Pass charta öfver s[yd] ostra delen af Östersjön

Graverad af Fr. AkrelKarttalehdellä: Landskänninga

Pass charta öfver Bälterne, Sundet och S. Westra delen af Östersjön

Graverad af Fr. AkrelSisältää myös kartakkeet: Special charta öfver Åhus-Redd jemte Nya Hamnen därstädes tillika med Landö-Hamn ; Special charta öfver Carlshamns hamn och redd tillika med Winhamn, Matviks hamn, Guo - och JärnavikKarttalehdellä: Landskänninga

Pass charta öfver Botten wiken

Graverad af Fr. AkrelKarttalehdellä myös: Landkänninga

Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. Three proteins designated Vesicular glutamate transporter 1-3 (VGLUT1-3) possess the capability of packaging glutamate into presynaptic vesicles for release of glutamate at the nerve terminal. The present study aimed at determining the role of VGLUT2 in neuronal circuits of higher brain function, emotion, and reward-pocessing. A conditional knockout (cKO) strategy was utilised, and three different mouse lines were produced to delete VGLUT2 in specific neuronal circuits in a temporally and spatially controlled manner. First, we produced a cKO mouse in which Vglut2 was deleted in specific subpopulations of the cortex, amygdala and hippocampus from preadolescence. This resulted in blunted aspects in cognitive, emotional and social behaviour in a schizophrenia-related phenotype. Furthermore, we showed a downstream effect of the targeted deletion on the dopaminergic system. In a subsequent analysis of the same cKO mice, we showed that female cKO mice were more affected their male counterparts, and we also found that female schizophrenia patients, but not male patients, had increased Vglut2 levels in the cortex.  Second, we produced and analysed cKO mice in which Vglut2 was deleted in the cortex, amygdala and hippocampus already from midgestation, and could show that this deletion affected emotional, but not cognitive, function. Third, we addressed the role of VGLUT2 in midbrain dopamine neurons by targeting Vglut2 specifically in these neurons. These cKO mice showed a blunted activational response to the psychostimulant amphetamine and increased operant self-administration of both sugar and cocaine reinforcers. Further, the cKO mice displayed strongly enhanced cocaine-seeking in response to cocaine-associated cues, a behaviour of relevance for addiction in humans. In summary, this thesis work has addressed the role of the presynaptic glutamatergic neuron in different neuronal circuits and shown that the temporal and spatial distribution of VGLUT2 is of great significance for normal brain function

The interaction of diversity : The production of social capital within intercultural relations

Sweden has developed into a country of ethnic and cultural diversity. Research highlight the importance of reciprocal integration and intercultural venues. Minority and majority population must participate in the process of integration, by mutually accepted conditions. The civil society offers social venues but these venues are culturally segregated which prevent intercultural relationships to develop. Språkvän is a civic organization that takes on this challenge. By examining how reciprocity is created within these intercultural relations, knowledge of how reciprocal integration can develop in practice will be created. Reciprocity is developed through social relationships, and the relationship in its entirety must therefore be studied. Theories of social capital enable the study of social relations, based on three features: a structural, a cognitive and a relational dimension. The aim of this study has been to examine how social capital is created within the intercultural relationships, and participants of Språkvän has been interviewed. Volunteers and newcomers were interviewed in focus groups, based on a qualitative and hermeneutic approach. The study showed that there is a discrepancy regarding expectations of the relationship. In line with previous research the terms of the relationships are not reciprocal which endangers the cohesion and perseverance of the relationships

Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. Three proteins designated Vesicular glutamate transporter 1-3 (VGLUT1-3) possess the capability of packaging glutamate into presynaptic vesicles for release of glutamate at the nerve terminal. The present study aimed at determining the role of VGLUT2 in neuronal circuits of higher brain function, emotion, and reward-pocessing. A conditional knockout (cKO) strategy was utilised, and three different mouse lines were produced to delete VGLUT2 in specific neuronal circuits in a temporally and spatially controlled manner. First, we produced a cKO mouse in which Vglut2 was deleted in specific subpopulations of the cortex, amygdala and hippocampus from preadolescence. This resulted in blunted aspects in cognitive, emotional and social behaviour in a schizophrenia-related phenotype. Furthermore, we showed a downstream effect of the targeted deletion on the dopaminergic system. In a subsequent analysis of the same cKO mice, we showed that female cKO mice were more affected their male counterparts, and we also found that female schizophrenia patients, but not male patients, had increased Vglut2 levels in the cortex.  Second, we produced and analysed cKO mice in which Vglut2 was deleted in the cortex, amygdala and hippocampus already from midgestation, and could show that this deletion affected emotional, but not cognitive, function. Third, we addressed the role of VGLUT2 in midbrain dopamine neurons by targeting Vglut2 specifically in these neurons. These cKO mice showed a blunted activational response to the psychostimulant amphetamine and increased operant self-administration of both sugar and cocaine reinforcers. Further, the cKO mice displayed strongly enhanced cocaine-seeking in response to cocaine-associated cues, a behaviour of relevance for addiction in humans. In summary, this thesis work has addressed the role of the presynaptic glutamatergic neuron in different neuronal circuits and shown that the temporal and spatial distribution of VGLUT2 is of great significance for normal brain function

Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. Three proteins designated Vesicular glutamate transporter 1-3 (VGLUT1-3) possess the capability of packaging glutamate into presynaptic vesicles for release of glutamate at the nerve terminal. The present study aimed at determining the role of VGLUT2 in neuronal circuits of higher brain function, emotion, and reward-pocessing. A conditional knockout (cKO) strategy was utilised, and three different mouse lines were produced to delete VGLUT2 in specific neuronal circuits in a temporally and spatially controlled manner. First, we produced a cKO mouse in which Vglut2 was deleted in specific subpopulations of the cortex, amygdala and hippocampus from preadolescence. This resulted in blunted aspects in cognitive, emotional and social behaviour in a schizophrenia-related phenotype. Furthermore, we showed a downstream effect of the targeted deletion on the dopaminergic system. In a subsequent analysis of the same cKO mice, we showed that female cKO mice were more affected their male counterparts, and we also found that female schizophrenia patients, but not male patients, had increased Vglut2 levels in the cortex.  Second, we produced and analysed cKO mice in which Vglut2 was deleted in the cortex, amygdala and hippocampus already from midgestation, and could show that this deletion affected emotional, but not cognitive, function. Third, we addressed the role of VGLUT2 in midbrain dopamine neurons by targeting Vglut2 specifically in these neurons. These cKO mice showed a blunted activational response to the psychostimulant amphetamine and increased operant self-administration of both sugar and cocaine reinforcers. Further, the cKO mice displayed strongly enhanced cocaine-seeking in response to cocaine-associated cues, a behaviour of relevance for addiction in humans. In summary, this thesis work has addressed the role of the presynaptic glutamatergic neuron in different neuronal circuits and shown that the temporal and spatial distribution of VGLUT2 is of great significance for normal brain function

Pass charta öfver norra delen af Botten-Hafwet

Graverad af E. ÅkerlandKarttalehdellä myös: Landkänninga

Special charta öfver kusten från Söderhamn til Stockholm

Graverad af Fr. AkrelKarttalehdellä: Charta öfver Geele inlopp ; Landskänninga

Pass charta öfver Finska wiken

Graverad af Fredr. AkrelKarttalehdellä: LandskänningarSisältää myös kartakkeet: Special charta öfver Rågervik ; Special charta öfver inloppet till Hangö-Reidd ; Special charta öfver redden af Revel ; Special charta öfver inloppet til Lovisa genom Orrengrund ; Special charta öfver inloppet till Friedrichshamn genom Finska Aspö ; Special charta öfver inloppet till Wibor