identity, community and gender, knowledge that is threatened by detraditionalisation, feminism, and modernity's emphasis on the autonomous individual. The bloodline myth's move into the category of fiction further blurs the boundaries between the legitimately true and the mythically false

Effects of the herbicide Roundup on freshwater microbial communities: a mesocosm study

The impact of the widely used herbicide glyphosate has been mainly studied in terrestrial weed control, laboratory bioassays, and field studies focusing on invertebrates, amphibians, and fishes. Despite the importance of phytoplankton and periphyton communities at the base of the aquatic food webs, fewer studies have investigated the effects of glyphosate on freshwater microbial assemblages. We assessed the effect of the commercial formulation Roundup using artificial earthen mesocosms. The herbicide was added at three doses: a control (without Roundup) and two treatments of 6 and 12 mg/L of the active ingredient (glyphosate). Estimates of the dissipation rate (k) were similar in the two treatments (half-lives of 5.77 and 7.37 d, respectively). The only two physicochemical parameters showing statistically significant differences between treatments and controls were the downward vertical spectral attenuation coefficient kd(λ), where λ is wavelength, and total phosphorus concentration (TP). At the end of the experiment, the treated mesocosms showed a significant increase in the ratio kd(490 nm)/kd(550 nm) and an eightfold increase in TP. Roundup affected the structure of phytoplankton and periphyton assemblages. Total micro- and nanophytoplankton decreased in abundance in treated mesocosms. In contrast, the abundance of picocyanobacteria increased by a factor of about 40. Primary production also increased in treated mesocosms (roughly by a factor of two). Similar patterns were observed in the periphytic assemblages, which showed an increased proportion of dead : live individuals and increased abundances of cyanobacteria (about 4.5-fold). Interestingly, the observed changes in the microbial assemblages were captured by the analysis of the pigment composition of the phytoplankton, the phytoplankton absorption spectra, and the analysis of the optical properties of the water. The observed changes in the structure of the microbial assemblages are more consistent with a direct toxicological effect of glyphosate rather than an indirect effect mediated by phosphorus enrichment.Fil: Pérez, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Torremorell, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Mugni, Hernan Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Limnología ; ArgentinaFil: Rodriguez, Patricia Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Vera, Maria Solange. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Do Nascimento, Mauro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Allende, Luz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bustingorry, Jose Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Escaray, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Ferraro, Marcela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Izaguirre, Irina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; ArgentinaFil: Pizarro, Haydee Norma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; ArgentinaFil: Bonetto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Limnología ; ArgentinaFil: Morris, Donald P.. Lehigh University; Estados UnidosFil: Zagarese, Horacio Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentin

An evaluation of data quality in Canada’s Continuing Care Reporting System (CCRS): secondary analyses of Ontario data submitted between 1996 and 2011

Abstract Background Evidence informed decision making in health policy development and clinical practice depends on the availability of valid and reliable data. The introduction of interRAI assessment systems in many countries has provided valuable new information that can be used to support case mix based payment systems, quality monitoring, outcome measurement and care planning. The Continuing Care Reporting System (CCRS) managed by the Canadian Institute for Health Information has served as a data repository supporting national implementation of the Resident Assessment Instrument (RAI 2.0) in Canada for more than 15 years. The present paper aims to evaluate data quality for the CCRS using an approach that may be generalizable to comparable data holdings internationally. Methods Data from the RAI 2.0 implementation in Complex Continuing Care (CCC) hospitals/units and Long Term Care (LTC) homes in Ontario were analyzed using various statistical techniques that provide evidence for trends in validity, reliability, and population attributes. Time series comparisons included evaluations of scale reliability, patterns of associations between items and scales that provide evidence about convergent validity, and measures of changes in population characteristics over time. Results Data quality with respect to reliability, validity, completeness and freedom from logical coding errors was consistently high for the CCRS in both CCC and LTC settings. The addition of logic checks further improved data quality in both settings. The only notable change of concern was a substantial inflation in the percentage of long term care home residents qualifying for the Special Rehabilitation level of the Resource Utilization Groups (RUG-III) case mix system after the adoption of that system as part of the payment system for LTC. Conclusions The CCRS provides a robust, high quality data source that may be used to inform policy, clinical practice and service delivery in Ontario. Only one area of concern was noted, and the statistical techniques employed here may be readily used to target organizations with data quality problems in that (or any other) area. There was also evidence that data quality was good in both CCC and LTC settings from the outset of implementation, meaning data may be used from the entire time series. The methods employed here may continue to be used to monitor data quality in this province over time and they provide a benchmark for comparisons with other jurisdictions implementing the RAI 2.0 in similar populations.http://deepblue.lib.umich.edu/bitstream/2027.42/112338/1/12911_2012_Article_635.pd

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Municipios Buga, Cúcuta e Ibagué.

Se ha realizado el trabajo final para el diplomado de profundización acompañamiento psicosocial en escenarios de violencia como opción de grado construyendo el documento a través del análisis de los relatos de violencia del libro “Voces: Relatos de violencia y esperanza en Colombia” por el cual se extrajo fragmentos del relato del caso de Fabián Medina que más impacto tuvieron en los integrantes del grupo, a su vez se analizó el caso Pandurí para lo cual fue muy importante para profundizar en las problemáticas psicosociales que producen los escenarios de violencia en las víctimas, y en el caso seleccionado, Fabián Medina a pesar de pertenecer a un grupo armado también es considerado como víctima de la guerra, con este trabajo se pretende llegar a una reflexión de las secuelas que deja la violencia y las posibilidades de cambio y transformación para la sociedad. Se realiza el análisis sobre el impacto que tuvo la guerra en el contexto de Fabián teniendo en cuenta el cambio de rol que tuvo, de ser un miembro del ejército luchando por unos ideales que no iban acorde a los mandatos del gobierno, para luego desertar y convertirse en miembro de un grupo armado para desde allí protegerse y tratar de realizar un cambio social, dándose cuenta de que los ideales del grupo son más de tipo monetario que social, se encuentra entre la espada y la pared por el juego de poder entre gobierno y miembros de las FARC dejando de lado las necesidades de las comunidades, y en la cual Fabián resulta afectado a través de amenazas de muerte por tratar de cambiar esta condición. En el caso Pandurí también se relata los problemas que provoca la guerra, las muertes del mismo juego de poder asesinando a los miembros más destacados de la comunidad imponiendo un régimen de terror para garantizar la obediencia de los pobladores, así como en la experiencia del ejercicio de foto voz se analizaron las formas sutiles de violencia en el contexto de cada uno de los estudiantes del grupo, a través de fotografías tomadas en lugares que recorren diariamente. Palabras Clave: Violencia, FARC, Voces, Significados, Psicosocial, Víctimas, Potenciación.The final work has been done for the diploma of deepening psychosocial accompaniment in violence scenarios as an option of degree building the document through the analysis of the stories of violence in the book "Voices: Stories of Violence and Hope in Colombia" by which extracted fragments of the story of Fabián Medina's case that had the greatest impact on the members of the group; in turn, the Pandurí case was analyzed for which it was very important to deepen into the psychosocial problems that the violence scenarios in the victims produce; and In the selected case, Fabián Medina, despite belonging to an armed group, is also considered a victim of the war, with this work he intends to arrive at a reflection on the consequences of violence and the possibilities of change and transformation for society. An analysis is made of the impact of the war in the context of Fabián taking into account the change of role he had, of being a member of the army fighting for ideals that were not in accordance with the mandates of the government, then deserting and become a member of an armed group to protect themselves from it and try to make a social change, realizing that the ideals of the group are more of a monetary than a social type, they are between a rock and a hard place because of the power game between government and members of the FARC leaving aside the needs of the communities, and in which Fabián is affected through death threats for trying to change this condition. In the case Pandurí also talks about the problems caused by the war, the deaths of the same power game, killing the most outstanding members of the community imposing a regime of terror to guarantee the obedience of the inhabitants, as well as the experience of the exercise. of voice photo, the subtle forms of violence were analyzed in the context of each of the students of the group, through photographs taken in places that travel daily. Key words: Violence, FARC, Voices, Meanings, Psychosocial, Victims, Empowerment

Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139073/1/jah31693.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139073/2/jah31693_am.pd

Effects of the herbicide Roundup on freshwater microbial communities: a mesocosm study

The impact of the widely used herbicide glyphosate has been mainly studied in terrestrial weed control, laboratory bioassays, and field studies focusing on invertebrates, amphibians, and fishes. Despite the importance of phytoplankton and periphyton communities at the base of the aquatic food webs, fewer studies have investigated the effects of glyphosate on freshwater microbial assemblages. We assessed the effect of the commercial formulation Roundup using artificial earthen mesocosms. The herbicide was added at three doses: a control (without Roundup) and two treatments of 6 and 12 mg/L of the active ingredient (glyphosate). Estimates of the dissipation rate (k) were similar in the two treatments (half-lives of 5.77 and 7.37 d, respectively). The only two physicochemical parameters showing statistically significant differences between treatments and controls were the downward vertical spectral attenuation coefficient kd(k), where k is wavelength, and total phosphorus concentration (TP). At the end of the experiment, the treated mesocosms showed a significant increase in the ratio kd(490 nm)/kd(550 nm) and an eightfold increase in TP. Roundup affected the structure of phytoplankton and periphyton assemblages. Total micro- and nanophytoplankton decreased in abundance in treated mesocosms. In contrast, the abundance of picocyanobacteria increased by a factor of about 40. Primary production also increased in treated mesocosms (roughly by a factor of two). Similar patterns were observed in the periphytic assemblages, which showed an increased proportion of dead : live individuals and increased abundances of cyanobacteria (about 4.5-fold). Interestingly, the observed changes in the microbial assemblages were captured by the analysis of the pigment composition of the phytoplankton, the phytoplankton absorption spectra, and the analysis of the optical properties of the water. The observed changes in the structure of the microbial assemblages are more consistent with a direct toxicological effect of glyphosate rather than an indirect effect mediated by phosphorus enrichment.Facultad de Ciencias Naturales y Muse

PAR1 is selectively over expressed in high grade breast cancer patients: a cohort study

<p>Abstract</p> <p>Background</p> <p>The protease-activated receptor (PAR1) expression is correlated with the degree of invasiveness in cell lines. Nevertheless it has never been directed involved in breast cancer patients progression. The aim of this study was to determine whether PAR1 expression could be used as predictor of metastases and mortality.</p> <p>Methods</p> <p>In a cohort of patients with infiltrating ductal carcinoma studied longitudinally since 1996 and until 2007, PAR1 over-expression was assessed by immunoblotting, immunohistochemistry, and flow citometry. Chi-square and log rank tests were used to determine whether there was a statistical association between PAR1 overexpression and metastases, mortality, and survival. Multivariate analysis was performed including HER1, stage, ER and nodes status to evaluate PAR1 as an independent prognostic factor.</p> <p>Results</p> <p>Follow up was 95 months (range: 2–130 months). We assayed PAR1 in a cohort of patients composed of 136 patients; we found PAR1 expression assayed by immunoblotting was selectively associated with high grade patients (50 cases of the study cohort; P = 0.001). Twenty-nine of 50 (58%) patients overexpressed PAR1, and 23 of these (46%) developed metastases. HER1, stage, ER and PAR1 overexpression were robustly correlated (Cox regression, P = 0.002, P = 0.024 and P = 0.002 respectively). Twenty-one of the 50 patients (42%) expressed both receptors (PAR1 and HER1 P = 0.0004). We also found a statistically significant correlation between PAR1 overexpression and increased mortality (P = 0.0001) and development of metastases (P = 0.0009).</p> <p>Conclusion</p> <p>Our data suggest PAR1 overexpression may be involved in the development of metastases in breast cancer patient and is associated with undifferentiated cellular progression of the tumor. Further studies are needed to understand PAR1 mechanism of action and in a near future assay its potential use as risk factor for metastasis development in high grade breast cancer patients.</p