Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies

Pulmonary neuroendocrine tumors are rare, and there have been very few reports regarding optimal chemotherapeutic regimens. Two molecular targeted agents, everolimus and sunitinib, have recently been shown to provide an additional treatment benefit for pulmonary neuroendocrine tumors. However, little information is available regarding the usefulness of streptozocin chemotherapy. Here, we encountered a case of relapsed and refractory mediastinal atypical carcinoid tumor associated with multiple endocrine neoplasia type 1 for various cytotoxic and molecular targeted agents. The patient showed a good response to streptozocin monotherapy. We describe the case and review streptozocin chemotherapy in patients with pulmonary neuroendocrine tumors

Central nervous system infection following allogeneic hematopoietic stem cell transplantation

Objective/background: Here, we described the clinical characteristics and outcomes of central nervous system (CNS) infections occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a single institution over the previous 6 years. Methods: Charts of 353 consecutive allogeneic transplant recipients were retrospectively reviewed for CNS infection. Results: A total of 17 cases of CNS infection were identified at a median of 38 days (range, 10–1028 days) after allo-HSCT. Causative pathogens were human herpesvirus-6 (n = 6), enterococcus (n = 2), staphylococcus (n = 2), streptococcus (n = 2), varicella zoster virus (n = 1), cytomegalovirus (n = 1), John Cunningham virus (n = 1), adenovirus (n = 1), and Toxoplasma gondii (n = 1). The cumulative incidence of CNS infection was 4.1% at 1 year and 5.5% at 5 years. Conclusion: Multivariate analysis revealed that high-risk disease status was a risk factor for developing CNS infection (p = .02), and that overall survival at 3 years after allo-HSCT was 33% in patients with CNS infection and 53% in those without CNS infection (p = .04). Keywords: Allogeneic hematopoietic stem cell transplantation, Central nervous system infections, Human herpesvirus

Cell Polysaccharides of the Bacillus Calmette-Guerin (BCG)

Defatted BCG cells were extracted by successive treatments with warm water, hot water and alkali solution, and the polysaccharide fractions I, II and III were obtained. Paper electrophoresis showed that Polysaccharides I and II each consisted of one component, while III contained three components. An attempt was made to fractionate this with methanol. The chemical and serological properties of these polysaccharide fractions were studied. In addition to mannose, arabinose and glucosamine, glucose and galactose were identified in the polysaccharides on hydrolysis. The neutral sugars were determined by using ion exchange chromatography. The polysaccharide fraction having a high serological activity showed a high hexosamine content