Study of the atmospheric conditions at Cerro Armazones using astronomical data

Aims: We studied the precipitable water vapour (PWV) content near Cerro Armazones and discuss the potential use of our technique of modelling the telluric absorbtion lines for the investigation of other molecular layers. The site is designated for the European Extremely Large Telescope (E-ELT) and the nearby planned site for the Cherenkov Telescope Array (CTA). Methods: Spectroscopic data from the Bochum Echelle Spectroscopic Observer (BESO) instrument were investigated by using line-by-line radiative transfer model (LBLRTM) radiative transfer models for the Earths atmosphere with the telluric absorption correction tool molecfit. All observations from the archive in the period from December 2008 to the end of 2014 were investigated. The dataset completely covers the El Nino event registered in the period 2009-2010. Models of the 3D Global Data Assimilation System (GDAS) were used for further comparison. Moreover, for those days with coincidence of data from a similar study with VLT/X-shooter and microwave radiometer LHATPRO data at Cerro Paranal, a direct comparison is presented. Results: This analysis shows that the site has systematically lower PWV values, even after accounting for the decrease in PWV expected from the higher altitude of the site with respect to Cerro Paranal, using the average atmosphere found with radiosondes. We found that GDAS data are not a suitable method for predicting of local atmospheric conditions - they usually systematically overestimate the PWV values. Due to the large sample, we were furthermore able to characterize the site with respect to symmetry across the sky and variation with the years and within the seasons. This kind of technique of studying the atmospheric conditions is shown to be a promising step into a possible monitoring equipment for CTA.Comment: Accepted for publication in Astronomy and Astrophysics, 7 pages, 9 figure

Fungal and Bacterial Diversity Patterns of Two Diversity Levels Retrieved From a Late Decaying Fagus sylvatica Under Two Temperature Regimes

Environmental fluctuations are a common occurrence in an ecosystem, which have an impact on organismic diversity and associated ecosystem services. The aim of this study was to investigate how a natural and a species richness-reduced wood decaying community diversity were capable of decomposing Fagus sylvatica dead wood under a constant and a fluctuating temperature regime. Therefore, microcosms with both diversity levels (natural and species richness-reduced) were prepared and incubated for 8 weeks under both temperature regimes. Relative wood mass loss, wood pH, carbon dioxide, and methane emissions, as well as fungal and bacterial community compositions in terms of Simpson‘s diversity, richness and evenness were investigated. Community interaction patterns and co-occurrence networks were calculated. Community composition was affected by temperature regime and natural diversity caused significantly higher mass loss than richness-reduced diversity. In contrast, richness-reduced diversity increased wood pH. The bacterial community composition was less affected by richness reduction and temperature regimes than the fungal community composition. Microbial interaction patterns showed more mutual exclusions in richness-reduced compared to natural diversity as the reduction mainly reduced abundant fungal species and disintegrated previous interaction patterns. Microbial communities reassembled in richness-reduced diversity with a focus on nitrate reducing and dinitrogen-fixing bacteria as connectors in the network, indicating their high relevance to reestablish ecosystem functions. Therefore, a stochastic richness reduction was followed by functional trait based reassembly to recover previous ecosystem productivity. © Copyright © 2021 Muszynski, Maurer, Henjes, Horn and Noll

Kollaborative Wege in die Smart City: Dynamische Planungsinstrumente für die kommunale Wärmewende

Im Mittelpunkt dieses Beitrags steht ein kollaborativer Ansatz zur Entwicklung eines dynamischen Wärmekatasters, das als Planungs­instrument für die Wärmewende in der Smart City und zur Erreichung des Ziels klimaneutraler Städte dienen soll. Vor diesem Hintergrund wird aufgezeigt, wie in einem transdisziplinären Technikentwicklungsprozess Elemente der Nutzer*innenbeteiligung zum Tragen kommen und wie auf diese Weise ein an die mehrschichtigen Anforderungen der Stakeholder angepasstes Instrumentarium entwickelt werden kann.This article focuses on a collaborative research approach to developing a dynamic heat map as a planning tool for the heat transition in smart cities and for achieving the goal of climate-neutral cities. Against this background, it is shown how elements of user involvement come into play in a transdisciplinary technology development process and how, in this way, a set of instruments can be developed that is adapted to the multi-layered requirements of the stakeholders

Modulation of Liver Inflammation and Fibrosis by Interleukin-37

Background and Aims: Chronic inflammation induces liver fibrosis, cirrhosis and potentially liver cancer. Kupffer cells modulate hepatic stellate cells by secreting immunologically active proteins as TGF-beta. TGF-beta promotes liver fibrosis via the activation of Sma- and Mad-related protein 3. IL-37 broadly suppresses innate and adaptive immune responses. Intracellular IL-37 interacts with Smad3. We hypothesize that IL-37 downregulates the activation of hepatic Kupffer and stellate cells and interferes with the TGF-beta signaling cascade to modulate liver fibrogenesis. Methods: The role of IL-37 on liver inflammation and fibrogenesis was assessed in three mouse models as well as isolated Kupffer- and stellate cells. Serum IL-37 was tested by ELISA in a clinical cohort and correlated with liver disease severity. Results: Transgene expression of IL-37 in mice extends survival, reduces hepatic damage, expression of early markers of fibrosis and histologically assessed liver fibrosis after bile duct ligation. IL-37tg mice were protected against CCl4-induced liver inflammation. Colitis-associated liver inflammation and fibrosis was less severe in IL-10 knockout IL-37tg mice. Spontaneous and LPS/TGF-beta-induced cytokine release and profibrogenic gene expression was lower in HSC and KC isolated from IL-37tg mice and IL-37 overexpressing, IL-1 beta stimulated human LX-2 stellate cells. However, administration of recombinant human IL-37 did not modulate fibrosis pathways after BDL in mice, LX2 cells or murine HSCs. In a large clinical cohort, we observed a positive correlation of serum IL-37 levels with disease severity in liver cirrhosis. Conclusions: Predominantly intracellular IL-37 downregulates liver inflammation and fibrosis. The correlation of serum IL-37 with disease severity in cirrhosis suggests its potential as a novel target modulating the course of liver fibrosis

Haemodynamically irrelevant pericardial effusion is associated with increased mortality in patients with chronic heart failure

Aims Pericardial effusion (PE) is a common finding in cardiac patients with chronic heart failure. The prognostic relevance of a small, haemodynamically non-compromising PE in such patients, however, remains to be determined. Methods and results All patients referred to our heart failure clinic and having a baseline echocardiography and follow-up clinical visits were included. Patients with a haemodynamically relevant PE, acute myo-/pericarditis, systemic sclerosis, rheumatoid arthritis, heart transplantation, heart surgery within the last 6 months or malignancies within the last 3 years were excluded. Patients with or without a haemodynamically irrelevant PE were compared regarding all-cause mortality as the primary and cardiovascular death or need for heart transplantation as secondary outcomes. A total of 897 patients (824 patients in the control vs. 73 patients in the PE group) were included. In the PE group, left ventricular ejection fraction (LVEF) was lower [31%, interquartile range (IQR): 18.0-45.0] than in controls (34%, IQR: 25.0-47.0; P = 0.04), while the end-systolic diameters of the left ventricle and the left atrium were larger (P = 0.01 and P = 0.001, respectively). Similarly, in patients with PE, the right ventricle (RV) systolic function was lower (P < 0.005 for both the fractional area change and the tricuspid annulus movement), the dimensions of RV and right atrium (RA) were larger (P < 0.05 for RV and P < 0.01 for RA), and the degree of tricuspid regurgitation was higher (P < 0.0001). Furthermore, in the PE group, the heart rate was higher (P < 0.001) and the leukocyte count as well as CRP values were increased (P = 0.004 and P < 0.0001, respectively); beta-blocker use was less frequent (P = 0.04), while spironolactone use was more frequent (P = 0.03). The overall survival was reduced in the PE group compared with controls (P = 0.02). Patients with PE were more likely to suffer cardiovascular death (1-year estimated event-free survival: 86 ± 5 vs. 95 ± 1%; P = 0.01) and to require heart transplantation (1-year estimated event-free survival: 88 ± 4 vs. 95 ± 1%; P = 0.009). A multivariate Cox proportional hazard model revealed the following independent predictors of mortality: (a) PE (P = 0.04, hazard ratio (HR): 1.95, 95% confidence interval (CI): 1.0-3.7), (b) age (P = 0.04, HR: 1.02, 95% CI: 1.0-1.04) and (c) LVEF <35% (P = 0.03, HR: 1.7, 95% CI: 1.1-2.8). Conclusion In chronic heart failure, even minor PEs are associated with an increased risk of all-cause mortality, cardiac death, and need for transplantatio

Internet Retailing as a Marketing Strategy

We analyze the incentives for incumbent bricks-and-mortar firms and new entrants to start an online retail channel in a differentiated goods market. To this end we set up a two-stage model where firms first decide whether or not to build the infrastructure necessary to start an online retail channel and then compete in prices using the channels they have opened up. Consumers trade-off the convenience of online shopping and the ease to compare prices, with online uncertainties. Without a threat of entry by a third pure online player we find that for most parameter constellations firms' dominant strategy is not to open an online retail channel as this cannibalizes too much on their conventional sales. As the cannibalization effect is not present for a pure Internet player, we show that these firms will start online retail channels under a much wider range of parameter constellations. The threat of entry may force incumbent bricks-and-mortar firms to deter entry by starting up an Internet retail channel themselves. We also show that a low cost of building up an online retail channel or online shopping conveniences may not be to the benefit of online shopping as the strategic interaction between firms may be such that no online retail channel is built when the circumstances seem to be more favourable

SL-COMP: Competition of Solvers for Separation Logic

International audienceSL-COMP aims at bringing together researchers interested on improving the state of the art of the automated deduction methods for Separation Logic (SL). The event took place twice until now and collected more than 1K problems for different fragments of SL. The input format of problems is based on the SMT-LIB format and therefore fully typed; only one new command is added to SMT-LIB's list, the command for the declaration of the heap's type. The SMT-LIB theory of SL comes with ten logics, some of them being combinations of SL with linear arithmetics. The competition's divisions are defined by the logic fragment, the kind of decision problem (satisfiability or entailment) and the presence of quantifiers. Until now, SL-COMP has been run on the StarExec platform, where the benchmark set and the binaries of participant solvers are freely available. The benchmark set is also available with the competition's documentation on a public repository in GitHub