From the Vaults: Objects Relating to the Canadian Experience in Hong Kong

This article focuses on the material culture of Canadians’ experiences during and after the Battle of Hong Kong. Stories of combat, captivity, and the return home are told through this selection of personal objects now preserved in the collections of the Canadian War Museum. These artifacts highlight the particular circumstances and harsh conditions faced by prisoners of war and civilian detainees, and serve as entry points into the wider history of the battle, its aftermath and its lasting consequences. Cet article porte sur la culture matérielle des expériences des Canadiens et Canadiennes pendant et après la bataille de Hong Kong. Des histoires de combat, de captivité et de retour au pays sont racontées à travers cette sélection d’objets personnels maintenant conservés dans les collections du Musée canadien de la guerre. Ces artefacts mettent en lumière les circonstances particulières et les conditions difficiles auxquelles sont confrontés les prisonniers de guerre et les détenus civils. Ils servent aussi de points d’entrée dans l’histoire plus large de la bataille, ses répercussions et ses conséquences à long terme

Individual common variants exert weak effects on the risk for autism spectrum disorders.

While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest

Spatial constraints dictate glial territories at murine neuromuscular junctions

Spatial competition between glial cells causes them to partition neuromuscular junctions into discrete domains within a synapse

Effects of a carbohydrate-restricted diet on emerging plasma markers for cardiovascular disease

BACKGROUND: Increasing evidence supports carbohydrate restricted diets (CRD) for weight loss and improvement in traditional markers for cardiovascular disease (CVD); less is known regarding emerging CVD risk factors. We previously reported that a weight loss intervention based on a CRD (% carbohydrate:fat:protein = 13:60:27) led to a mean weight loss of 7.5 kg and a 20% reduction of abdominal fat in 29 overweight men. This group showed reduction in plasma LDL-cholesterol and triglycerides and elevations in HDL-cholesterol as well as reductions in large and medium VLDL particles and increases in LDL particle size. In this study we report on the effect of this intervention with and without fiber supplementation on plasma homocysteine, lipoprotein (a) [Lp(a)], C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). METHODS: Twenty nine overweight men [body mass index (BMI) 25–35 kg/m(2)] aged 20–69 years consumed an ad libitum CRD (% carbohydrate:fat:protein = 13:60:27) including a standard multivitamin every other day for 12 wk. Subjects were matched by age and BMI and randomly assigned to consume 3 g/d of either a soluble fiber supplement (n = 14) or placebo (n = 15). RESULTS: There were no group or interaction (fiber × time) main effects, but significant time effects were observed for several variables. Energy intake was spontaneously reduced (-30.5%). This was accompanied by an increase in protein intake (96.2 ± 29.8 g/d to 107.3 ± 29.7 g/d) and methionine intake (2.25 ± 0.7 g/d, to 2.71 ± 0.78 g/d; P < 0.001). Trans fatty acid intake was significantly reduced (-38.6%) while dietary folate was unchanged, as was plasma homocysteine. Bodyweight (-7.5 ± 2.5 kg) was reduced as was plasma Lp(a) (-11.3%). Changes in plasma Lp(a) correlated with reductions in LDL-cholesterol (r = .436, P < 0.05) and fat loss (r = .385, P < 0,05). At wk 12, both CRP (-8.1%) and TNF-α (-9.3%) were reduced (P < 0.05) independently of weight loss. IL-6 concentrations were unchanged. CONCLUSION: A diet based on restricting carbohydrates leads to spontaneous caloric reduction and subsequent improvement in emerging markers of CVD in overweight/obese men who are otherwise healthy

The origins of Canada's first Eastern Arctic Patrol, 1919-1922

It is widely believed among historians that in 1920, the Danish explorer Knud Rasmussen and the Danish government challenged Canada's sovereignty over Ellesmere Island. This paper draws on a wide range of Canadian and British government files and private papers to contest this view. It demonstrates that Prime Minister Arthur Meighen and others in Ottawa were initially convinced by Vilhjalmur Stefansson that Denmark harboured territorial ambitions in the north, but most realised in the spring of 1921 that they had been mistaken. However, one civil servant, J. B. Harkin, stubbornly maintained his belief in the Danish threat. After Mackenzie King's Liberals came to power, Harkin was able to obtain a hearing for his views. It was largely due to Harkin's persistence that the first Eastern Arctic Patrol went north in 1922

Explorer without a country: The question of Vilhjalmur Stefansson's citizenship

Confusion has long existed on the subject of Vilhjalmur Stefansson's citizenship. A Canadian (that is, a British subject) by birth, Stefansson was brought up and educated in the United States. When his father became an American citizen in 1887, according to the laws of the time Stefansson too became an American. Dual citizenship was not then permitted by either the British or the American laws. Therefore, Stefansson was no longer a British subject. After he took command of the government sponsored Canadian Arctic Expedition in 1913, Stefansson was careful to give the impression that his status had never changed. Although Stefansson swore an oath of allegiance to King George V in May 1913, he did not take the other steps that would have been required to restore him to being Canadian. But, by an American act passed in 1907, this oath meant the loss of Stefansson's American citizenship. In the 1930s American officials informed Stefansson that he must apply for naturalisation in order to regain it. From 1913 until he received his American citizenship papers in 1937, Stefansson was a man without a country