STENOSI VALVOLARE AORTICA STUDIO DEGLI OUTCOME ECOCARDIOGRAFICI DOPO INTERVENTO DI CORREZIONE CHIRURGICA E VALUTAZIONE DELLA PREDITTIVITA\u2019 DI COMPLICANZE TACHIARITMICHE ATRIALI POSTOPERATORIE DEI \u201cNUOVI INDICI ECOCARDIOGRAFICI\u201d

Background: The hemodynamic advantages of the surgical aortic valve replacement on the mass regression, left ventricular sistolic and diastolic function, the timing and the influence of PPM on these outcomes are the first aim of this echocardiographic study. Postoperative atrial fibrillation (POAF) is a common and clinically relevant complication after surgical aortic valve replacement (AVR), however it is hardly predictable. Aim of the study was also to test the role of pre-operative left atrial (LA) longitudinal strain as a predictor of POAF in clinical practice. Methods: Patients referred for AVR for severe isolated aortic valve stenosis were prospectively enrolled and underwent a clinical, biochemical and transthoracic echocardiographic assessment before and after surgery ( follow-up 12 months). Left ventricular mass, systolic and diastolic function, left atrial strain derived PALS (peak atrial longitudinal strain) and PACS (peak atrial contraction strain) were obtained. Results: Prospectively enrolled patients were 91. The follow-up was possible for 72 of them. Severe PPM (EAOi <0.65 cm2 / m2) was found in 12 (16.6%) patients. There was no statistical modification in the average ejection fraction between pre and post-intervention (FE 59% vs 62%, p 0.008). Left ventricular mass showed a reduction of approximately 24.7% (67g) at the 1st month, a further slight reduction at 6 months, remaining unchanged between 6 and 12 months. In a multivariate model, the preoperative mass ( r 0.21 p 0.032)and the 6 months valve area (r2 0.644 <0.001) were the only factors significantly related to the mass regression at 6 months; Immediate improvement of diastolic function was seen at the first month post-intervention (97.3% of patients). No significant difference was found in the improvement of diastolic function between the groups with or without PPM (p 0.641). b) POAF was present in 34 (48%) of the patient. Age was the only clinical variable significantly related with POAF (p=0,04), whereas pre-operative symptoms, cardiovascular risk factors, medications, or biochemical data showed no-link to POAF. Regarding echocardiographic parameters, only PALS and PACS indexes revealed a strong, significant association with the occurrence of arrhythmia (p<0,0001). Cut-off of 23% for PALS and 10% for PACS had the best sensitivity (92% for PACS) and specificity. In two comprehensive multivariate models, PALS and PACS remained significant predictors of POAF (OR:0.72 [0.58-0.89], p=0,002; and OR:0.69 [0.55-0.88], p=0,003). No significant interaction was detected between PALS or PACS and other clinical and echocardiographic variables, including age, E/E\u2019 ratio, left atrial enlargement. Conclusions: This study indicates that adequate surgical timing allows early, significant mass regression and optimal recovery of diastolic function in short and medium postoperative times. PALS and PACS indexes are routinely feasible and useful to predict POAF when applied to the real-world clinical practice. Given the absence of any cue beyond age, LA strain should be routinely considered to assess the pre-operative risk of POAF

Konseling Model Transteoritik dalam Perubahan Perilaku Merokok pada Remaja

Perkembangan perokok di kalangan anak-anak dan remaja semakin meningkat, baik secara kuantitas maupun kualitas. Data Global Youth Tobacco Survey terakhir di tahun 2009, menunjukkan 20,3% anak sekolah 13 - 15 tahun merokok. Perokok pemula usia 10 - 14 tahun naik 2 kali lipat dalam 10 tahun terakhir dari 9,5% pada tahun 2001 menjadi 17,5% pada tahun 2010. Angka perokok pada usia remaja yang tinggi meningkatkan risiko penyakit. Berdasarkan penelitian, para perokok yang terus merokok dalam jangka panjang memiliki risiko kematian tiga kali lebih tinggi daripada mereka yang bukan perokok. Individu mulai merokok disebabkan oleh pengaruh lingkungan sosial, seperti teman-teman, orang tua, dan media sehingga diperlukan suatu konseling terhadap remaja, salah satu metode konseling dengan pendekatan model transteoritik. Dalam beberapa kajian, terbukti model transteoritik efektif dalam mengubah perilaku merokok pada remaja. Berdasarkan kajian tersebut, diharapkan para konselor dalam memberikan konseling hendaknya memperhatikan kesiapan klien dalam mengubah perilaku hidupnya (aktivitas fisik) sesuai dengan tahap-tahapan yang ada dalam model transteoritik.The quantitiy and quality of smoking habits in adolescents are rising, steadily. According to Data Global Youth Tobacco Survey in 2009, showed 20.3% of school children 13 - 15 years were smoking. A beginner smokers aged 10 - 14 years increased 2-fold in the last 10 years from 9.5% in 2001 to 17.5% in 2010. High number of smokers in adolescence will increase the risk of disease. Based on studies, smokers who keep smoking in the long term would face the possibility of death three times higher than nonsmokers. People started to smoke because the influence of the social environment such as friends, parents, and the media thus needed a counseling to adolescents that is one with the approaches of counseling methods transtheoritical model (TTM).Transtheoritical models in several studies provedeffective in changing smoking behavior in adolescents. Based on the study is expected to provide counselors should keep in readiness counseling clients in behavioral change his life (physical activity), it has been doing according to the stages in the transtheoritical model

The influence of foreigners&#8217; buzzing on TripAdvisor ranking of restaurants in Venice: implications for the sustainability of over-touristed heritage cities

Local and global coexist in any tourist destination, and the challenge of tourism sustainability is what remains in the balance between these two dimensions. Social and consumer-generated media are changing how local and global are coming together in the local system. These media\u2019s effects are even more important in overtouristed places, where a significant imbalance between local and tourist development already exists. In this paper, the effects from foreigners\u2019 reviews in crowd-based ranking systems in overtouristed cities are investigated. Based on a case study of TripAdvisor\u2019s restaurant rankings in Venice, our findings suggest that foreigners\u2019 reviews systematically rate tourist experiences\u2019 quality higher than non-foreigners\u2019 reviews, and that their attitude significantly affects the ranking of these experiences. This discloses these systems\u2019 limited reliability in overtouristed cities when it comes to rank quality, as well as the potential risks deriving from their large and uncontrolled adoption. The study concludes that a governance system is needed that is more respectful and inclusive of these places\u2019 specific requirements

REGULASI DIRI DALAM BELAJAR MAHASISWA DITINJAU DARI ORIENTASI TUJUAN DAN KELEKATAN TEMAN SEBAYA

Self-regulated learning is the ability of an individual to play an active role in the learning process both in metacognition, motivation, anda behavior. One of the factors that influence self-regulated learning is goal orientation and peer attachment. The study aims to analyze the&nbsp; relationship between goal orientation and peer attachment with self-regulated in student learning. The implication in this study is how students pursue meaningful learning by using self-regulated in good learning. This type of research is quantitative. The method of data collection in this study was to use three types of psychological scales, namely self-regulates learning, goal orientation, and peer attachment in the from of a questionnaire distributed throught google from media. The subjects in this study were 480 active students of UIN Raden Intan Lampung. The sampling technique using accidental sampling. Validity in this study using content validity and reliability using cronbach’s alpha. In this study using partial correlation and multiple regression data analysis techniques wuth the JASP software version 0.16.3.0. The results in this study obtained a value of R = 0.843 with a value of F = 165.083 (p&lt;0.01) it shows that there is a significant positive relationship between goal orientation and peer attachment with self-regulated learning in university students.&nbsp; Goal orientation variables and peer attachment have an effect of&nbsp; 71.1% on self-regulated learning in university sudents.

An analytical approach to reveal the addition of heat-denatured whey proteins in lab-scale cheese making

A simple analytical procedure for the detection of self-aggregated heat-denatured whey proteins (HDWP) in model cheeses was developed. The principle of the approach lies in the solubilization of the cheese matrix by a sodium citrate solution (0.2 M, pH 7.0) resulting in the dissociation of the casein micelles and the insolubilization of HDWP aggregates, which are collected in the pellet after a centrifugation step. The reliability of the procedure was tested in lab-scale cheeses from peroxidase-positive pasteurized milk with different protein-based ingredients (microparticulated whey protein concentrate, milk protein concentrate, whey protein isolate and Ricotta cheese) at concentrations ranging from 0.2 to 1.2% protein (w/v on cheese milk). A linear relationship between the amount of the HDWP added to cheese milk and that recovered from model cheeses was observed. Heat-damage indicators, furosine and lysinoalanine, showed levels in the experimental cheese samples not related with added HDWP, but represented a source of information on the ingredients other than liquid milk. Overall, in the model cheeses, the proposed method was an easy-to-apply and reliable tool for the evaluation of the presence of HDWP-based products. Further investigation is required for the application to real cheeses and for the evaluation of possible interferences from proteolysis during ripening

Acquis scientifiques et perspectives pour un développement durable des zones arides

L'étude des phénomènes de ruissellement, de transport solide et d'érosion a été menée dans l'Aveyron (piedmont méditerranéen de la façade sud de la France). L'utilisation intensive des terres pour l'élevage ovin, proximité des caves Roquefort, a provoqué une accélération des phénomènes de dégradation des sols. Pour aborder le diagnostic de ce processus, nous avons simulé des séries de pluies dans le cadre de quatre pratiques culturales suivantes : le semis direct ; un labour conventionnel suivi de 2 hersages ; un labour, 2 hersages et 2 passages de rouleau cultipacker ; un travail simplifié (passage vibroculteur suivi de 2 hersages). Chaque traitement a reçu trois averses de 60 mm/h, le protocole suivi comprenait une première pluie sur sol sec, simulant la saison sèche, une seconde pluie, 24 h après la précédente simulant la saison humide et une troisième pluie une heure après reproduisant les conditions de la fin de saison humide. Les résultats obtenus montrent que : l'état de surface évolue en cours d'averse ; le passage fréquent des engins agricoles modifie la structure des sols ; les pertes en terre sont très fortes sur les parcelles nues tassées au cultipacker ; le semis direct est peu érodible, ce qui permet de dire que la suppression du labour est un moyen de lutte contre l'érosion hydrique dans les Rougiers de Camarès (sud Aveyron) et elle permet de réduire le nombre de passage des engins au strict minimum, limitant ainsi la destruction du sol et permettant une éonomie en main d'oeuvre et en énergie. Cette technique de simulation de pluies pourra être appliquée en zones arides caractérisées par la variabilité et la torrentialité du régime pluviométrique. (Résumé d'auteur

Effect of the grape must extraction steps on the content of varietal thiol precursors

The varietal thiols 3-sulfanyl-3-methylpentan-2-one, 3-sulfanylhexan-1-ol and its acetyl ester are the main responsible for boxwood, grapefruit and passion fruit notes of many white wines. These compounds occur in grape only as non-volatile precursors bound to S-glutathionyl- or S-cysteinyl- moieties but they are released by the yeast over the fermentation. However, the amount of these volatile compounds in wine is seldom related to the amount of their precursors in grape [1] because the lyase activity of yeast is a strain-dependent characteristic [2] and the probable contribution of hydrogen sulphide to the neoformation of the volatile thiols [3]. Fracassetti et al. [4, 5] reported massive loss of glutathione and glutathionyl- bounded varietal thiols as result of the grape juice extraction under production in industrial-scale conditions. Particularly, more than 60% of the precursors S-glutathionyl-3-sulfanylhexan-1-ol (GSH-3MH) and its aldehyde form (S-glutathionyl-3-sulfanylhexanal, GSH-3MHAl) got lost from Grillo and Catarratto bianco grape cultivars, the main Sicilian white grape cultivars, as result of the juice extraction. Such a behaviour can seriously detrimentally affect the flavouring properties of the final wine and it points out a further source of the lacking correlation between the amount of precursors in grape and volatile thiols in wine. The reasons for such behaviour were investigated in Grillo grape pressed under industrial-scale production. Must samples were collected after crashing, at draining, at pressing yield of 20%, 40%, 60% and 70%, during transfer in clarification tank, in the clarification tank and after clarification. The must was either air-exposed or air-free during the pre-fermentative steps. Thiol precursors were determined in SPE-purified must samples by UPLC-HRMS [5]. The concentration of thiol precursors detected following the crushing was comparable to the value found in grape, but it dramatically decreases (&lt; 95%) in the must from the press loading. The concentration of thiol precursors increased as the must yield increased, and eventually equals the levels in the grape when a must yield of 60% was achieved. The final loss of thiol precursors was about 80% and 95% for GSH-3MH and GSH-3MHAl, respectively, in the must sampled at the clarification vat (the last juice fraction was excluded). Higher loss of thiol precursors was observed when the must was produced under air-free condition, whereas higher amounts were recorded in laboratory-made must, especially when sodium fluoride or EDTA were added prior the pressing. The results show that the contact of must with the grape skin leads to a loss of thiol precursors. Oxygen seems to be not involved in the oxidative loss of thiol precursor The protective behaviour of the cation-binding compounds suggests that the cations occurring on the grape skin can be responsible for the loss of thiol precursors during the pre-fermentative steps

Penerapan Pembelajaran Kooperatif Model Kartu Arisan untuk Meningkatkan Prestasi Belajar Siswa pada Pokok Bahasan Reaksi Reduksi dan Oksidasi di Kelas X SMA Negeri 5 Pekanbaru

Detailed examination has been completed about subject reduction and oxidation in class X SMAN 5 Pekanbaru. This research aims to increase student achievement on the subject reduction and oxidation in class X SMAN 5 Pekanbaru. This research is a kind of experiment research with pretest-posttest design. The research was conducted in SMAN 5 Pekanbaru. The samples of this research were the students of class X1 as the experimental class and students of class X2 as the control class. Experimental class is a class that is applied the application. Data analysis technique used is the t-test. Based on analysis of data obtained tarithmetic> ttable is 5,53 > 1,67. The conclusion of examination is the application of lottery card model can improve student achievement on the subject of atomic structure class X SMAN 5 Pekanbaru, increase learning of 29,62%