Effectiveness of carnosine on disturbed electrolytes homeostasis induced by cisplatin

We aimed to assess the effect of well known antioxidant carnosine on disturbed plasma and intraerythrocytes electrolytes and Na+-K+-ATPase activity by cisplatin. 24 male albino Wistar rats were selected and divided into 4 groups: Group I = untreated control; Group II = cisplatin control (received cisplatin at a dose of 3 mg/ kg body weight; i.p. for 13 alternate days); Group III = carnosine alone (treated group at a dose of 10 mg/kg body weight; i.p. for 13 consecutive days); Group IV = carnosine + cisplatin pretreated group. Carnosine was administered 30 min prior to cisplatin. Carnosine significantly restored the intra – erythrocytes Na+, K+ and Na+-K+-ATPase level which consequently affect the plasma Na+, Ca++, and Mg++ level. Effective role conferred by carnosine exhibits its protective activity.Key words: Cisplatin, carnosine, electrolytes, Na+-K+-ATPase

Optical Characteristics of CdSSe Films Prepared by Thermal Evaporation Technique

Thin films of cadmium sulphoselenide (CdSSe) have been prepared by a thermal evaporation method on glass substrate, and with pressure of 4x10-5 mbar. The optical constants such as (refractive index n, dielectric constant ?i,r and Extinction coefficient ?) of the deposition films were obtained from the analysis of the experimental recorded transmittance spectral data. The optical band gap of (CdSSe) films is calculate from (?h?)2 vs. photon energy curve. CdSSe films have a direct energy gap, and the values of the energy gap were found to increase when increasing annealing temperature. The band gap of the films varies from 1.68 – 2.39 eV

Tsallis holographic dark energy under Complex form of Quintessence model

In this paper, we use a Tsallis holographic dark energy model in two forms, interacting and non-interacting cases, to acquire some parameters as the equation of state for the energy density of the Tsallis model in the FRW universe concerning the complex form of quintessence model. We will study the cosmology of complex quintessence by revamping the potential and investigating the scalar field dynamics. Then we analyze ($\omega-\omega'$) and stability in two cases, i.e., non-interacting and interacting. We will explore whether these cases describe a real universe by calculating fractional energy density $\Omega_{D}$ and concerning two parts of the quintessence field effect ( complex and real part ) by considering the real part of this field to be a slow-roll field. We know that the part in which the fractional energy density ($\Omega_{D} > 1$) does not describe a real universe. Also, we specified an interacting coupling parameter $b^{2}$ that depends on the constant parameter of the Tsallis holographic model ($\delta$) with respect to fractional energy density ($0.73$). Unlike independence between the fractional energy density and interacting coupling in the real quintessence model, we determine a relationship among these parameters in this theory. Finally, by plotting some figures, we specify the features of ($\omega-\omega'$) and ($\nu_{s}^{2}$) in two cases and compare the result with each other.Comment: 22 pages, 4 figures, Accepted for publication in Communications in Theoretical Physic

Linkage to Care Is Important and Necessary When Identifying Infections in Migrants.

Migration is an important driver of population dynamics in Europe. Although migrants are generally healthy, subgroups of migrants are at increased risk of a range of infectious diseases. Early identification of infections is important as it prevents morbidity and mortality. However, identifying infections needs to be supported by appropriate systems to link individuals to specialist care where they can receive further diagnostic tests and clinical management. In this commentary we will discuss the importance of linkage to care and how to minimise attrition in clinical pathways

Electrical and dielectric properties of kevlar - carbon hybrid fiber / epoxy laminated composites

This paper reports a.c., d.c. conductivity and dielectric behavior of Ep-hybrid composite with12 Vol.% Kevlar-Carbon hybrid . D.C. conductivity measurements are conducted on the graded composites by using an electrometer over the temperature range from (293-413) K. It was shown then that conductivity increases by increasing number of Kevlar –Carbon fiber layers (Ep1, Ep2, Ep3), due to the high electrical conductivity of Carbon fiber. To identify the mechanism governing the conduction, the activation energies at low temperature region (LTR) and at high temperature region (HTR) have been calculated. The activation energy values for hybrid composite decrease with increasing number of fiber layers. The a.c. conductivity was measured over frequency range 100 Hz-1MHz. It was found that? ?(?) values increase with increasing frequency according to the relation ? (?)=Aws . The values of frequency exponent (s) were found to increase with number of layers

Automatic Speaker Recognition System in Adverse Conditions — Implication of Noise and Reverberation on System Performance

Speaker recognition has been developed and evolved over the past few decades into a supposedly mature technique. Existing methods typically utilize robust features extracted from clean speech. In real-world applications, especially security and forensics related ones, reliability of recognition becomes crucial, meanwhile limited speech samples and adverse acoustic conditions, most notably noise and reverberation, impose further complications. This paper is presented from a study into the behavior of typical speaker recognition systems in adverse retrieval phases. Following a brief review, a speaker recognition system was implemented using the MSR Identity Toolbox by Microsoft. Validation tests were carried out with clean speech and the speech contaminated by noise and/or reverberation of varying degrees. The image source method was adopted to take into account real acoustic conditions in the spaces. Statistical relationships between recognition accuracy and signal to noise ratios or reverberation times have therefore been established. Results show noise and reverberation can, to different extents, degrade the performance of recognition. Both reverberation time and direct to reverberation ratio can affect recognition accuracy. The findings may be used to estimate the accuracy of speaker recognition and further determine the likelihood a particular speaker

Is there any putative mediatory role of inflammatory markers on the association between ultra-processed foods and resting metabolic rate?

The resting metabolic rate (RMR) represents the largest component of total daily energy expenditure. The sale of ultra-processed foods (UPF) is increasing globally; however, UPF can have many adverse effects, including increasing inflammatory markers and altering RMRs. This cross-sectional study included 285 healthy overweight and obese women. Anthropometric measurements were evaluated using a bioelectrical impedance analyzer InBody 770 scanner. High-sensitivity C-reactive protein (hs-CRP), plasminogen activator-1 (PAI-1), monocyte chemoattractant protein (MCP-1), and interleukin-1 beta (IL-1β) blood levels were measured after a 12-h fasting. Indirect calorimetry was used to evaluate the RMR by using the Weir equation, and RMR deviation (RMR estimated - RMR actual), RMR per body mass index (BMI), and free fat mass (FFM) were estimated. A validated food frequency questionnaire (FFQ) was used, and seven groups of UPFs were extracted based on the NOVA method. A negative association between the RMR [β = −0.159, 95% confidence interval (CI): −0.471, −0.052, P = 0.044], RMR per BMI (β = −0.014, 95% CI: −0.025, −0.006, P = 0.036), and RMR per FFM (β = −0.241, 95% CI: −0.006, −0.000, P = 0.041) using the NOVA score was observed after adjusting for confounders. This association disappeared after inclusion of each inflammatory marker. All the markers may inversely mediate the relationship between the mentioned variables and the NOVA score. hs-CRP and MCP-1 also had a negative effect on the relationship between the NOVA score and RMR deviation. Finally, UPF intake is likely related with the RMR, mediated through changes in the production of hs-CRP, PAI-1, MCP-1, and IL-1β

Letter to the editor: Pre-exposure prophylaxis for HIV in Europe: The need for resistance surveillance

__To the editor:__ In a recent paper by Hauser et al. in this journal, a prevalence of 10.8% of transmitted drugresistant viruses was reported among newly diagnosed HIV cases in Germany in 2013 and 2014. The authors conclude that genotypic resistance testing remains important for treatment as well as HIV prevention. We comment on the use of pre-exposure prophylaxis (PrEP) in relation to drug resistance in HIV infections and the need for European surveillance of drug resistance

The Association of Inflammatory Markers, IL-1α and TGF-β, with Dietary Insulin Load and Dietary Insulin Index in Overweight and Obese Women with Healthy and Unhealthy Metabolic Phenotypes: A Cross-Sectional Study

Context Research has shown IL-1α might play a role in the associations between the MH group and DII and DIL. Objective. We evaluated the association of inflammatory markers, IL-1α and TGF-β, with dietary insulin load and index in women with healthy and unhealthy obesity phenotypes. Materials and Methods. 228 obese/overweight women aged 18–48 years were included in this study. Biochemical factors were obtained from blood samples. Body composition, anthropometric measures, and physical activity assessments were performed. Dietary intakes, DII, and DIL were assessed. Results. Significant associations were observed between the MH group and the DII group (OR = 2.142, 95% CI = 1.421, 2.850, and p = 0.040), in which IL-1α may play a role. Discussion and Conclusion. Significant associations were observed between the MH group and DII. IL-1α might play a role in these associations