Pepper (Capsicum annum L.)

This tool focuses on the capsicum crop. It provides information on the plant physiology, the traditional varieties available in Italy as well as the seed production, conservation and selection

Aubergine (Solanum melogena L.)

This tool focuses on the aubergine crop. It provides information on the plant physiology, the traditional varieties available in Italy as well as the seed production, conservation and selection

Potato (Solanum tuberosum L.)

This tool focuses on the potato crops. It provides information on the plant physiology, the traditional varieties available in Italy as well as the seed production, conservation and selection

The main diseases of Solanaceae transmitted by seeds

This tool provides a clear overview of possible diseases transmitted by seeds that can be observed in the Solanaceae family. There is also a description of the conditions increasing the development of pathogens and the possible treatments

Tomato (Lycopersicon esculentum Mill.)

This tool focuses on the tomato crop. It provides information on the plant physiology, the traditional varieties available in Italy as well as the seed production, conservation and selection

Solanaceae

This tool provides detailed information on the life cycle of solanaceae plants, including good practices of crop management. It covers seeds and transplanting as well as physiological problems and specific disease such as downy mildew. The tool clearly describes which treatments are allowed in organic farming

Design, Synthesis, and Antiviral Activities of New Benzotriazole-Based Derivatives

Several human diseases are caused by enteroviruses and are currently clinically untreatable, pushing the research to identify new antivirals. A notable number of benzo[d][1,2,3]triazol-1(2)-yl derivatives were designed, synthesized, and in vitro evaluated for cytotoxicity and antiviral activity against a wide spectrum of RNA positive- and negative-sense viruses. Five of them (11b, 18e, 41a, 43a, 99b) emerged for their selective antiviral activity against Coxsackievirus B5, a human enteroviruses member among the Picornaviridae family. The EC50 values ranged between 6 and 18.5 μM. Among all derivatives, compounds 18e and 43a were interestingly active against CVB5 and were selected to better define the safety profile on cell monolayers by transepithelial resistance test (TEER). Results indicated compound 18e as the hit compound to investigate the potential mechanism of action by apoptosis assay, virucidal activity test, and the time of addition assay. CVB5 is known to be cytotoxic by inducing apoptosis in infected cells; in this study, compound 18e was proved to protect cells from viral infection. Notably, cells were mostly protected when pre-treated with derivative 18e, which had, however, no virucidal activity. From the performed biological assays, compound 18e turned out to be non-cytotoxic as well as cell protective against CVB5 infection, with a mechanism of action ascribable to an interaction on the early phase of infection, by hijacking the viral attachment process